Tag: M.W=200-250

Tsukamoto, Issei published the artcileOptimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V₂ receptor agonists and discussion of their binding modes, Name: Methyl 4-fluoro-2-(trifluoromethyl)benzoate, the publication is Bioorganic & Medicinal Chemistry (2009), 17(24), 8161-8167, database is CAplus and MEDLINE.

A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives were optimized to achieve potent agonistic activity, both in vitro and in vivo, for the arginine vasopressin V₂ receptor, resulting in the eventual discovery of compound 1g. Mol. modeling of compound 1g with V₂ receptor was also examined to evaluate the binding mode of this series of compounds

Bioorganic & Medicinal Chemistry published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C7H13BrSi, Name: Methyl 4-fluoro-2-(trifluoromethyl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Yuwen published the artcileDetermination of phenolic compounds in beverages by three-flow channel isocratic HPLC with electrochemical detections using a column-switching technique, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is Chemical & Pharmaceutical Bulletin (2022), 70(1), 43-49, database is CAplus.

For the quant. anal. of phenolic compounds in beverage samples, a three-flow channel isocratic HPLC with electrochem. detection (3LC-ECD) system was devised using a column-switching technique. Phenolic compounds with significantly different hydrophobicity (the range of calculated log P: -0.77 to 3.02) were simultaneously measured to draw three chromatograms by the 3LC-ECD; the peaks of gallic acid (GA), protocatechuic acid (PCA), and gallocatechin (GC) were observed at electrochem. detector 1 (D1) within 42 min, the peaks of procyanidin B3 (B3), epigallocatechin (EGC), catechin (C), epicatechin (EC), procyanidin B2 (B2), Et gallate (Eg), and epigallocatechin gallate (EGCg) were observed at D2 within 50 min, and the peaks of epicatechin gallate (ECg), gallocatechin gallate (GCg), catechin gallate (Cg), Pr gallate (Pg), and resveratrol (RVT) were observed at D3 within 70 min. The relationships between the phenolic compound concentrations and their chromatog. peak heights gave good linearity with correlation coefficients of more than 0.998. The detection limits of the phenolic compounds by the 3LC-ECD ranged from 0.6 to 3.0μg/L. Further, the phenolic compound concentrations of com. available teas and wines were determined with a relative standard deviation (RSD) of less than 4.9% (n = 6), and their recoveries ranged from 91 to 109%. These results indicate that the 3LC-ECD system provided an accurate, precise, and specific determination of the phenolic compounds in beverages without affecting the matrixes derived from these samples.

Chemical & Pharmaceutical Bulletin published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C15H23BO2, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Demkowicz, Sebastian published the artcilePhosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors, Category: esters-buliding-blocks, the publication is Drug Development Research (2015), 76(2), 94-104, database is CAplus and MEDLINE.

Preclin. Research In the present work, we report convenient methods for the synthesis and biol. evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 4′-hydroxy-biphenyl-4-carboxylic acid Et ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were tested on STS isolated from human placenta and led to two compounds of interest, 5a and 5d with IC₅₀ values of 28.0 and 22.1 μM, resp. and that had interesting new binding modes in the STS active site. Drug Dev Res, 2015. © 2015 Wiley Periodicals, Inc.

Drug Development Research published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brewer, J. Wayne published the artcileForest Lepidoptera attracted to six synthetic pheromones in Czechoslovakia, Quality Control of 16974-11-1, the publication is Zeitschrift fuer Angewandte Entomologie (1985), 100(4), 372-81, database is CAplus.

The attractiveness of 6 synthetic pheromones to forest Lepidoptera was studied at 2 locations in Czechoslovakia during 1983. The synthetic attractants tested included pheromones for Choristoneura fumiferana (Tortricidae), Eucosma sonomana (Olethreutidae), Lymantria dispar (Lymantriidae), Orgyia pseudotsugata, Rhyacionia frustrana, and R. buoliana. The attractant for R. buoliana, (E)-9-dodecenyl acetate, was prepared in Czechoslovakia for use with European species but the other 5 materials are of North American origin and intended for use with species there. Sticky traps baited with these pheromones captured some 32 species in 26 genera with significant numbers of species as follows: Traps with the C. fumiferana attractant contained Acleris sparsana and Cnephasia stephensiana. Those with the E. sonomana attractant contained Enarmonia formosana and Caradrina morpheus. The L. dispar pheromone attracted 354 L. monacha and merely 14 L. dispar. The traps for O. pseudotsugata contained O. antiqua and those baitedwith the R. frustrana pheromone contained Cnephasia interjectana and Dichrorampha simpliciana. Traps with the R. buoliana attractant contained Gypsonoma oppressana. Thus, substantial species, genus and family cross attraction occurs with some of the synthetic sex attractants tested.

Zeitschrift fuer Angewandte Entomologie published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Quality Control of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thesen, Manuel W. published the artcileInvestigation of spacer influences in phosphorescent-emitting nonconjugated PLED systems, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2010), 48(2), 389-402, database is CAplus.

An assay was introduced to clarify influences on electroluminescent behavior for RGB-colored phosphorescent terpolymers with N,N-Di-p-tolyl-aniline as hole-transporting unit, 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (tert-BuPBD) as electron-transporting unit, and different iridium complexes in RGB-colors as triplet emitting materials. All monomers were attached with spacer moieties to the “para” position of a polystyrene. Polymer light emitting diodes (PLEDs) were built to study the electro-optical behavior of these materials. The gist was a remarkable influence of hexyl-spacer units to the PLED performance. For all three colors only very restricted PLED performances were found. In comparison RGB-terpolymers were synthesized with directly attached charge transport materials to the polymer backbone. For this directly linked systems efficiencies were 28 cd A^-1 @ 6 V (green), 4.9 cd A^-1 @ 5 V (red) and 4.3 cd A^-1 @ 6 V (bluish). In summary we assume that an improved charge percolation pathways regarding to the higher content of semiconducting mols. and an improved charge transfer to the phosphorescent dopant in the case of the copolymers without spacers are responsible for the better device performance comparing the copolymers with hexyl spacers. The approach of the directly connected charge transport materials at the nonconjugated styrene polymer backbone should be favored for further investigations, therefore. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 389-402, 2010.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C9H9NO6S, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pathak, Purnendu Kumar published the artcileA novel electrocatalytic nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated imprinted polymer for ultra-trace sensing of temozolomide, Safety of Benzyl diethylcarbamodithioate, the publication is New Journal of Chemistry (2018), 42(16), 13486-13496, database is CAplus.

A new nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated molecularly imprinted polymer at the surface of a screen-printed carbon electrode was developed for the electroanal. of an anticancerous drug, temozolomide, at the ultra-trace level. For this, a hybrid of reduced graphene oxide/silver nanocubes was successfully obtained through the simultaneous reduction of Ag⁺ and graphene oxide via simple one-pot green synthesis. Among the various shapes of nanomaterials used in imprinted polymer synthesis, silver nanocubes, as evident from SEM, TEM and, X-ray diffraction methods, have been found to render high surface to volume ratios and a higher electrocatalytic activity. Herein, the synergistic electrocatalytic effect of reduced graphene oxide and silver nanocubes was utilized for decreasing the analyte oxidation overpotential, without any interfacial barrier in between the imprinted film and the electrode surface, owing to the porous texture of the coating. Consequently, approx. 3-fold differential pulse anodic stripping current and ∼5-fold electron transfer rate kinetics were obtained on the reduced graphene oxide/silver nanocube hybrid compared with the simple graphene oxide decorated sensor. The covalent Ag-S links, in between the imprinted film and the silver nanocube decorated screen-printed carbon electrode, were crucial for imparting higher stability to the coating of the film. A perfect linearity in the current-concentration profile was observed, in the range 1.09-144.21 ng mL^-1, with the detection limits of 0.16 (aqueous), 0.24 (blood plasma), 0.31 (pharmaceutics), and 0.42 (urine) ng mL^-1 (S/N = 3). The proposed sensor was found to be useful in aqueous and real samples (human blood plasma, human urine, and pharmaceutics), without any matrix effect, cross-reactivity, or false-positives.

New Journal of Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Safety of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prasad, Bhim Bali published the artcileSol-gel derived multiwalled carbon nanotubes ceramic electrode modified with molecularly imprinted polymer for ultra trace sensing of dopamine in real samples, HPLC of Formula: 3052-61-7, the publication is Electrochimica Acta (2011), 56(20), 7202-7211, database is CAplus.

A new class of composite electrodes made of sol-gel derived ceramic-multiwalled C nanotubes was used for the growth of a nanometer thin film adopting surface grafting-from approach. For this the multiwalled C nanotubes-ceramic electrode surface is 1st modified with an iniferter (benzyl N,N-diethyldithiocarbamate) and then dopamine imprinted polymer, under UV irradiation, for differential pulse anodic stripping voltammetric sensing of dopamine in aqueous, blood serum, cerebrospinal fluid, and pharmaceutical samples (detection limit 0.143-0.154 ng mL^-1, 3σ), without any cross reactivity, interferences and false-pos. contributions. Such composite electrodes offer higher stability, electron kinetics, and renewable porous surface of larger electroactive area (with insignificant capacitance) than C ceramic electrodes. Addnl. cyclic voltammetry (stripping mode) and chronocoulometry experiments were performed to explore electrodics and kinetics of electrooxidation of dopamine.

Electrochimica Acta published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

La, JinWook published the artcileEvaluation of solvent effects on the DPPH reactivity for determining the antioxidant activity in oil matrix, Category: esters-buliding-blocks, the publication is Food Science and Biotechnology (2021), 30(3), 367-375, database is CAplus and MEDLINE.

Reactivity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in methanol, ethanol, isopropanol, isooctane, and Et acetate, was evaluated to assess the antioxidant capabilities in medium chain triacylglycerol. DPPH loss values were obtained over 30 min, with sampling every 5 min. Even the same concentration of antioxidants showed different DPPH reactivity depending on solvent. In methanol, 5 min was enough for α-tocopherol to react with DPPH, whereas BHT did not react with DPPH even after 30 min. Gallate series showed higher DPPH reactivity than TBHQ, sesamol, or BHA in methanol, while lower reactivity in isooctane. Antioxidants in ethanol and isopropanol reacted with DPPH less efficiently compared to those in methanol, the exception being sesamol. DPPH reactivity of gallate series in isooctane was lower than that of sesamol, TBHQ, and α-tocopherol. Combinatorial usage of methanol and isooctane for DPPH reactivity could provide reliable information on the antioxidant capacities of chems. in edible oils.

Food Science and Biotechnology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Han, Yilin published the artcileTowards 3D Bioprinted Spinal Cord Organoids, Product Details of C10H12O5, the publication is International Journal of Molecular Sciences (2022), 23(10), 5788, database is CAplus and MEDLINE.

Three-dimensional (3D) cultures, so-called organoids, have emerged as an attractive tool for disease modeling and therapeutic innovations. Here, we aim to determine if boundary cap neural crest stem cells (BC) can survive and differentiate in gelatin-based 3D bioprinted bioink scaffolds in order to establish an enabling technol. for the fabrication of spinal cord organoids on a chip. BC previously demonstrated the ability to support survival and differentiation of co-implanted or co-cultured cells and supported motor neuron survival in excitotoxically challenged spinal cord slice cultures. We tested different combinations of bioink and crosslinked material, analyzed the survival of BC on the surface and inside the scaffolds, and then tested if human iPSC-derived neural cells (motor neuron precursors and astrocytes) can be printed with the same protocol, which was developed for BC. We showed that this protocol is applicable for human cells. Neural differentiation was more prominent in the peripheral compared to central parts of the printed construct, presumably because of easier access to differentiation-promoting factors in the medium. These findings show that the gelatin-based and enzymically crosslinked hydrogel is a suitable bioink for building a multicellular, bioprinted spinal cord organoid, but that further measures are still required to achieve uniform neural differentiation.

International Journal of Molecular Sciences published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Product Details of C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zheng, Jinjian published the artcileA Full Evaporation Static Headspace Gas Chromatography Method with Nitrogen Phosphorous Detection for Ultrasensitive Analysis of Semi-volatile Nitrosamines in Pharmaceutical Products, Safety of Propyl 3,4,5-trihydroxybenzoate, the publication is AAPS Journal (2022), 24(1), 23, database is CAplus and MEDLINE.

The recent detection of potent carcinogenic nitrosamine impurities in several human medicines has triggered product recalls and interrupted the supply of critical medications for hundreds of millions of patients, illuminating the need for increased testing of nitrosamines in pharmaceutical products. However, the development of anal. methods for nitrosamine detection is challenging due to high sensitivity requirements, complex matrixes, and the large number and variety of samples requiring testing. Herein, we report an anal. method for the anal. of a common nitrosamine, N-nitrosodimethylamine (NDMA), in pharmaceutical products using full evaporation static headspace gas chromatog. with nitrogen phosphorous detection (FE-SHSGC-NPD). This method is sensitive, specific, accurate, and precise and has the potential to serve as a universal method for testing all semi-volatile nitrosamines across different drug products. Through elimination of the detrimental headspace-liquid partition, a quantitation limit of 0.25 ppb is achieved for NDMA, a significant improvement upon traditional LC-MS methods. The extraction of nitrosamines directly from solid sample not only simplifies the sample preparation procedure but also enables the method to be used for different products as is or with minor modifications, as demonstrated by the anal. of NDMA in 10+ pharmaceutical products. The in situ nitrosation that is commonly observed in GC methods for nitrosamine anal. was completely inhibited by the addition of a small volume solvent containing pyrogallol, phosphoric acid, and isopropanol. Employing simple procedures and low-cost instrumentation, this method can be implemented in any anal. laboratory for routine nitrosamine anal., ensuring patient safety and uninterrupted supply of critical medications.

AAPS Journal published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C24H29N5O3, Safety of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics