Tag: M.W=200-250

Gaballa, Heba; Theato, Patrick published the artcile< Glucose-Responsive Polymeric Micelles via Boronic Acid-Diol Complexation for Insulin Delivery at Neutral pH>, Electric Literature of 71195-85-2, the main research area is insulin micelle boronic acid polymer diabetes.

In the present study, glucose-responsive polymeric complex micelles based on the complexation of phenylboronic-acid-based (PBA-based) block copolymer and diol-functionalized polymers are reported. The phenylboronic-acid- and diol-based block copolymers were successfully synthesized in only two reaction steps using reversible addition-fragmentation chain-transfer (RAFT) polymerization and postpolymn. modification of the obtained poly[(N-acryloylmorpholine-block-(N-acryloylmorpholine-co-pentafluorophenyl acrylate)], poly[(AMP-b-(AMP-co-PFPA)], reactive block copolymer. The self-assembly of the complex micelles was investigated under neutral conditions using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The interaction of the PBA block copolymer and diol-containing polymer via boronate ester bond was investigated by 1H NMR and UV-vis spectroscopy. The complex micelles enhanced the glucose responsiveness under physiol. conditions compared to simple PBA micelles. Furthermore, the successful glucose-triggered release of FITC-insulin from the polymeric micelles was investigated.

Biomacromolecules published new progress about Antidiabetic agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Li Qun; Yap, Beatrice Swee Min; Wang, Rong; Neoh, Koon-Gee; Kang, En-Tang; Fu, Guo Dong published the artcile< Catecholamine-Induced Electroless Metallization of Silver on Silica@Polymer Hybrid Nanospheres and Their Catalytic Applications>, HPLC of Formula: 71195-85-2, the main research area is silver electroless metalization catechol modified polyacrylate silica catalyst.

Narrowly dispersed raspberry-like SiO2@poly(dopamine acrylamide-co-methacrylic acid-co-ethylene glycol dimethacrylate)/Ag (or SiO2@PDA/Ag) composite nanospheres were synthesized via a combination of sol-gel reaction, distillation-precipitation polymerization, reactive ester-amine reaction, and electroless metalization. In this approach, SiO2@poly(pentafluorophenyl acrylate-co-methacrylic acid-co-ethylene glycol dimethacrylate) (or SiO2@PPFA) core-shell nanospheres were first prepared by distillation-precipitation polymerization, using the SiO2-3-(trimethoxysilyl)propyl methacrylate (SiO2-MPS) nanospheres from sol-gel reaction as seeds. The reactive pentafluorophenyl (PFP) ester moieties on SiO2@PPFA nanospheres can readily react with dopamine hydrochloride to form amide linkages with no side reaction under a mild condition. The catecholamine moieties in the resulting SiO2@PDA nanospheres were utilized for simultaneous reduction of Ag+ ions and coordinative binding of the metal nanoparticles. The SiO2-MPS, SiO2@PPFA, and SiO2@PDA nanospheres as well as the raspberry-like SiO2@PDA/Ag composite nanospheres were characterized by field-emission transmission electron microscopy (FETEM), thermogravimetric anal. (TGA), dynamic light scattering (DLS), XPS, and FT-IR spectroscopy. Furthermore, the as-synthesized SiO2@PDA/Ag composite nanospheres were explored for the catalytic reduction of p-nitrophenol and degradation of rhodamine 6G (R6G) dye.

Industrial & Engineering Chemistry Research published new progress about Decomposition catalysts. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishiyama, Yoshitake; Misawa, Yoshihiro; Hazama, Yuki; Oya, Kazuhiro; Yoshida, Suguru; Hosoya, Takamitsu published the artcile< Synthesis of diverse 3-Azido-5-(azidomethyl)benzene derivatives via formal C-H azidation and functional group-selective transformations>, Reference of 2557-13-3, the main research area is aliphatic aromatic diazido building block preparation; disubstituted benzene regioselective borylation deborylative azidation key step.

3-Azido-5-(azidomethyl)benzene derivatives are useful compounds for preparing diverse bistriazole compounds and photoaffinity probes for target identification of bioactive compounds To more easily synthesize a diverse range of diazido compounds, a facile method for synthesizing diazido compounds bearing a transformable functional group, such as iodo, bromo, methoxycarbonyl, or cyano group, was developed. This method is based on formal C-H azidation of 1,3-disubstituted benzenes via regioselective borylation followed by deborylative azidation with subsequent transformations, such as that of a one-carbon unit on the benzene ring to an azidomethyl group. The functional groups of the diazido compounds were efficiently transformed to various connecting groups, including carboxy, (succinimidyloxy)carbonyl, hydroxymethyl, formyl, bromomethyl, tosylthiomethyl, ethynyl, diazoacetyl, bromoacetyl, boryl, hydroxy, aminocarbonyl, amino, and isothiocyanato groups, leaving the azido groups untouched. Several diazido building blocks were used to prepare diazido compounds by forming amide, thiourea, and sulfide bonds via conjugation at the connecting groups. These results show that the method described here would facilitate diazido probe syntheses and bistriazole library construction.

Heterocycles published new progress about Azidation. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Reference of 2557-13-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Caicong; Liu, Jie; Peng, Hailong; Sui, Yuan; Song, Jian; Liu, Yang; Huang, Wei; Chen, Xiaowei; Shen, Jinghui; Ling, Yao; Huang, Chongyu; Hong, Youwei; Huang, Weiguo published the artcile< A Camel Nose-Inspired Highly Durable Neuromorphic Humidity Sensor with Water Source Locating Capability>, Name: Perfluorophenyl acrylate, the main research area is camel nose inspired neuromorphic humidity sensor capacitance; artificial synaptic behaviors; excellent durability; high sensitivity and discriminability; intelligent humidity sensors; water source-locating capability.

Numerous emerging applications in modern society require humidity sensors that are not only sensitive and specific but also durable and intelligent. However, conventional humidity sensors do not have all of these simultaneously because they require very different or even contradictory design principles. Here, inspired by camel noses, we develop a porous zwitterionic capacitive humidity sensor. Relying on the synergistic effect of a porous structure and good chem. and thermal stabilities of hygroscopic zwitterions, this sensor simultaneously exhibits high sensitivity, discriminability, excellent durability, and, in particular, the highest respond speed among reported capacitive humidity sensors, with demonstrated applications in the fast discrimination between fresh, stale, and dry leaves, high-resolution touchless human-machine interactive input devices, and the real-time monitoring humidity level of a hot industrial exhaust. More importantly, this sensor exhibits typical synapse behaviors such as paired-pulse facilitation due to the strong binding interactions between water and zwitterions. This leads to learning and forgetting features with a tunable memory, thus giving the sensor artificial intelligence and enabling the location of water sources. This work offers a general design principle expected to be applied to develop other high-performance biochem. sensors and the next-generation intelligent sensors with much broader applications.

ACS Nano published new progress about Annealing. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Name: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cho, Hyungjun; Liu, Peng; Boyle, Amanda J.; Reilly, Raymond M.; Winnik, Mitchell A. published the artcile< Synthesis of a metal-chelating polymer with NOTA pendants as a carrier for 64Cu, intended for radioimmunotherapy>, Category: esters-buliding-blocks, the main research area is metal chelating polymer NOTA pendant copper64 carrier radioimmunotherapy.

As a positron emitter, 64Cu is useful for positron emission tomog. It can also generate Auger electrons that are useful for therapy. Many radioimmunoconjugates labeled with 64Cu involve covalent attachment of bifunctional chelators directly to the antibody (Ab) of interest. To increase its therapeutic potential, a metal-chelating polymer (MCP) with multiple chelators can be conjugated the Ab. In this way, one can incorporate multiple 64Cu ions per Ab. Here we describe the synthesis of a MCP designed for attachment to trastuzumab (tmab), an antibody (Ab) used to treat breast cancer patients with tumors that overexpress human epidermal growth factor receptor 2. We chose 1,4,7-triazacyclononane-N,N′,N′′-triacetic acid (NOTA) chelator to complex with 64Cu, and in our design, the polymer would carry multiple copies of the NOTA chelator as pendant groups. The Cu2+/NOTA complex has a net neg. charge. We began by using RAFT polymerization to synthesize an end-functional poly(2-aminoethyl acrylamide) polymer, in which we could use the amino groups to attach the chelator and other substituents. In a previous study (Biomacromols. 13 (2012) 2831-2842), we found that MCP radioimmunoconjugates with a neg. charge in the repeat unit led to high liver up-take in a mouse model. Thus, we chose to introduce ca. 50% methoxy-dodecaethylene glycol (mPEG12) pendant groups to confer “”stealth””. As a control, we also synthesized a similar polymer with ca. 50% methoxyethyl pendants (EO1). NOTA chelators were attached to remaining pendant groups. We then end-capped the MCPs with succinic acid, radiolabeled the MCPs with 64Cu and injected the radiolabeled MCPs into healthy Balb/c mice via the tail vein. We observed that a large amount of the MCPs were retained in the kidneys. We discuss what properties of the MCPs may have contributed to its accumulation in the kidneys.

European Polymer Journal published new progress about Antibodies and Immunoglobulins Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Zheng; Zhao, Ziwei; Li, Yong; Zhong, Yanxia; Zhang, Qiuyue; Liu, Qingbin; Solan, Gregory A.; Ma, Yanping; Sun, Wen-Hua published the artcile< Ruthenium-catalyzed hydrogenation of CO2 as a route to methyl esters for use as biofuels or fine chemicals>, Name: Methyl 3-(trifluoromethyl)benzoate, the main research area is carbon dioxide hydrogenation methyl ester ruthenium catalyst.

A novel robust diphosphine-ruthenium(II) complex has been developed that can efficiently catalyze both the hydrogenation of CO2 to methanol and its in situ condensation with carboxylic acids to form Me esters; a TON of up to 3260 is achievable for the CO2 to methanol step. Both aromatic and aliphatic carboxylic acids can be transformed to their corresponding Me esters with high conversion and selectivity (17 aliphatic and 18 aromatic examples). On the basis of a series of experiments, a mechanism has been proposed to account for the various steps involved in the catalytic pathway. More importantly, this approach provides a promising route for using CO2 as a C1 source for the production of biofuels, fine chems. and methanol.

Chemical Science published new progress about Biofuels. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Name: Methyl 3-(trifluoromethyl)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Boever, Raphael; Langlois, Adam; Li, Xu; Claverie, Jerome P. published the artcile< Graphitic Dots Combining Photophysical Characteristics of Organic Molecular Fluorophores and Inorganic Quantum Dots>, Application of C9H3F5O2, the main research area is graphitic carbon dot organic mol fluorophore photoluminescence.

Thanks to their photophys. properties, both organic mol. fluorophores (MFs) and inorganic quantum dots (QDs) are extensively used for bioimaging applications. However, limitations such as photobleaching for the former or blinking, size, and toxicity for the latter still constitute a challenge for numerous applications. We report here that embedding MFs in graphitic carbon dots (GDs) results in fluorophores which entirely tackle this challenge. Characterized by ultranarrow, bright, and excitation-independent emission devoid of blinking and photobleaching, these hybrid-featured nanoparticles also demonstrate their unique photophys. performances at the single-nanoparticle scale, making them appealing candidates for bioimaging applications.

JACS Au published new progress about Binding energy. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Sanghwa; Kim, Hwan; Chae, Seungyong; Sohn, Byeong-Hyeok published the artcile< Diblock copolymer micelles as surface-functionalized particles and direct decoration of nanoparticles on their surface>, Related Products of 71195-85-2, the main research area is diblock copolymer micelle surface functionalized particle decoration nanoparticle.

Surface modification is essential to attach optically or catalytically active nanoparticles on the surface of colloidal particles. In this article, we demonstrated that diblock copolymer micelles can be used as surface-functionalized particles and they can be coated with Ag or TiO2 nanoparticles without surface modification. We first obtained dopamine-functionalized diblock copolymers which were synthesized by the reversible addition fragmentation chain transfer polymerization and followed by the post-polymerization modification. By dissolving this amphiphilic diblock copolymer in water, spherical micelles with the dopamine-functionalized coronas were induced, which are essentially equivalent to polymeric particles with dopamine-functionalized surface. Thus, without addnl. surface functionalization, we were able to directly decorate these particles with Ag and TiO2 nanoparticles due to the dopamine functionality on their surface.

Polymer published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Related Products of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Sul Hwa; Patra, Malay; Ferrari, Stefano; Ramirez Garcia, Paulina; Veldhuis, Nicholas A.; Kaminskas, Lisa M.; Graham, Bim; Quinn, John F.; Whittaker, Michael R.; Gasser, Gilles; Davis, Thomas P. published the artcile< Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles>, HPLC of Formula: 71195-85-2, the main research area is phototoxic organometallic rhenium complex star polymer drug delivery nanoparticle; human cervical cancer nanoparticle delivery.

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(i) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N’-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(i) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Branched polymers, star-branched Role: SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiao, Jing; Purro, Max; Liu, Zhi; Xiong, May P. published the artcile< Terpyridine-Micelles for Inhibiting Bacterial Biofilm Development>, Electric Literature of 71195-85-2, the main research area is antibacterial biofilm iron terpyridine micelle; Tpy−micelle; biofilm; cystic fibrosis.

Iron plays a critical role in bacterial infections and is especially critical for supporting biofilm formation. Until recently, Fe(III) was assumed to be the most relevant form of iron to chelate in therapeutic antimicrobial strategies due to its natural abundance under normal oxygen and physiol. conditions. Recent clin. data obtained from cystic fibrosis (CF) patients found that there is actually quite an abundance of Fe(II) present in sputum and that there exists a significant relationship between sputum Fe(II) concentration and severity of the disease. A biocompatible mixed micelle formed from the self-assembly of poly(lactic-co-glycolic acid)-block-methoxy poly(ethylene glycol) (PLGA-b-mPEG) and poly(lactic-co-glycolic acid)-block-poly(terpyridine)5 [PLGA-b-p(Tpy)5] polymers was prepared to chelate Fe(II) (Tpy-micelle). Tpy-micelles showed high selectivity for Fe(II) over Fe(III), decreased biofilm mass more effectively under anaerobic conditions at >4 μM Tpy-micelles, reduced bacteria growth in biofilms by >99.9% at 128 μM Tpy-micelles, effectively penetrated throughout a 1-day old biofilm, and inhibited biofilm development in a concentration-dependent manner. This study reveals that Fe(II) chelating Tpy-micelles are a promising addition to Fe(III) chelating strategies to inhibit biofilm formation in CF lung infections.

ACS Infectious Diseases published new progress about Antibacterial agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics