Tag: M.W=200-250

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Product Details of C10H18N2O4.

Huang, Wenlin;Hulverson, Matthew A.;Choi, Ryan;Arnold, Samuel L. M.;Zhang, Zhongsheng;McCloskey, Molly C.;Whitman, Grant R.;Hackman, Robert C.;Rivas, Kasey L.;Barrett, Lynn K.;Ojo, Kayode K.;Van Voorhis, Wesley C.;Fan, Erkang research published 《 Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy》, the research content is summarized as follows. Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently, there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are effective in both in vitro and in vivo models of Cryptosporidium parvum. Potential cardiotoxicity in some BKIs led to the continued exploration of the 5-aminopyrazole-4-carboxamide scaffold to find safe and effective drug candidates for Cryptosporidium. A series of newly designed BKIs were tested for efficacy against C. parvum using in vitro and in vivo (mouse infection model) assays and safety issues. Compound 6 (BKI 1708) was found to be efficacious at 8 mg/kg dosed once daily (QD) for 5 days with no observable signs of toxicity up to 200 mg/kg dosed QD for 7 days. Compound 15 (BKI 1770) was found to be efficacious at 30 mg/kg dosed twice daily (BID) for 5 days with no observable signs of toxicity up to 300 mg/kg dosed QD for 7 days. Compounds 6 and 15 are promising preclin. leads for cryptosporidiosis therapy with acceptable safety parameters and efficacy in the mouse model of cryptosporidiosis.

Product Details of C10H18N2O4, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Formula: C10H18N2O4.

Guo, Zheng;Xie, Jinglei;Hu, Tao;Chen, Yunrong;Tao, Houchao;Yang, Xiaoyu research published 《 Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines》, the research content is summarized as follows. An efficient kinetic resolution of N-aryl β-amino alcs. (S)-RCH(CHR¹OH)NH(3-R²-C₆H₄) (R = Ph, 2-methylphenyl, 4-bromophenyl, naphthalen-2-yl, etc.; R¹ = H, Me, Et, i-Pr; R² = H, Me, OMe, Cl, F) and I (R³ = Et, i-Pr, t-Bu, Bn) has been developed via asym. para-aminations of anilines RCH(CHR¹OH)NH(3-R²C₆H₄) with azodicarboxylates R³OC(O)N=NC(O)OR³ enabled by chiral phosphoric acid catalysis. Broad substrate scope and high kinetic resolution performances were afforded with this method. Control experiments supported the critical roles of the NH and OH group in these reactions.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Formula: C10H18N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Computed Properties of 87-13-8.

Gurjar, Vinod Kumar;Pal, Dilipkumar research published 《 Design, in silico studies, and synthesis of new 1,8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects》, the research content is summarized as follows. New 1,8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and evaluated for their in vivo antihistaminic activity on guinea pig trachea by using chlorpheniramine as the standard drug. It was found that compound 5a1 displayed a promising bronchorelaxant effect in conscious guinea pigs using the in vivo model. A mol. docking study was performed to understand the mol. interaction and binding mode of the compounds in the active site of the H1 receptor. Furthermore, in silico computational studies were also performed to predict the binding modes and pharmacokinetic parameters of these derivatives Prior to the start of exptl. lab work, PASS software was used to predict the biol. activities of these compounds An in silico PASS, Swiss ADME assisted docking approach was found to be suitable to derive and synthesize effective antihistaminic agents for the present study.

Computed Properties of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Category: esters-buliding-blocks.

Haffner, Curt D.;Charnley, Adam K.;Aquino, Christopher J.;Casillas, Linda;Convery, Maire A.;Cox, Julie A.;Elban, Mark A.;Goodwin, Nicole C.;Gough, Peter J.;Haile, Pamela A.;Hughes, Terry V.;Knapp-Reed, Beth;Kreatsoulas, Constantine;Lakdawala, Ami S.;Li, Huijie;Lian, Yiqian;Lipshutz, David;Mehlmann, John F.;Ouellette, Michael;Romano, Joseph;Shewchuk, Lisa;Shu, Arthur;Votta, Bartholomew J.;Zhou, Huiqiang;Bertin, John;Marquis, Robert W. research published 《 Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors》, the research content is summarized as follows. Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallog. was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide 11 represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.

Category: esters-buliding-blocks, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Reference of 87-13-8.

Hassan, Aisha Y.;El Deeb, Moshira A.;Sarg, Marwa T.;El Rabeeb, Shaimaa I. research published 《 Annelation of substituted 3-Hydrazinylimidazo [2,1-c] [1,2,4]triazolone to a series of fused [1,2,4]triazepine and [1,2,4]triazine analogues and evaluation of their anticancer activity》, the research content is summarized as follows. Versatile straightforward synthetic pathways for a novel series of annelated imidazo[2,1-c][1,2,4]triazole derivatives were performed. Newly synthesized compounds were prepared from the reactive binucleophile 3-hydrazinyl-5-(4-methoxybenzylidene)-7-phenyl-5H-imidazo[2,1-c][1,2,4]triazol-6(7H)-one applying different synthetic strategies. The annelated derivatives were different imidazo [2′,1′:3,4] [1,2,4]triazolo [5,1-c] [1,2,4] triazepines; imidazo[2′,1′:3,4] [1,2,4]triazolo [5,1-c] [1,2,4,6]tetrazepine; imidazo[2′,1′:3,4] [1,2,4]triazolo [5,1-c] [1,2,4]triazines and imidazo [1,2-d] [1,2,4]triazolo [4,3-b] [1,2,4]triazole analog. Thirteen compounds had been subjected to screening for in vitro anticancer activity. This screening had been conducted at the National Cancer Institute (NCI), USA at a single dose (10^-5 M) against full NCI 60 cell panel. The screening results indicated a considerable anticancer activity for compoundsI and II against CNS cancer (SNP-75) cell line with growth inhibition percent 46.56 and 42.27, resp. Moreover, a moderate anticancer activity against renal Cancer (UO-31) cell line was common with imidazotriazolotriazepines and imidazotriazolotriazines with growth inhibition percent 31.54-39.52.

Reference of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Electric Literature of 87-13-8.

Hassen, Manel Ben;Masmoudi, Fatma;Zribi, Lazhar;Trigui, Mohamed;Ismaili, Lhassane;Marco-Contelles, Jose;Chabchoub, Fakher research published 《 Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5-a]pyridine Derivatives》, the research content is summarized as follows. Herein, the reaction of 2-(5-aryl-4H-1,2,4-triazol-3-yl)acetonitriles I (R = H, Me) with appropriate Michael acceptors (E)-R¹C(OCH₂CH₃)=C(R²)R³ (R¹ = H, Me, Et; R² = CN, C(O)OCH₂CH₃; R³ = CN, C(O)OCH₂CH₃) gives novel [1,2,4]triazolo[1,5-a]pyridines II and III whose antioxidant properties have been investigated. A plausible reaction mechanism, supported by DFT calculations, has been proposed to explain the total observed regioselective formation of [1,2,4]triazolo[1,5-a]pyridine derivatives II and III depending on the type of substituents on the Michael acceptor.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Electric Literature of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application of C10H18N2O4.

He, Faqian;Shen, Guosong;Yang, Xiaoyu research published 《 Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones》, the research content is summarized as follows. An efficient method for asym. synthesis of acyclic α-tertiary amine derivatives RCCC(O)C(R¹)(R²)N(C(O)OR³)NH(C(O)OR³) (R = cyclopropyl, Ph, thiophen-2-yl, etc.; R¹ = Ph, 4-methoxyphenyl, 3-fluorophenyl, etc.; R² = Me, Et, Bn, etc.; R³ = Et, i-Pr, t-Bu, Bn) has been achieved through enantioselective aminations of α-branched ynones RCCC(O)CH(R¹)R² with azodicarboxylates R³OC(O)N=NC(O)OR³ enabled by chiral phosphoric acid catalysis. Moreover, kinetic resolution of racemic starting material was realized under these conditions, which gave access to valuable enantioenriched α-substituted ketones (R)-RCCC(O)CH(R¹)R². A wide array of α-aryl and alkyl-substitutions, and the substituted alkynyl groups were well compatible with this method, producing both the amination products and the recovered ketones with good to high enantioselectivities.

Application of C10H18N2O4, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Computed Properties of 870-50-8.

Finck, Lucie;Oestreich, Martin research published 《 Transition-Metal-Free Coupling of Polyfluorinated Arenes and Functionalized, Masked Aryl Nucleophiles》, the research content is summarized as follows. A chemoselective C(sp²)-C(sp²) coupling of sufficiently electron-deficient fluorinated arenes and functionalized N-aryl-N’-silyldiazenes as masked aryl nucleophiles is reported. The fluoride-promoted transformation involves the in situ generation of the aryl nucleophile decorated with various sensitive functional groups followed by a stepwise nucleophilic aromatic substitution (S_NAr). These reactions typically proceed at room temperature within minutes. This catalytic process allows for the functionalization of both coupling partners, furnishing highly fluorinated biaryls in good yields. Thus, e.g., diazene I + hexafluorobenzene → II (92%, 79% isolated) in presence of CsF in DMF.

Computed Properties of 870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Name: Diethyl 2-(ethoxymethylene)malonate.

Forezi, Luana da S. M.;Ribeiro, Mariana M. J.;Marttorelli, Andressa;Abrantes, Juliana L.;Rodrigues, Carlos R.;Castro, Helena Carla;Souza, Thiago Moreno L.;Boechat, Fernanda da C. S.;de Souza, Alessandra M. T.;de Souza, Maria Cecilia B. V. research published 《 Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors》, the research content is summarized as follows. Human immunodeficiency virus type 1 (HIV-1) is a public health problem that affects over 38 million people worldwide. Although there are highly active antiretroviral therapies, emergence of antiviral resistant strains is a problem which leads to almost a million death annually. Thus, the development of new drugs is necessary. The viral enzyme reverse transcriptase (RT) represents a validated therapeutic target. Because the oxoquinoline scaffold has substantial biol. activities, including antiretroviral, a new series of 4-oxoquinoline ribonucleoside derivatives obtained by mol. hybridization were studied here. All synthesized compounds, e.g. I (R = H, Me), were tested against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT), and I (R = H, Me) displayed the highest antiviral activities, with IC₅₀ values of 1.4 and 1.6μM, resp. These compounds were less cytotoxic than AZT and showed CC₅₀ values of 1486 and 1394μM, resp. Mol. docking studies showed that the most active compounds bound to the allosteric site of the enzyme, suggesting a low susceptibility to the development of antiviral resistance. In silico pharmacokinetic and toxicol. evaluations reinforced the potential of the active compounds as anti-HIV candidates for further exploration. Overall, this work showed that I (R = H, Me) are promising scaffold for future anti-HIV-1 RT drug design.

Name: Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. SDS of cas: 870-50-8.

Garrison, Aaron T.;Orsi, Douglas L.;Capstick, Rory A.;Whomble, David;Li, Jinming;Carter, Trever R.;Felts, Andrew S.;Vinson, Paige N.;Rodriguez, Alice L.;Han, Allie;Hajari, Krishma;Cho, Hyekyung P.;Teal, Laura B.;Ragland, Madeline G.;Ghamari-Langroudi, Masoud;Bubser, Michael;Chang, Sichen;Schnetz-Boutaud, Nathalie C.;Boutaud, Olivier;Blobaum, Anna L.;Foster, Daniel J.;Niswender, Colleen M.;Conn, P. Jeffrey;Lindsley, Craig W.;Jones, Carrie K.;Han, Changho research published 《 Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M₅ Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder》, the research content is summarized as follows. The muscarinic acetylcholine receptor (mAChR) subtype 5 (M₅) represents a novel potential target for the treatment of multiple addictive disorders, including opioid use disorder. Through chem. optimization of several functional high-throughput screening hits, VU6019650 (27b)(I) was identified as a novel M₅ orthosteric antagonist with high potency (human M₅ IC₅₀ = 36 nM), M₅ subtype selectivity (>100-fold selectivity against human M_1-4) and favorable physicochem. properties for systemic dosing in preclin. addiction models. In acute brain slice electrophysiol. studies, 27b blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area, a part of the mesolimbic dopaminergic reward circuitry. Moreover, 27b also inhibited oxycodone self-administration in male Sprague-Dawley rats within a dose range that did not impair general motor output.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., SDS of cas: 870-50-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics