Tag: M.W=150-200

Singh, Sukhvinder published the artcileIntegrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection, SDS of cas: 617-52-7, the publication is Cell Reports Medicine, database is CAplus and MEDLINE.

The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive. Here, we used integrated metabolomics and transcriptomics to show that the immunomodulatory metabolite itaconate and immune-responsive gene 1 (Irg1) are induced in bacterial (Staphylococcus aureus)-infected mouse eyes, bone-marrow-derived macrophages (BMDMs), and Muller glia. Itaconate levels are also elevated in the vitreous of patients with bacterial endophthalmitis. Irg1 deficiency in mice led to increased ocular pathol. Conversely, intraocular administration of itaconate protects both Irg1-/- and wild-type mice from bacterial endophthalmitis by reducing inflammation, bacterial burden, and preserving retinal architecture and visual function. Notably, itaconate exerts synergistic effects with antibiotics. The protective, anti-inflammatory effects of itaconate are mediated via activation of NRF2/HO-1 signaling and inhibition of NLRP3 inflammasome. Collectively, our study demonstrates the Irg1/itaconate axis is a regulator of intraocular inflammation and provides evidence for using itaconate, along with antibiotics, to treat bacterial infections.

Cell Reports Medicine published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C24H20Ge, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lamut, Andraz published the artcileSecond-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors, HPLC of Formula: 1877-71-0, the publication is Future Medicinal Chemistry (2020), 12(4), 277-297, database is CAplus and MEDLINE.

DNA gyrase and topoisomerase IV are essential bacterial enzymes, and in the fight against bacterial resistance, they are important targets for the development of novel antibacterial drugs. Building from our first generation of 4,5,6,7-tetrahydrobenzo[d]thiazole-based DNA gyrase inhibitors, we designed and prepared an optimized series of analogs that show improved inhibition of DNA gyrase and topoisomerase IV from Staphylococcus aureus and Escherichia coli, with IC₅₀ values in the nanomolar range. Importantly, these inhibitors also show improved antibacterial activity against Gram-pos. strains. The most promising inhibitor, 29, is active against Enterococcus faecalis, Enterococcus faecium and S. aureus wild-type and resistant strains, with min. inhibitory concentrations between 4 and 8 g/mL, which represents good starting point for development of novel antibacterials.

Future Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, HPLC of Formula: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Hongze published the artcileDirect Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins, Category: esters-buliding-blocks, the publication is Journal of the American Chemical Society, database is CAplus and MEDLINE.

We herein report a direct intermol. anti-Markovnikov hydroazidation method for unactivated olefins, which is promoted by a catalytic amount of bench-stable benziodoxole at ambient temperature This method facilitates previously difficult, direct addition of hydrazoic acid across a wide variety of unactivated olefins in both complex mols. and unfunctionalized commodity chems. It conveniently fills a synthetic chem. gap of existing olefin hydroazidation procedures, and thereby provides a valuable tool for azido-group labeling in organic synthesis and chem. biol. studies.

Journal of the American Chemical Society published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gajare, A. S. published the artcileNatural kaolinitic clay and EPZG: efficient solid catalysts for selective regeneration of carboxylic acids from their corresponding allyl or cinnamyl esters, COA of Formula: C12H14O2, the publication is Synthetic Communications (1998), 28(1), 25-33, database is CAplus.

Natural kaolinitic clay and EPZG are efficient catalysts for selective regeneration of carboxylic acids from their corresponding allyl or cinnamyl esters. E.g., BzOCH₂CH:CMe₂ gave 100% benzoic acid.

Synthetic Communications published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, COA of Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Saha, Rajib published the artcileSelective oxidation of alkylarenes to aromatic acids/ketone in water by using reusable binaphthyl stabilized Pt nanoparticles (Pt-BNP) as catalyst, Computed Properties of 1877-71-0, the publication is Applied Catalysis, B: Environmental (2019), 325-336, database is CAplus.

An efficient methodol. for the selective and controlled oxidation of petroleum waste methylarenes/alkylarenes to aromatic carboxylic acids/ketone using easily recoverable and recyclable binaphthyl stabilized Pt nanoparticles (Pt-BNP) as a catalyst has been developed. The greener oxidant aqueous tert-Bu hydroperoxide (TBHP) and green solvent water have been utilized in this oxidation reaction. The methodol. is well tolerated with different functional groups. The less reactive electron deficient toluenes are also oxidized by Pt-BNP and gave a good yield of corresponding carboxylic acids with a high turnover number (TON) 738-1448. The Pt-BNP catalyst was recovered and reused up to five catalytic cycles. The heterogeneous test suggested that the reaction is catalyzed by heterogeneous Pt-BNP catalysts. Based on control experiments and literature reports, a possible reaction mechanism has been proposed.

Applied Catalysis, B: Environmental published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Computed Properties of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sathya, Elavarasan published the artcileNutritional and gas chromatography-mass spectrometry analysis of Andrographis lawsonii gamble, Formula: C10H10O2, the publication is Asian Journal of Pharmaceutical and Clinical Research (2022), 15(1), 47-51, database is CAplus.

Andrographis lawsonii Gamble is a medicinal herb species, Endemic to India: Karnataka (Dakshina kannada or south Canara district), Kerala (Palakkad district), and Tamil Nadu (Coimbatore and Nilgiris districts). The Andrographis is a large genus of the family Acanthaceae. This study focused to check the preliminary phytochem. nutritive anal., leaf stem and root and gas chromatog.-mass spectrometry (GC-MS) anal. leaf methanol extract The plant samples were subjected to Soxhlet extraction for phytochem. anal. and further exptl. studies. The test on phytochem. studies indicated the presence of alkaloids, saponins, glycosides, and flavonoids glycosides within the plant parts, resp. The estimation of carbohydrate protein starch methanol leaves extracts to have high activity compared to others. Preliminary phytochem. and Nutritional anal. in A. lawonii. Nutritional anal. in carbohydrate protein and starch content was found to be high in leaf methanol extract Highly medicinal compound anal. in this GC-MS Anal. 50 compound present in methanol leaf extract The leaf methanol extract of A. lawsonii has exhibited remarkable preliminary phytochem. anal. and nutritional anal. GC-MS anal. to the medicinal plant.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Spasojevic, Pavle published the artcileOptimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study, Related Products of esters-buliding-blocks, the publication is Polymers (Basel, Switzerland) (2021), 13(16), 2667, database is CAplus and MEDLINE.

Nowadays, unsaturated polyester resins (UPR) are mainly obtained from non-renewable resources. The ever-increasing regulations and the continuous demand for more sustainability have led to extensive research towards more environmentally suitable alternatives to petroleum-based materials. However, one of the main disadvantages of bio-based UPR is their relatively high viscosity compared to petrochem. ones. In order to overcome this drawback, in this work, we investigated the possibility to lower the resin viscosity utilizing a mixture of di-Me itaconate (DMI) and Me methacrylate (MMA) as a reactive diluent. The effect of the DMI and MMA ratio on resin rheol. properties was investigated. The optimal curing parameters were determined and all UPRs had a high gel content, which was shown to be dependent on the DMI and MMA ratio in the formulation. Furthermore, thermomech. and mech. properties of the resulting network were also found to be affected by the used reactive diluent mixture A small substitution of DMI by MMA proved to be advantageous since it offers lower resin viscosity and improved mech. properties.

Polymers (Basel, Switzerland) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C11H21BF4N2O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gajare, Anil S. published the artcileMicrowave accelerated selective and facile deprotection of allyl esters catalyzed by Montmorillonite K-10, Name: 3-Methylbut-2-en-1-yl benzoate, the publication is Perkin 1 (2000), 639-640, database is CAplus.

Carboxylic acids are regenerated from their corresponding substituted allyl esters by Montmorillonite K-10 using microwave irradiation under solvent free conditions to afford enhanced yields and reduced reaction times compared to thermal conditions.

Perkin 1 published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Name: 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Qiuyan published the artcileMacrocyclic Photoinitiator Based on Prism[5]arene Matching LEDs Light with Low Migration, Application of Ethyl 4-dimethylaminobenzoate, the publication is Macromolecular Rapid Communications (2021), 42(17), 2100299, database is CAplus and MEDLINE.

In this work, a naphthalene-based macrocycle prism[5]arene (NP₅OCH₃) is developed as a novel kind of photoinitiator. When NP₅OCH₃ is irradiated under light, the bond between methylene and naphthalene can be quickly broken owning to the existence of ring tension. The macrocycle is cleaved to linear oligomer biradicals, which can effectively initiate the free radical photopolymerization of acrylate monomers. Compared with conventional photoinitiators, NP₅OCH₃ has strong light absorption in the wavelength range of 365-405 nm, so it can well match the environment-friendly light-emitting diodes (LEDs) light source to realize highly efficient initiation. In addition, there is no small mol. fragment generated during NP₅OCH₃ fracture, and the resulted linear oligomer biradicals can be immobilized in the polymer after initiating polymerization, so NP₅OCH₃ photoinitiators show much lower migration rate and cytotoxicity. Cleavable macrocycle prismarene may provide a new idea for the design of safe and efficient photoinitiators matching long wavelength light.

Macromolecular Rapid Communications published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C2H4ClNO, Application of Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Yantao published the artcileHighly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids, COA of Formula: C9H8O4, the publication is Nature Communications (2022), 13(1), 10, database is CAplus and MEDLINE.

The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivity. In this paper, authors report the synthesis of all-carbon tetrasubstituted alkenes from readily available carboxylic acids and alkenyl triflates with the synergistic catalysis of cyclo-octa-1,5-diene(tetramethyl-1,4-benzoquinone)nickel and visible light under an air atm., thus avoiding the need for a glovebox or a Schlenk line. A wide range of aromatic carboxylic acids and cyclic and acyclic alkenyl triflates underwent the C-C coupling process smoothly, forming structurally diverse alkenes stereospecifically in moderate to good yields. The practicality of the method is further illustrated by the late-stage modification of complex mols., the one pot synthesis and gram-scale applications. This is an important step towards the valuable utilization of carboxylic acids, and it also simplifies the exptl. operation of metallophotoredox catalysis with moisture sensitive nickel(0) catalysis.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics