Tag: M.W=150-200

McCourt, Ruairi O. published the artcileAtmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes, HPLC of Formula: 5205-11-8, the publication is Chemistry – A European Journal (2020), 26(68), 15804-15810, database is CAplus and MEDLINE.

A mild, metal-free, atm. oxygen-mediated radical hydrothiolation of alkenes (and alkyne) was reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atm. oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnished a range of functionalized products. Biomols. proved tolerant to the conditions and the procedure was robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirmed that the process proceeded through radical intermediates in a thiol-ene reaction manifold. The methodol. offered an efficient “green” approach for thiol-ene mediated “click” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Chemistry – A European Journal published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, HPLC of Formula: 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hajipour, Abdol R. published the artcileTriazine-hyperbranched polymer-modified magnetic nanoparticles-supported nano-cobalt for C-C cross-coupling reactions, Application of Methyl 3-phenyl-2-propenoate, the publication is Journal of the Iranian Chemical Society (2021), 18(12), 3219-3233, database is CAplus.

Design of hyperbranched polymers (HBPs) and crafting them in catalytic systems especially in organic chem. are a relatively unexplored domain. This paper reports the utilization of triazine hyperbranched polymer (THBP)-coated magnetic chitosan nanoparticles (MCs) as stabilizing matrix for cobalt nanoparticles. Cobalt nanoparticles were fabricated by coordination cobalt(II) ions with amine-terminated triazine polymer and then reduced into Co(0) using sodium borohydride in aqueous medium. The Co(0)-THBP@MCs were fully characterized by FT-IR, SEM-EDX, TEM, and TGA analyses. The presence of metallic cobalt was determined by ICP and XRD techniques. This novel hyperbranched polyaromatic polymer-encapsulated cobalt nanoparticles showed high catalytic activity in Mizoroki-Heck and Suzuki-Miyaura cross-coupling reactions. Heck and Suzuki reactions were carried out using 0.35 and 0.4 mol% of cobalt nanoparticles in which the turnover number (TON) values were calculated as 271 and 225, resp. In addition, the produced heterogeneous catalyst could be recovered and reused without considerable loss of activity. Oxygen stability and high reusability over 7 runs with trace leaching of the cobalt into the reaction media as well as moisture stability of the immobilized cobalt nanoparticles are their considerable worthwhile advantages.

Journal of the Iranian Chemical Society published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Application of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nannaware, Ashween Deepak published the artcileEco-friendly solar distillation apparatus for improving the yield of essential oils with enhancing organoleptic characteristics, Formula: C10H10O2, the publication is Renewable Energy (2022), 345-356, database is CAplus.

Solar-operated distillation unit (SDU) was designed and fabricated for extraction of valuable essentials from aromatic crops with a reduced cost of operation without carbon-credits to the environment. It comprised of distillation still, mesh grid frame, packed column, condenser, oil receiver, energy meter, resistive heating elements, and solar panels. This improved SDU can process 20 kg of aromatic crops in a batch type of operation. Resistive heating elements (4.5 kW) with controllers powered by the solar photovoltaic panel (5 kW) were used to produce the uniform steam generation within 20 min. This produced steam was adequate for continuous distillation (~3 h) of aromatic crops to collect valuable essentials in an oil receiver. The total power consumed by the SDU in carrying out the distillation operation was calculated (13.5 kWh). The extraction studies of Ocimum cultivars (CIM-Shishir, 100 and 102) through SDU and Clevenger-type apparatus (standard set) revealed that the SDU process was yielded improved essential oil (0.36-0.73%). GC-FID and GC/MS analyses divulged that the essential oil obtained through SDU was superior in quality with improved percentage of biomarkers such as linalool (up to 62.8%) and Me chavicol. Designed SDU has saved about 20 kg of wood per batch as compared to practiced wood-based distillation operation.

Renewable Energy published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shegavi, Mahadev L. published the artcileRecyclable Copper Nanoparticles-Catalyzed Hydroboration of Alkenes and β-Borylation of α,β-Unsaturated Carbonyl Compounds with Bis(Pinacolato)Diboron, Related Products of esters-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2021), 363(9), 2408-2416, database is CAplus.

Nano-ferrite-supported Cu nanoparticles (Fe-dopamine-Cu NPs) catalyzed anti-Markovnikov-selective hydroboration of alkenes with B₂pin₂ is reported under mild reaction conditions. This protocol can be applied to a broad range of substrates with high functional group compatibility. In addition, authors demonstrated the use of Fe-dopamine-Cu NPs as a catalyst for the β-borylation of α,β-unsaturated ketones and ester, providing alkylboronate esters in up to 98% yield. Reuse of the magnetically recyclable catalyst resulted in no significant loss of activity in up to five reaction runs for both systems.

Advanced Synthesis & Catalysis published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C18H28B2O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thornbury, Richard T. published the artcileThe development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes, Quality Control of 1877-71-0, the publication is Chemical Science (2017), 8(4), 2890-2897, database is CAplus and MEDLINE.

A mild palladium-catalyzed ligand-controlled regioselective 1,3-arylfluorination of 2[H]-chromenes was developed. The products with a syn-1,3 substitution pattern were obtained with high enantiomeric excess using a PyrOx ligand, wherein the utility of these pyranyl-fluorides was further demonstrated through their participation in a diastereoselective C-C bond forming reaction. Ligand dependent divergent formation of both the 1,3- and 1,2- alkene difunctionalization products was observed The nature of this bifurcation was investigated through exptl. studies in combination with computational and statistical anal. tools. Ultimately, the site selectivity was found to rely on ligand denticity and metal electrophilicity, the electronics of the boronic acid, and the donor ability of the directing group in the substrate.

Chemical Science published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C65H82N2O18S2, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nobsathian, Saksit published the artcileThe insecticidal potential of Piper ribesioides (Piperales: Piperaceae) extracts and isolated allelochemicals and their impact on the detoxification enzymes of Spodoptera exigua (Lepidoptera: Noctuidae), Synthetic Route of 103-26-4, the publication is Phytoparasitica (2021), 49(4), 659-673, database is CAplus.

The dried twigs of Piper ribesioides were used to prepare various extracts in different solvents. Each extract was evaluated for their toxicity against 2nd instar larvae of Spodoptera exigua. The highest acute toxicity was observed for Et acetate extract with an LD50 of 3.25 and 2.50 μg/larva and LD90 of 9.19 and 8.15 μg/larva after 24 and 48 h post-treatment after topical application. Piperine, Me piperate, N-cinnamoyl-(2-phenylethyl) amine, pinostrobin, pinocembrin, cinnamic acid, lemairamin, N,N-Diphenylcinnamide, and Me cinnamate were isolated from this extract that was toxic to S. exigua larvae. Cinnamic acid was the most active compound with a LD50 of 0.17 μg/larva after 48 h of topical treatment. Piperine was significantly similar in activity (LD50 = 0.19 μg/larva), but toxicity decreased with the change in structural configuration as observed with Me piperate (LD50 = 0.73 μg/larva). Other compounds were 3 to 11-fold less toxic than cinnamic acid and piperine. Growth of survived S. exigua larvae until adult emergence after topical application was recorded and maximum inhibition of about 70% was observed after the application of cinnamic acid. Egg hatch was only 29.11% after cinnamic acid treatment, compared to 97.38% in controls. Neither induction nor inhibition of detoxification enzymes due to treatment of extracts were statistically significant, however, individual compounds like cinnamic acid, Me cinnamate, piperine, pinostrobin, pinocembrin, and lemairamin did show a moderate impact on these enzymes.

Phytoparasitica published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Joseph, Jayan T. published the artcileRoom Temperature Carbonylation of (Hetero) Aryl Pentafluorobenzenesulfonates and Triflates using Palladium-Cobalt Bimetallic Catalyst: Dual Role of Cobalt Carbonyl, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Advanced Synthesis & Catalysis (2017), 359(3), 419-425, database is CAplus.

An efficient method for the carbonylation of (hetero) aryl pentafluorobenzenesulfonates and triflates under exceptionally mild conditions using palladium/dicobalt octacarbonyl [Pd/Co₂(CO)₈] has been developed. Besides acting as carbon monoxide (CO) source, Co₂(CO)₈ enhances the reaction rate by accelerating the CO insertion through an in situ generated bimetallic palladium cobalt tetracarbonyl [Pd-Co(CO)₄] complex. Under the optimized reaction condition, carbonylation of a wide range of activated and deactivated, as well as sterically hindered and heteroaromatic, substrates proceeded efficiently at room temperature The high chemoselectivity and improved synthesis of biol. relevant Isoguvacine and Lazabemide intermediates highlights its scope as a valuable synthetic method. The generality of this protocol was further extended to other electrophiles (bromides, chlorides and tosylates).

Advanced Synthesis & Catalysis published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vandyck, Koen published the artcileSynthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV), Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2018), 61(14), 6247-6260, database is CAplus and MEDLINE.

Small mol. induced hepatitis B virus (HBV) capsid assembly modulation is considered an attractive approach for new antiviral therapies against HBV. Here we describe efforts toward the discovery of a HBV capsid assembly modulator in a hit-to-lead optimization, resulting in JNJ-632, a tool compound used to further profile the mode of action. Administration of JNJ-632 (54) in HBV genotype D infected chimeric mice resulted in a 2.77 log reduction of the HBV DNA viral load.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C7H13NO2, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Treacy, Sean M. published the artcileCopper Catalyzed C(sp³)-H Bond Alkylation via Photoinduced Ligand-to-Metal Charge Transfer, Recommanded Product: Dimethyl adipate, the publication is Journal of the American Chemical Society (2021), 143(7), 2729-2735, database is CAplus and MEDLINE.

The functionalization of numerous feedstock chems. via the coupling of unactivated C(sp³)-H bonds with electron-deficient olefins was reported. The active cuprate catalyst undergoes ligand-to-metal charge transfer enabled the generation of a chlorine radical which acted as a powerful hydrogen atom transfer reagent capable of abstracting strong electron-rich C(sp³)-H bonds. Of note is that the chlorocuprate catalyst was an exceedingly mild oxidant (0.5 V vs SCE) and that a proposed protodemetalation mechanism offered a broad scope of electron-deficient olefins, offered high diastereoselectivity in the case of endocyclic alkenes. The coupling of chlorine radical generation with Cu reduction through LMCT enabled the generation of a highly active HAT reagent in an operationally simple and atom economical protocol.

Journal of the American Chemical Society published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C12H17NO2, Recommanded Product: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abuhafez, Naba published the artcileRuthenium-catalysed oxidative coupling of vinyl derivatives and application in tandem hydrogenation, Computed Properties of 627-93-0, the publication is Catalysis Science & Technology (2021), 11(17), 5772-5776, database is CAplus.

The first ruthenium-catalyzed oxidative homo- and cross-coupling of exclusive vinyl derivatives RC(R¹)=CH₂ (R = methoxycarbonyl, butoxycarbonyl, Ph, etc.; R¹ = H, Me) giving highly valued 1,3-diene building blocks (Z,E/E,E/Z,Z)-RC(R¹)=CHCH=C(R¹)R is reported. The catalytic system is based on readily available reagents and it mainly delivers the E,E isomer. This methodol. also enables the synthesis of adipic acid ester derivatives R(CH₂)₄R (R = methoxycarbonyl, butoxycarbonyl) in a one-pot fashion after in situ ruthenium-catalyzed hydrogenation.

Catalysis Science & Technology published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Computed Properties of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics