Tag: M.W=200-300

These common heterocyclic compound, 61837-46-5, name is Methyl 2-bromo-4-methylpentanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 61837-46-5

Example 109 2-(6-Chloro-2,3-dioxo-2,3-dihydro-indol-1-yl)-4-methyl-pentanoic acid thiazol-2-ylamide A mixture of sodium hydride (60% in oil, 264 mg) in N,N-dimethylformamide at 0 C. was treated with a solution of 6-chloro-1H-indole-2,3-dione (1.0 g) in N,N-dimethyl formamide (total volume is 25 mL). The reaction mixture was then stirred for 30 min at 0 C. After this time, the reaction mixture was treated with 2-bromo-4-methyl-pentanoic acid methyl ester (prepared as in Example 9, 1.38 g) and stirred for another 1 h at 0 C. The reaction mixture was then allowed to warm to room temperature and stirred for 3 h. After this time, the reaction was diluted with water and extracted with methylene chloride. The organic layers were combined and then dried over sodium sulfate, filtered to remove the drying agent and the filterate concentrated in vacuo. The residue obtained was then purified by silica gel column chromatography to afford 2-(6-chloro-2,3-dioxo-2,3-dihydro-indol-1-yl)-4-methyl-pentanoic acid methyl ester (1.3 g, 76%).

The synthetic route of Methyl 2-bromo-4-methylpentanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kester, Robert Francis; US2012/142705; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 17449-48-8, name is Dimethyl 5-fluoroisophthalate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17449-48-8, Recommanded Product: 17449-48-8

General procedure: An aqueous 1 M NaOH solution (1.0 eq)was added to a solution of diester No.12a-b (1.0 eq) in MeOH (1 mL/0.1 mmol of the diester). Afterstirring at room temperature for 16 h, the solution was acidified with aqueous 5% KHSO4 solution topH 3, diluted with water (20 mL) and extracted with EtOAc (3 x 20 mL). Combined organic extractswere washed with brine (20 mL), dried over anhydrous Na2SO4 and evaporated under reducedpressure to afford monoester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-fluoroisophthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J.; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 344 – 352;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 609-12-1, name is Ethyl 2-bromo-3-methylbutanoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H13BrO2

Under a nitrogen atmosphere, 4. 07 g of potassium ethoxide and 150 mL of purified tetrahydrofuran were added to a 250 mL three-necked flask equipped with a refluxing device and 8 g of ethyl 2-cyclopentyl-2-cyanoacetate was added. The reaction was stirred at room temperature (about 25 C). And then slowly added dropwise to a solution of ethyl 2-bromoisovalerate (9. 2 g) in 50 mL of tetrahydrofuran,And the mixture was heated under reflux for 8 hours. The solvent was then removed by evaporation to give a red viscous liquid and a mixture of white solids. Extracted with ether, washed with water, 5% sodium hydrogencarbonate, and then washed with water until the organic phase was neutral. The organic phase was dried over anhydrous magnesium sulphate for 12 h. Filtering, concentrating the solvent to obtain crude product, and then vacuum distillation, the unreacted raw materials and low boiling point of the material evaporated, 2-cyclopentyl-3-isopropyl-2-cyano-succinate 9. 5 g. The mass spectrum and infrared spectrum of the product were consistent with the structure of the target compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 609-12-1.

Reference:
Patent; China Petroleum & Chemical Corporation; SINOPECBeijing Research InstituteofChemicalIndustry; XIE, LUNJIA; TIAN, YU; FENG, ZAIXING; ZHAO, SIYUAN; SUN, ZHUFANG; (18 pag.)CN104418770; (2016); B;,
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Adding a certain compound to certain chemical reactions, such as: 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41841-16-1, Formula: C9H9BrO2

Step 1: Preparation of methyl 2-(4-bromophenyl)propanoate Methyl 2-(4-bromophenyl)acetate (220 mg) prepared in Step 1 of Example 1 was dissolved in dimethylformamide (3 mL), NaH (53 mg) was added thereto, and the mixture was stirred for 30 mins at room temperature. Iodomethane (0.14 mL) was added to the mixture which was heated to 50 C., followed by stirring for 2 hrs. The reaction mixture was cooled down to room temperature, and water and ethyl acetate were added to form an organic and an aqueous layer. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered and distilled under reduced pressure, and purified by Prep. TLC (n-Hex:EA=1:1) to obtain the title compound (200 mg). 1H NMR (300 MHz, DMSO-d6): delta 7.50 (d, 2H), 7.27 (d, 2H), 3.81 (q, 1H), 3.58 (s, 3H), 1.37 (d, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(4-bromophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HANMI PHARMACEUTICAL CO., LTD.; Park, Chul Hyun; Kim, Won Jeoung; Jung, Young Hee; Kim, Nam Du; Chang, Young Kil; Kim, Maeng Sup; US2014/163226; (2014); A1;,
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Related Products of 35450-37-4, A common heterocyclic compound, 35450-37-4, name is Methyl 3-bromo-4-methoxybenzoate, molecular formula is C9H9BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl 3-bromo-4-methoxybenzoate (0.90 g, 3.67 mmol), [4-(2-ethoxyethoxy)-2,6-dimethylphenyl]boronic acid (0.87 g, 3.67 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.13 g, 0.15 mmol), 2-(dicyclohexylphosphino)biphenyl (79 mg, 0.22 mmol), tripotassium phosphate (1.56 g, 7.34 mmol) and toluene (20 mL) was stirred under a nitrogen atmosphere at 90C for 18 hr. After cooling the reaction mixture, the insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=9/1-hexane/ethyl acetate=1/1) to give the title compound (0.71 g, yield 54%) as a yellow oil. MS (ESI+): 359 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1726580; (2006); A1;,
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Synthetic Route of 99548-54-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a flask was added methyl 3-bromo-2-methylbenzoate (2 Ig, 91.7 mmol), potassium hexacyanoferrate (II) trihydrate (9.7g, 22.9 mmol), Na2Ctheta3 (9.7g, 91.7 mmol) and Pd(OAc)2 (102 mg) in N,N-dimethylacetamide (100 mL). The flask’s atmosphere was evacuated and replaced with nitrogen, and the reaction mixture heated at 1200C for 10 hours. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (150 mL). The resultant slurry was filtered and washed thoroughly with ethyl acetate (2 x 50 mL). The combined filtrate was washed with brine and water, dried over Na2SO4 and evaporated under reduced pressure. The residue obtained after the concentration was purified using flash chromatography (ethyl acetate-hexanes (1:9) as the eluent) to provide methyl 3-cyano-2-methylbenzoate (11.2g, 70% yield). 1H NMR spectrum (in DMSO-d6): delta 8.03 (d, J= 8.1 Hz, IH); 7.98 (d, J= 7.9 Hz, IH); 7.49 (t, IH); 3.84 (s, 3H); 2.65 (s, 3H).

The synthetic route of Methyl 3-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INOTEK PHARMACEUTICALS CORPORATION; WO2008/106619; (2008); A2;,
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These common heterocyclic compound, 150529-73-0, name is Methyl 2-(3-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H9BrO2

INTERMEDIATE 72-(3-BromophenyD-2-methylpropionic acid methyl esterA solution of Intermediate 6 (15.85 g, 69.2 mmol) in THF (50 mL) was added as a steady stream over about 5 minutes to a suspension of sodium hydride (60% dispersion in mineral oil, 8.32 g, 208 mmol) in THF (100 mL) under nitrogen in an ice-water bath whilst maintaining the internal temperature between 1O0C and 200C. After the addition was complete, the mixture was stirred at r.t. for 1 h. The mixture was cooled again in an ice-water bath, and a solution of methyl iodide (10.6 mL, 24.6 g, 173 mmol) in THF (100 mL) was added slowly so as to maintain the temperature of the reaction at <25C. After the addition was complete the mixture was stirred for a further 15 minutes with the ice- water bath, and then for 18 h. The mixture was poured slowly (over a period of about 2 minutes) onto a mixture of ice (approximately 100 g) and saturated ammonium chloride solution (100 mL). The resulting mixture was evaporated and extracted with DCM (2 x 50 mL). The combined organic phases were dried (MgSO4), the solvent removed in vacuo and purified by column chromatography (SiO2, 10-100% EtOAc in heptane) to give the title compound (17.3 g) as a pale straw-coloured oil. deltaH (CDCl3) 7.48 (t, IH), 7.38 (m, IH), 7.23-7.29 (m, IH), 7.19 (t, IH), 3.66 (s, 3H), 1.56 (s, 6H). The synthetic route of Methyl 2-(3-bromophenyl)acetate has been constantly updated, and we look forward to future research findings. Reference:
Patent; UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; WO2010/52448; (2010); A2;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20330-90-9 as follows. Computed Properties of C10H9ClO4

A mixture of dimethyl 5-chloroisophthalate (6.84 g, 30 mmol), in methanol (150 mL) was treated with 1M sodium hydroxide (27 mL, 27 mmol) and the reaction stirred at room temperature for 16 hours. The mixture was concentrated under vacuum and the resulting residue was dissolved in water. The mixture was extracted with ethyl acetate three times. The organic extract was dried over anhydrous sodium sulfate, filtered and concentrated to afford 3-chloro-5-(methoxycarbonyl)benzoic acid (4.8 g, 75%).

According to the analysis of related databases, 20330-90-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gerritz, Samuel; Shi, Shuhao; Zhu, Shirong; US2006/287287; (2006); A1;,
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Application of 57381-59-6, These common heterocyclic compound, 57381-59-6, name is Methyl 5-bromo-2-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sequentially add tri-tert-butylphosphine (88 mg, 0. 437 mmol) in anhydrous 1, 4- dioxane (1 mL), diisopropylethylamine (1. 5 mL, 8. 74 mmol), 5-bromo-2-fluorobenzoic acid methyl ester, (prepared as described in PREPARATION 42), (1. 69 g, 7. 28 mmol) and a solution of 5-ethynylnicotinonitrile, (prepared as described in PREPARATION 4), (0. 93 g, 7. 28 mmol) in anhydrous 1, 4-dioxan (4 mL), to a stirring mixture of dichloro (benzonitrile) palladium (II) (84 mg, 0. 218 mmol) and copper (I) iodide (28 mg, 0. 146 mmol) in anhydrous 1, 4-dioxan (1 mL) under nitrogen. Stir for 2 h and concentrate. Purify the residue twice by silica gel chromatography, eluting with 10 : 90 ethyl acetate : hexanes, to give the title compound as a white solid (0. 9 g, 44%). 1H NMR (400 MHz, CDCl3) 6 1. 48 (s, 3H), 3. 87 (s, 3H), 7. 07-7. 12 (m, 1H), 7. 58-7. 62 (m, 1H), 7. 96-7. 98 (m, 1H), 8. 06 (dd, J = 2. 7 Hz, J = 6. 5 Hz, 1H), 8. 74 (br s, lH), 8. 84 (br s, 1H) ; MS (ES) : m/z = 280. 9 [M+H] +.

The synthetic route of 57381-59-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39503-58-7, name is Methyl 5-bromo-2-methoxy-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks

Amixture of methyl 5-bromo-2-methoxy-4-methylbenzoate (41,100 mg, 0.39 mmol), Zn(CN)2 (31.7 mg, 0.27 mmol), xantphos(2.23 mg, 0.0039 mmol), Pd2(dba)3 (21.2 mg, 0.0232 mmol) andN,N,N’,N’-tetramethylenediamine (8.97 mg, 0.0772 mmol) inanhydrous DMF (1 mL) was placed in a 5 mL tube. Nitrogen wasbubbled through the mixture for 5 min, then the tube was immediatelysealed and heated to 160 C (under microwave irradiations)for 200 s. The mixture was then cooled down to room temperatureand diluted with EtOAc (30 mL). The organic phase was washedwith brine (3*10 mL), dried over Na2SO4, filtered, and concentratedunder reduced pressure. The crude was purified by flash columnchromatography on silica gel (EtOAc in petroleum ether, 0%e50%)to afford the title compound (73 mg, 92%) as a white solid. 1H NMR(400 MHz, CDCl3): delta 8.09 (s, 1H), 6.89 (s, 1H), 3.97 (s, 3H), 3.90 (s,3H), 2.59 (s, 3H). MS m/z 206 [M+H]+.

The synthetic route of 39503-58-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lovering, Frank; Morgan, Paul; Allais, Christophe; Aulabaugh, Ann; Brodfuehrer, Joanne; Chang, Jeanne; Coe, Jotham; Ding, WeiDong; Dowty, Heather; Fleming, Margaret; Frisbie, Richard; Guzova, Julia; Hepworth, David; Jasti, Jayasankar; Kortum, Steve; Kurumbail, Ravi; Mohan, Shashi; Papaioannou, Nikolaos; Strohbach, Joseph W.; Vincent, Fabien; Lee, Katherine; Zapf, Christoph W.; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 606 – 621;,
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