Tag: M.W=200-250

Leonhardt, B. A. published the artcileGas chromatographic mass spectrometric indication of double bond position in monounsaturated primary acetates and alcohols without derivatization, Formula: C14H26O2, the publication is Organic Mass Spectrometry (1983), 18(1), 9-11, database is CAplus.

Electron impact mass spectra of 54 straight chain, monounsaturated C₁₂, C₁₄, and C₁₆ alcs. and their corresponding acetates are useful in the determination of the double bond position on an empirical basis. The ratio of intensities of the m/z 55 and m/z 54 ions increases proportionately as the double bond is moved away from the acetate or alc. functional group. The intensity to the m/z 61 ion also can be correlated with the double bond position. Results are generally accurate to ±1 C atom.

Organic Mass Spectrometry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Drzewinski, W. published the artcileOrthoconic antiferroelectrics. Synthesis and mesomorphic properties of optically active (S)-(+)-4-(1-methylheptyloxycarbonyl)phenyl 4′-(fluoroalkanoyloxyalkoxy)biphenyl-4-carboxylates and 4′-(alkanoyloxyalkoxy)biphenyl-4-carboxylates, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Polish Journal of Chemistry (2002), 76(2-3), 273-284, database is CAplus.

Convenient methods for preparing optically active (S)-(+)-4-RCO₂(CH₂)_mOC₆H₄C₆H₄CO₂C₆H₄CO₂CHMe(CH₂)₅Me [R = Me, Et, Pr, F₃CCH₂CH₂, F₃CCF₂CF₂] and their intermediates are described. The phase transitions of the prepared esters have been investigated by differential scanning calorimetry.

Polish Journal of Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Drzewinski, Witold published the artcileAntiferroelectric liquid crystals with fluorinated parts of terminal chains. I. Synthesis of liquid crystalline compounds and their intermediates, Category: esters-buliding-blocks, the publication is Biuletyn Wojskowej Akademii Technicznej (1998), 47(7-8), 53-68, database is CAplus.

The method of preparing the optically active hydroxyesters: 1-hydroxy-4-(octyl-2-oxycarbonyl)benzene, 4-hydroxy-4′-(octyl-2-oxycarbonyl)biphenyl, 4-(octyl-2-oxycarbonyl)-Ph 4′-hydroxybiphenyl-4-carboxylate and 4′-(octyl-2-oxycarbonyl)biphenyl-4-yl 4-hydroxybenzoate, has been elaborated. These intermediates were used for the synthesis of liquid crystalline homologous series of di- and triesters exhibiting the presence of tilted phases C_A^* and C^*.

Biuletyn Wojskowej Akademii Technicznej published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Shaofu published the artcileA splitless injector for capillary gas chromatography in the trace analysis of insect pheromones, Category: esters-buliding-blocks, the publication is Kunchongxue Yanjiu Jikan (1986), 265-70, database is CAplus.

A splitless injector for gas chromatog. with a septum purge and liner purge flow for clearing off materials from the septum and minimizing solvent tails was designed and made, which can increase injected volume and sensitivity. The splitless injector was set up on a SP-103 gas chromatograph and used for the determination of insect pheromones. By using the splitless injector and a PEG-20 M capillary column, satisfactory results were obtained in separating geometrical and positional isomers of insect pheromones. The splitless injector is suitable for the determination of insect pheromones and other trace anal.

Kunchongxue Yanjiu Jikan published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C4H11NO, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dey, Tanmay published the artcileApoplastic reactive oxygen species mediated escape growth of root during illumination in Vigna radiata (L.) Wilczek seedlings, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is Acta Physiologiae Plantarum (2021), 43(11), 145, database is CAplus.

Besides gravity, roots are also guided by light to grow deep into the soil and sensitivity of roots to light is evidently due to presence of photoreceptors like phototropins. Such light-induced root growth (light-escape growth) presumably involves reactive oxygen species (ROS). Present study explores the possibility of ROS action in this event during early seedling growth of Vigna radiata based on pharmacol. evidences. Germinated (20 h) seeds were incubated in dark or light in presence of general ROS scavenger (Pr gallate), specific scavengers of O^·₂^– (copper chloride; CuCl₂), H₂O₂ [dimethylthiourea (DMTU) and potassium iodide (KI)] and ^·OH (sodium benzoate) and ROS-producing enzyme inhibitors [zinc chloride (ZnCl₂), inhibitor of NADPH oxidase (NOX); diethyldithiocarbamate (DEDTC), inhibitor of superoxide dismutase (SOD) and salicylhydroxamic acid (SHAM), inhibitor of peroxidase]. Light-induced root growth of 3-day seedlings diminished signifcantly in case of all the treatments suggesting for a pos. role of ROS in light-escape growth. This is supported by elevated level of apoplastic ROS in light grown roots as evident from ROS-specific staining [nitroblue tetrazolium chloride (NBT) for O^·₂^– and 3,3,5,5-tetramethylbenzidine (TMB) for H₂O₂] and spectrophotometric estimation of apoplastic ROS production (O^·₂^– and H₂O₂). In addition, higher activity of membrane bound NOX (producing O^·₂^– ) and apoplastic class III peroxidase (Prx, producing ^·OH) in light grown roots further corroborates the view that apoplastic ROS (initiated with NOX-generated O^·₂^– , which is converted, either spontaneously or by the activity of SOD, to H₂O₂ and further metabolized by Prx to ^·OH that participates in cell wall relaxation required for growth) is instrumental in light-escape growth of roots.

Acta Physiologiae Plantarum published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sartwell, Charles published the artcileMating disruption of western pine shoot borer (Lepidoptera: Tortricidae) with widely spaced releasers of synthetic pheromone, COA of Formula: C14H26O2, the publication is Journal of Economic Entomology (1983), 76(5), 1148-51, database is CAplus.

Damage by Eucosma sonomana to Pinus ponderosa was significantly reduced (46-73%) by mating disruption with low seasonal dosages (3.5-5 g/ha) of a synthetic pheromone, a 4:1 mixture of (Z)-9- [16974-11-1] and (E)-9-dodecenyl acetate  [35148-19-7], released from widely spaced (20-50 m) point sources in 3 Oregon tests covering 225 ha. Com. available Hercon laminated type dispensers were as effective as laboratory-prepared polyvinyl chloride releasers.

Journal of Economic Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, COA of Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

McDonough, L. M. published the artcileApple ermine moth, Yponomeuta malinellus Zeller: two components of female sex pheromone gland highly effective in field trapping tests, Safety of (Z)-Dodec-9-en-1-yl acetate, the publication is Journal of Chemical Ecology (1990), 16(2), 477-86, database is CAplus and MEDLINE.

When electroantennog. responses of male Y. malinellus to model compounds were determined at dosages of 0.3-30 ng, the strongest responses were obtained from (Z)-9-dodecen-1-ol acetate (Z9-12:Ac). Also, strong responses were obtained from (Z)-11-tetradecenal (Z11-14:Al) and (Z)-11-tetradecen-1-ol (Z11-14:OH). At a dosage of 0.3 ng, Z11-14:Al produced a stronger response than Z11-14:OH, while at a dosage of 30 ng, Z11-14:OH and Z11-14:Al produced equal responses. Gas chromatog. and mass spectral anal. of extracts of female sex pheromone glands showed the presence of Z9-12:Ac, tetradecan-1-ol (14:OH), (E)-11-tetradecen-1-ol (E11-14:OH), Z11-14:OH, hexadecan-1-ol, and hexadecan-1-ol acetate in a ratio of 0.6:200:37:100:140:35. In field tests, Z9-12:Ac and Z11-14:OH together were required for trap catch, and addition of Z11-14:Al, E11-14:OH, 14:OH, or (Z)-11-tetradecen-1-ol acetate did not increase catch. Ratios in rubber spectra of 0.5:99.5 to 1.5:98.5 (Z9-12:Ac/Z11-14:OH) captured the most males and captures were statistically equivalent for dosages of 10-1000 μg/rubber septum. Traps baited with the synthetic lure produced better catches than those baited with females.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Safety of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pellevoisin, C. published the artcilePre-validation of SENS-IS assay for in vitro skin sensitization of medical devices, Category: esters-buliding-blocks, the publication is Toxicology In Vitro (2021), 105068, database is CAplus and MEDLINE.

According to ISO 10993-1:2018, the skin sensitization potential of all medical devices must be evaluated, and for this endpoint ISO 10993-10:2010 recommends the use of in vivo assays. The goal of the present study was to determine if the in vitro SENS-IS assay could be a suitable alternative to the current in vivo assays. The SENS-IS assay uses the Episkin Large and SkinEthic RHE reconstructed human epidermis models to evaluate marker genes. In our study, the SENS-IS assay correctly identified 13 sensitizers spiked in a non-polar solvent. In a subsequent anal. six medical device silicone samples previously impregnated with sensitizers were extracted with polar and non-polar solvents. The SENS-IS assay correctly identified five of these extracts, while a sixth extract, which contained the weak sensitizer Ph benzoate, was classified as neg. However, when this extract was concentrated, or a longer exposure time was used, the assay was able to detect Ph benzoate. The SENS-IS assay was transferred to a naive laboratory which correctly identified sensitizers in six blinded silicone samples, including the one containing Ph benzoate. In light of these results, we conclude that the SENS-IS assay is able to correctly identify the presence of sensitizers in medical devices extracts

Toxicology In Vitro published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Parker, Belinda S. published the artcileMitoxantrone mediates demethylation and reexpression of cyclin D2, estrogen receptor and 14.3.3σ in breast cancer cells, Quality Control of 122110-53-6, the publication is Cancer Biology & Therapy (2003), 2(3), 259-263, database is CAplus and MEDLINE.

In addition to its action as a topoisomerase II poison, mitoxantrone is activated by formaldehyde to bind DNA, forming DNA-adducts specifically at 5’CpG and CpA sequences, with an enhancement of adducts at methylated CpG sites. The butyric acid prodrug, AN-9 (pivaloyloxymethyl butyrate), releases formaldehyde upon cellular hydrolysis and our previous studies have shown that mitoxantrone acts synergistically with AN-9 in cytotoxicity assays. In this paper, we investigated the impact of methylation levels in the cell on mitoxantrone-induced cytotoxicity using the colon cancer cell line HCT116 and its derived DNA methyltransferase (DNMT) 1 and DNMT 3a knockout (DKO8) cell line. We found that decreased methylation levels in the DNMT-null cells led to at least a 2-fold reduction in mitoxantrone-induced cytotoxicity. Next, we studied the impact of mitoxantrone alone, and in combination with AN-9, on hypermethylated genes and their mRNA expression in breast cancer cells. Using methylation-specific PCR and RT-PCR, we found that mitoxantrone treatment of breast cancer cell lines resulted in demethylation of the 14.3.3σ, cyclin D2 and ERα genes, followed by re-expression of their mRNA. The effect of mitoxantrone on re-expression of key genes involved in cell cycle regulation, and ensuing death of the cells may be an addnl., previously undiscovered mechanism of action of mitoxantrone.

Cancer Biology & Therapy published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Quality Control of 122110-53-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shih, Y. L. published the artcileField attraction experiment of the synthetic sex pheromones of smaller tea tortrix and oriental tea tortrix in Taiwan, COA of Formula: C14H26O2, the publication is Zhonghua Nongxue Huibao (1985), 108-14, database is CAplus.

Formulated sex pheromones of small tea tortrix (Adoxophyes) and the oriental tea tortrix (Homona) attracted both the males of A. privatara and H. magnanima in a tea plantation. Besides the target species H. magnanima, males of Cosmopteryx fulminella were also identified in the sticky trap for the first time by using sex pheromone technique. All sex pheromone samples tested could be used in field condition for ≥2 mo.

Zhonghua Nongxue Huibao published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C6H10O7, COA of Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics