Tag: M.W=200-250

Behera, Archanamayee; Rai, Diksha; Kulkarni, Suvarn S. published the artcile< Total Syntheses of Conjugation-Ready Trisaccharide Repeating Units of Pseudomonas aeruginosa O11 and Staphylococcus aureus Type 5 Capsular Polysaccharide for Vaccine Development>, Category: esters-buliding-blocks, the main research area is immunotherapy vaccine protecting group stereoselective glycosylation trisaccharide uronate; trisaccharide Pseudomonas aeruginosa preparation stereoselective glycosylation antibiotic fucosamine antigen.

Here, we report the first total synthesis of the conjugation-ready trisaccharide repeating unit of Pseudomonas aeruginosa O11 via a highly stereoselective and efficient assembly of rare L-fucosamine and D-fucosamine containing 1,2-cis linked disaccharide motif and its regioselective glycosylation at O3. A systematic study was conducted for the notoriously difficult glycosylation with the most un-reactive axial 4-OH of the rare disaccharide and the successful outcome was utilized to accomplish the total synthesis of an aminopropyl linker-attached trisaccharide repeating unit of Staphylococcus aureus capsular polysaccharide type 5, which is also a potential antigen for immunotherapy and vaccine development. Judicious selection of protecting groups and reaction conditions allowed the stereoselective assembly and selective functional group inter-conversions to access the structurally complex linker-attached trisaccharide repeating units, which are valuable tools for immunol. evaluation and vaccine development. The strategy is useful for the synthesis of other structurally related complex glycans.

Journal of the American Chemical Society published new progress about Antibiotics. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lim, Jaehoon; Borg, Lisa zur; Dolezel, Stefan; Schmid, Friederike; Char, Kookheon; Zentel, Rudolf published the artcile< Strategy for Good Dispersion of Well-Defined Tetrapods in Semiconducting Polymer Matrices>, SDS of cas: 71195-85-2, the main research area is strategy dispersion tetrapod semiconducting polymer matrixes; morphology; organic-inorganic hybrids; semiconducting polymers; tetrapods.

The morphol. or dispersion control in inorganic/organic hybrid systems is studied, which consist of monodisperse CdSe tetrapods (TPs) with grafted semiconducting block copolymers with excess polymers of the same type. Tetrapod arm-length and amount of polymer loading are varied in order to find the ideal morphol. for hybrid solar cells. Addnl., polymers without anchor groups are mixed with the TPs to study the effect of such anchor groups on the hybrid morphol. A numerical model is developed and Monte Carlo simulations to study the basis of compatibility or dispersibility of TPs in polymer matrixes are performed. The simulations show that bare TPs tend to form clusters in the matrix of excess polymers. The clustering is significantly reduced after grafting polymer chains to the TPs, which is confirmed exptl. Transmission electron microscopy reveals that the block copolymer-TP mixtures (“”hybrids””) show much better film qualities and TP distributions within the films when compared with the homopolymer-TP mixtures (“”blends””), representing massive aggregations and cracks in the films. This grafting-to approach for the modification of TPs significantly improves the dispersion of the TPs in matrixes of “”excess”” polymers up to the arm length of 100 nm.

Macromolecular Rapid Communications published new progress about Acrylic polymers, fluorine-containing, block, diblock Role: POF (Polymer in Formulation), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, SDS of cas: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Njeri, Dancan K.; Valenzuela, Erik Alvarez; Ragains, Justin R. published the artcile< Leveraging Trifluoromethylated Benzyl Groups toward the Highly 1,2-Cis-Selective Glucosylation of Reactive Alcohols>, COA of Formula: C11H15NO3, the main research area is glycoside disaccharide stereoselective glycosylation catalyst methylsilyl iodide phenyl phosphine.

Here, we demonstrate that substitution of the benzyl groups of glucosyl imidate donors with trifluoromethyl results in a substantial increase in 1,2-cis-selectivity when activated with TMS-I in the presence of triphenylphosphine oxide. Stereoselectivity is dependent on the number of trifluoromethyl groups (4-trifluoromethylbenzyl vs 3,5-bis-trifluoromethylbenzyl). Particularly encouraging is that we observe high 1,2-cis-selectivity with reactive alc. acceptors.

Organic Letters published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, COA of Formula: C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huo, Chang-Xin; Dhara, Debashis; Baliban, Scott M.; Tahmasebi Nick, Setare; Tan, Zibin; Simon, Raphael; Misra, Anup Kumar; Huang, Xuefei published the artcile< Synthetic and immunological studies of Salmonella enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines>, Reference of 34637-22-4, the main research area is synthetic tetrasaccharide Salmonella vaccine.

The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Q� High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antibacterial vaccines. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Reference of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Natalie; Kessler, Daniel; Theato, Patrick published the artcile< Reactive Coatings in Glass Capillaries: Preparation of Temperature- and Light-Responsive Surfaces and Accurate Determination of Wettability Switching>, Electric Literature of 71195-85-2, the main research area is capillary tube wettability wetting contact angle.

The inner walls of thin glass capillaries are coated with a reactive precursor coating that can be converted into different temperature- and light-responsive coatings. The switching range of wettability can be determined by measuring the meniscus height of water inside these capillaries at different temperatures and upon UV-light irradiation In comparison with the sessile drop measurement, very accurate equilibrium contact angles are obtained by this method.

Macromolecular Chemistry and Physics published new progress about Attenuated-total-reflectance IR spectra. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubilis, Artur; Abdulkarim, Ali; Eissa, Ahmed M.; Cameron, Neil R. published the artcile< Giant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions>, HPLC of Formula: 71195-85-2, the main research area is giant polymersome virus particle glycan lectin.

Despite the low complexity of their components, several simple phys. systems, including microspheres, coacervate droplets and phospholipid membrane structures (liposomes), have been suggested as protocell models. These, however, lack key cellular characteristics, such as the ability to replicate or to dock with extracellular species. Here, we report a simple method for the de novo creation of synthetic cell mimics in the form of giant polymeric vesicles (polymersomes), which are capable of behavior approaching that of living cells. These polymersomes form by self-assembly, under electroformation conditions, of amphiphilic, glycosylated block copolymers in aqueous solution The glycosylated exterior of the resulting polymeric giant unilamellar vesicles (GUVs) allows their selective interaction with carbohydrate-binding receptor-functionalized particles, in a manner reminiscent of the cell-surface docking of virus particles. We believe that this is the first example of a simple protocell model displaying cell-like behavior through a native receptor-ligand interaction.

Scientific Reports published new progress about Amphipathicity. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daikos, Olesya; Naumov, Sergej; Knolle, Wolfgang; Heymann, Katja; Scherzer, Tom published the artcile< Peculiarities of the photoinitiator-free photopolymerization of pentabrominated and pentafluorinated aromatic acrylates and methacrylates>, Electric Literature of 71195-85-2, the main research area is photopolymerization pentabrominated pentafluorinated aromatic acrylate methacrylate.

Pentabrominated and fluorinated aromatic (meth)acrylates as well as their non-halogenated counterparts have been studied with the aim to avoid conventional photoinitiators and to overcome some neg. consequences related to their use. Therefore, RTIR spectroscopy, laser flash photolysis and GC/MS were utilized. Even low concentrations (1 to 5 wt%) of brominated (meth)acrylates in the model varnish lead to initiation of a photopolymerization reaction under exposure to UV light with æµ?> 300 nm. This is due to the fact that excitation of the aryl moiety leads to the homolysis of bromine-Ph bonds with a high quantum yield of é–?.15-0.3. Both, bromine radicals released from either ortho, meta or para position as well as the corresponding tetrabromoaryl radicals, may initiate the polymerization of brominated aromatic (meth)acrylates. In contrast, fluorinated aromatic (meth)acrylates undergo æµ?cleavage of the carboxyl group (as in the case of non-halogenated aromatic (meth)acrylates), if excitation of the acrylic double bonds is done with UV-C light (æµ?< 280 nm). Radical formation occurs with a comparable quantum yield of 0.1-0.22 (fluorinated) and 0.16-0.36 (non-halogenated compounds), despite the different pathway of fragmentation. Thus, in all cases the efficiency of initiation is comparable to conventional photoinitiators. Quantum chem. calculations of orbitals involved and of the Gibbs free energy of transients and products support the suggested reaction pathway. Physical Chemistry Chemical Physics published new progress about Density functional theory, B3LYP. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Cong; Feng, Shiyu; Li, Caicong; Sui, Yuan; Shen, Jinghui; Huang, Chongyu; Wu, Yonggang; Huang, Weiguo published the artcile< Synthesizing Organo/Hydrogel Hybrids with Diverse Programmable Patterns and Ultrafast Self-Actuating Ability via a Site-Specific ""In Situ"" Transformation Strategy>, Reference of 71195-85-2, the main research area is organo hydrogel hybrid diverse programmable ultrafast self actuating.

A simple yet robust strategy called “”‘in situ’ transformation”” is developed to prepare organo/hydro binary gels based on the aminolysis of poly(pentafluorophenyl acrylate) (pPFPA). Treated with desired hydrophilic, oleophilic alkylamines, and their mixtures, pPFPA-based organogels can be thoroughly transformed to targeted hydrogels, organogels, and even organohydrogels with outstanding mech. properties. Further, relying on programed aminolysis procedures, site-specific “”in situ”” transformation can be realized, giving rise to organo/hydro binary gels with diverse patterns and morphologies, such as macroscopic layered organo/hydrogel with a smooth-transitioned yet mech. robust interface, reconfigurable microscale organo/hydrogel hybrids with a high spatial-resolution pattern capable of reversibly transforming between 2D sheets and 3D helixes with controlled chirality in different solvents, and core-shell structured organo/hydrogel hybrids with readily adjustable core/shell dimensions, tunable internal stress, and transparency. Finally, an oscillator based on a bilayered organo/hydrogel hybrid is developed. Attributing to the synergistic effect of organogel expansion and hydrogel contraction, as well as the robust interfacial mech. properties, this oscillator is capable of ultrafast self-actuating through harvesting surrounding chem. and thermal energy. This work provides new design principles and highly efficient synthetic strategy for organo/hydro binary gels, and expands their potential applications in soft robotics.

Advanced Functional Materials published new progress about Acrylic polymers, fluorine-containing Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vakili, Mohammad; Cunningham, Victoria J.; Trebbin, Martin; Theato, Patrick published the artcile< Polymerization-Induced Thermal Self-Assembly of Functional and Thermo-Responsive Diblock Copolymer Nano-Objects via RAFT Aqueous Polymerization>, Product Details of C9H3F5O2, the main research area is polymerization induced self assembly diblock copolymer micellization.

The polymerization-induced self-assembly (PISA) of amphiphilic diblock copolymer nano-objects, which are synthesized via reversible addition-fragmentation chain-transfer (RAFT) aqueous polymerization, is discussed. First, the effectiveness of the (S)-2-(Et propionate)-(O-Et xanthate) as a RAFT chain transfer agent for the polymerization of N,N-dimethylacrylamide (DMAm) yielding a water-soluble macro RAFT agent is investigated. In a second step, poly(DMAm) macro-CTA is chain-extended with acrylate monomers in water inducing a PISA process. Besides the use of pentafluorophenyl acrylate (PFPA) as core-forming block, the thermo-responsive nature of N-isopropylacrylamide (NIPAm) and the reactive character of pentafluorophenyl acrylate (PFPA) for a subsequent post-modification is exploited. Monomer conversion and reaction kinetics are determined via NMR spectroscopy, while gel permeation chromatog. is used to evaluate the mol. weight distribution of the polymers. The obtained spherical nanostructures are analyzed via dynamic light scattering, SEM, transmission electron microscopy and at. force microscopy.

Macromolecular Chemistry and Physics published new progress about Emulsion polymerization. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Product Details of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hayward, Adam S.; Eissa, Ahmed M.; Maltman, Daniel J.; Sano, Naoko; Przyborski, Stefan A.; Cameron, Neil R. published the artcile< Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes>, COA of Formula: C9H3F5O2, the main research area is galactose polyHIPE scaffold mammal hepatocyte culture.

Three-dimensional (3D) cell culture is regarded as a more physiol. relevant method of growing cells in the laboratory compared to traditional monolayer cultures. Recently, the application of polystyrene-based scaffolds produced using polyHIPE technol. (porous polymers derived from high internal phase emulsions) for routine 3D cell culture applications has generated very promising results in terms of improved replication of native cellular function in the laboratory These materials, which are now available as com. scaffolds, are superior to many other 3D cell substrates due to their high porosity, controllable morphol., and suitable mech. strength. However, until now there have been no reports describing the surface-modification of these materials for enhanced cell adhesion and function. This study, therefore, describes the surface functionalization of these materials with galactose, a carbohydrate known to specifically bind to hepatocytes via the asialoglycoprotein receptor (ASGPR), to further improve hepatocyte adhesion and function when growing on the scaffold. We first modify a typical polystyrene-based polyHIPE to produce a cell culture scaffold carrying pendent activated-ester functionality. This was achieved via the incorporation of pentafluorophenyl acrylate (PFPA) into the initial styrene (STY) emulsion, which upon polymerization formed a polyHIPE with a porosity of 92% and an average void diameter of 33 娓璵. Histol. anal. showed that this polyHIPE was a suitable 3D scaffold for hepatocyte cell culture. Galactose-functionalized scaffolds were then prepared by attaching 2′-aminoethyl-ç?d-galactopyranoside to this PFPA functionalized polyHIPE via displacement of the labile pentafluorophenyl group, to yield scaffolds with approx. ca. 7-9% surface carbohydrate. Experiments with primary rat hepatocytes showed that cellular albumin synthesis was greatly enhanced during the initial adhesion/settlement period of cells on the galactose-functionalized material, suggesting that the surface carbohydrates are accessible and selective to cells entering the scaffold. This porous polymer scaffold could, therefore, have important application as a 3D scaffold that offers enhanced hepatocyte adhesion and functionality.

Biomacromolecules published new progress about Animal tissue culture. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics