Tag: M.W=150-200

Hafizi, Hamid published the artcileMagnetically recyclable Schiff-based palladium nanocatalyst [Fe₃O₄@SiNSB-Pd] and its catalytic applications in Heck reaction, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Arabian Journal of Chemistry (2022), 15(7), 103914, database is CAplus.

A magnetically separable palladium nanocatalyst has been synthesized through the immobilization of palladium onto 3-aminopropylphenanthroline Schiff based functionalized silica coated superparamagnetic Fe₃O₄ nanoparticles. The nanocatalyst (Fe₃O₄@SiNSB-Pd) was fully characterized using several spectroscopic techniques, such as FT-IR, HR-SEM, TEM, XRD, ICP, and XPS. The microscopic image of Fe₃O₄ showed spherical shape morphol. and had an average size of 150 nm. The Pd-nanoparticles exhibited an average size 3.5 ± 0.6 nm. The successful functionalization of Fe₃O₄@SiNSB-Pd was identified by FT-IR spectroscopy and the appearance of palladium species in Fe₃O₄@SiNSB-Pd was confirmed by XRD anal. While XPS has been utilized for the determination of the chem. oxidation state of palladium species in Fe₃O₄@SiNSB-Pd. Several activated and deactivated arene halides and olefines were employed for Mizoroki-Heck cross-coupling reactions in the presence of Fe₃O₄@SiNSB-Pd, each of which produced the resp. cross-coupling products with excellent yields. The Fe3O4@SiNSB-Pd shows good reactivity and reusability for up to seven consecutive cycles.

Arabian Journal of Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Qin, Tao published the artcileCobalt-Catalyzed Radical Hydroamination of Alkenes with N-Fluorobenzenesulfonimides, Synthetic Route of 103-26-4, the publication is Angewandte Chemie, International Edition (2021), 60(49), 25949-25957, database is CAplus and MEDLINE.

An efficient and general radical hydroamination of alkenes using Co(salen) as catalyst, N-fluorobenzenesulfonimide (NFSI) and its analogs as both nitrogen source and oxidant was successfully disclosed. A variety of alkenes, including aliphatic alkenes, styrenes, α, β-unsaturated esters, amides, acids, as well as enones, were all compatible to provide desired amination products. Mechanistic experiments suggest that the reaction underwent a metal-hydride-mediated hydrogen atom transfer (HAT) with alkene, followed by a pivotal catalyst controlled SN₂-like pathway between in-situ generated organocobalt(IV) species and nitrogen-based nucleophiles. Moreover, by virtue of modified chiral cobalt(II)-salen catalyst, an unprecedented asym. version was also achieved with good to excellent level of enantiocontrol. This novel asym. radical C-N bond construction opened a new door for the challenging asym. radical hydrofunctionalization.

Angewandte Chemie, International Edition published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Jie published the artcileAmbient Hydrogenation and Deuteration of Alkenes Using a Nanostructured Ni-Core-Shell Catalyst, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Angewandte Chemie, International Edition (2021), 60(34), 18591-18598, database is CAplus and MEDLINE.

A general protocol for the selective hydrogenation and deuteration of a variety of alkenes is presented. Key to success for these reactions is the use of a specific nickel-graphitic shell-based core-shell-structured catalyst, which is conveniently prepared by impregnation and subsequent calcination of nickel nitrate on carbon at 450 °C under argon. Applying this nanostructured catalyst, both terminal and internal alkenes, which are of industrial and com. importance, were selectively hydrogenated and deuterated at ambient conditions (room temperature, using 1 bar hydrogen or 1 bar deuterium), giving access to the corresponding alkanes and deuterium-labeled alkanes in good to excellent yields. The synthetic utility and practicability of this Ni-based hydrogenation protocol is demonstrated by gram-scale reactions as well as efficient catalyst recycling experiments

Angewandte Chemie, International Edition published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Smith, Jeffrey S. published the artcileA robust structure-activity relationship (SAR) model for esters that cause skin irritation in humans, Safety of 3-Methylbut-2-en-1-yl benzoate, the publication is Toxicological Sciences (2000), 55(1), 215-222, database is CAplus and MEDLINE.

A structure-activity relationship (SAR) model has been developed to discriminate skin irritant from nonirritant esters. The model is based on the physicochem. properties of 42 esters that were tested in humans for skin irritation. Nineteen physicochem. parameters that represent transport, electronic, and steric properties were calculated for each chem. Best subsets regression anal. indicated candidate models for further anal. Regression analyses identified significant models (p < 0.05) that had variables that were also significant (p < 0.05). These candidate models were evaluated using linear discriminant anal. to determine if the irritant esters could be discriminated from nonirritant esters. The stability of the model was evident from the consistency of parameters among ten submodels generated using multiple random sampling of the database. The sensitivity of the ten models, evaluated by “leave-one-out” cross-validation, ranged from 0.846 to 0.923, with a mean of 0.885±0.025 (95% CI). The specificity ranged from 0.615 to 0.923, with a mean of 0.738±0.06 (CI). Compared with nonirritant esters, irritant esters had lower d., lower water solubility, lower sum of partial pos. charges, higher Hansen hydrogen bonding parameter, and higher Hansen dispersion parameter. The results indicate that physicochem. features of esters contribute to their ability to cause skin irritation in humans, and that chem. partitioning into the epidermis and intermol. reactions are likely important components of the response. This model is applicable for prediction of human irritation of esters yet untested.

Toxicological Sciences published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C19H14O2, Safety of 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shao, Changdong published the artcileOxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Organic & Biomolecular Chemistry (2017), 15(23), 5033-5040, database is CAplus and MEDLINE.

An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as a CO source was developed. The reaction features high safety, low catalyst loading, and a broad substrate scope, and provided a safe and tractable approach to access a variety of aromatic carboxylic acid compounds Mechanistic studies revealed the decomposition pattern of oxalic acid.

Organic & Biomolecular Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C7H5Cl2NO, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Paridala, Kumaraswamy published the artcileTandem one-pot CO₂ reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids, Quality Control of 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(82), 11574-11577, database is CAplus and MEDLINE.

The present study disclosed the synthesis of aryl/vinyl carboxylic acids from Csp²-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO₂ and hydrosilane) as an instant CO-surrogate. Hydrosilane provided hydride for reduction and its oxidation product silanol served as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Di published the artcileA likely protective effect of dimethyl itaconate on cerebral ischemia/reperfusion injury, Name: Dimethyl itaconate, the publication is International Immunopharmacology (2019), 105924, database is CAplus and MEDLINE.

As a membrane-permeable derivative of itaconate, di-Me itaconate (DMI) was recently showed to limit inflammatory response of activated macrophages, and to decrease the generation of reactive oxygen species and reduce cardiac ischemia/reperfusion injury. However, the effect of DMI in the context of cerebral ischemia/reperfusion injury remains unclear. Here, we treated the transient middle cerebral artery occlusion (tMCAO) mice with DMI or saline at the beginning of occlusion, and allowed them to recover for 3 days. We found that DMI obviously decreased the neurol. deficit score. Further, DMI significantly inhibited the toxic conversion of the peri-infarct microglia, and decreased the protein level of interleukin 1β. The present findings suggest that DMI might be recognized as a promising candidate for the treatment of ischemic stroke.

International Immunopharmacology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H10O, Name: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bollenbach, Maud published the artcileDesign and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model, Product Details of C9H8O4, the publication is European Journal of Medicinal Chemistry (2019), 269-290, database is CAplus and MEDLINE.

Herein, a series of aminophthalazine I [R = H, Ph, 1-piperidyl, etc.; R¹ = H, CF₃; R² = 3-ClC₆H₄NH, 4-MeOC₆H₄CH₂NH, Ph(CH₂)₂NH, etc.] and aminoindazole derivatives II [R³ = H, Cl, CF₃; R⁴ = H, Me, Ph, etc.; R⁵ = 3-ClC₆H₄, 4-MeOC₆H₄CH₂, 3-F-4-MeOC₆H₃CH₂, etc.] were synthesized and evaluated for their inhibitory activity toward PDE5. Selectivity profiles towards other PDE1-4 isoenzymes, water solubility and stability in acidic medium of the most potent PDE5 inhibitors were determined and the aminophthalazine I [R = Ph, R¹ = CF₃, R² = 4-OMeC₆H₄CH₂NH] and its mimetic compound II [R³ = CF₃, R⁴ = 3-pyridyl, R⁵ = 4-OMeC₆H₄CH₂NH] were evaluated in comparison to MY 5445 in vivo in a model of neuropathic pain induced by sciatic nerve cuffing in mice (3 and 0.5 mg/kg, i.p. twice a day). Both compounds showed the same efficacy on neuropathic allodynia as MY 5445 and thus produced a significant relief of mech. hypersensitivity after 12 days of treatment.

European Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Khachatoorian, Careen published the artcileE-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models, Safety of Methyl 3-phenyl-2-propenoate, the publication is Toxicology In Vitro (2021), 105234, database is CAplus and MEDLINE.

Our goal was to evaluate the effects of EC refill fluids and EC exhaled aerosol residue (ECEAR) on cultured human keratinocytes and MatTek EpiDerm, a 3D air liquid interface human skin model. Quantification of flavor chems. and nicotine in Dewberry Cream and Churrios refill fluids was done using GC-MS. The dominant flavor chems. were maltol, ethyl maltol, vanillin, Et vanillin, benzyl alc., and furaneol. Cytotoxicity was determined with the MTT and LDH assays, and inflammatory markers were quantified with ELISAs. Churrios was cytotoxic to keratinocytes in the MTT assay, and both fluids induced ROS production in the medium (ROS-Glo) and in cells (CellROX). Exposure of EpiDerm to relevant concentrations of Dewberry Cream and Churrios for 4 or 24 h caused secretion of inflammatory markers (IL-1α, IL-6, and MMP-9), without altering EpiDerm histol. Lab made fluids with propylene glycol (PG) or PG plus a flavor chem. did not produce cytotoxic effects, but increased secretion of IL-1α and MMP-9, which was attributed to PG. ECEAR derived from Dewberry Cream and Churrios did not produce cytotoxicity with Epiderm, but Churrios ECEAR induced IL-1α secretion. These data support the conclusion that EC chems. can cause oxidative damage and inflammation to human skin.

Toxicology In Vitro published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Safety of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Yi published the artcileDiscovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma, SDS of cas: 1877-71-0, the publication is Journal of Medicinal Chemistry (2020), 63(9), 4701-4715, database is CAplus and MEDLINE.

While proteasome inhibitors such as bortezomib showed satisfactory clin. benefits in the initial treatment of multiple myeloma (MM), drug resistance and relapse are unavoidable. Recent studies suggested inhibition of histone deacetylases (HDACs) restored sensitivity of bortezomib-resistant MM. Hence, we designed dual inhibitors targeting both HDACs and proteasomes to address the resistance of bortezomib. The most potent inhibitors, ZY-2 and ZY-13 showed excellent inhibition against proteasome and good selectivity against HDACs. In particular, ZY-2 not only exhibited good antiproliferative activities on the MM cell lines RPMI-8226, U266, and KM3 (IC₅₀ values of 6.66, 4.31, and 10.1 nM, resp.) but also showed more potent antiproliferative activities against the bortezomib-resistant MM cell line KM3/BTZ compared with bortezomib (IC₅₀ values of 8.98 vs. 226 nM, P < 0.01) and even better than the combination of the HDAC inhibitor MS-275 and bortezomib (1:1) (IC₅₀ values of 8.98 vs. 98.0 nM, P < 0.01).

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C3H10ClNS, SDS of cas: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics