Tag: M.W=200-250

Liu, Meina; Miao, Dengyun; Wang, Xingyou; Wang, Caiyun; Deng, Wei published the artcile< Precise synthesis of heterogeneous glycopolymers with well-defined saccharide motifs in the side chain via post-polymerization modification and recognition with lectin>, Recommanded Product: Perfluorophenyl acrylate, the main research area is heterogeneous glycopolymer post polymerization modification property.

Heterogeneous glycopolymers with different sugar units in the side chain have been receiving considerable attention due to their potential properties in enhancing mol. recognition abilities toward a specific receptor, yet there are limited synthetic approaches to introduce different sugar motifs into the glycopolymer backbone. Herein, a series of heterogeneous glycopolymers consisting of different sugar units in the side chains were synthesized by post-polymerization modification of activated PFPA ester precursor polymers. The functionalized amines bearing two different sugar motifs have been synthesized by gradient CuAAC reaction, which could serve as a platform for achieving heterogeneous sugar units with functional control in concise steps. Isothermal titration calorimetry (ITC) measurements of the obtained glycopolymers with Con A indicated that the heterogeneous glycopolymers, poly(Man-å°¾Glu-OH) and poly(Man-å°¾Ga-OH) bearing ä¼?D-mannose and other non-binding å°?Glucose or å°?Galatose units, show higher affinities toward Con A in comparison to monoglycopolymer poly(Man-Alkyne-OH) in which the non-binding sugar motifs was substituted with non-sugar unit due to synergistic effects of non-binding sugar units. Moreover, this work allows for precise fabrication of a broad variety of glycopolymers in which it significantly broadens the library of accessible polymer structures, either homogeneous or heterogeneous glycopolymers.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Eunsun; Lee, Sun Joo; Moon, Heegyum; Park, Jongmi; Jeon, Hyeonho; Hwang, Ji Sun; Hwang, Hayoung; Hong, Ki Bum; Han, Seung-Hee; Choi, Sun; Kang, Soosung published the artcile< Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors>, Electric Literature of 287114-25-4, the main research area is methyl pyrrolopyridine carboxamide preparation Janus kinase inhibitor mol docking.

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Anal. of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamides I (R = H, Me, cyclopropyl, cyclopentyl) as a JAK1-selective scaffold, and the synthesis of various Me amide derivatives e.g., II, provided III as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of III exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of III on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-�induced hepatic stellate cells (HSCs). Specifically, III significantly inhibited TGF-�induced migration of HSCs at 0.25渭M in wound-healing assays.

Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 287114-25-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H22N2O2, Electric Literature of 287114-25-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sakai, Holt A.; MacMillan, David W. C. published the artcile< Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp3)-C(sp3) Cross-Coupling via Radical Sorting>, Reference of 34637-22-4, the main research area is amide preparation; alc carboxylic acid nontraditional fragment coupling radical sorting photocatalyst.

In this report, the C(sp3)-C(sp3) cross-coupling of alcs. and carboxylic acids through the dual combination of N-heterocyclic carbene (NHC)-mediated deoxygenation and hypervalent iodine-mediated decarboxylation were described. This mild and practical Ni-catalyzed radical-coupling protocol was employed to prepare a wide array of alkyl-alkyl cross-coupled products, including highly congested quaternary carbon centers from the corresponding tertiary alcs. or tertiary carboxylic acids. Synthetic applications of this methodol. to alc. C1-alkylation and formal homologation, as well as to the late-stage functionalization of drugs, natural products, and biomols. were demonstrated.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Reference of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shanthamurthy, Chethan D.; Kikkeri, Raghavendra published the artcile< Linear Synthesis of De novo Oligo-Iduronic Acid>, Synthetic Route of 34637-22-4, the main research area is oligoiduronic acid synthesis IdoA glycosaminoglycan iduronic conformational plasticity.

L-Iduronic acid (IdoA) plays a pivotal role in glycosaminoglycan (GAG) protein interactions. However, the structural microheterogeneity of GAG appears to impede the systematic investigation of IdoA functions. Under such conditions, oligo-Iduronic acid (Oligo-IdoA) are ideal and straightforward heparin mimetics to unravel the relationship between IdoA structure and functions. Herein, we report for the first-time linear synthesis of rare oligo-IdoA precursor utilizing anhydrous β-L-idopyranosyl and IdoA thiophenol building block. After screening various synthetic strategies, we have installed successive IdoA by 5 step reactions with 25-26 % overall yield. These oligo-IdoA are expected to be excellent probes to understand conformational plasticity of IdoA and fine tune carbohydrate-protein interactions.

European Journal of Organic Chemistry published new progress about Glycosaminoglycans Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Synthetic Route of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yefeng; Liu, Peng; Majonis, Daniel; Winnik, Mitchell A. published the artcile< Polymeric dipicolylamine based mass tags for mass cytometry>, Computed Properties of 71195-85-2, the main research area is polymeric dipicolylamine mass tag cytometry.

Mass cytometry is an emerging powerful bioanal. technique for high-dimensional single-cell anal. In this technique, cells are stained with metal-isotope-tagged antibodies and are analyzed by an inductively coupled plasma time-of-flight mass spectrometer. While there are more than 100 stable isotopes available in the m/z 75 to 209 detection range of the instrument, only about 50 parameters can be measured per cell because current reagents are metal-chelating polymers with pendant aminocarboxylate chelators that only bind hard metal ions such as the rare earths and Bi3+. Here we describe the synthesis and characterization of a new type of metal-chelating polymer with pendant dipicolylamine chelators suited to binding intermediate to soft metals such as rhenium and platinum. We introduce two different conjugation strategies, a thiol-maleimide reaction that works well for rhenium, and a DBCO-azide click reaction designed to avoid potential complications of Pt and other heavy metals interacting with thiol groups. We show that these polymers can serve as new elemental mass tags for mass cytometry. Antibody-polymer conjugates of CD20 and CD8a prepared by both coupling reactions were employed in conjunction with com. metal-conjugated antibodies for multi-parameter single-cell immunoassays.

Chemical Science published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Geiselhart, Christina M.; Mutlu, Hatice; Tzvetkova, Pavleta; Barner-Kowollik, Christopher published the artcile< Chemiluminescent self-reporting supramolecular transformations on macromolecular scaffolds>, Computed Properties of 71195-85-2, the main research area is macromol scaffold chemiluminescent self reporting supramol transformation.

We introduce the synthesis of a self-reporting system with chemiluminescent output, which is regulated via dynamic supramol. complex formation. By free radical polymerization and subsequent post-polymerization modification, a copolymer decorated with luminol and superbase (i.e. 1,5,7-triaza-bicyclo-[4.4.0]dec-5-ene (TBD)) moieties was synthesized, which in turn forms supramol. host-guest-complexation with randomly methylated β-cyclodextrin. Upon hydrogen peroxide addition, the host-guest-interactions with the self-assembly are broken, and the luminol is oxidized to 3-aminophthalic acid (3-APA). Critically, no addnl. base, buffer or catalyst is required to generate the striking blue light emission of the polymeric system that is detectable by the naked eye. Thus, a fast and easy detection of reactive oxygen species (ROS), such as hydrogen peroxide, under mild conditions is established. The self-reporting system and its chemiluminescent properties are characterized by 1D and 2D NMR spectroscopy (particularly NOESY), dynamic light scattering (DLS), UV/Vis spectroscopy and chemiluminescence (CL) measurements.

Polymer Chemistry published new progress about Chemiluminescence. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Canale, Vittorio; Frisi, Valeria; Bantreil, Xavier; Lamaty, Frederic; Zajdel, Pawel published the artcile< Sustainable Synthesis of a Potent and Selective 5-HT7 Receptor Antagonist Using a Mechanochemical Approach>, Quality Control of 287114-25-4, the main research area is benzenesulfonamide PZ1361 synthesis antidepressant serotonin 5HT7 receptor.

A mechanochem. procedure was developed to obtain PZ-1361, a potent and selective 5-HT7 receptor antagonist, with antidepressant properties in rodents. The elaborated protocol offered several advantages over classical batch synthesis, including improvement of the overall yield (from 34% to 64%), reduction of reaction time (from 60 to 5.5 h), limitation of the use of toxic solvents, and the formation of byproducts. This approach represents a rare example of the synthesis of biol. active compounds exclusively performed using mechanochem. reactions.

Journal of Organic Chemistry published new progress about 5-HT7 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 287114-25-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H22N2O2, Quality Control of 287114-25-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metz, N.; Lange, B.; Zentel, R.; Theato, P. published the artcile< Functionalized nanoparticles using active ester monomers as shell component>, Application of C9H3F5O2, the main research area is core shell polymer monodisperse nanoparticle preparation.

Colloidal photonic crystals were prepared from monodisperse core-shell particles. The shell is formed from a functional monomer, which can perform chem. reactions and the core from a standard monomer, which yields highly monodisperse colloids. It was possible to crystallize artificial opals with excellent optical properties, which have glycidylmethacrylate or different reactive ester monomers as shell material. Reactions on the functional surface of the colloids were carried out, which lead to a significant rise of mech. stability and to a modification of the surface with biomaterials and subsequent growth of a gold layer.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about Core-shell polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Blazejewski, Jean-Claude; Hofstraat, Johannes W.; Lequesne, Christelle; Wakselman, Claude; Wiersum, Ulfert E. published the artcile< Halogenoaryl acrylates: preparation, polymerization and optical properties>, Application In Synthesis of 71195-85-2, the main research area is acrylate perhalophenyl perhalopyridyl polymer preparation; optical property perhalophenyl acrylate polymer.

Perhaloaryl and perhalo-4-pyridyl acrylates were obtained and their bulk polymerization was studied. Thermal and optical properties of the polymers are described. The light losses of poly(pentafluorophenyl acrylate) at 1300 and 1500 nm were found to be <0.1 and <0.2 dB/cm, resp. Journal of Fluorine Chemistry published new progress about Fluoropolymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application In Synthesis of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Obata, Makoto; Masuda, Satoshi; Takahashi, Masaki; Yazaki, Kohei; Hirohara, Shiho published the artcile< Effect of the hydrophobic segment of an amphiphilic block copolymer on micelle formation, zinc phthalocyanine loading, and photodynamic activity>, Electric Literature of 71195-85-2, the main research area is zinc phthalocyanine amphiphilic block copolymer mieclle photodynamic therapy.

A series of amphiphilic block copolymers, i.e., poly(N-substituted acrylamide)-block-poly(polyethylene glycol monomethyl ether acrylate) (P(R)-b-PPEGA) were prepared via RAFT polymerization and post-polymerization modification, and the formation of polymeric micelles as zinc(II) phthalocyanine (ZnPc) carriers for photodynamic therapy was investigated. The effect of hydrophobic R groups at the hydrophobic segment of the block copolymer on critical micelle concentration, hydrodynamic diameters ZnPc-loading ability, and in vitro photocytotoxicity of the polymer micelles was examined The hydrodynamic diameters of the polymer micelles were insensitive to R groups and falls in a narrow range between 23 and 25 nm, whereas those of the ZnPc-loaded micelles vary from 167 to 230 nm depending on the R groups. The Q bands in UV-vis spectra of the ZnPc-loaded micelles indicate that the presence of aromatic R groups results in loose ZnPc aggregates, whereas those containing aliphatic R groups are well packed. The photodynamic effect examined in RGK-1 cell lines was also dependent on the R groups; ZnPc-loaded micelles having aromatic R groups exert higher photodynamic effect than those with aliphatic R groups. These findings indicate that aromatic R groups form larger polymeric micelles with loosely packed ZnPc aggregates, leading to enhanced release of ZnPc in cellular environment and therefore higher photodynamic effect.

European Polymer Journal published new progress about Critical micelle concentration. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics