Tag: M.W=200-250

O’Malley, Elissa published the artcilePer capita loads of organic UV filters in Australian wastewater influent, HPLC of Formula: 71617-10-2, the main research area is wastewater organic UV filter Australia; Australia; Census; Influent; Sunscreen; UV filter; Wastewater.

Per capita loads of six UV filters were estimated in wastewater influent samples from 36 wastewater treatment plants in Australia collected over a weekend period during the 2016 Australian Census. Of the analyzed samples, 99% contained at least one of the target compounds Ph benzimidazole sulfonic acid (PBSA) was the most prevalent (99%), followed by benzophenone 4 (BP4) (97%), benzophenone 3 (BP3) (87%), benzophenone 1 (BP1) (84%), 4-methylbenzylidene camphor (4-MBC) (22%) and isoamyl 4-methoxycinnamate (IMC) (1.5%). The highest concentrations were 3780 and 5070 ng L-1 for PBSA and BP4, resp. Total per capita UV filter loads in influent across all plants were calculated using population data from the Australian Census and ranged from 0.21 to 3.4 mg day-1 person-1. Notably, a relationship was found between latitude and total per capita daily mass load of UV filters with an increase in mass load from southern to northern catchments. Compared to international studies, mass loads were generally similar with higher loads of BP4 found in Australia. This study provides insight into the occurrence of UV filters in influent wastewater from across Australia and provides the first comprehensive nationwide baseline of UV filter loads.

Science of the Total Environment published new progress about Solar radiation. 71617-10-2 belongs to class esters-buliding-blocks, name is Isopentyl 3-(4-methoxyphenyl)acrylate, and the molecular formula is C15H20O3, HPLC of Formula: 71617-10-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sillapachaiyaporn, Chanin published the artcileHIV-1 Protease and Reverse Transcriptase Inhibitory Activities of Curcuma aeruginosa Roxb. Rhizome Extracts and the Phytochemical Profile Analysis: In Vitro and In Silico Screening, Application In Synthesis of 71617-10-2, the main research area is Curcuma aeruginosa human immunodeficiency virus type 1 protease inhibitor; ADMET analysis; AIDS; Curcuma aeruginosa Roxb.; HIV-1 protease inhibitor; HIV-1 reverse transcriptase inhibitor; drug discovery; immunodeficiency virus; virtual screening.

Human immunodeficiency virus type-1 (HIV-1) infection causes acquired immunodeficiency syndrome (AIDS). Currently, several anti-retroviral drugs are available, but adverse effects of these drugs have been reported. Herein, we focused on the anti-HIV-1 activity of Curcuma aeruginosa Roxb. (CA) extracted by hexane (CA-H), Et acetate (CA-EA), and methanol (CA-M). The in vitro HIV-1 protease (PR) and HIV-1 reverse transcriptase (RT) inhibitory activities of CA extracts were screened. CA-M potentially inhibited HIV-1 PR (82.44%) comparable to Pepstatin A (81.48%), followed by CA-EA (67.05%) and CA-H (47.6%), resp. All extracts exhibited moderate inhibition of HIV-1 RT (64.97 to 76.93%). Besides, phytochem. constituents of CA extracts were identified by GC-MS and UPLC-HRMS. Fatty acids, amino acids, and terpenoids were the major compounds found in the extracts Furthermore, drug-likeness parameters and the ability of CA-identified compounds on blocking of the HIV-1 PR and RT active sites were in silico investigated. Dihydroergocornine, 3β,6α,7α-trihydroxy-5β-cholan-24-oic acid, and 6β,11β,16α,17α,21-Pentahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide showed strong binding affinities at the active residues of both HIV-1 PR and RT. Moreover, antioxidant activity of CA extracts was determined CA-EA exhibited the highest antioxidant activity, which pos. related to the amount of total phenolic content. This study provided beneficial data for anti-HIV-1 drug discovery from CA extracts

Pharmaceuticals published new progress about AIDS (disease). 71617-10-2 belongs to class esters-buliding-blocks, name is Isopentyl 3-(4-methoxyphenyl)acrylate, and the molecular formula is C15H20O3, Application In Synthesis of 71617-10-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bernardo, Naissa Previde published the artcileVolatile Composition of Sparkling Wines of cv. Chardonnay Cultivated under Different Training Systems in Serra da Mantiqueira (Brazil), SDS of cas: 6259-76-3, the main research area is sparkling wine training system volatile composition; GC-MS; GDC; HS-SPME; aroma; crop; lyre.

The grapevine is a climbing plant and allows for the manipulation of vegetative canopies to change the microclimate and exposure of leaves and clusters to solar radiation, affecting the primary and secondary metabolisms of plants. Thus, this work aimed to evaluate how the lyre and Geneva double-curtain (GDC) training systems could contribute to the volatile composition of sparkling wines in replicates of vinifications carried out in the Serra da Mantiqueira (Brazil) in two consecutive summer harvests (2017 and 2018). Fifty-four free volatile compounds were identified by HS-SPME/GC-MS in the wines in both systems and vintages. Multivariate anal. differentiated the vintages in component 1 (22.7%) and the training systems in component 2 (7.1%). The crops were differentiated by aldehydes in 2017 and in 2018 by isoamyl acetate ester, probably derived from the amino acid leucine, the season having been more humid, with lower temperatures and less radiation. For the training systems, besides the alc. compounds, the GDC was differentiated by the terpenoid compounds geranylacetone and β-damascenone, which may contribute more pleasant aromas to sparkling wines. This work promotes addnl. research and enables winegrowers, through the management of their vineyards, to achieve sparkling wines with different volatile compositions

Foods published new progress about Soils, vineyard. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, SDS of cas: 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alepee, Nathalie published the artcileUsefulness of the EpiSkin reconstructed human epidermis model within Integrated Approaches on Testing and Assessment (IATA) for skin corrosion and irritation, Category: esters-buliding-blocks, the main research area is EpiSkin skin corrosion corrosive irritant irritation.

Predictive capacity of the EpiSkin model was evaluated on 87 chems. using the Bottom-Up and the Top-Down testing approaches recommended within Integrated Approach on Testing and Assessment for the identification of both skin irritation and corrosion hazards. Classified (UN GHS Cat. 1 and Cat. 2) chems. were identified with a very high sensitivity (�4%) and the non-classified (UN GHS Cat. 3 and No Cat.) chems. with an appropriate specificity (70%). Very high sensitivities were obtained for the identification of Cat. 1 chems. (�8%), very high specificities for non-Cat. 1 chems. (93%), and accuracies of -95% for the identification of skin corrosives vs. non-corrosives by both approaches. Overall accuracies of 72% were found for predicting the single (sub)categories: non-classified, Cat. 2, Subcat. 1B/1C and Subcat. 1A. Results indicated the testing strategies to be more predictive than the individual assays on a conservative safety approach. Finally, no extreme misclassifications (no under-prediction of in vivo Subcat. 1A as non-Cat. 1, and no over-prediction of non-classified chem. as Subcat. 1A) occur. These findings, independently of the approach used, confirm the usefulness of the EpiSkin in vitro model for a safe prediction of the skin irritant and corrosive hazards of chems.

Toxicology In Vitro published new progress about Artificial skin. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cabanes, A. published the artcileNew methods to remove volatile organic compounds from post-consumer plastic waste, Recommanded Product: Hexyl 2-hydroxybenzoate, the main research area is volatile organic compound plastic waste hot air stripping extraction; Contaminant; Deodorization; NIA; Odor; Polyethylene; Smell.

While the annual European demand for polyolefins is 25 million tonnes, only 3 million tonnes of recycled polyolefins find their place in the market, despite collecting 15 million tonnes of post-consumer polyolefins every year. Brand owners of care products are showing their interest in using post-consumer recycled plastics for their packaging. However, there is a general concern in using these materials, as recycled polymers can contain unwanted substances that may expose the consumer to health risks or make the packaging unattractive. Accordingly, the presence of these contaminants narrows the market opportunity of recycled plastics to applications with low-quality requirements and in which the product is not in direct contact with the consumer. Though mech. recycling is the most widespread solution presents limitations in terms of decontamination, as only superficial substances are removed. Thereby, the volatile organic compounds (VOCs) migrated to the polymer matrix remain inside. Consequently, there is a need to find a solution to purify recycled plastics and increase their market share. This study focuses on removing VOCs from post-consumer recycled HDPE through two innovative methods applied for the first time in this field, steam stripping and polyethylene glycol (PEG) extraction The methodol. implemented to analyze the volatile organic compounds in HDPE was HS-SPME-GC/MS. Both methods showed a decrease above 70% in the VOCs content compared to extrusion-degassing. Moreover, these were compared to hot air stripping, a new technol. developed at an industrial scale for the removal of VOCs. As a result, steam stripping improved efficiency in reducing the overall VOCs compared to hot air stripping. The PEG extraction method lowered the volatile polar compounds further than using hot air stripping. Addnl., none of these technologies modified the HDPE melting flow index.

Science of the Total Environment published new progress about Biodegradability. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Recommanded Product: Hexyl 2-hydroxybenzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pang, Wenwen published the artcileAnticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma, COA of Formula: C13H18O3, the main research area is Zanthoxylum malignant melanoma seed oil anticancer; Cell cycle arrest; Invasion; Malignant melanoma; Seed oil Apoptosis; Zanthoxylum bungeanum.

Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported.for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms. The chem. composition of ZBSO was analyzed by Ultra Performance Liquid Chromatog. A375 cells exposure at different concentrations of ZBSO to examine the selectivity vs. normal skin cells, invasion, apoptosis and cell cycle arrest. Furthermore, transcriptome anal. was employed to investigate potential anticancer mechanisms of ZBSO. Major compounds of ZBSO were identified and unsaturated fatty acid made up the major compound ZBSO-treated A375 cells showed more typical apoptotic morphol. features than normal cells. ZBSO can significantly inhibit invasion and proliferation of A375 cells by G1 phase arrest and induction of apoptosis. Transcriptome anal. showed that ZBSO may affect cell cycle and MAPK signaling pathway of A375 cells. ZBSO possessed anticancer activities that were selectively effective to A375 cells. This study support the hypothesis that ZBSO is a capable candidate for anti-melanoma agent, and provide new insights for future work on investigating the utilization of ZBSO in malignant melanoma treatment.

Journal of Ethnopharmacology published new progress about Antitumor agents. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, COA of Formula: C13H18O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Benede, Juan L. published the artcileA paper-based polystyrene/nylon Janus platform for the microextraction of UV filters in water samples as proof-of-concept, Application of Isopentyl 3-(4-methoxyphenyl)acrylate, the main research area is polystyrene nylon Janus platform microextraction UV filter water; Cellulose paper-based microextraction; Environmental analysis; Janus platform; LC-MS/MS; Mixed-mode chemistry platform; Sustainable synthesis; UV filters.

A new mix-mode cellulose-based sorptive phase is described that combines two different polymeric domains (i.e., nylon and polystyrene), thus providing simultaneous hydrophilic and hydrophobic features as a result. By analogy with Janus materials, the new paper-based sorptive phase has been named paper-based polystyrene/nylon Janus-platform (P-Ps/Ny-JP). The main advantages of the proposed P-Ps/Ny-JP are the sustainability, simplicity in synthesis, and low cost of this extraction device. The main parameters affecting the synthesis (i.e., coating procedure and polymers proportion) have been studied, and the resulting material has been characterized via SEM and IR spectroscopy. As a proof-of-concept, the simultaneous extraction of fourteen UV filters of a wide range of polarity, with log P values ranging from – 0.234 to 16.129, from water samples and their determination by liquid chromatog.-tandem mass spectrometry (LC-MS/MS) has been performed. The proposed methodol. enables the determination of these chems. with limits of detection from 12 to 71 ng L-1, and the precision, expressed as a relative standard deviation, was below 15%. The extraction device was applied to the anal. of real water samples likely to contain UV filters (i.e., two private swimming pool water and one seawater) and the recovery values were in the range 73-121%.

Microchimica Acta published new progress about Coating materials. 71617-10-2 belongs to class esters-buliding-blocks, name is Isopentyl 3-(4-methoxyphenyl)acrylate, and the molecular formula is C15H20O3, Application of Isopentyl 3-(4-methoxyphenyl)acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishijo, Taku published the artcileSensitivity of KeratinoSens and h-CLAT for detecting minute amounts of sensitizers to evaluate botanical extract, SDS of cas: 6259-76-3, the main research area is CD86 CD54 diphenylcyclopropenone oxazolone lymph node skin sensitization KeratinoSens; Botanical extract; Detection limit; KeratinoSensTM; LLNA; Skin sensitization; h-CLAT.

Cosmetic ingredients are often complex mixtures from natural sources such as botanical extracts that might contain minute amounts of constituents with sensitizing potential. The sensitivity of in vitro skin sensitization test methods such as KeratinoSens and h-CLAT for the detection of minute amounts of sensitizer in mixtures remains unclear. In this study, we assessed the detection sensitivity of the binary test battery comprising KeratinoSens and h-CLAT for minute amounts of sensitizers by comparing the LLNA EC3 (estimated concentration of a substance expected to produce a stimulation index of 3) values to the min. detection concentrations (MDCs) exceeding the pos. criteria for each of the two in vitro test methods. 146 Sensitizers with both sets of in vitro data and LLNA data were used. MDC values for KeratinoSens and h-CLAT were calculated from exposure concentrations exceeding pos. criteria for each in vitro test method (EC1.5 and min. induction thresholds, resp.). The dilution rate used to expose culture medium was also considered. For 86% of analyzed sensitizers, the in vitro test methods showed MDC values lower than LLNA EC3 values, suggesting that the binary test battery with KeratinoSens and h-CLAT have greater sensitivity for detection of minute amounts of sensitizer than LLNA. These results suggest the high applicability of KeratinoSens and h-CLAT for detecting skin sensitizing constituents present in botanical extract

Journal of Toxicological Sciences published new progress about Bioassay (h-CLAT). 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, SDS of cas: 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valentini, Federica published the artcileTailor-Made POLITAG-Pd0 Catalyst for the Low-Loading Mizoroki-Heck Reaction in γ-Valerolactone as a Safe Reaction Medium, Safety of Isopentyl 3-(4-methoxyphenyl)acrylate, the main research area is tailor POLITAG Pd0 catalyst Mizoroki Heck gamma valerolactone safe.

In this contribution, we have reported our study on the fine-tuned design and synthesis of new POLITAGs-Pd0 (POLymeric Ionic TAG) catalytic systems with the intention of defining highly efficient heterogeneous palladium catalysts stabilized by ionic tags able to operate at a very low loading while being fully recoverable/reusable. By varying both the support and the ratio between the metal and immobilized ionic tag, we have accessed five different heterogeneous catalytic systems that have been fully characterized (EA, XPS, TEM, and HR-TEM) to investigate their morphol. differences. The catalytic efficiency of the newly prepared POLITAGs-Pd0 materials was then tested and compared in the representative Mizoroki-Heck cross-coupling reaction, a universally investigated and widely useful process. A close correlation between the catalyst support and catalytic performances has been highlighted. The best system POLITAG-Pd0-HM features a high TOF value (26,786 h-1), affording the final products in high isolated yields by using as little as only 0.0007 mol % of Pd. Moreover, this high catalytic activity coupled with the use of γ-valerolactone (GVL) as a green reaction medium has led to the definition of a very efficient waste-minimized protocol. The newly designed catalyst has been utilized in the representative synthesis of Amiloxate, a widely used sunscreen agent, that could be prepared with negligible metal contamination and very low E-factor.

ACS Sustainable Chemistry & Engineering published new progress about Catalyst supports. 71617-10-2 belongs to class esters-buliding-blocks, name is Isopentyl 3-(4-methoxyphenyl)acrylate, and the molecular formula is C15H20O3, Safety of Isopentyl 3-(4-methoxyphenyl)acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Jie published the artcileCharacterization of Key Aroma Compounds in Tartary Buckwheat (Fagopyrum tataricum Gaertn.) by Means of Sensory-Directed Flavor Analysis, Recommanded Product: Hexyl 2-hydroxybenzoate, the main research area is aroma flavor Fagopyrum tartary buckwheat; aroma extract dilution analysis; aroma-active compounds; chiral analysis; sensory-directed flavor analysis; tartary buckwheat.

The key odorants of tartary buckwheat (TB) were researched by a sensory-directed flavor anal. approach for the first time. After the volatiles of TB were isolated by solvent-assisted flavor evaporation (SAFE), 49 aroma-active components with flavor dilution (FD) factors in the range of 1-2187 were identified using gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) combined with aroma extract dilution anal. (AEDA). Geranylacetone, phenethyl alc., and β-damascone showed the highest FD factors of 2187. All 49 odorants were further quantitated by the internal standard curve method, and their odor activity values (OAVs) were obtained. The overall aroma of TB was successfully simulated (similarity > 98.16%) by mixing 16 odorants (OAV â‰?1) with their natural concentrations The omission tests revealed that geosmin, α-isomethylionone, α-methylionone, β-ionone, linalool, β-damascone, geranylacetone, guaiacol, Et hexanoate, geraniol, vanillin, tetrahydrolinalool, and 2,5-dimethyl-4-hydroxy-3-(2H)-furanone were the key odorants of TB. Chiral anal. showed that tetrahydrolinalool and linalool existed as racemics in the com. TB. The relative content of R-enantiomers of α-isomethylionone and α-methylionone was slightly higher than that of their S-enantiomers. The odor thresholds of R- and S-enantiomer of tetrahydrolinalool were first detected as 0.029 and 3.8μg/L in air, resp.

Journal of Agricultural and Food Chemistry published new progress about Chiral resolution. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Recommanded Product: Hexyl 2-hydroxybenzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics