Tag: M.W=200-250

Niitsu, Nozomi published the artcileAnticancer derivative of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity, COA of Formula: C10H18O4, the publication is Molecular Pharmacology (2000), 58(1), 27-36, database is CAplus and MEDLINE.

Pivalyloxymethyl butyrate (AN9) is an anticancer derivative of butyric acid. In this study, doxorubicin (DXR) and AN9 synergistically inhibited the growth of lymphoma and lung carcinoma cells, whereas there was no synergy between AN9 and antimetabolites. AN9 did not affect the intracellular uptake of DXR. Among anthracyclines and their derivatives, the synergistic effect was prominent in compounds with a daunosamine moiety, suggesting that AN9 may affect the catabolism of these compounds The degradation of DXR in the extract from AN9-treated cells was much less than that in extract from untreated cells. AN9 did not directly inhibit the enzyme activity but rather suppressed expression of the enzyme. With respect to the expression of drug resistance-related genes, there was no significant difference between untreated and AN9-treated cells. However, AN9 significantly down-regulated the levels NADPH-cytochrome P 450 reductase and DT-diaphorase mRNA in the presence of DXR but not the level of xanthine oxidase mRNA. The enhancement of the sensitivity to anthracyclines was closely associated with the suppression of the mRNA expression.

Molecular Pharmacology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, COA of Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sugie, Hajime published the artcileIdentification of the sex pheromone of the three-spotted plusia, Acanthoplusia agnata Staudinger (Lepidoptera: Noctuidae), Formula: C14H26O2, the publication is Applied Entomology and Zoology (1990), 25(4), 467-73, database is CAplus.

The sex pheromone of the three-spotted plusia, A. agnata, was extracted from abdominal tips of virgin females. The crude extract was purified by Florisil column chromatog., HPLC, and gas chromatog. Male moths were released and captured in a field cage to detect the activity of fractionated samples. The sex pheromone components of A. agnata were estimated to be (Z)-7- and (Z)-9-dodecenyl acetates according to anal. by capillary GC and GC-MS. A plastic, capsule-loaded 1.1 mg of mixture of the 2 compounds in a 10:1 ratio attracted male moths under field conditions. Thus, the sex pheromone of A. agnata was determined to be a 10:1 mixture of (Z)-7- and (Z)-9-dodecenyl acetates. This mixture also attracted male moths of Chrysodeixis eriosoma.

Applied Entomology and Zoology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C5H9IO2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Paliwal, Chetan published the artcileDynamic allocation of carbon flux triggered by task-specific chemicals is an effective non-gene disruptive strategy for sustainable and cost-effective algal biorefineries, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 129413, database is CAplus.

Chem. mols. such as butylated hydroxyanisole (CBHA), Pr gallate (CPG), and acetylcholine (CACH) enhance cell growth and/or lipid productivities effectively at the nanomolar concentration (100 nM) in microalgae Scenedesmus dimorphus UTEX1237. The biomass and lipid productivities were improved by 11% (181.60 ± 1.94 mgL-1d-1) and 48% (18.71 ± 0.20 mgL-1d-1), resp., with biomass yields reaching up to 2 g L-1 in CBHA-treated cells compared to Control (Co; 163.62 ± 1.57 mgL-1d-1). In contrast, CACH-treated cells have 41.38% (33.04 ± 0.30 mgL-1d-1), 25.24% (15.88 ± 0.14 mgL-1d-1) and 117% (4.38 ± 0.00μgL-1d-1) higher productivities of carbohydrates, lipids, and tocopherols, resp. compared to Co. However, optimum proteins have been observed in forskolin (CFORS) treatment (59.15 ± 1.83 mgL-1 d-1). The metabolomic anal. illustrates the role of CBHA in the rerouting of carbon flux towards lipids and/or sterols, by enhancing the accumulation of glycolysis-based metabolite, namely acetic acid. At the same time, CACH downregulates it by improving pyruvic acid. In contrast, a citric acid cycle metabolite 2-ketoglutaric acid is downregulated in CACH. These modulators target specific pathways in a given condition to initiate the biosynthesis of metabolites. For instance, Brefeldin (CBREF), Jasmonic acid (CJA), and CACH showed enhancement in total tocopherols and β-carotene. In contrast, all other modulators except CBHA and CACH were also involved in increasing the total carotenoid productivity. Henceforth, such media engineering perspective demonstrates the utilization of specific chems. to dynamically divert the carbon flux towards the biosynthesis of unique metabolites, an effective non-gene disruptive strategy for sustainable and cost-effective algal biorefineries.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Petrushkina, E. A. published the artcileCopper-catalyzed cross-coupling of (Z)-allyl phenyl ethers with Grignard compounds in the synthesis of insect pheromones, Product Details of C14H26O2, the publication is Russian Journal of General Chemistry (2008), 78(10), 1897-1899, database is CAplus.

(8Z)-Dodec-8-en-1-yl acetate (pheromone of oriental fruit moth Grapholita molesta) and (9Z)-dodec-9-en-1-yl acetate (pheromone of grape berry moth Paralobesia viteana) containing impurities of isomeric structures were synthesized via copper-catalyzed cross-coupling of (Z)-1-phenoxyhex-2-ene and (Z)-1-phenoxypent-2-ene, resp., with Grignard compounds in the key stage.

Russian Journal of General Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Product Details of C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hoshino, Koji published the artcileIon-conductive liquid crystals: formation of stable smectic semi-bilayers by the introduction of perfluoroalkyl moieties, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Macromolecular Chemistry and Physics (2002), 203(10/11), 1547-1555, database is CAplus.

Two liquid-crystalline compounds having perfluoroalkyl-terminated mesogens at both ends of poly-(ethylene oxide) chains have been prepared These compounds show smectic A (S_A) and C phases over 100°C. The S_A-Iso (isotropic) transition temperatures are higher by about 70°C than those of the two corresponding alkyl-substituted compounds The incorporation of lithium triflate into the perfluoroalkyl-terminated mesogen-containing compounds widens the temperature ranges of the S_A phases for the resulting complexes. The complexes of these compounds containing 50 mol-% of lithium triflate exhibit columnar phases. The ionic conductivities of the homotropically aligned complexes based on fluoroalkyl-terminated compounds along the direction perpendicular to the mol. director of the S_A phases are higher than those of the corresponding compound containing alkyl groups. The increase of the ionic conductivities as well as the stabilization of the smectic phases for these perfluoroalkyl-terminated compounds may be due to the formation of more stabilized layered structures through the intermol. interactions among the perfluoroalkyl moieties.

Macromolecular Chemistry and Physics published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Watanabe, Junji published the artcileBioconjugate polymer by photo-iniferter approach: Hydrophilic random or block copolymer-coated surface, Application of Benzyl diethylcarbamodithioate, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2009), 29(7), 2287-2293, database is CAplus.

The fabrication of a high-performance polymer material is important, since it would have the potential of being utilized as a highly effective platform for bioconjugation. In the present study, hydrophilic random or block polymers were designed by a photo-iniferter approach. As typical monomers, Bu methacrylate (BMA) and acrylic acid (AA) were selected to prepare a surface modifier on a substrate. As surface modifiers, the monomers were copolymerized in block and random sequences, and the resulting polymer-coated surfaces were compared in terms of surface wettability and the bioconjugation of the fluorescence-labeled protein. The most favorable characteristic of the resulting polymers was that they offered a dual function: the stability of the adsorbed polymer layer and bioconjugation via functional groups. In the present study, the authors focused on the phys. properties of the polymer-coated surface. Bioconjugation and cell viability were also evaluated.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H6BrF3S, Application of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Danko, Lisa published the artcileField evaluation of pheromone-baited traps for monitoring grape berry moth (Lepidoptera: Olethreutidae), Category: esters-buliding-blocks, the publication is Journal of Economic Entomology (1983), 76(3), 480-3, database is CAplus.

Four pheromone trap designs (Pherocon IC, Pherocon ICP, Delta, and Kitterman), trap placement on the trellis, and 2 com. sex pheromone dispensers (Pherocon rubber septa and Albany International capillary tubes) were evaluated for specificity and use for monitoring the grape berry moth (Endopiza viteana, GBM) in Erie County, Pa., during 1979 and 1981 using the pheromone cis-9-dodecenyl acetate  [16974-11-1]. Placement of pheromone dispenser within the trap and an entrance modification on the Delta trap were also studied. The traps were about equal in their ability to capture GBM, although the Pherocon ICP trap captured fewer GBM than the Pherocon IC trap in one test. Both pheromone dispensers were effective in attracting GBM, but the Albany International dispenser attracted significantly more of a nontarget moth, Episimus argutanus. No differences were observed in number of GBM captured when pheromone dispensers were placed at various locations in the various traps. Traps captured the most GBM and were easiest to service when hung from the top trellis wire. The Delta trap captured fewer E. argutanus when the entrance was enlarged by leaving the flaps open. A nontarget species, the redbanded leafroller (Argyrotaenia velutiana) was captured in low numbers in all pheromone and trap combinations.

Journal of Economic Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kang, Suk Hoon published the artcileEmbedding Nanofibers in a Polymer Matrix by Polymerization of Organogels Comprising Heterobifunctional Organogelators and Monomeric Solvents, Category: esters-buliding-blocks, the publication is Chemistry of Materials (2008), 20(17), 5532-5540, database is CAplus.

We demonstrate the embedding of nanofibers in a polymer matrix through the polymerization of an organogel. A series of organogelators based on a biphenyl ester having two different polymerizable groups, namely, acryl and diacetylene groups, are prepared The resulting heterobifunctional gelators show the ability to gelate various monomeric solvents. The photopolymerization of an organogel of a heterobifunctional gelator (1.5 or 10 wt %), formed in hexyl methacrylate (HMA), is carried out by UV irradiation in the presence of 2,2-dimethoxy-2-phenylacetophenone (photoinitiator, 4 wt %). The polymerization of HMA forms a polymer matrix, while the polymerization of the acryl and diacetylene groups of the gelator forms the nanofibers with a cross-linked structure. The copolymerization of a gelator and HMA at the interface will improve the adhesion between the nanofiber and the polymer matrix. The polymerized gels appear yellowish and exhibit strong fluorescence when irradiated with 365 nm UV light. This is due to the presence of polydiacetylene chains. The fluorescent polydiacetylene nanofibers embedded in the polymer matrix are visualized by using confocal laser scanning microscopy. The thermal and mech. properties of the nanofibers embedded in polyHMA are investigated using differential scanning calorimetry, dynamic mech. anal., and a universal testing machine. The polymerized gels show improved thermal and phys. properties in comparison to the matrix polymer (polyHMA).

Chemistry of Materials published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Roelofs, Wendell L. published the artcileBiosynthetic enzymes regulating ratios of sex pheromone components in female redbanded leafroller moths, Safety of (Z)-Dodec-9-en-1-yl acetate, the publication is Bioorganic & Medicinal Chemistry (1996), 4(3), 461-466, database is CAplus and MEDLINE.

Artificial selection of female redbanded leafroller moths that produced either higher or lower ratios of 14-/12-carbon pheromone components was used to study how the biosynthetic pathways were affected in the high and low populations. The chain shortening enzymes were selective for the (E) isomer and so left the 14-carbon acyl intermediates enriched in the (Z) isomer. Thus, the high population, which has a higher amount of 12-carbon components, also has a lower ratio of E11-/Z11-14:OAc pheromone components. The data also suggested that chain shortening occurred prior to reduction and acetylation of the 14-carbon components. These changes are not sufficient to isolate the redbanded leafroller populations, but we discuss some cases where significant changes in pheromone component ratios are affected by the chain-shortening enzymes.

Bioorganic & Medicinal Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Safety of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 50670-76-3, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Quality Control of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics