Tag: M.W=200-250

Aviram, Adina published the artcileEffect of the cytostatic butyric acid pro-drug, pivaloyloxymethyl butyrate, on the tumorigenicity of cancer cells, Recommanded Product: (Pivaloyloxy)methyl butyrate, the publication is Journal of Cancer Research and Clinical Oncology (1997), 123(5), 267-271, database is CAplus and MEDLINE.

Pivaloyloxymethyl butyrate (AN-9) was demonstrated to be a cytostatic but not cytotoxic agent in a myelomonocytic cell line (WEHI). The expression of the early regulatory genes, c-myc and c-jun were changed. Although these events occurred already after 1 h of exposure to AN-9, the tumorigenicity of these reduced only after 4 h of exposure. Tumorigenicity of the highly metastatic subclone of Lewis lung carcinoma was almost diminished after 1h of exposure. In both cell types a 10-fold higher concentration of BA did not affect the tumorigenicity of the cells as did AN-9.

Journal of Cancer Research and Clinical Oncology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Recommanded Product: (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yin, Xiumei published the artcileSynthesis of camostat mesilate, Recommanded Product: 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, the publication is Huaxue Yanjiu Yu Yingyong (2004), 16(6), 859-860, database is CAplus.

Camostat mesilate was synthesized from 4-aminobenzoic acid by adding cyanamide to obtain 4-guanidinobenzoic acid HCl, esterifying 4-hydroxyphenylacetic acid 2-dimethylamino-2-oxoethyl ester that was prepared from 4-hydroxyphenylacetic acid and N,N-dimethylchloroacetamide, neutralizing, and converting to the salt. The structures of the intermediates and product were confirmed by MS, IR, and ¹H-NMR. The overall yield of the improved procedure was 56%.

Huaxue Yanjiu Yu Yingyong published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C15H21BO2, Recommanded Product: 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rephaeli, Ada published the artcileDerivatives of butyric acid as potential anti-neoplastic agents, COA of Formula: C10H18O4, the publication is International Journal of Cancer (1991), 49(1), 66-72, database is CAplus and MEDLINE.

A novel derivative of butyric acid, pivalyloxymethyl butyrate (AN-9) was shown, in vitro, to: (a) induce cytodifferentiation and inhibit the proliferation of leukemic cells; (b) inhibit the growth and formation of Lewis lung carcinoma colonies in semi-solid agar. AN-9 affect cells at about 10-fold lower concentration and at a faster rate than does butyric acid. The pivalyloxymethyl esters of propionic, isobutyric and valeric acids do not elicit effects similar to those of AN-9, while the isobutyryloxymethyl butyrate does, which strongly suggests that the activity of AN-9 stems from intracellular metabolic degradation of the pro-drug to butyric acid. In vivo, AN-9, increased the survival of mice in Lewis lung carcinoma primary cancer model and significantly decreased the number of lung lesions of the animals inoculated with highly metastatic cells, but did not affect their life span. Acute LD₅₀ studies showed that AN-9 possesses low toxicity. AN-9 is a potential antineoplastic agent as well as a tool for investigation of the differentiation induction mechanism.

International Journal of Cancer published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, COA of Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nguyen Huu, Cuong published the artcileSynergistic inactivation of bacteria based on a combination of low frequency, low-intensity ultrasound and a food grade antioxidant, Application In Synthesis of 121-79-9, the publication is Ultrasonics Sonochemistry (2021), 105567, database is CAplus and MEDLINE.

This study evaluated a synergistic antimicrobial treatment using a combination of low frequency and a low-intensity ultrasound (LFU) and a food-grade antioxidant, Pr gallate (PG), against a model gram-pos. (Listeria innocua) and the gram-neg. bacteria (Escherichia coli O157:H7). Bacterial inactivation kinetic measurements were complemented by characterization of biophys. changes in liposomes, changes in bacterial membrane permeability, morphol. changes in bacterial cells, and intracellular oxidative stress upon treatment with PG, LFU, and a combination of PG + LFU. Combination of PG + LFU significantly (>4 log CFU/mL, P < 0.05) enhanced the inactivation of both L. innocua and E. coli O157:H7 compared to PG or LFU treatment. As expected, L. innocua had a significantly higher resistance to inactivation compared to E. coli using a combination of PG + LFU. Biophys. measurements in liposomes, bacterial permeability measurements, and scanning electron microscope (SEM)-based morphol. measurements show rapid interactions of PG with membranes. Upon extended treatment of cells with PG + LFU, a significant increase in membrane damage was observed compared to PG or LFU alone. A lack of change in the intracellular thiol content following the combined treatment and limited effectiveness of exogenously added antioxidants in attenuating the synergistic antimicrobial action demonstrated that oxidative stress was not a leading mechanism responsible for the synergistic inactivation by PG + LFU. Overall, the study illustrates synergistic inactivation of bacteria using a combination of PG + LFU based on enhanced membrane damage and its potential for applications in the food and environmental systems.

Ultrasonics Sonochemistry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application In Synthesis of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Wei Chuan published the artcilePartially fluorinated analogs of (Z)-9-dodecenyl acetate: probes for pheromone hydrophobicity requirements, Computed Properties of 16974-11-1, the publication is Tetrahedron Letters (1990), 31(6), 801-44, database is CAplus.

(Z)-RCH:CH(CH₂)₈OAc (R = CF₃CF₂, CF₃CH₂, MeCF₂) and (Z)-EtCH:CHCF₂(CH₂)₇OAc were prepared to probe the requirements for hydrophobicity of the alkyl terminus in pheromone activity. These compounds show unexpected and varied behavioral activities in assays using the European grape berry moth.

Tetrahedron Letters published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C65H82N2O18S2, Computed Properties of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Konecny, V. published the artcileSynthesis and biological properties of dithiocarbamic acid derivatives. IV. Herbicidal activity of some esters of N, N-diethyldithiocarbamic acid, Category: esters-buliding-blocks, the publication is Acta Facultatis Rerum Naturalium Universitatis Comenianae, Chimia (1971), 47-57, database is CAplus.

The herbicidal effectiveness of N,N-diethyldithiocarbamic acid esters [(Et)2NC(:S)SR] or [(Et)2NC(:S)SCH2C(O)R] as foliar sprays or as preplant treatments in agricultural crops was most promising with N,N-diethyl-S-(2-chloroallyl)dithiocarbamidate (Vegadex) [95-06-7]. Similar herbicidal effects could be demonstrated with preplant or foliar applications of N,N-diethyl-S-propyldithiocarbamidate [19047-77-9] or with preplant applications of N,N-diethyl-S-(N’,N’-dimethylcarbamidomethyl)dithiocarbamidate [23257-85-4]. The synthesis of the title compounds was reported in an earlier paper.

Acta Facultatis Rerum Naturalium Universitatis Comenianae, Chimia published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jain, Shubham published the artcilePassion fruit seed extract as an antioxidant additive for biodiesel; shelf life and consumption kinetics, Product Details of C10H12O5, the publication is Fuel (2021), 119906, database is CAplus.

One of the primary concerns in the use of biodiesel is its susceptibility towards radical-mediated oxidative reactions. The presence of unsaturated Me esters renders biodiesel vulnerable to oxidation It necessitates strategic interventions, which among a few others, includes the use of antioxidant additives. Natural antioxidants have multiple significant advantages over their synthetic counterparts. In the present study, the activity of methanolic passion fruit seed (PFS) extract as an antioxidant additive for waste cooking oil (soybean) biodiesel has been evaluated. The PFS extract contained a high proportion of phenolic compounds and exhibited excellent antiradical activity against model radical DPPH, which encouraged us to explore the case of unstable biodiesel further. At a concentration of 200 ppm, the PFS extract augmented the fuel’s resistance towards oxidation to levels where it could comply with European and the Indian specifications for blend-stock biodiesel. The performance of PFS extract was comparable to that of synthetic antioxidants, including butylated hydroxyanisole and butylated hydroxytoluene. The present study substantiates the utility of plant extracts rich in phenolics as an antioxidant additive for biodiesel.

Fuel published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Product Details of C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fehrentz, Jean-Alain published the artcileSynthesis of chiral N-protected α-amino aldehydes by reduction of N-protected N-carboxyanhydrides (UNCAs), Name: (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, the publication is Tetrahedron Letters (1994), 35(48), 9031-4, database is CAplus.

Pure N-protected (Boc, Z, Fmoc) α-amino aldehydes were obtained in high yields by reduction of N-protected N-carboxyanhydrides with equivalent amounts of LiAlH(OCMe₃)₃ or lithium tris[(3-ethyl-3-pentyl)oxy]aluminum hydride (LTEPA) in THF as solvent. The reaction is simple, rapid and proceeds without detectable racemization.

Tetrahedron Letters published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Name: (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rosenau, Thomas published the artcileOn the role of N-methylmorpholine-N-oxide (NMMO) in the generation of elemental transition metal precipitates in cellulosic materials, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Cellulose (Dordrecht, Netherlands) (2021), 28(16), 10143-10161, database is CAplus.

Several literature reports describe the role of aqueous solutions of N-methylmorpholine-N-oxide monohydrate (NMMO) as a suitable medium for the generation of transition metal (nano)particles in or on cellulosic materials and further elaborate its role as a co-reactant of the transition metal salts that are reduced to the elemental metal. However, this would assign NMMO the role of a reductant, which is in contradiction of its obvious oxidative nature. In the present study, the exemplary cases of silver, gold, and platinum salts as the precursors of the resp. metal (nano)particles in aqueous NMMO/cellulose mixtures were investigated. Naturally, NMMO did not act as a reducing agent in any case-this role was taken over by the frequently used NMMO stabilizer Pr gallate, or by cellulose itself, into which carbonyl and carboxyl groups were introduced. Also, hypochlorite-produced intermediately from chloride ions and subsequently undergoing disproportionation into chloride and chlorate-or transient N-methylene(morpholinium) ions generated from NMMO, which are in turn oxidized to formyl morpholide, can act as the corresponding reductants while the metal ions are reduced, depending on the reaction conditions. Apart from providing interesting mechanistic insights, the study points to the importance of a precise description of the composition of the chem. systems used, as well as the importance of seemingly inert auxiliaries, which turned out to be essential co-reactants in the metal (nano)particle generation.

Cellulose (Dordrecht, Netherlands) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Deng, Jifeng published the artcileThe highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes, Recommanded Product: Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate, the publication is European Journal of Medicinal Chemistry (2010), 46(1), 71-76, database is CAplus and MEDLINE.

Some dipeptidyl peptidase IV inhibitors, e.g., I, were designed based on alogliptin using a scaffold-hopping strategy. All of the compounds constructed on a thienopyrimidine scaffold demonstrated good inhibition and selectivity for DPP-IV. Compound I exhibited subnanomolar (IC₅₀ = 0.33 nM) DPP-IV inhibitory activity, good in vivo efficacy and an acceptable pharmacokinetic profile. A pharmacokinetic-driven optimization of I may lead to a class of clin. candidate DPP-IV inhibitors.

European Journal of Medicinal Chemistry published new progress about 1094619-74-5. 1094619-74-5 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Thiophene,Fluoride,Amine,Ester, name is Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate, and the molecular formula is C7H6F3NO2S, Recommanded Product: Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics