Tag: M.W=200-250

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. HPLC of Formula: 870-50-8.

Morisawa, Takuto;Sawamura, Masaya;Shimizu, Yohei research published 《 Boron-Catalyzed α-Amination of Carboxylic Acids》, the research content is summarized as follows. A boron-catalyzed α-amination of simple carboxylic acids was developed. Catalytically generated boron enolates of carboxylic acids reacted with an electrophilic aminating reagent, diisopropyl azodicarboxylate, to provide amino acid derivatives The catalysis afforded not only α-monosubstituted glycine derivatives but also α,α-disubstituted derivatives The resulting α-aminocarboxylic acid was easily converted to carboxylic acid derivatives Extension to a catalytic asym. variant was possible by introducing a chiral ligand on the boron catalyst.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., HPLC of Formula: 870-50-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. as in the substitution reaction of a carboxylic acid and an alcohol. Application In Synthesis of 870-50-8.

Nakajima, Kazunari;Zhang, Yulin;Nishibayashi, Yoshiaki research published 《 Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions》, the research content is summarized as follows. Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-Bu azodicarboxylate to prepare alkyl amine derivatives under heating conditions. The alkylation reactions via C-C bond cleavage of the dihydropyridines are achieved in the absence of catalysts and additives.

Application In Synthesis of 870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Recommanded Product: Diethyl 2-(ethoxymethylene)malonate.

Nascimento Mello, Angelica Lauria;Sagrillo, Fernanda Savacini;de Souza, Alan Goncalves;Costa, Amanda Rodrigues Pinto;Campos, Vinicius Rangel;Cunha, Anna Claudia;Imbroisi Filho, Ricardo;da Costa Santos Boechat, Fernanda;Sola-Penna, Mauro;de Souza, Maria Cecilia Bastos Vieira;Zancan, Patricia research published 《 Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy》, the research content is summarized as follows. AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering with this enzyme activity has been extensively studied as putative mechanism for cancer therapy. The present work aims to identify a specific AMPK activator for cancer cells among a series of novel heterocyclic compounds A series of novel hybrid heterocyclic compounds, namely naphtoquinone-4-oxoquinoline and isoquinoline-5,8-quinone-4-oxoquinoline derivatives, were synthesized via Michael reaction and their structures confirmed by spectral data: IR; ¹H and ¹³C NMR spectroscopy (COSY, HSQC, HMBC); and high-resolution mass spectrometry (HRMS). The novel compounds were screened and tested for antitumoral activity and have part of their mechanism of action scrutinized. Here, we identified a selective AMPK activator among the new hybrid heterocyclic compounds This new compound presents selective cytotoxicity on breast cancer cells but not on non-cancer counterparts. We identified that by specifically activating AMPK in cancer cells, the drug downregulates unfolded protein response pathway, as well as inhibits mTOR signaling. These effects, that are selective for cancer cells, lead to activation of autophagy and, ultimately, to cancer cells death. Taken together, our data support the promising anticancer activity of this novel compound which is a strong modulator of metabolism

Recommanded Product: Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Recommanded Product: Diethyl 2-(ethoxymethylene)malonate.

Machado Fernandes, Caio;Faro, Leticia V.;Pina, Vitoria G. S. S.;de Souza, Maria Cecilia B. V.;Boechat, Fernanda C. S.;de Souza, Marcos Costa;Briganti, Matteo;Totti, Federico;Ponzio, Eduardo A. research published 《 Study of three new halogenated oxoquinolinecarbohydrazide N-phosphonate derivatives as corrosion inhibitor for mild steel in acid environment》, the research content is summarized as follows. Three new and original halogenated oxoquinolinecarbohydrazide N-phosphonate derivatives (DHOP-F, DHOP-Cl and DHOP-Br) were prepared from the corresponding 4-oxo-1,4-dihydroquinoline-3-carboxylates (81, 71 and 65% yields, resp.), characterized by IR, ¹H, ¹³C and ³¹P NMR spectroscopy and HRMS and evaluated as corrosion inhibitors for mild steel AISI 1020 in hydrochloric acid media. Electrochem. Impedance Spectroscopy, Linear Polarization Resistance and Weight Loss Study revealed an anticorrosive efficiency of 93.0, 84.2 and 66.8%, resp., for DHOP-Br, DHOP-Cl and DHOP-F, at a very low concentration (0.48 mmol L^-1). Phys. chem. calculations showed that the adsorption process is spontaneous, and all mols. obey the Langmuir theory. Data crossing between electrochem. and gravimetric measurements reveals a protection mechanism of adsorption by organic monolayer formation on the metal surface. Polarization curves proves that the organic mols. are all mixed-type corrosion inhibitors and Atomic Force Microscopy images suggest the formation of a protective layer on the metal surface. Ab initio calculations are in great agreement with the exptl. results and, therefore, used to rationalize the reason why the bromide derivative is the best inhibitor.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Recommanded Product: Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Synthetic Route of 87-13-8.

Malbari, Khushboo D.;Chintakrindi, Anand S.;Ganji, Lata R.;Gohil, Devanshi J.;Kothari, Sweta T.;Joshi, Mamata V.;Kanyalkar, Meena A. research published 《 Structure-aided drug development of potential neuraminidase inhibitors against pandemic H1N1 exploring alternate binding mechanism》, the research content is summarized as follows. The rate of mutability of pathogenic H1N1 influenza virus is a threat. The emergence of drug resistance to the current competitive inhibitors of neuraminidase, such as oseltamivir and zanamivir, attributes to a need for an alternative approach. The design and synthesis of new analogs with alternate approach are particularly important to identify the potential neuraminidase inhibitors which may not only have better anti-influenza activity but also can withstand challenge of resistance. Five series of scaffolds, namely aurones (1a-1e), pyrimidine analogs (2a-2b), cinnamic acid analogs (3a-3k), chalcones (4a-4h) and cinnamic acid linkages (5a-5c), were designed based on virtual screening against pandemic H1N1 virus. Mol. modeling studies revealed that the designed analogs occupied 430-loop cavity of neuraminidase. Docking of sialic acid in the active site preoccupied with the docked analogs, i.e. in 430-loop cavity, resulted in displacement of sialic acid from its native pose in the catalytic cavity. The favorable analogs were synthesized and evaluated for the cytotoxicity and cytopathic effect inhibition by pandemic H1N1 virus. All the designed analogs resulting in displacement of sialic acid suggested alternate binding mechanism. Overall results indicated that aurones can be measured best among all as potential neuraminidase inhibitor against pandemic H1N1 virus.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Synthetic Route of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Recommanded Product: Di-tert-butyl diazene-1,2-dicarboxylate.

Mallik, Sumitava;Bhajammanavar, Vinod;Baidya, Mahiuddin research published 《 Regioselective Nitrosocarbonyl Aldol Reaction of Deconjugated Butyrolactams: Synthesis of γ-Heterosubstituted α,β-Unsaturated γ-Lactams》, the research content is summarized as follows. The nitrosocarbonyl aldol reaction of deconjugated butyrolactams is developed employing quinidine as organocatalyst. The nitrosocarbonyl species generated in situ from hydroxamic acids react with a variety of deconjugated butyrolactams at room temperature, offering valuable α,β-unsaturated γ-lactams bearing heterosubstituted quaternary carbon center in very high yields. This nitrosocarbonyl aldol reaction is O-selective and proceeds exclusively at the γ-center of deconjugated butyrolactams. The reaction is scalable, accommodates diverse functional groups, and is also effective with azodicarboxylates.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Recommanded Product: Di-tert-butyl diazene-1,2-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application In Synthesis of 87-13-8.

Mao, Qing;Dai, Xiwen;Xu, Gaoyang;Su, Yu;Zhang, Bing;Liu, Dan;Wang, Shaojie research published 《 Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors》, the research content is summarized as follows. A series of 2-(4-alkoxy-3-cyano)phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivatives I [R = O, NH; R¹ = i-Pr, allyl, Bn, etc.; R² = H, Me] was synthesized as novel xanthine oxidase (XO) inhibitors. These compounds exhibited remarkable in vitro XO inhibitory potency with IC₅₀ values ranging from 0.0181 μM to 0.5677 μM. Specifically, compounds I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂, 2-methylallyl], with IC₅₀ values of 0.0240 μM and 0.0181 μM, resp., emerged as the most potent XO inhibitors and their potencies were comparable to that of febuxostat. Structure-activity relationship anal. revealed that the Me group at 4-position of pyrimidine ring could damage the potency and the XO inhibitory potency was maintained when carbonyl group was changed to an imino group. Lineweaver-Burk plot anal. revealed that the representative compound I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂] acted as a mixed-type inhibitor. A potassium oxonate induced hyperuricemia model in rats was chosen to further confirm the hypouricemic effect of compound I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂] and the results showed that compound I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂] (5 mg/kg) was able to significantly lower the serum uric acid level. Furthermore, in acute oral toxicity study, no sign of toxicity was observed when the mice were administered with a single 2000 mg/kg oral dose of compound I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂]. These results suggested that compound I [R = NH; R¹ = (CH₂)₂CH(CH₃)₂] was a potent and promising uric acid-lowing agent for the treatment of hyperuricemia.

Application In Synthesis of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Reference of 87-13-8.

Maqbool, Mudasir;Rajvansh, Roshani;Srividya, Kottapalli;Hoda, Nasimul research published 《 Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy》, the research content is summarized as follows. Parkinson’s disease (PD), a calamitous neurodegenerative disorder with no cure till date, is closely allied with the misfolding and aggregation of α-Synuclein (α -Syn). Inhibition of α-Syn aggregation is one of the optimistic approaches for the treatment for PD. Here, we carried out hypothesis-driven studies towards synthesizing a series of pyrazolo-pyridine carboxylate containing compounds (7a-7m) targeted at reducing deleterious α-Syn aggregation. The target compounds were synthesized through multi-step organic synthesis reactions. From docking studies, compounds 7b, 7g and 7i displayed better interaction with the key residues of α-Syn with values: -6.8, -8.9 and -7.2 Kcal/mol, resp. In vivo transgenic C. elegans model of Synucleinopathy was used to evaluate the ability of the designed and synthesized compounds to inhibit α-Syn aggregation. These lead compounds 7b, 7g and 7i displayed 1.7, 2.4 and 1.5-fold inhibition of α-Syn with respect to the control. Further, the strategy of employing pyrazolo-pyridine-based compounds worked with success and these scaffolds could be further modified and validated for betterment of endpoints associated with PD.

Reference of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Category: esters-buliding-blocks.

Marra, Roberta K. F.;Kummerle, Arthur E.;Guedes, Guilherme P.;Barros, Caroline de S.;Gomes, Rafaela S. P.;Cirne-Santos, Claudio C.;Paixao, Izabel Christina N. P.;Neves, Amanda P. research published 《 Quinolone-N-acylhydrazone hybrids as potent Zika and Chikungunya virus inhibitors》, the research content is summarized as follows. This work reports the synthesis of quinolone-N-acylhydrazone hybrids, namely 6-R-N’-(2-hydxoxybenzylidene)-4-oxo-1,4-dihydroquinoline-3-carbohydrazide (I; R = H: 5a, F: 5b, Cl: 5c and Br: 5d), which exhibited excellent activity against arbovirus Zika (ZIKV) and Chikungunya (CHIKV). In vitro screening towards ZIKV and CHIKV inhibition revealed that all substances have significant antiviral activity, most of them being more potent than standard Ribavirin (5a-d: EC₅₀ = 0.75-0.81μM, Ribavirin: EC₅₀ = 3.95μM for ZIKV and 5a-d: 1.16-2.85μM, Ribavirin: EC₅₀ = 2.42μM for CHIKV). The quinolone-N-acylhydrazone hybrids were non-toxic against Vero cells, in which compounds 5c and 5d showed the best selectivities (SI = 1410 and 630 against ZIKV and CHIKV, resp.). Antiviral activity was identified by inhibition of viral RNA production in a dose-dependent manner. In the evaluation of the time of addition of the compounds, we observed that 5b and 5c remain with strong effect even in the addition for 12 h after infection. The above results indicate that quinolone-N-acylhydrazones represent a new and promising class to be further investigated as anti-ZIKV and anti-CHIKV agents.

Category: esters-buliding-blocks, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. as in the substitution reaction of a carboxylic acid and an alcohol. Electric Literature of 870-50-8.

Martin, Laura;Maestro, Alicia;Andres, Jose M.;Pedrosa, Rafael research published 《 Bifunctional thiourea-modified polymers of intrinsic microporosity for enantioselective α-amination of 3-aryl-2-oxindoles in batch and flow conditions》, the research content is summarized as follows. Two novel polymers of intrinsic microporosity decorated with chiral thioureas were used as recoverable organocatalysts in enantioselective α-amination of 3-aryl-substituted oxindoles, creating a quaternary stereocenter. Both catalysts were able to promote the reaction in excellent yields and good enantioselection. Catalyst II, with a pyridyl nucleus, was used in recycling experiments maintaining the activity without addnl. reactivation, and in flow processes allowing the synthesis of the amination product in multigram scale.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Electric Literature of 870-50-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics