Tag: M.W=150-200

Saha, M. N. published the artcileSmall molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents, Quality Control of 72835-26-8, the main research area is small mol MIRA1 antimyeloma doxorubicin dexamethasone Velcade synergism; multiple myeloma.

Background: Small mol. MIRA-1 induced mutant p53-dependent apoptosis in several types of solid tumors. However, anti-tumor activity of MIRA-1 in haematol. malignancies including multiple myeloma (MM) is unknown. In this study, we evaluated the effect of MIRA-1 in MM. Methods: We examined the anti-tumor activity of MIRA-1 alone or in combination with current anti-myeloma agents in a panel of MM cell lines, primary MM samples, and in a mouse xenograft model of MM. Results: MIRA-1 treatment resulted in the inhibition of viability, colony formation, and migration and increase in apoptosis of MM cells irresp. of p53 status accompanied by upregulation of Puma and Bax and downregulation of Mcl-1 and c-Myc. Genetic knockdown of p53 did not abrogate apoptotic response of MIRA-1. MIRA-1 triggered activation of PERK and IRE-α leading to splicing of XBP1 indicating an association of endoplasmic reticulum stress response. Furthermore, combined treatment of MIRA-1 with dexamethasone, doxorubicin or velcade displayed synergistic response in MM cells. Importantly, MIRA-1 alone or in combination with dexamethasone retarded tumor growth and prolonged survival without showing any untoward toxicity in the mice bearing MM tumor. Conclusions: Our data provide the preclin. framework for clin. evaluation of MIRA-1 as a novel therapeutic agent to improve patient outcome in MM.

British Journal of Cancer published new progress about Apoptosis. 72835-26-8 belongs to class esters-buliding-blocks, name is (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, and the molecular formula is C8H9NO4, Quality Control of 72835-26-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parlow, John J. published the artcileSynthesis of pyrazolecarbonylaminopyridinecarboxamides as herbicides, Category: esters-buliding-blocks, the main research area is pyridinecarboxamide pyrazolecarboxamide preparation herbicide; pyrazolecarboxamidopyridinecarboxamide preparation herbicide.

Target compounds from a herbicide lead area, pyrazolecarboxamides, were selected and synthesized. These targets were chosen based on structural similarities with other known bleaching herbicides and the structure activity relationship previously established with analogs of one of the lead compounds Syntheses of the three target compounds I (X, R = C, MeO; N, MeO; N, H) were accomplished, two of which involved various transformations and regioselective additions with a pyridine nucleus to afford novel pyridine derivatives I were tested in whole plant assays with the herbicidal data reported.

Journal of Heterocyclic Chemistry published new progress about Herbicides. 217314-47-1 belongs to class esters-buliding-blocks, name is Methyl 3-amino-5-methoxybenzoate, and the molecular formula is C9H11NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Rong published the artcileA modified Prins reaction for the facile synthesis of structurally diverse substituted 5-(2-hydroxyethyl)-3,3-dihydrofurane-2(3H)-ones, Product Details of C9H16O2, the main research area is hydroxyethyltetrahydrofuranone preparation; allyl carboxylic acid preparation Prins reaction hydrolysis lactonization.

Furanones are important synthetic intermediates commonly found in natural products, receptor ligands, and drug mols. Unacceptable yields of substituted furanones obtained using a previously reported Prins reaction led to the development of a modified approach. Readily prepared substituted allylic esters were reacted under Prins reaction conditions catalyzed by a protic acid to provide structurally diverse substituted furanones in modest to good yields. The reaction goes through a protected caprolactone intermediate that was isolated and characterized for selected compounds The approach supplies an efficient, versatile, and higher yield method for the synthesis of these important heterocyclic intermediates.

Tetrahedron Letters published new progress about Hydrolysis. 86549-27-1 belongs to class esters-buliding-blocks, name is Ethyl 2,2-dimethylpent-4-enoate, and the molecular formula is C9H16O2, Product Details of C9H16O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Noguchi, Takuya published the artcileBiocatalytic hydrolysis of various esters using Baker’s yeast under neutral conditions without sucrose, Safety of Ethyl nonanoate, the main research area is enzymic hydrolysis bakers yeast.

It was found that biocatalytic hydrolysis of various esters using Baker’s yeast proceeds efficiently under neutral conditions without sucrose. Hydrolysis of Et, Me, Pr, iso-Pr, benzyl, allyl, prenyl, and vinyl esters of 3-phenylpropanoic acid using Baker’s yeast gave easily 3-phenylpropanoic acid in 52-86% yields. In contrast, Baker’s yeast did not hydrolyze the rigid structural esters such as cinnamyl and Ph 3-phenylpropanoates. Then, Baker’s yeast hydrolyzed various Et esters of 3-arylpropanoic acids, 4-phenylbutanoic acid, and fatty acids to afford the corresponding acids in 29-85% yields.

Tetrahedron Letters published new progress about Hydrolysis. 123-29-5 belongs to class esters-buliding-blocks, name is Ethyl nonanoate, and the molecular formula is C11H22O2, Safety of Ethyl nonanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsujikawa, Kenji published the artcileDegradation of 1-phenyl-2-propanone during long-term storage: useful information for methamphetamine impurity profiling, Formula: C9H10O2, the main research area is phenyl propanone methamphetamine impurity degradation storage.

1-Phenyl-2-propanone (P2P) is a main precursor of methamphetamine. The authors investigated the formation of P2P degradation products during long-term storage and the factors that affected P2P degradation Samples of neat P2P, 1 mg/mL P2P in methanol and in Et acetate were prepared These samples were stored at room temperature or 4°C for 1, 3, and 6 mo; then the samples were analyzed by gas chromatog.-mass spectrometry. A similar experiment (but stored only for 1 mo) was also performed for phenylacetylcarbinol. Neat P2P stored at room temperature gave degradation products after 3-mo storage, and the degradation proceeded over the next 3 mo. Benzaldehyde, benzoic acid, benzyl acetate, 1-phenyl-1,2-propanedione, phenylacetylcarbinol, 1-acetoxy-1-phenyl-2-propanone, and 1,1-diphenylacetone were identified as degradation products after 6-mo storage. The degradation was prevented incompletely by storage at 4°C and almost completely by storage in the organic solvents. Neat phenylacetylcarbinol stored at room temperature was remarkably decomposed Benzaldehyde, benzoic acid, 1-phenyl-1,2-propanedione, and 1-acetoxy-1-phenyl-2-propanone were regarded as the degradation products. The degradation was prevented incompletely by storage at 4°C and almost completely by storage in the organic solvents. These results suggested that P2P and phenylacetylcarbinol were oxidized by oxygen in air and that the organic solvents inhibited the oxidation P2P was presumed to be initially oxidized to phenylacetylcarbinol, then it was converted to benzaldehyde, benzoic acid, 1-phenyl-1,2-propanedione, and 1-acetoxy-1-phenyl-2-propanone. Production of phenylacetylcarbinol from P2P is useful information for methamphetamine impurity profiling because phenylacetylcarbinol is a precursor of ephedrines, the other methamphetamine precursors.

Forensic Toxicology published new progress about Impurities. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Formula: C9H10O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liao, Yinfei published the artcileAlkanes-esters mixed collector enhanced low rank coal flotation: Interfacial interaction between oil drop and coal particle, Recommanded Product: Ethyl octanoate, the main research area is coal particle rank flotation interfacial interaction oil drop.

The interaction between oil collector drop and coal particle is important for low-rank coal (LRC) flotation. This paper investigated such interactions using dodecane (D), Et esters (E) and dodecane-esters mixed collector (MC). Measurements of oil drop-coal induction time and detachment force were conducted at a mesoscopic scale. The micro adsorption mechanism of oil collectors was revealed by wetting heats and FTIR measurements. Flotation results showed MC, especially dodecane-Et laurate, obtained high yield and low ash clean coal. There was a shorter induction time and higher adhesion strength between LRC particle and MC drop. The wetting heat of MC was greater than the sum of wetting heat of the two single collectors. FTIR anal. indicated that D validly adsorbed to the Me or aromatic groups, and E bonded with the oxygen-containing groups. The macro flotation results was well interpreted by the interfacial interaction of collector-coal at the mesoscopic and micro scales.

Fuel published new progress about Actuators. 106-32-1 belongs to class esters-buliding-blocks, name is Ethyl octanoate, and the molecular formula is C10H20O2, Recommanded Product: Ethyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Behera, Satyaranjan published the artcileAn efficient, economical and eco-friendly acylation of alcohols and amines by alum doped nanopolyaniline under solvent-free condition, Application In Synthesis of 140-11-4, the main research area is alum nanopolyaniline catalyst alc amine acylation.

We report acylation of alcs. and amines employing acetic acid as an acylating agent in solvent-free condition by using alum doped nanopolyaniline (NDPANI) as a catalyst. This environmentally benign method does not use corrosive acid anhydrides and acid chlorides for acylation and does not produce waste product. Also, a non-toxic potash alum was used for doping of polyaniline rather than corrosive acids. The reaction conditions represent an advance over established method not only in omitting the need for expensive catalysts or solvents but also in shortening the reaction time significantly. The advantages of this catalyst are non-hazardous, cheap, reusable, easy to prepare and handling.

Applied Catalysis, A: General published new progress about Acylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Application In Synthesis of 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ait Khouya, Ahmed published the artcileCoating of polydopamine on polyurethane open cell foams to design soft structured supports for molecular catalysts, Safety of Benzyl acetate, the main research area is polyurethane open cell foam polydopamine coating catalyst support.

Polydopamine-coated polyurethane open cell foams are used as structured supports for mol. catalysts through the covalent anchoring of alkoxysilyl arms by the catechol groups of the mussel-inspired layer. This strong bonding prevents their leaching. No alteration of the mech. properties of the flexible support is observed after repeated uses of the catalytic materials.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Safety of Benzyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luna-Mora, Ricardo Alfredo published the artcileSimultaneous infrared-ultrasound irradiation in organic synthesis: acylation of amines alcohols and amino alcohols, Application of Benzyl acetate, the main research area is amine acylation IR ultrasonication green chem; alc acylation IR ultrasonication.

The acylation of both aliphatic and aromatic amines, alcs. and amino alcs. by simultaneous IR-ultrasound irradiation (SIUI) in solvent-free conditions in short reaction times and with good to excellent yields was achieved. The results obtained with SIUI and for thermal, IR and ultrasound energy sources are compared. This is the first report regarding to the application of SIUI in acylation reactions.

Journal of the Mexican Chemical Society published new progress about Acylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Application of Benzyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tandon, Nitin published the artcileMagnetically recyclable silica-coated ferrite magnetite-K10 montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions, Quality Control of 140-11-4, the main research area is silica coated ferrite magnetite montmorillonite nanocatalyst; oxygen nitrogen sulfer acylation reaction solvent free condition.

Novel silica-coated ferrite nanoparticles supported with montmorillonite (K10) have been prepared successfully by using a simple impregnation method. Further, these nanoparticles were characterized by using different anal. methods like FT-IR, PXRD, EDS, and FE-SEM techniques. In addition, these nanoparticles have been explored for their catalytic activity for the O, N, and S-acylation reactions under solvent-free conditions which gave moderate to excellent yields in a much shorter reaction time. Moreover, these nanoparticles could easily be separated out from the reaction medium after the reaction completion by using an external magnetic field and have been re-used for 10 cycles without any significant loss of the catalytic activity.

RSC Advances published new progress about Acylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Quality Control of 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics