Tag: M.W=200-250

Popovtzer, Rachela published the artcileElectrochemical lab on a chip for high-throughput analysis of anticancer drugs efficiency, HPLC of Formula: 122110-53-6, the publication is Nanomedicine (New York, NY, United States) (2008), 4(2), 121-126, database is CAplus and MEDLINE.

We describe a new method for rapid, sensitive, and high-throughput detection of colon cancer cells’ response to differentiation therapy, using a novel electrochem. lab-on-a-chip system. Differentiation-inducing agents such as butyric acid and its derivatives were introduced to miniature colon cancer samples within the nanovolume chip chambers. The efficacy of each of the differentiation-inducing agents was evaluated by electrochem. detection of the cellular enzymic activity level, whereas reappearance of normal enzymic activity denotes effective therapy. The results demonstrate the ability to evaluate simultaneously multiplex drug effects on miniature tumor samples (∼15 cells) rapidly (5 min) and sensitively, with quant. correlation between cancer cells’ number and the induced current. The use of miniature anal. devices is of special interest in clin. relevant samples, in that it requires less tissue for diagnosis, and enables high-throughput anal. and comparison of various drug effects on one small tumor sample, while maintaining uniform biol. and environmental conditions.

Nanomedicine (New York, NY, United States) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, HPLC of Formula: 122110-53-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nghiem, Quoc Dat published the artcileControlled/living radical polymerization of vinylcyclicsilazane by RAFT process and their block copolymers, Computed Properties of 3052-61-7, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2008), 46(13), 4594-4601, database is CAplus.

High mol. weight poly(vinyl)silazane were synthesized successfully by reversible addition fragmentation chain transfer (RAFT) polymerization in toluene at 120 °C, using dithiocarbamate derivatives and 2,2′-azobis-isobutyrylnitrile (AIBN) as the RAFT agents and thermal initiator, resp. The polymerization of a vinylcyclicsilazane oligomer with 82.5% conversion was readily controlled to increase the mol. weight from 1000 to 12,000 g/mol with a narrow polydispersity <1.5. The resulting polymer showed a high ceramic yield of 70 wt % at 1000 °C. Moreover, the approach was extended successfully to the synthesis of poly(vinyl)silazane-block-polystyrene as an inorganic-organic diblock copolymer.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Computed Properties of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xia, Wen published the artcileA recyclable cucurbit[6]uril-supported silicotungstic acid catalyst used in the esterification reaction, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Inorganica Chimica Acta (2021), 120418, database is CAplus.

The esterification reaction used to prepare Bu paraben (BP) and Pr gallate (PG) catalyzed using a cucurbit[6]uril-supported Keggin-type silicotungstic acid (Q[6]-STA) catalyst has been investigated. The Q[6]-STA catalyst has been characterized using FTIR spectroscopy, XRD, SEM, EDS, thermal anal., and surface area studies. Q[6]-STA was easy to prepare in high yield and exhibited some advantageous properties, such as high catalytic activity and its convenient recovery. Moreover, a reusability study showed that the Q[6]-STA catalyst was stable and active.

Inorganica Chimica Acta published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C8H13NO3, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Johnson, Carl R. published the artcileSyntheses of thiiranes from aldehydes or ketones and sulfur-stabilized carbanions, HPLC of Formula: 3052-61-7, the publication is Tetrahedron Letters (1975), 2865-8, database is CAplus.

S-stabilized carbanionic compounds with alkyllithium and aldehydes gave homologated derivatives which with alkali or on heating decomposed to thiiranes. E.g., the thiazoline I (R = H) and the pyridine II (R = H) with BuLi and PhCHO gave homologs I and II [R = CH(OH)Ph] which with base gave thiiranes III (R = H, Ph, resp.). Similarly, Et2NCS2CH2Ph with LiN(CHMe2)2 and EtCHO gave, after treatment with NaH, III (R = Et).

Tetrahedron Letters published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamashita, Keiji published the artcilePreparation of photoresist polymer by a photoreactive monomer containing N,N-diethyldithiocarbamate group, Application of Benzyl diethylcarbamodithioate, the publication is Journal of Applied Polymer Science (1988), 35(2), 465-73, database is CAplus.

p-Et₂NCS₂CH₂C₆H₄CH:CH₂ (I) was synthesized and copolymerized with styrene, Me methacrylate, acrylonitrile, and vinyl acetate by AIBN initiation. The copolymers obtained had efficient photocrosslinking abilities, and were thermally stable. Therefore, there was no loss of dithiocarbamoyl group during radical polymerization, and the polymerization proceeded through vinyl groups. The degree of UV photocrosslinking was proportional to the concentration of the photosensitive group, but photosensitivity of the polymer was not. Water-soluble photoreactive copolymers of I with acrylamide (II) and methacrylic acid were also prepared I–II copolymer had good photosensitivity at only 3 mol% I incorporation. Photocrosslinking yields of these polymers depends on the viscosity of the original polymers except in the case of low concentration of I. The relation between copolymer composition and glass transition temperature (T_g) was also investigated. Investigation of T_g, showed that the copolymer structure largely affected the ΔT_g. The mechanism of photocrosslinking was studied by photodecomposition of benzyl N,N-diethyldithiocarbamate, and the decreases of sulfur content was clearly related to photocrosslinking points.

Journal of Applied Polymer Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H10BNO3, Application of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamashita, Keiji published the artcilePreparation of photoresist polymer by a photoreactive monomer containing N,N-diethyldithiocarbamate group, Computed Properties of 3052-61-7, the publication is Journal of Applied Polymer Science (1988), 35(2), 465-73, database is CAplus.

The title monomer, 4-vinylbenzyl diethyldithiocarbamate (I), was synthesized and copolymerized with some vinyl monomers by AIBN. The copolymers obtained had efficient photocrosslinking abilities, and were thermally stable. There was no loss of the dithiocarbamoyl group during radical polymerization, and the polymerization proceeded through the vinyl group. The degree of photocrosslinking was proportional to the concentration of the photosensitive group, but the photosensitivity of the polymer was not. Water-soluble photoreactive copolymers, of I with acrylamide (II) or methacrylic acid were also prepared The I–II copolymer had good photosensitivity at 3% I incorporation. Photocrosslinking yields of these polymers depended on the viscosity of the original polymers except for low I amounts The relation between copolymer composition and glass transition temperature (T_g) indicated that the copolymer structure largely depended on ΔT_g. The mechanism of photocrosslinking was studied by photodecomposition of benzyl diethyldithiocarbamate, showing that decreases of S content were clearly related to the photocrosslinking points.

Journal of Applied Polymer Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C7H3BrF3I, Computed Properties of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Florit, Federico published the artcileDesign of dynamic trajectories for efficient and data-rich exploration of flow reaction design spaces, Category: esters-buliding-blocks, the publication is Reaction Chemistry & Engineering (2021), 6(12), 2306-2314, database is CAplus.

Batch and continuous reactors both enable exploration of a chem. design space. The former rely on transient experiments, thus experiencing a wide variety of operating conditions over time, whereas the latter are usually operated at steady state and are representative of only one set of conditions. Operating a continuous reactor under dynamic conditions allows more efficient exploration of the underlying reaction space for extraction of kinetics and optimization of performance. We present a methodol. to efficiently explore a design space using a tubular flow reactor installed on an automatic platform (equipped with FTIR and HPLC anal.) operated in a transient regime using sinusoidal variations of the parameters. This data-dense method proves to be quicker with respect to steady-state operations because of the larger amount of information collected during a single experiment A computational anal. provides a simple criterion for the design of dynamic experiments in order for them to be representative of steady-state conditions. The methodol. is applied exptl. to the synthesis of a pharmaceutical intermediate via an esterification reaction in the presence of base. In the experiments, up to three parameters (reaction time, base equivalent, and temperature) are changed simultaneously. Proper design of the trajectories in the design space allows verification of the consistency of the results by exploiting the self-crossings within each trajectory and crossings between different trajectories. The experiments further validate the developed criterion for dynamic operations.

Reaction Chemistry & Engineering published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C12H15NO4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sayar, Noel published the artcileFacile total synthesis of thailandepsins D-F: Novel bicyclic depsipeptide histone deacetylase inhibitors isolated from a microorganism, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, the publication is Synthesis (2019), 51(6), 1419-1426, database is CAplus.

The naturally occurring bicyclic depsipeptide histone deacetylase inhibitors thailandepsins D-F were efficiently synthesized for the first time in 49-61% overall yield over five steps, starting from known amine and carboxylic acid segments. The synthesis includes the condensation of the two known starting materials to directly assemble the corresponding seco-acids, which are the key precursors for macrolactonization. The seco-acids are then macrolactonized using the Shiina method to construct the requisite 15-member macrocycles.

Synthesis published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takizawa, Toshiya published the artcileSynthetic studies on spiruchostatin A, a potent histone deacetylase inhibitor, Quality Control of 106391-88-2, the publication is Journal of Tohoku Pharmaceutical University (2007), 33-47, database is CAplus.

Spiruchostatin A (I), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel mol.-targeted anticancer agents. We envisioned that I would be synthesized through twofold macrolactam/macrolactone cyclization of a fully elaborated acyclic disulfide. The key segments, required for the preparation of the advanced key intermediate, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce a desired key intermediate. Upon deprotection of the N-Boc and the Me ester groups, the crucial cyclization formation was achieved using PyBOP to provide a desired macrolactam, a potential key precursor for I. Further investigations concerning the transformation of 16 to the target mol. I were also described.

Journal of Tohoku Pharmaceutical University published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C8H11NO, Quality Control of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Marsh, Alexandra M. R. published the artcileHistone deacetylase inhibitors: recent outcomes from clinical trials and the implications for oncology treatment approaches, Product Details of C10H18O4, the publication is Clinical Investigation (London, United Kingdom) (2013), 3(6), 571-594, database is CAplus.

A review. Histone deacetylases play an important role in multiple processes, including gene expression, proliferation, apoptosis, cytoskeletal organization, migration and angiogenesis. Histone deacetylase inhibitors are able to induce cell death and growth arrest as targeted anticancer agents. While only two, vorinostat and romidepsin, are licensed in oncol., several have reached Phase III trials and many more are in Phase I and II. In addition to this, multiple novel drugs, including more targeted agents, are emerging from preclin. studies. This paper examines the outcomes of recent clin. trials in 11 key histone deacetylase inhibitors, both as monotherapy and in combination with other antitumor drugs. An overview of the advantages and disadvantages between the different classes and individual drugs is discussed, as well as a brief outlook on the future developments in the field.

Clinical Investigation (London, United Kingdom) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Product Details of C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics