Tag: M.W=200-250

Liu, Meina; Wang, Xingyou; Miao, Dengyun; Wang, Caiyun; Deng, Wei published the artcile< Synthesis of well-defined heteroglycopolymers via combining sequential click reactions and PPM: the effects of linker and heterogeneity on Con A binding>, Category: esters-buliding-blocks, the main research area is heteroglycopolymer sequential click reaction post polymerization modification.

Heteroglycopolymers displaying different sugar motifs have been increasingly used as tools to investigate the inherent heterogeneity in carbohydrate-protein binding to date. Herein a library of well-defined homo and hetero-glycopolymers consisting of different sugar units in the side chain were generated by reacting poly(pentafluorophenyl acrylate) (pPFPA) with difunctionalized sugar amines via post-polymerization modification, in which one class of sugar motifs is linked by the flexible thiol ether bond while the same or different sugar motifs are connected by the rigid triazole ring in the side chain. A series of difunctionalized sugar amines were synthesized by implementing sequential CuAAC and thiol-ene click reactions, which could serve as a facile methodol. for achieving heterogeneous sugar synthetic blocks with functional control. Isothermal titration calorimetry (ITC) measurements of the obtained glycopolymers with Con A as the model receptor indicated that heterogeneous glycopolymers bearing binding units D-mannose and non-binding sugar motifs in the side chains show higher affinities to Con A as compared to monoglycopolymer. More surprisingly, heterogeneous glycopolymers in which α-D-mannose is linked by the flexible thiol ether bond in the side chain showed higher binding affinity to Con A in comparison with the heterogeneous glycopolymer in which α-D-mannose is linked by the rigid triazole ring since the flexible linker could provide more spaces on the polymer.

Polymer Chemistry published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yiliu; Pauloehrl, Thomas; Presolski, Stanislav I.; Albertazzi, Lorenzo; Palmans, Anja R. A.; Meijer, E. W. published the artcile< Modular Synthetic Platform for the Construction of Functional Single-Chain Polymeric Nanoparticles: From Aqueous Catalysis to Photosensitization>, Electric Literature of 71195-85-2, the main research area is single chain polymer nanoparticle photosensitization photodynamic therapy.

Single-chain polymeric nanoparticles (SCPNs) are intriguing systems for multiple applications. In order to arrive at a controlled, but random, positioning of the different side groups to the polymer backbone, alternative synthetic routes have to be developed. Here, a general postpolymn. modification strategy of poly(pentafluorophenyl acrylate) (pPFPA) is presented as a versatile method to rapidly access functional SCPNs. We first show that the sequential addition of a benzene-1,3,5-tricarboxamide-based amine, acting as the supramol. recognition motif, and water-soluble polyetheramine (Jeffamine) to pPFPA affords random copolymers that fold in water into SCPNs. The scope of the modular platform is illustrated by preparing two types of functional SCPNs. First, we prepared SCPNs designed for bio-orthogonal catalysis by attaching pendant mono(benzimidazoylmethyl)-bis(pyridylmethyl) (Bimpy), phenanthroline (Phen), or 2,2′-bipyridine (BiPy), ligands capable of binding either Cu(I) or Pd(II). The Bimpy- and Phen-containing SCPNs ligated to Cu(I) significantly accelerate azide-alkyne cycloaddition reactions while Bipy-containing SCPNs ligated to Pd(II) efficiently catalyze depropargylation reactions. In all cases, reactions proceeded efficiently in phosphate buffer at a physiol. pH and at low substrate concentrations Next, the potential of SCPNs for photodynamic therapy was evaluated. Introducing porphyrins in SCPNs leads to novel photosensitizers that can produce singlet oxygen (1O2) upon photoirradiation Addnl., by attaching both porphyrins and prodrug models, attached via 1O2-cleavable amino-acrylate linker, to the SCPNs, we show that irradiation of the SCPNs results in a cascade reaction of 1O2 generation followed by cleavage of the amino-acrylate linkers, releasing the drug model. The modular synthesis strategy reported here provides rapid and controlled access to SCPNs with tunable amounts of active units that fulfill different functions.

Journal of the American Chemical Society published new progress about Pharmaceutical nanoparticles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yanxin; Zhang, Han; Zhao, Ying; Guo, Zhongwu; Gao, Jian published the artcile< Efficient Strategy for α-Selective Glycosidation of D-Glucosamine and Its Application to the Synthesis of a Bacterial Capsular Polysaccharide Repeating Unit Containing Multiple α-Linked GlcNAc Residues>, Formula: C11H15NO3, the main research area is stereoselective glycosylation catalyst aminoglycoside preparation disaccharide oligosaccharide.

An efficient α-selective glycosylation method was developed for the synthesis of 2-deoxy-2-amino-D-glucosides based on synergetic α-directing effects of the TolSCl/AgOTf promotion system and the functional groups at the corresponding azido donor 6-O-position to exert steric β-shielding effect or remote participation in the glycosylation reaction. Its practicability was verified with a wide range of monosaccharide glycosyl acceptors and the first, one-pot synthesis of the challenging pentasaccharide repeating unit of an Acinetobacter baumannii K47 capsular polysaccharide.

Organic Letters published new progress about Acinetobacter baumannii. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Formula: C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hao, Qiubo; Wang, Zhixiong; Zhao, Wei; Wen, Liewei; Wang, Wenhui; Lu, Siyu; Xing, Da; Zhan, Meixiao; Hu, Xianglong published the artcile< Dual-Responsive Polyprodrug Nanoparticles with Cascade-Enhanced Magnetic Resonance Signals for Deep-Penetration Drug Release in Tumor Therapy>, Category: esters-buliding-blocks, the main research area is cell penetrating hyperbranched polymer prodrug amphiphile magnetic resonance antitumor; cascade degradation; magnetic resonance imaging; polyprodrug; reduction-responsive drug release; tumor deep penetration.

Smart transformable nanocarriers are promising to treat deep-seated diseases but require adaptable diagnostic/imaging potency to reflect the morphol. change and therapeutic feedback, yet their design and synthesis remains challenging. Herein, stimuli-responsive polyprodrug nanoparticles (SPNs) are formulated from the co-assembly of neg. charged corona and pos. charged polyprodrug cores, exhibiting high loading content of camptothecin (CPT, ~28.6 wt %) tethered via disulfide linkages in the core. SPNs are sequentially sensitive to tumor acidic condition and elevated reductive milieu in the cytosol for deep-penetration drug delivery. Upon accumulation at acidic tumor sites, SPNs dissociate to release smaller pos. charged polyprodrug nanoparticles, which efficiently enter deep-seated tumor cells to trigger high-dosage parent CPT release in the reductive cytosolic milieu. Meanwhile, the polyprodrug cores of SPNs labeled with DTPA(Gd), a magnetic resonance imaging contrast agent, can trace the cascade degradation and biodistribution of SPNs as well as the resulting intracellular CPT release. The longitudinal relaxivity of SPNs increases stepwise in the above two processes. The size-switchable polyprodrug nanoparticles exhibit remarkable tumor penetration and noteworthy tumor inhibition in vitro and in vivo, which are promising for endogenously activated precision diagnostics and therapy.

ACS Applied Materials & Interfaces published new progress about Antitumor agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hou, Zhanyao; Nau, Werner M.; Hoogenboom, Richard published the artcile< Reversible covalent locking of a supramolecular hydrogel via UV-controlled anthracene dimerization>, Recommanded Product: Perfluorophenyl acrylate, the main research area is supramol hydrogel UV irradiation anthracene dimerization.

Supramol. hydrogels gained significant attention as shear-thinning, self-healing materials. However, the introduction of non-covalent crosslinks inherently decreases the strength and stability of the hydrogel. In this work, we developed a novel supramol. hydrogel that undergoes a reversible transformation to the corresponding covalently crosslinked hydrogel upon UV-irradiation The supramol. hydrogel was developed based on the ternary host-guest interaction of two anthracene moieties and one large macrocyclic host. Anthracene functionalized poly(N-acryloylmorpholine)s were synthesized by post-polymerization modification of a copolymer consisting of N-acryloylmorpholine and an activated ester comonomer, whereby two different polymers were prepared having either neutral anthracene side-chains or carrying a pos. charge next to the anthracene to enhance the interaction with the host. The binding affinity of the anthracene side chains with and without an addnl. cationic charge were studied with two macrocyclic hosts, namely cucurbit[8]uril and γ-cyclodextrin (γ-CD) by UV-Vis titration revealing a markedly stronger binding in the presence of the cationic charge due to addnl. ion-dipole one of the macrocyclic hosts, cucurbit[8]uril. Subsequently, the effect of the binding affinity on the hydrogelation was investigated, indicating that the stronger binding affinity facilitated the hydrogel formation at lower concentration Finally, the reversible transformation of the supramol. hydrogel to a chem. hydrogel by anthracene dimerization was studied by the UV irradiation of the hydrogel at 365 nm for covalent crosslinking or at 254 nm for decrosslinking. It could be demonstrated that the dynamic nature of the hydrogel, that is responsible for the shear-thinning behavior, was indeed lost upon UV-irradiation indicative of the formation of a covalently crosslinked hydrogel. The capabilities of the formed supramol. hydrogel that is easily processable and able to reversibly convert to a chem. hydrogel, provides potential applications in applying mech. robust covalently crosslinked hydrogels in complex shapes and difficult to reach locations making use of the dynamic nature of the supramol. crosslinks.

Polymer Chemistry published new progress about Hydrogels. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Shaojian; Schattling, Philipp; Theato, Patrick published the artcile< Thermo- and CO2-responsive linear polymers and hydrogels as CO2 capturing materials>, Recommanded Product: Perfluorophenyl acrylate, the main research area is carbon dioxide responsive polymer hydrogel preparation critical solution concentration.

A series of poly(N-cyclopropyl acrylamide-co-L-Arginine Me ester acrylamide)s (P(CPAM-co-AME)s) with varying arginine content, and corresponding hydrogels (P(CPAM-co-AME) gels) for the CO2 capture were prepared via post-polymerization modification of reactive poly(pentafluorophenyl acrylate) with com. available amines. The resulting polymers are reversibly responsive to temperature and CO2. P(CPAM-co-AME)s can capture CO2 in water and exhibit CO2-switchable LCSTs. The LCSTs transition of P(CPAM-co-AME)s are unusual and decrease after bubbling CO2 through the solution This unusual phenomenon also happens in corresponding hydrogels. P(CPAM-co-AME) gels exhibit a CO2-switchable change in volume after treatment with CO2, i.e., the P(CPAM-co-AME) gels can undergo reversible shrinking and swelling cycles upon alternating treatment with CO2 and Ar, resp. Therefore, P(CPAM-co-AME)s and corresponding gels are suggested as potential polymers for CO2 capture.

Science of Advanced Materials published new progress about Hydrogels. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manfrin, Alessandro; Hanggli, Aline; van den Wildenberg, Jeroen; McNeill, Kristopher published the artcile< Substituent Effects on the Direct Photolysis of Benzotrifluoride Derivatives>, Name: Methyl 3-(trifluoromethyl)benzoate, the main research area is benzotrifluoride derivative direct photolysis substituent effect.

The chem. class of benzotrifluoride derivatives is widely used in active ingredients of various com. products, such as pharmaceuticals, pesticides, herbicides, and crop protection agents. Past studies have shown that some benzotrifluorides are not stable under UV irradiation in water and convert into benzoic acids due to C-F bond hydrolysis. It was also observed, but never systematically studied, that the ring substituents play an important role on the direct photochem. reactivity of the CF3 moiety. In the present work, we explore the structure-reactivity relationship between ring substituent and direct photodefluorination for 16 different substituents, by determining fluoride production rates, quantum yields, and half-lives, and found that strong electron-donating groups enhance the reactivity toward hydrolysis. In addition, flufenamic acid, travoprost, dutasteride, cyflumetofen, flutoanil, and teriflunomide were also examined, finding that their direct photochem. reactivity could be qual. predicted based on their ring substituents. We provide here a tool to evaluate the environmental persistence of benzotrifluoride contaminants, as well as to design more photodegradable new active ingredients.

Environmental Science & Technology published new progress about Defluorination. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Name: Methyl 3-(trifluoromethyl)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eissa, Ahmed M.; Abdulkarim, Ali; Sharples, Gary J.; Cameron, Neil R. published the artcile< Glycosylated Nanoparticles as Efficient Antimicrobial Delivery Agents>, Category: esters-buliding-blocks, the main research area is nanoparticle antibiotic glycosylation polybutyl acrylate.

Synthetic polymer nanoparticles that can be tailored through multivalent ligand display on the surface, while at the same time allowing encapsulation of desired bioactive mols., are especially useful in providing a versatile and robust platform in the design of specific delivery vehicles for various purposes. Glycosylated nanoparticles (glyco-NPs) of a poly(Bu acrylate) (pBA) core and poly(N-2-(β-D-glucosyloxy)ethyl acrylamide) (p(NβGlcEAM)) or poly(N-2-(β-D-galactosyloxy)ethyl acrylamide) (p(NβGalEAM)) corona were prepared via nanopptn. in aqueous solutions of preformed amphiphilic glycopolymers. Well-defined block copolymers of poly(pentafluorophenyl acrylate) (pPFPA) and pBA were first prepared by RAFT polymerization followed by postpolymn. functionalization with aminoethyl glycosides to yield p(NβGlcEAM-b-BA) and p(NβGalEAM-b-BA), which were then used to form glyco-NPs (glucosylated and galactosylated NPs, Glc-NPs and Gal-NPs, resp.). The glyco-NPs were characterized by dynamic light scattering (DLS) and TEM. Encapsulation and release of ampicillin, leading to nanoparticles that we have termed “”glyconanobiotics””, were studied. The ampicillin-loaded glyco-NPs were found to induce aggregation of Staphylococcus aureus and Escherichia coli and resulted in antibacterial activity approaching that of ampicillin itself. This glyconanobiotics strategy represents a potential new approach for the delivery of antibiotics close to the surface of bacteria by promoting bacterial aggregation. Defined release in the proximity of the bacterial envelope may thus enhance antibacterial efficiency and potentially reduce the quantities of agent required for potency.

Biomacromolecules published new progress about Antibacterial agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bracchi, Michael E.; Dura, Gema; Fulton, David A. published the artcile< The Synthesis of poly(arylthiols) and their Utilization in the preparation of cross-linked dynamic covalent polymer nanoparticles and hydrogels>, Related Products of 71195-85-2, the main research area is polyarylthiol crosslinked dynamic covalent polymer nanoparticle hydrogel self assembly.

Dynamic covalent bonds can be utilized to endow polymer-based structures, such as nanoparticles or hydrogel networks, with the abilities to adapt their structures or compositions in response to an external stimuli. In this work we investigate the potential of aromatic thiols, which because they exhibit vastly different reactivities, pKa’s and nucleophilicities in comparison to aliphatic thiols, present an alternative reversible thiol/disulfide system for utilization within polymer-based structures. We demonstrate that water-soluble arylthiol pendant-functional random copolymers capable of forming dynamic disulfide bonds can be prepared and show how they can be cross-linked into polymeric nanoparticles and hydrogel networks through the formation of disulfide cross-links which can then be cleaved to reafford the initial aromatic thiol-functionalized polymers. We highlight how careful control of reaction conditions is required to drive the self-assembly of these polymers into nanoparticles in a process which is predominately under kinetic control. The potential of these arylthiol appended polymers to be utilized within a more complex orthogonal dynamic covalent polymer system also featuring polymer chains cross-linked through reversible imine bond formation was also investigated. This work expands the utility of aromatic disulfides in dynamic polymer systems and will broaden the range and versatility of dynamic covalent disulfide-based materials available to researchers in the fields of nanochem. and functional materials.

Polymer Chemistry published new progress about Crosslinking. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Related Products of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mugemana, Clement; Grysan, Patrick; Dieden, Reiner; Ruch, David; Bruns, Nico; Dubois, Philippe published the artcile< Self-Healing Metallo-Supramolecular Amphiphilic Polymer Conetworks>, Related Products of 71195-85-2, the main research area is pentafluorophenyl acrylate polydimethylsiloxane zinc supramol amphiphilic polymer conetwork.

The current challenge in self-healing materials resides in the design of materials which exhibit improved mech. properties and self-healing ability. The design of phase-separated nanostructures combining hard and soft phases represents an attractive approach to overcome this limitation. Amphiphilic polymer conetworks are nanostructured materials with robust mech. properties, which can be tailored by tuning the polymer composition and chem. functionality. This article highlights the design of phase-separated nanostructured polymers from metallo-supramol. amphiphilic polymer conetworks, and their application for self-healing surfaces. The synthesis of poly(N-(pyridin-4-yl)acrylamide)-l-polydimethylsiloxane polymer conetworks from the poly(pentafluorophenyl acrylate)-l-polydimethylsiloxane activated ester is presented. Loading of ZnCl2 salt into the phase-separated polymer conetwork strengthens the network by crosslinking the poly(N-(pyridin-4-yl)acrylamide) phases, while offering reversible interactions needed for self-healing ability.

Macromolecular Chemistry and Physics published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Related Products of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics