Tag: M.W=200-250

Patch, Raymond J. published the artcileIdentification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents, HPLC of Formula: 220141-23-1, the publication is Journal of Medicinal Chemistry (2011), 54(3), 788-808, database is CAplus and MEDLINE.

Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of diaryl ether based thiazolidenediones, which function as selective ligands against this receptor. Series optimization provided several potent analogs that inhibit the recruitment of a coactivator peptide fragment in in vitro biochem. assays (IC₅₀ < 150 nM) and cellular two-hybrid reporter assays against the ligand binding domain (IC₅₀ = 1-5 μM). A cocrystal structure of the ligand-binding domain of ERRα with lead compound 29 (I) revealed the presence of a covalent interaction between the protein and ligand, which has been shown to be reversible. In diet-induced murine models of obesity and in an overt diabetic rat model, oral administration of 29 normalized insulin and circulating triglyceride levels, improved insulin sensitivity, and was body weight neutral. This provides the first demonstration of functional activities of an ERRα ligand in metabolic animal models.

Journal of Medicinal Chemistry published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C9H6F4O2, HPLC of Formula: 220141-23-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tsukatani, Tadayuki published the artcileCombined effects of fumaric, lactic, and ferulic acid against food-borne pathogenic biofilms, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Food Control (2022), 109024, database is CAplus.

In the present study, we selected food additives with potent biofilm eradication activities against food-borne pathogens. The min. biofilm eradication concentrations (MBECs) of 24 food additives against Escherichia coli and Staphylococcus aureus were estimated by a combined method of biofilm formation on the 96-pin microtiter plate lid, followed by a colorimetric microbial viability assay based on the reduction of tetrazolium salt. Fumaric acid alone demonstrated potent biofilm eradication activities against both E. coli and S. aureus. Furthermore, the combined effects of fumaric acid with other food additives against food-borne pathogenic biofilms were evaluated. Fumaric acid in combination with lactic acid and ferulic acid could effectively reduce the MBECs of a wide variety of food-borne bacteria. The selected combination was applied to the storage tests of fruit drinks and lightly pickled vegetables contaminated with biofilms. The findings of the present study revealed that the combination of fumaric acid, lactic acid, and ferulic acid can serve as an effective and safe inhibitor for use against biofilms by a wide variety of food-borne bacteria.

Food Control published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C8H7NO4, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

del Carmen Alcudia-Leon, Maria published the artcileDetermination of the three main components of the grapevine moth pest pheromone in grape-related samples by headspace-gas chromatography- mass spectrometry, Formula: C14H26O2, the publication is Separations (2017), 4(4), 31/1-31/7, database is CAplus.

The grapevine moth (Lobesia botrana) is the most significant pest of viticulture. This article reports the development of an anal. method that allows the instrumental determination of the three main pheromone components of the pest ((E,Z)-7,9-dodecadien-1-yl acetate, (E,Z)-7,9-dodecadien-1-ol and (Z)-9-dodecen-1-yl acetate) in grape-related samples (must, table grape and wine grape). The combination of headspace, gas chromatog. and mass spectrometry provides limits of detection in the range of 60-420 ng/Kg and precision, expressed as a relative standard deviation, better than 8.5%. This anal. approach is rapid and simple and opens a door to the study of the pest incidence on the final products.

Separations published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guldberg, T. S. published the artcileAnalysis of synthetic antioxidants in salmon silage using QuEChERS extraction method followed by determination by LC-MS/MS; a single-laboratory validation study, SDS of cas: 121-79-9, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2021), 122715, database is CAplus and MEDLINE.

A new method was developed and inhouse validated to determined ethoxyquin (EQ), butylated hydroxyanisole (BHA) and Pr gallate (PG) in fish silage and fish oil used for production of animal feed. Sample pre-treatment comprises use of QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction and gives extracts for liquid chromatog.-triple quadrupole mass spectrometry anal. without matrix interferences. The results allow quantification of the antioxidants in all matrixes by using deuterated internal standards and calibration curves made in solvent, as well as establishing low detection limits (0.012-0.015 mg/kg) and quantification limits (0.040-0.050 mg/kg) needed regarding the recent suspension of EQ as feed additive within the European Union. The proposed method was validated in terms of linearity, accuracy (relative error, ±1.4%), precision (RSD, â‰?.7%) and recovery (matrix effect, 97-101%) where all the parameters show acceptable results according to recognized guidelines (including EuraChem) within method validation. Combined expanded measurement uncertainty was estimated with a coverage factor of 2 by including all contributors to anal. variation, showing results of ±15% or better. The combined QuEChERS and LC-MS/MS method was successfully applied to salmon silage samples and their corresponding aqueous and oil fractions.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bandgar, B. P. published the artcileA one-pot rapid synthesis of dithiocarbamates from alcohols using a polymer supported diethyl dithiocarbamate anion⁺, Formula: C12H17NS2, the publication is Journal of Chemical Research, Synopses (2000), 450-451, database is CAplus.

A polymer supported diethyldithiocarbamate anion reacts with primary and secondary alcs. via their trifluoracetates giving alkylated diethyldithiocarbamates in good yields. For example, a solution of benzyl alc. in dichloromethane was added trifluoroacetic anhydride. The trifluoroacetic acid thus formed was evaporated together with the solvent and the residue (benzyl trifluoroacetate) was diluted with acetonitrile and added to Amberlite IRA-400-supported N,N-diethyldithiocarbamate and the mixture was stirred at 25° for 5 min. The resin was removed by filtration and the product, diethylcarbamodithioic acid phenylmethyl ester, was obtained in 84% yield.

Journal of Chemical Research, Synopses published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Soleimani, Adel published the artcileSynthesis, Characterization and Thermal Properties of Intrinsic Self-Healing Polyurethane Nanocomposites, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is ChemistrySelect (2022), 7(16), e202103978, database is CAplus.

A hybrid thermo-reversible crosslinking polyurethane nanocomposite containing 0.5, 1, and 2 weight% of nano-silica was prepared with three intrinsic self-healing bonds (reversible covalent bonds supported by intrinsic hydrogen bonds and dangling chains). Owing to the introduction of pseudo-tannin and polyester diol that could form phenol-urethane networks and using nano-silica that causes dangling chains and hydrogen bonds, the prepared polyurethanes are capable of being reversed at 110°C and rejoin at low temperatures Thermoset self-healing polyurethane nanocomposites are prepared from pseudo-tannin, nano-silica, and a urethane-based prepolymer. The investigations of chem. structure, self-healing behavior, and crosslink network are carried out by Fourier Transform IR Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) technique, and swelling test. Dissociation of phenolic urethane at 110°C was confirmed by temperature variable FTIR. By swelling test, it was found that the self-healing polyurethane nanocomposites with 0.5 weight% of nano-silica have the most hard-domain, gel content, and crosslink d. in the samples. DSC technique shows that polyurethane samples have two heat transfer transitions (dangling chains and self-healing). Thermogravimetric anal. (TGA) findings show that nanocomposites decompose at elevated temperatures than neat PU, and the rate of degradation diminishes as silica content increases.

ChemistrySelect published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C11H21BF4N2O2, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dutta, Soumya published the artcileIodine mediated direct coupling of benzylic alcohols with dithiocarbamate anions: An easy access of S-benzyl dithiocarbamate esters under neat reaction condition, Recommanded Product: Benzyl diethylcarbamodithioate, the publication is Tetrahedron Letters (2020), 61(41), 152382, database is CAplus.

An efficient, metal and solvent free synthesis of S-benzylic dithiocarbamate esters has been demonstrated via the iodine mediated direct C-S coupling of benzylic alcs. with dithiocarbamate anions generated in-situ by the reactions of amines and carbon disulfide. All the reactions were very fast (15-30 min) and performed under open air atm. Cyclic and acyclic secondary amines, primary amine, aromatic amine actively participated in the one-pot coupling reactions with different benzylic alcs. Non benzylic alcs. offer the synthesis of O-thiocarbamate compounds under the identical reaction condition.

Tetrahedron Letters published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Recommanded Product: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Delfanian, Mojtaba published the artcileEffect of Steric Structure on the Mechanism of Antioxidant Activity of Alkyl Gallates in Soybean Oil Triacylglycerols-A Kinetic Approach, SDS of cas: 121-79-9, the publication is European Journal of Lipid Science and Technology (2021), 123(9), 2100019, database is CAplus.

From an interfacial phenomena standpoint, the effect of the alkyl chain length is evaluated on the mechanism of antioxidant activity of gallic acid ester derivatives (Me, Pr, octyl, dodecyl, and stearyl gallates) in bulk phase oil. A combinational kinetic model is used to estimate the oxidation kinetic parameters, such as induction period, the maximum concentration of lipid hydroperoxides, and critical reverse micelle concentration These kinetic parameters are estimated much better with the combinational model compared to the tangent method. The nonlinear behavior is observed for inhibitory activities of homologous series of antioxidants in soybean triacylglycerols. In terms of different kinetics parameters, including antioxidant effectiveness and activity, Me gallate has the highest inhibitory effect during lipid peroxidation Gallic acid and alkyl gallates are able to protect bulk oils against peroxidation (induction period > 336 h) in terms of the extent of their participation in the main reaction of chain termination and pro-oxidative side reactions of chain initiation, and anti-oxidative side reactions of chain propagation. This work explains the effect of the esterification in the inhibitory activity of alkyl gallates, mechanism action of alkyl gallates in bulk oil systems, antiradical potency as a function of the interfacial phenomena, and free radical chain mechanism, the impact of antioxidant activity on critical reverse micelle concentration of hydroperoxides. Moreover, in this study, it is confirmed that the combinational kinetic model can be employed as a reliable method for determining the oxidation kinetic parameters.

European Journal of Lipid Science and Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Trollss, Mikael published the artcileNovel Thermally Stable Polymer Materials for Second-Order Nonlinear Optics, Product Details of C15H14O3, the publication is Macromolecules (1996), 29(7), 2590-8, database is CAplus.

A novel method of preparing thermally stable thin films with intrinsic second-order nonlinear optical activity is described. Design and synthesis yielded new ferroelec. bifunctional liquid crystalline acrylate monomer mixtures with a fast electro-optical response in the chiral smectic C (SmC*) phase. The ferroelec. liquid crystalline monomer mixtures were poled and subsequently cross-linked by in-situ photopolymerization in the surface-stabilized ferroelec. liquid crystal state. After crosslinking the polarization is no longer reversible, hence the material is pyroelec. and not ferroelec. The cross-linked pyroelec. materials displayed a thermally stable nonlinear optical response.

Macromolecules published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C18H26ClN3O, Product Details of C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kumar, Vinod published the artcileTuning Cationic Micelle Properties with an Antioxidant Additive: A Molecular Perspective, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Langmuir (2021), 37(15), 4611-4621, database is CAplus and MEDLINE.

In this work, we characterize the micellization and morphol. transition induced in aqueous cetyltrimethylammonium bromide (CTAB) solution by the addition of the antioxidant Pr gallate (PG) using tensiometry, rheol., and small-angle neutron scattering (SANS) techniques combined with the mol. dynamics (MD) simulation approach. The adsorption of CTAB at the air-water interface in the presence of varying [PG] revealed a progressive decrease in the critical micelle concentration (CMC), while the changes in different interfacial parameters indicated enhancement of the hydrophobicity induced by PG in the CTAB micellar system. The dynamic rheol. behavior indicated an increase in the flow viscosity (η) as a function of [PG]. Moreover, the rheol. components (storage modulus, G’, and loss modulus, G”) depicted the viscoelastic features. SANS measurements depicted the existence of ellipsoidal micelles with varying sizes and aggregation number (N_agg) as a function of [PG] and temperature Computational simulation performed using d. functional theory (DFT) calculations and mol. dynamics (MD) provided an insight into the at. composition of the examined system. The mol. electrostatic potential (MEP) anal. depicted a close proximity of CTAB, i.e., emphasized favorable interactions between the quaternary nitrogen of CTAB and the hydroxyl group of the PG monomer, further validated by the two-dimensional nuclear Overhauser enhancement spectroscopy (2D-NOESY), which showed the penetration of PG inside the CTAB micelles. In addition, various dynamic properties, viz., the radial distribution function (RDF), the radius of gyration (R_g), and solvent-accessible surface area (SASA), showed a significant microstructural evolution of the ellipsoidal micelles in the examined CTAB-PG system, where the changes in the micellar morphol. with a more elongated hydrophobic chain and the increased R_g and SASA values indicated the notable intercalation of PG in the CTAB micelles.

Langmuir published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics