Tag: M.W=200-250

Pechenov, Sergei published the artcileDevelopment of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease, Safety of Propyl 3,4,5-trihydroxybenzoate, the publication is Scientific Reports (2021), 11(1), 22521, database is CAplus and MEDLINE.

Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience, especially for chronic diseases. Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation. Here, we have used glucagon-like peptide-1 (GLP-1) as a model peptide therapeutic for treating obesity-linked type 2 diabetes, a common chronic disease. We describe a comprehensive multidisciplinary approach leading to the development of MEDI7219, a GLP-1 receptor agonist (GLP-1RA) specifically engineered for oral delivery. Sites of protease/peptidase vulnerabilities in GLP-1 were removed by amino acid substitution and the peptide backbone was bis-lipidated to promote MEDI7219 reversible plasma protein binding without affecting potency. A combination of sodium chenodeoxycholate and Pr gallate was used to enhance bioavailability of MEDI7219 at the site of maximal gastrointestinal absorption, targeted by enteric-coated tablets. This synergistic approach resulted in MEDI7219 bioavailability of ∼ 6% in dogs receiving oral tablets. In a dog model of obesity and insulin resistance, MEDI7219 oral tablets significantly decreased food intake, body weight and glucose excursions, validating the approach. This novel approach to the development of MEDI7219 provides a template for the development of other oral peptide therapeutics.

Scientific Reports published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Safety of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mayadunne, Roshan T. A. published the artcileLiving Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (RAFT Polymerization) Using Dithiocarbamates as Chain Transfer Agents, Product Details of C12H17NS2, the publication is Macromolecules (1999), 32(21), 6977-6980, database is CAplus.

Living radical polymerization with reversible addition-fragmentation chain transfer (RAFT polymerization) can be achieved with the use of dithiocarbamate derivatives that have the nonbonded electron pair of the nitrogen included as part of an aromatic system. These compounds have been shown to be highly effective in RAFT polymerization of styrene and (meth)acrylate esters to produce polymers of predetermined mol. weight and narrow polydispersity (usually <1.2). By contrast, simple N,N-dialkyl dithiocarbamates (those compounds previously described as “photoiniferters”) are ineffective as RAFT agents. The reasons for the different behavior are discussed.

Macromolecules published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Product Details of C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Andrade, Romano published the artcileOptimization of a pheromone lure for Spodoptera frugiperda (Smith) in Central America, SDS of cas: 16974-11-1, the publication is Journal of the Brazilian Chemical Society (2000), 11(6), 609-613, database is CAplus.

Mass trapping of Spodoptera frugiperda (Smith) in Central America required a high performance lure with consistent capture rates. S. frugiperda lures from North America and England gave erratic capture rates under field conditions. A reinvestigation of four acetate attractants (Z9-14Ac, Z11-16Ac, Z7-12Ac and Z9-12Ac) for S. frugiperda present in Costa Rica revealed that Z7-12Ac and Z9-12Ac were highly attractive to S. frugiperda when presented alone. Binary combination of Z7-12Ac with Z9-14Ac significantly increased attraction and was at least 10 times more attractive to S. frugiperda in Costa Rica than North American or English lures. Addition of Z11-16Ac to binary combinations of Z9-14Ac and Z7-12Ac marginally increased capture rates. If the concentration of Z7-12Ac is increased to 5% in lures containing Z9-14Ac, Z11-16Ac and Z7-12Ac capture rates significantly decrease. The optimized lure contains Z7-12Ac that is a component not previously reported in S. frugiperda from the Caribbean region.

Journal of the Brazilian Chemical Society published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, SDS of cas: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kim, Junheon published the artcileA co-attractant mixture of (Z)-11-tetradecenyl acetate and (Z)-9-dodecenyl acetate for Neocalyptis angustilineata and Homona magnanima, HPLC of Formula: 16974-11-1, the publication is Journal of Asia-Pacific Entomology (2014), 17(4), 659-661, database is CAplus.

While monitoring for the seasonal occurrence of the tea tortrix moth, Homona magnanima Diakonoff (Lepidoptera: Tortricidae), a number of Neocalyptis angustilineata (Walsingham) were attracted to traps baited with H. magnanima attractant, a 9:1 blend of (Z)-11-tetradecenyl acetate (Z11-14Ac) and (Z)-9-dodecenyl acetate (Z9-12Ac). We evaluated a 1:1 blend (1 mg) and a 9:1 blend (1 mg) of Z11-14Ac and Z9-12Ac for their attractiveness to the two moth species. H. magnanima was attracted only to the 9:1 blend. However, N. angustilineata was equally attracted to both blends. Thus, we report the 9:1 blend as a co-attractant for N. angustilineata and H. magnanima. This blend is the first finding for the attractant for N. angustilineata.

Journal of Asia-Pacific Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, HPLC of Formula: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Toumi, Meriem published the artcileElectrogenerated base-promoted synthesis of dithiocarbamate acid esters and 3-(N-substituted-amino)-2-cyanodithiocrotonates from primary or secondary amines and carbon disulfide, Quality Control of 3052-61-7, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2007), 182(10), 2477-2490, database is CAplus.

Dithiocarbamates and 3-amino-2-cyanodithiocrotonates were prepared by condensation of secondary and primary amines with carbon disulfide alkylation reagent and acetonitrile, promoted by electrogenerated acetonitrile anion. Condensation of secondary amines R¹R²NH with CS₂ and R³X in MeCN, promoted by acetonitrile anion electrogeneration, gave dithiocarbamates R¹R²NCS₂R³ (1, R¹, R² = Et, ⁱPr; R¹R²N = 1-pyrazolyl, 1-imidazolyl, 9-carbazolyl, 4-morpholinyl) as the main products, together with 3-amino-2-cyanodithiocrotonates R³S₂CC(CN):C(Me)NH₂, resulting from autocondensation of two acetonitrile mols. followed by addition of CS₂ and alkylation. Primary amines R¹NH₂ gave mainly the 3-amino-2-cyanodithiocrotonates R³S₂C(CN):C(Me)NHR¹ as a result of condensation of amide anion R¹NH^– with two acetonitrile mols., ammonia elimination and condensation with CS₂. The mechanisms are discussed.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C6H13I, Quality Control of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bengtsson, M. published the artcileFluorine-substituted pheromone components affect the behavior of the grape berry moth, HPLC of Formula: 16974-11-1, the publication is Experientia (1990), 46(11-12), 1211-13, database is CAplus.

Partially fluorinated analogs of (Z)-9-dodecenyl acetate, the major pheromone component of the grape berry moth, Eupoecilia ambiguella, produced a variety of different behaviors in wind tunnel and field trapping experiments A difluoro analog was a potent attractant, the trifluoromethyl analog had little attractancy, and the pentafluoroethyl analog was a potent synergist for the natural pheromone.

Experientia published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, HPLC of Formula: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Arn, Heinrich published the artcileSex pheromone of Eupoecilia ambiguella female: analysis and male response to ternary blend, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Journal of Chemical Ecology (1986), 12(6), 1417-29, database is CAplus and MEDLINE.

Sex gland extracts and washes of E. ambiguella contained 10-20 ng/female of the primary sex pheromone component Z-9-dodecenyl acetate (Z9-12:Ac), accompanied by a number of related compounds These are (E9-12:Ac), Z-9-dodecen-1-ol (Z9-12:OH), saturated acetates of 12, 16, 18, and 20 Cs, and traces of a doubly unsaturated acetate, tentatively identified as a 9,11-dodecadienyl acetate. Octadecyl acetate (18:Ac) predominated among the pheromone-related components, making up 1-2, occasionally 20-30-fold the amount of Z9-12:Ac. The same compounds were also found in field-collected females and in effluvia. Z-9-Undecenyl acetate, which is a male attractant on its own, was also found in a sample of female effluvia. A hierarchy in the ethol. function of the pheromone components was observed Z9-12:Ac was an attractant for E. ambiguella males. Dodecyl acetate (12:Ac) was not attractant on its own, but augmented male catch when added to the main attractant. Addition of 18:Ac augmented attraction only when both Z9-12:Ac and 12:Ac were present. Wind-tunnel tests demonstrated that 18:Ac also raised the disorientation threshold, as previously shown for 12:Ac. Other compounds, with the possible exception of addnl. saturated acetates, had either no effect on trap catch or, in the case of E9-12:Ac, Z9-12:OH, and E-9,11-dodecadienyl acetate, were inhibitory above a certain level. A blend of roughly equal parts of Z9-12:Ac, 12:Ac, and 18:Ac provided the best blend for E. ambiguella known to date.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Arn, Heinrich published the artcileSex pheromone blends of three tortricid pests in European vineyards, Name: (Z)-Dodec-9-en-1-yl acetate, the publication is Agriculture, Ecosystems & Environment (1988), 21(1-2), 111-17, database is CAplus.

The sex pheromone glands of the 3 most important tortricids of European vineyards, Eupoecilia ambiguella, Sparganothis pilleriana, and Lobesia botrana have been chem. investigated and found to contain up to 15 different straight-chain acetates and alcs. Behavioral observations in the wind tunnel and field trapping demonstrate that in each species at least 3 female-produced components are involved in male attraction.

Agriculture, Ecosystems & Environment published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Name: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nesterova, I. P. published the artcileDetermining the rate of release of the synthetic sexual insect attractants from preparative form using vapor-phase gas-liquid chromatography, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Agrokhimiya (1994), 98-100, database is CAplus.

The rate of release of dodecyl alc., cis-9-dodecenyl acetate, trans,trans-8,10-dodecadienol, and cis,trans-dodecadienyl acetate from a rubber tube was 233.63, 212.75, 21.29, and 22.90 μg/day, resp. Thus, the functional group and the number of double bonds of the attractant determined the rate of release from rubber. The rate of cis-9-dodecenyl acetate and trans,trans-8,10-dodecadienol release from Al foil was 336.51 and 1521.51 μg/day, resp., from a dense, small-pore filter 556.26 and 2149 μg/day, resp., and from polysulfone membrane PSU-40-s 10.20 and 784.55 μg/day, resp. This emphasizes the effects of the carrier.

Agrokhimiya published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kasukabe, T. published the artcileAn anticancer derivative of butyric acid (pivalyloxymethyl butyrate) and daunorubicin cooperatively prolong survival of mice inoculated with monocytic leukemia cells, Synthetic Route of 122110-53-6, the publication is British Journal of Cancer (1997), 75(6), 850-854, database is CAplus and MEDLINE.

Pivalyloxymethyl butyrate (AN-9) inhibited the proliferation of and induced apoptosis in mouse monocytic leukemia Mm-A cells; Na butyrate, but not AN-9, induced differentiation of the cells. AN-9 and various DNA-specific antineoplastic agents synergistically inhibited the growth of Mm-A cells, and simultaneous treatment was required to evoke the maximum growth-inhibitory effect. On the other hand, there was no synergy between butyrate and these drugs, or between AN-9 and several antimetabolic agents, in inhibiting the growth of the cells, suggesting that the synergistic effect is specific to AN-9 and DNA-reacting agents. AN-9, given alone, dose-dependently prolonged the survival of mice inoculated with Mm-A cells. Moreover, administration of AN-9 plus daunorubicin (DNR) further prolonged survival.

British Journal of Cancer published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Synthetic Route of 122110-53-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics