Tag: M.W=150-200

Cordes, Thekla published the artcileItaconate alters succinate and coenzyme A metabolism via inhibition of mitochondrial complex II and methylmalonyl-CoA mutase, Quality Control of 617-52-7, the publication is Metabolites (2021), 11(2), 117, database is CAplus and MEDLINE.

Itaconate is a small mol. metabolite that is endogenously produced by cis-aconitate decarboxylase-1 (ACOD1) in mammalian cells and influences numerous cellular processes. The metabolic consequences of itaconate in cells are diverse and contribute to its regulatory function. Here, we have applied isotope tracing and mass spectrometry approaches to explore how itaconate impacts various metabolic pathways in cultured cells. Itaconate is a competitive and reversible inhibitor of Complex II/succinate dehydrogenase (SDH) that alters tricarboxylic acid (TCA) cycle metabolism leading to succinate accumulation. Upon activation with CoA (CoA), itaconyl-CoA inhibits adenosylcobalamin-mediated methylmalonyl-CoA (MUT) activity and, thus, indirectly impacts branched-chain amino acid (BCAA) metabolism and fatty acid diversity. Itaconate, therefore, alters the balance of CoA species in mitochondria through its impacts on TCA, amino acid, vitamin B12, and CoA metabolism Our results highlight the diverse metabolic pathways regulated by itaconate and provide a roadmap to link these metabolites to potential downstream biol. functions.

Metabolites published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Champion, Aymeric published the artcileA Simple and Efficient Model to Determine the Photonic Parameters of a Photopolymerizable Resin Usable in 3D Printing, Recommanded Product: Ethyl 4-dimethylaminobenzoate, the publication is ChemPhotoChem (2021), 5(9), 839-846, database is CAplus.

This study provides insight into the relationship between the photochem. reactivity and the photonic parameters of an acrylate formulation usable in digital light processing (DLP) 3D printing. First the photoreactivity of riboflavin tetrabutyrate (RFT) used as a non-toxic photoinitiator is assessed by laser flash photolysis in the absence and in the presence of an amine as co-initiator. RFT alone is able to photopolymerize the acrylate formulation at a rate which is drastically increased when the co-initiator is added. Then, the depth of light penetration (Dp) and the critical energy (Ec) to form a polymer film were measured and compared to those determined from the Bouguer-Lambert-Beer law for Dp and from the Stockmayer equation and photopolymerization experiments for Ec. A new proposed model is able to predict the in-depth acrylate conversion within a printed part with a relatively low input of exptl. parameters. Confocal Raman microscopy is used to discuss the effect of the photobleaching of RFT in the absence of co-initiator on the photopolymerized films. Finally, it is shown that this formulation performs quite well for 3D printing with a resolution close to the best performance of the DLP printer.

ChemPhotoChem published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Recommanded Product: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Santiago, Celine B. published the artcileDeveloping a Modern Approach To Account for Steric Effects in Hammett-Type Correlations, Application In Synthesis of 1877-71-0, the publication is Journal of the American Chemical Society (2016), 138(40), 13424-13430, database is CAplus and MEDLINE.

The effects of aryl ring ortho-, meta-, and para-substitution on site selectivity and enantioselectivity were investigated in the following reactions: (1) enantioselective Pd-catalyzed redox-relay Heck reaction of arylboronic acids, (2) Pd-catalyzed β-aryl elimination of triarylmethanols, and (3) benzoylformate decarboxylase-catalyzed enantioselective benzoin condensation of benzaldehydes. Through these studies, it is demonstrated that the electronic and steric effects of various substituents on selectivities obtained in these reactions can be described by NBO charges, the IR carbonyl stretching frequency, and Sterimol values of various substituted benzoic acids. An extended compilation of NBO charges and IR carbonyl stretching frequencies of various substituted benzoic acids was used as an alternative to Hammett values. These parameters provide a correlative tool that allows for the anal. of a much greater range of substituent effects because they can also account for proximal and remote steric effects.

Journal of the American Chemical Society published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Application In Synthesis of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ward, Lucy C. published the artcileCarboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Angewandte Chemie, International Edition (2022), 61(14), e202117324, database is CAplus and MEDLINE.

Carboxyl methyltransferase (CMT) enzymes catalyze the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-L-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5-6. Potential for application in industrial biotechnol. was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF).

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C8H5F3N4, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Yiding published the artcilePhotoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins, Quality Control of 617-52-7, the publication is Organic Letters (2020), 22(15), 5746-5748, database is CAplus and MEDLINE.

Various sulfone tetrazoles were activated via iridium photoredox catalysis in the presence of DMAP to gave dialkyl sulfones such as I [R¹ = 4-FC₆H₄CH₂CH₂, 4-ClC₆H₄CH₂, tetralin-2-yl, etc.; R² = CN, C(O)OEt, C(O)O-Bn, etc., R³ = H, CH₂C(O)OMe; R²R³ = CH₂CH₂OC(O); R⁴ = H, Me]. The presumed sulfone radical intermediates were trapped by a range of electron-deficient olefins in generally good to excellent yields.

Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Khachatoorian, Careen published the artcileTracing the movement of electronic cigarette flavor chemicals and nicotine from refill fluids to aerosol, lungs, exhale, and the environment, HPLC of Formula: 103-26-4, the publication is Chemosphere (2022), 286(Part_3), 131494, database is CAplus and MEDLINE.

Given the high concentrations of nicotine and flavor chems. in EC (electronic cigarette) fluids, it is important to determine how efficiently they transfer to aerosols, how well they are retained by users (exposure), and if they are exhaled into the environment where they settle of surfaces forming ECEAR (EC exhaled aerosol residue). To quantify the flavor chems. and nicotine in refill fluids, inhaled aerosols, and exhaled aerosols. Then deduce their retention and contribution to ECEAR. Flavor chems. and nicotine were identified and quantified by GC-MS in two refill fluids, smoking machine-generated aerosols, and aerosols exhaled by 10 human participants (average age 21; 7 males). Machine generated aerosols were made with varying puff durations and two wattages (40 and 80). Participants generated exhale ad libitum; their exhale was quantified, and chem. retention and contribution to ECEAR was modeled.”. Dewberry Cream” had five dominant (≥1 mg/mL) flavor chems. (maltol, ethyl maltol, vanillin, Et vanillin, furaneol), while “Cinnamon Roll” had one (cinnamaldehyde). Nicotine transferred well to aerosols irresp. of topog.; however, transfer efficiencies of flavor chems. depended on the chem., puff volume, puff duration, pump head, and EC power. Participants could be classified as “mouth inhalers” or “lung inhalers” based on their exhale of flavor chems. and nicotine and retention. Lung inhalers had high retention and exhaled low concentrations of EC chems. Only mouth inhalers exhaled sufficient concentrations of flavor chems./nicotine to contribute to chem. deposition on environmental surfaces (ECEAR). These data help distinguish two types of EC users, add to our knowledge of chem. exposure during vaping, and provide information useful in regulating EC use.

Chemosphere published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mahajani, Nivedita S. published the artcileEster Formation via Symbiotic Activation Utilizing Trichloroacetimidate Electrophiles, Formula: C12H14O2, the publication is Journal of Organic Chemistry (2019), 84(12), 7871-7882, database is CAplus and MEDLINE.

Trichloroacetimidates are useful reagents for the synthesis of esters under mild conditions that do not require an exogenous promoter. These conditions avoid the undesired decomposition of substrates with sensitive functional groups that are often observed with the use of strong Lewis or Bronsted acids. With heating, these reactions have been extended to benzyl esters without electron-donating groups. These inexpensive and convenient methods should find application in the formation of esters in complex substrates.

Journal of Organic Chemistry published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guo, Wei published the artcileBase-Promoted Three-Component Cyclization and Coupling Strategy for the Synthesis of Substituted 3-Aryl-5-thio-1,3,4-thiadiazole-2-thiones, Safety of Dimethyl itaconate, the publication is Asian Journal of Organic Chemistry (2022), 11(3), e202100745, database is CAplus.

An effective base-promoted cyclization and coupling strategy for the construction of substituted 3-aryl-5-thio-1,3,4-thiadiazole-2-thiones I [R¹ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; R² = C(O)OMe, C(O)CH₂CH(Me)₂, C(O)N(Me)₂, etc.] from phenylhydrazines, olefins and CS₂ was developed through employing CS₂ as a sulfur feedstock. The reaction proceeded under mild reaction conditions in the absence of any external catalysts, transition metals and ligands. The one-step three-component procedure also showed the merits of simple operation, using available starting materials, wide substrate scopes, and high atom and step economy. This reaction provided facile access to substituted 3-aryl-5-thio-1,3,4-thiadiazole-2-thiones I, which could be used in the field of drug research.

Asian Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pizarro, Guadalupe del C. published the artcileMicroporous hybrid films from amphiphilic copolymers: surface coated with ZnS nanoparticles using the breath figure (BF) methodology, Safety of Dimethyl itaconate, the publication is Chemical Papers (2020), 74(8), 2605-2612, database is CAplus.

High-performance catalysts and photovoltaics form key components for various technol. applications. Because catalytic and photovoltaic reactions occur at the interfaces between reactants and surfaces, the chem., phys., and structural properties of interfaces have been the focus of many studies. One route towards the improvement and optimization of such interfaces is the preparation of microporous materials from amphiphilic copolymers, which can also be surface coated with inorganic nanoparticles to obtain different properties. In this work, we have prepared microporous hybrid films with fluorescent properties from amphiphilic block copolymers surface coated with ZnS (NPs) based on the breath figure (BF) mechanism, keeping constant the concentration of ZnS NPs, solvent, humidity and substrates. The morphol. and optical properties were investigated by microscopic and optical characterization techniques. As a result, the fabrication method facilitates the preparation of fluorescent porous films with varying morphol. properties (shapes and diameter pore). The hybrid porous films containing polystyrene-b-polyacrylic acid, polystyrene-b-polyitaconic acid and polystyrene-b-polydialylmalonic acid were obtained with an average pore size of 0.57 ± 0.04 μm, 0.78 ± 0.03 μm and 1.50 ± 0.04 μm, resp. An increase in the water contact angle (WCA) was observed in the block copolymer porous films after functional process with ZnS (NPs).

Chemical Papers published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pizarro, Guadalupe del C. published the artcileMorphological, optical and wettability characterization of honeycomb patterned films based on self-assembling copolymer under thermal annealing, Recommanded Product: Dimethyl itaconate, the publication is Chemical Physics (2020), 110715, database is CAplus.

A series of honeycomb-patterned porous films based on self-assembly block copolymers with different hydrophilic blocks were prepared using the breath figure (BF) method. The variation of hydrophilic moieties into the block copolymers provokes a response in the pore diameter size dispersity and in the surface pore distribution entropy. The morphol. properties are examined using SEM and AFM microscopies, wettability properties were also studied. The distribution of the pores at the surface and shape variations of the structured films were studied by Raman spectroscopy before and after thermal annealing. We report a significant increase of the order and dispersity narrowing of the pores after thermal annealing which affects the water contact angle (WCA). These results were attributed to the process mechanism of the polymer chain self-assembly of the different hydrophilic moieties as a result of thermal annealing at temperatures below the glass transition temperature (T_g).

Chemical Physics published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics