Tag: M.W=150-200

Mahmoud, Engy published the artcileDetermination of volatiles, antioxidant activity, and polyphenol content in the postharvest waste of Ocimum basilicum L, SDS of cas: 103-26-4, the publication is Food Chemistry (2022), 131692, database is CAplus and MEDLINE.

The treatment of postharvest wastes is an integral part of the food value chain. Therefore, Ocimum basilicum L. residues were dried in an oven and a microwave. Volatiles were extracted using hydrodistillation, headspace solid-phase microextraction (HS-SPME) and then analyzed by Gas Chromatog.-Mass Spectrometry (GC-MS). Thirty volatiles were identified in raw material, with β-linalool, methyleugenol, methylcinnamate, and estragole predominating. Meanwhile, 24 and 18 volatiles were detected in the oven- and microwave-dried samples, with a significant decrease of methyleugenol content. The highest radical scavenging ability and total phenolic content were achieved for microwaved wastes using photochemiluminescence, DPPH, and Folin-Ciocalteu test. Moreover, 8 phenolic acids and 9 flavonoids were identified in the LC-MS/MS anal., with significant contents of rosmarinic acid and luteolin (1042.45 and 11.68μg/g of dry matter, resp.) in the microwaved basil. This experiment pointed out that microwaved basil wastes could be re-used in the food, pharmacy and/or cosmetic industries.

Food Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, SDS of cas: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Schlumpberger, Philipp published the artcileDevelopment and evaluation of an automated solvent-assisted flavor evaporation (aSAFE), Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is European Food Research and Technology, database is CAplus.

Artifact-avoiding isolation of the volatiles from foods is a crucial step before anal. of odor-active compounds by gas chromatog. (GC). In the past 20 years, solvent extraction followed by solvent-assisted flavor evaporation (SAFE) has become the standard approach, particularly prior to GC-olfactometry. The manual valve of the SAFE equipment, however, leads to suboptimal yields and the risk of a contamination of the volatile isolate with non-volatiles. We thus developed an automated SAFE (aSAFE) approach by replacing the manual valve with an electronically controlled pneumatic valve. The aSAFE provides clearly higher yields than the manual SAFE (mSAFE), notably from extracts high in lipids and for odorants with comparably high b.ps. Addnl., aSAFE substantially reduces the risk of non-volatiles being transferred to the volatile isolate. Full automatisation is possible by combining the aSAFE approach with an automated liquid nitrogen refill system as well as an endpoint recognition and shut-off system.

European Food Research and Technology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Jin-Di published the artcileMild Copper-Catalyzed Addition of Arylboronic Esters to Di- tert -butyl Dicarbonate: An Easy Access to Methyl Arylcarboxylates, Synthetic Route of 103-26-4, the publication is Synlett (2021), 32(8), 833-837, database is CAplus.

An efficient copper-catalyzed addition of arylboronic esters to (Boc)₂O was developed. The reaction can be conducted under exceedingly mild conditions and was compatible with a variety of synthetically relevant functional groups. It therefore represents a useful alternative route for the synthesis of Me arylcarboxylates. A preliminary mechanistic study indicated the involvement of an addition-elimination mechanism.

Synlett published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C9H6N2O2, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Scheurlen, Katharina M published the artcileItaconate and leptin affecting PPARγ in M2 macrophages: A potential link to early-onset colorectal cancer., Application In Synthesis of 617-52-7, the publication is Surgery (2022), 171(3), 650-656, database is MEDLINE.

BACKGROUND: Along with the rising incidence of obesity, there has been an increase in patients diagnosed with early-onset colorectal cancer (<50 years old). In colorectal cancer, worse patient survival is associated with certain cytokine expression and downregulation of peroxisome proliferator activated receptor gamma expression. The effects of the obesity hormone leptin and macrophage-specific metabolite itaconate on these mechanisms are poorly understood. We investigated their impact on peroxisome proliferator activated receptor gamma and macrophage cytokine expression in vitro. METHODS: M2-like macrophages were treated with either leptin, 4-octyl itaconate, or dimethyl itaconate in a dose- and time-dependent manner. Gene expression after treatment with 4 doses (D1-4) of each compound was analyzed at 4 time points (3, 6, 18, and 24 hours). RESULTS: Peroxisome proliferator activated receptor gamma was downregulated after 4-octyl itaconate treatment at 18 hours (FC -32.67, P â‰?.001). Interleukin-8 was upregulated after leptin and dimethyl itaconate treatment at 6 hours (FC 26.35 at D4, P â‰?.001, and FC 23.26 at D3, P = .006). Dimethyl itaconate upregulated IL-1β at 24 hours (FC 18.00 at D4, P â‰?.001). Tumor necrosis factor-α showed maximum downregulation after 4-octyl itaconate at 18 hours (FC -103.25 at D4, P â‰?.001). CONCLUSIONS: Itaconate downregulates peroxisome proliferator activated receptor gamma as a tumor-suppressing factor and upregulates anti-inflammatory cytokines in M2-like macrophages. Itaconate provides a link between obesity and colorectal cancer and may be a key regulator in early-onset colorectal cancer.

Surgery published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yanagi, Tomoyuki published the artcileNi-Catalyzed Carboxylation of C(sp²)-S Bonds with CO₂: Evidence for the Multifaceted Role of Zn, Product Details of C9H8O4, the publication is ACS Catalysis (2020), 10(3), 2117-2123, database is CAplus.

Nickel-catalyzed reductive carboxylation reactions of aryl electrophiles typically require the use of metallic reducing agents. At present, the prevailing perception is that these serve as both a source of electrons and as a source of Lewis acids that may aid CO₂ insertion into the Ni-C bond. Herein, we provide evidence for the in situ formation of organometallic species from the metallic reductant, a step that has either been ruled out or has been unexplored in catalytic carboxylation reactions with metal powder reductants. Specifically, we demonstrate that Zn(0) acts as a reductant and that Zn(II) generates arylzinc species that might play a role in the C(sp²)-S carboxylation of arylsulfonium salts. Overall, the reductive Ni-catalyzed C(sp²)-S carboxylation reaction proceeds under mild conditions in a non-amide solvent, displays a wide substrate scope, and can be applied to the formal para C-H carboxylation of arenes.

ACS Catalysis published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C2H4ClNO, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aungtikun, Jirapon published the artcileImproved adulticidal activity against Aedes aegypti (L.) and Aedes albopictus (Skuse) from synergy between Cinnamomum spp. essential oils, Application In Synthesis of 103-26-4, the publication is Scientific Reports (2021), 11(1), 4685, database is CAplus and MEDLINE.

Improved natural adulticidal agents against mosquito vectors are in urgent need, and essential oils from Cinnamomum plants can assume this role quite readily. Cinnamomum verum, C. cassia, and C. loureiroi essential oils (EOs) were extracted from the barks and evaluated for their chem. composition by GC-MS. The major constituent of the three EOs was cinnamaldehyde. WHO susceptibility tests on individual and combined EOs as well as cinnamaldehyde were conducted against female adults of Aedes aegypti and Aedes albopictus. All EO combinations exhibited a synergistic effect, manifesting a higher toxicity, with a synergistic value ranging from 2.9 to 6.7. Their increasing mortality value was improved between 16.0 to 41.7%. The highest synergistic effect was achieved by an EO combination of 0.5% C. cassia + 0.5% C. loureiroi, while the highest insecticidal activity was achieved by 2.5% C. verum + 2.5% C. cassia and 1% cinnamaldehyde, with a knockdown and mortality rate of 100% and a KT50 between 0.7 and 2.1 min. This combination was more toxic to both mosquito species than 1% w/v cypermethrin. These findings demonstrate that cinnamaldehyde and synergistic combinations of C. verum + C. cassia EOs and C. cassia + C. loureiroi EOs have a high insecticidal efficacy against Aedes populations.

Scientific Reports published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Application In Synthesis of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Flores, Antonia published the artcileDevelopment of a headspace-solid phase micro extraction method for the analysis of volatile and semi-volatile organic compounds from polyurethane resins for leather finishing, Category: esters-buliding-blocks, the publication is Journal of the American Leather Chemists Association (2021), 116(8), 290-297, database is CAplus.

Volatile organic compounds (VOCs) and Semi-Volatile Organic Compounds (SVOCs) arise from the chems. used in the various stages of the leather manufacturing process. An important aim of the tanning industry is to minimize or eliminate VOCs and SVOCs, without lowering the quality of leather. This paper shows the development of a new headspace-solid phase micro extraction coupled with gas chromatog.-mass spectrometry (HS-SPME/GC-MS) method for the identification of VOCs and SVOCs emitted by newly designed polymers for the leather finishing operation. These new polymers are polyurethane resins designed to reduce the VOC and SVOC concentration This method enables a simple and fast determination of the qual. and semi-quant. content of VOCs and SVOCs in polyurethane-type finishing resins. The chems. that are of concern in this paper are the following: Dipropylene glycol Monomethyl Ether (DPGME), DBE-3 (a mixture of dibasic esters) and Triethylamine (TEA). The test conditions that have been determined to carry out the HS-SPME assay are the following: incubation time (2 h), extraction temperature and time (40°C; 5 min) and the desorption conditions (280°C, 50 s). Ten samples of laboratory scale resins were tested by HS-SPME followed by gas chromatog. (GC-MS). DPGME and DBE-3 (a mixture of di-Me adipate, di-Me glutarate and di-Me succinate) have been identified effectively. The compounds are identified by a quant. method using external calibration curves for the target compounds The technique is not effective to determine the TEA compound, since the chromatograms shown poor resolution peaks for the standard

Journal of the American Leather Chemists Association published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Krause, Andreas published the artcileMatsuda-Heck arylation of itaconates: a versatile approach to heterocycles from a renewable resource, Name: Dimethyl itaconate, the publication is Organic & Biomolecular Chemistry (2021), 19(19), 4292-4302, database is CAplus and MEDLINE.

Itaconic acid esters and hemiesters ROC(O)CH₂C(=CH₂)C(O)OR¹ (R = Me, Et, n-Bu, i-Pr; R¹ = H, Me, Et, n-Bu) undergo Pd-catalyzed coupling reactions with arene diazonium salts ArN₂BF₄ [4-methoxy-2-nitrophenyl, 2-(methoxycarbonyl)thiophen-3-yl, 2-oxo-2H-chromen-6-yl, 2H-1,3-benzodioxol-5-yl, etc.] in high to excellent yields of arylidene succinates (E)-ArCH=C(CH₂C(O)OR)C(O)OR¹. The coupling products of ortho-nitro arene diazonium salts (E)-2-NO₂-R²C₆H₃CH=C(CH₂C(O)OR)C(O)OR¹ (R² = H, 4-Br, 5-Cl, 4-OMe) can be converted in one or two steps to benzazepine-2-ones I (R³ = H, 8-Br, 7-Cl, 8-OMe; R⁴ = methoxycarbonyl, ethoxycarbonyl, hydroxymethyl).

Organic & Biomolecular Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Name: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Van Lijsebetten, Filip published the artcileReprocessing of Covalent Adaptable Polyamide Networks through Internal Catalysis and Ring-Size Effects, Name: Dimethyl adipate, the publication is Journal of the American Chemical Society (2021), 143(38), 15834-15844, database is CAplus and MEDLINE.

Here, we report the introduction of internally catalyzed amide bonds to obtain covalent adaptable polyamide networks that rely on the dissociation equilibrium between dicarboxamides and imides. While amide bonds are usually considered to be robust and thermally stable, the present study shows that their dynamic character can be activated by a smart choice of available building blocks without the addition of any external catalyst or other additives. Hence, a range of polyamide-based dynamic networks with variable mech. and viscoelastic properties were obtained in a systematic study, using a straightforward curing process of dibasic ester and amine compounds Since the dissociation process involves a cyclic imide formation, the correlation between ring size and the thermomech. viscosity profile was studied for five- to seven-membered ring intermediates, depending on the chosen dibasic ester monomer. This resulted in a marked temperature response with activation energies in the range of 116-197 kJ mol^-1, yielding a sharp transition between elastic and viscous behavior. Moreover, the ease and versatility of this chem. platform were demonstrated by selecting a variety of amines, resulting in densely cross-linked dynamic networks with T_g values ranging from -20 to 110°C. With this approach, it is possible to design amorphous polyamide networks with an acute temperature response, allowing for good reprocessability and, simultaneously, high resistance to irreversible deformation at elevated temperatures

Journal of the American Chemical Society published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C12H13F2N3O4S, Name: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aquino, Fernanda Lima Torres de published the artciletrans-Cinnamic acid, but not p-coumaric acid or methyl cinnamate, induces fibroblast migration through PKA- and p38-MAPK signalling pathways., COA of Formula: C10H10O2, the publication is Journal of tissue viability (2021), 30(3), 363-371, database is MEDLINE.

AIM: Hydroxycinnamic acids their derivatives have various pharmacological properties. The hydroxycinnamic acid derivatives, methyl cinnamate, trans-cinnamic, and p-coumaric acids have been the object of study in the treatment of skin wounds. However, it is unclear whether these derivatives exert a direct beneficial effect on fibroblast function. In this study, we evaluated the effects of methyl cinnamate, trans-cinnamic, and p-coumaric acids on fibroblast migration in vitro. MATERIALS AND METHODS: NIH 3T3 and L929 fibroblast cell lines were exposed to each drug at several concentrations and the effect on cell viability, cell cycle, and extracellular matrix production were assessed by MTT assay, flow cytometry, and immunofluorescence staining, respectively. The effect on cell migration was examined using scratch assay. RESULTS: The results showed that hydroxycinnamic acid derivatives not affect cell viability, but increase fibroblast migration in the in vitro scratch-wound healing assay. They also induced an increase in S and G2/M phases accompanied by a decrease in the G0/G1 phase of the cell cycle. The cell proliferation inhibitor mitomycin C abolished the effect induced by p-coumaric acid and methyl cinnamate, indicating that only the trans-cinnamic acid stimulated migration. A transwell migration assay confirmed that trans-cinnamic acid-treated fibroblasts exhibited increased migration compared with untreated cells. trans-Cinnamic acid-induced fibroblast migration was decreased by PKA inhibitor and p38-MAPK inhibitor but not by JNK inhibitor. Additionally, trans-cinnamic acid-treated fibroblasts showed an increase in the production of laminin and collagen type I. CONCLUSION: Our study showed that trans-cinnamic acid improves fibroblast migration and modulates extracellular matrix synthesis, indicating its potential for accelerating the healing process.

Journal of tissue viability published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, COA of Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics