Tag: M.W=150-200

Zhang, Heng; Guo, Tianyun; Wu, Mingzhong; Huo, Xing; Tang, Shouchu; Wang, Xiaolei; Liu, Jian published the artcile< 4CzIPN catalyzed photochemical oxidation of benzylic alcohols>, Reference of 94-02-0, the main research area is aldehyde ketone preparation green chem 4CzlPN catalyst; benzylic primary secondary alc photoredox oxidation.

A green photoredox oxidation of benzylic primary and secondary alcs. to aldehydes and ketones with air as an oxidant was reported. The oxidation shows broad substrate scope and excellent selectivity over benzylic alcs. to the aliphatic alcs. Further mechanistic studies revealed a quinuclidine mediated HAT process, and blue LEDs promoted 4CzlPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) photoredox cycle were involved in the oxidation

Tetrahedron Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wroblewski, A. E.; Applequist, J.; Takaya, A.; Honzatko, R.; Kim, S. S.; Jacobson, R. A.; Reitsma, B. H.; Yeung, E. S.; Verkade, J. G. published the artcile< Experimental and theoretical study of the structures and optical rotations of chiral bicyclic ortho esters>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is chiral bicyclic ortho ester preparation; optical rotation chiral trioxabicyclooctane preparation; crystal structure chiral trioxabicyclooctane; mol structure chiral trioxabicyclooctane; induced dipole moment chiral trioxabicyclooctane; asym synthesis bicyclic ortho ester; classical dipole interaction theory trioxabicyclooctane.

Three rigid (-)-1-R-2,7,8-trioxabicyclo[3.2.1]octanes I [R = H (II), Me (III), Ph (IV)] were prepared in high enantiomeric purity from (S)-1,2,4-butanetriol and RC(OMe)3 (same R). The structure of (-)-IV was determined by x-ray crystallog. From the crystallog. data, 4 refined structural models of IV were generated, which differed only in their degree of geometric optimization. Whereas one model is unrestrained, the other models are increasingly restrained to ideal geometry in order to correct the systematically short bonds associated with an unrestrained refinement. Molar rotations were calculated from classical dipole interaction theory with the structural parameters from the 4 models of IV and atom polarizabilities derived earlier. The calculated molar rotations from IV were correct in sign and insensitive to rotations of the Ph group about the C-C bond. The differences between the calculated values and the exptl. rotation decreased to within a factor of 4 concomitantly with the increased level of geometric optimization of the models. The difference between the theor. and exptl. values is attributable to small uncertainties in atom coordinates and atom polarizabilities. Similar results were obtained for II and III with the structural models obtained for IV. The identical signs and similar magnitudes of rotations for II-IV stem primarily from the chiral gauche arrangement of the butane fragment.

Journal of the American Chemical Society published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Application In Synthesis of 19241-24-8, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valeev, R. F.; Davletbaev, A. M.; Talipov, R. F.; Miftakhov, M. S. published the artcile< Synthesis of a chiral building block for the C6-C9fragment of epothilones>, HPLC of Formula: 617-55-0, the main research area is dimethyl trimethylsilyl butynyl dioxolane diastereoselective epothilone preparation.

A procedure for the synthesis of 1,3-dioxolane I was developed via multistep reaction sequence starting from L-malic acid. Compound I could be employed as a chiral building block in the construction of C6-C9 fragment of epothilone analogs. Diastereoselective preparation of dimethyl[(trimethylsilyl)butynyl]dioxolane as chiral building block for epothilone analogs.

Russian Journal of Organic Chemistry published new progress about Acetalization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. as in the substitution reaction of a carboxylic acid and an alcohol. Formula: C8H9BO4.

Hurlock, Matthew J.;Lare, Monipak F.;Zhang, Qiang research published 《 Two Cd-Based Luminescent Coordination Polymers Constructed from a Truncated Linker》, the research content is summarized as follows. Two Cd coordination polymers, WSU-30 and WSU-31, were synthesized through solvothermal methods by using the low-symmetry TPE-based linker m-H₄ETTC (4′,4”’,4””’,4”””’-(ethene-1,1,2,2-tetrayl)tetrakis[(1,1′-biphenyl)-3-carboxylic acid]). The m-H₄ETTC linker and both coordination polymers were fully characterized by using single-crystal x-ray diffraction, IR spectroscopy, and photoluminescent emission spectroscopy. Structural anal. of WSU-30 and WSU-31 showed that each compound contains previously unknown tetranuclear Cd(II) secondary building units. The topol. anal. revealed that the 4,8-connected net of WSU-30 contains the underlying topol., alb-4,8-P21/c-1, while the mixed linker WSU-31 possesses a 3,10-connected net known as 3,10T31 topol. If the m-ETTC linker is considered as two 3-connected nodes, WSU-30 possesses a very rare 3,3,8-connected 3,3,8T25 topol., and WSU-31 possesses a previously unknown 3,12-connected net, named 3,12T61.

99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Formula: C8H9BO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application In Synthesis of 99769-19-4.

Ismael, Aya;Skrydstrup, Troels;Bayer, Annette research published 《 Carbonylative Suzuki-Miyaura couplings of sterically hindered aryl halides: synthesis of 2-aroylbenzoate derivatives》, the research content is summarized as follows. A carbonylative approach to the synthesis of diversely substituted 2-aroylbenzoate esters ArC(O)R¹ (Ar = 2-methoxyphenyl, thiophen-2-yl, 2-naphthyl, etc.; R¹ = 2-methoxycarbonyl-6-methylphenyl, 2-methoxycarbonylphenyl, 2-methoxycarbonyl-4,5-dimethoxyphenyl, etc.) featuring a new protocol for the carbonylative coupling of aryl bromides R¹Br with boronic acids ArB(OH)₂ and a new strategy to favor carbonylative over non-carbonylative reactions were developed. Two different synthetic pathways – (i) the alkoxycarbonylation of 2-bromo benzophenones R²C₆H₄C(O)(2-BrC₆H₅) (R² = 2-F, 4-F, 3-OMe, 4-OMe) and (ii) the carbonylative Suzuki-Miyaura coupling of 2-bromobenzoate esters – were evaluated. The latter approach provided a broader substrate tolerance, and thus it was the preferred pathway. Here observed that 2-substituted aryl bromides were challenging substrates for carbonylative chem. favoring the non-carbonylative pathway. However, it is found that carbonylative Suzuki-Miyaura couplings can be improved by slow addition of the boronic acid, suppressing the unwanted direct Suzuki coupling and, thus increasing the yield of the carbonylative reaction.

Application In Synthesis of 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. as in the substitution reaction of a carboxylic acid and an alcohol. Synthetic Route of 2495-37-6.

Jia, Zhen-Sheng;Wu, Yong-Jie;Yao, Qi-Jun;Xu, Xue-Tao;Zhang, Kun;Shi, Bing-Feng research published 《 Pd(II)-Catalyzed atroposelective C-H allylation: Synthesis of enantioenriched N-aryl peptoid atropisomers》, the research content is summarized as follows. A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was developed for the synthesis of enantioenriched N-aryl peptoid atropisomers via β-H elimination using com. available and inexpensive L-pGlu-OH (L-Pyroglutamic acid) as a chiral ligand. Exclusive allylic selectivity was achieved. Addnl., a series of enantioenriched N-aryl peptoid atropisomers were obtained in synthetically useful yields with excellent enantioselectivities (up to 90% yield and 97% ee).

Synthetic Route of 2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., 2495-37-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. SDS of cas: 99769-19-4.

Jiang, Xunjin;Zeng, Zhixiong;Hua, Yuhui;Xu, Beibei;Shen, Yang;Xiong, Jing;Qiu, Huijuan;Wu, Yifan;Hu, Tianhui;Zhang, Yandong research published 《 Merging C-H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis》, the research content is summarized as follows. Pyridinium-containing polyheterocycles exhibit distinctive biol. properties and interesting electrochem. and optical properties and thus are widely used as drugs, functional materials, and photocatalysts. Here, we describe a unified two-step strategy by merging Rh-catalyzed C-H vinylation with two switchable electrocyclizations, including aza-6π-electrocyclization and all-carbon-6π-electrocyclization, for rapid and divergent access to dihydropyridoisoquinoliniums and dihydrobenzoquinolines. Through computation, the high selectivity of aza-electrocyclization in the presence of an appropriate “HCl” source under either thermal conditions or photochem. conditions is shown to result from the favorable kinetics and symmetries of frontier orbitals. We further demonstrated the value of this protocol by the synthesis of several complex pyridinium-containing polyheterocycles, including the two alkaloids berberine and chelerythrine.

SDS of cas: 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. as in the substitution reaction of a carboxylic acid and an alcohol. Formula: C8H9BO4.

Jing, Lanlan;Wu, Gaochan;Hao, Xia;Olotu, Fisayo A.;Kang, Dongwei;Chen, Chin Ho;Lee, Kuo-Hsiung;Soliman, Mahmoud E. S.;Liu, Xinyong;Song, Yuning;Zhan, Peng research published 《 Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries》, the research content is summarized as follows. Cell division cycle 25 (Cdc25) protein phosphatases play key roles in the transition between the cell cycle phases and their association with various cancers has been widely proven, which makes them ideal targets for anti-cancer treatment. Though several Cdc25 inhibitors have been developed, most of them displayed low activity and poor subtype selectivity. Therefore, it is extremely important to discover novel small mol. inhibitors with potent activities and significant selectivity for Cdc25 subtypes, not only served as drugs to treat cancer but also to probe its mechanism in transitions. In this study, miniaturized parallel click chem. synthesis via CuAAC reaction followed by in situ biol. screening were used to discover selective Cdc25 inhibitors. The bioassay results showed that compound M2N12 proved to be the most potent Cdc25 inhibitor, which also act as a highly selective Cdc25C inhibitor and was about 9-fold potent than that of NSC 663284. Moreover, M2N12 showed remarkable anti-growth activity against the KB-VIN cell line, equivalent to that of PXL and NSC 663284. An all-atom mol. dynamics (MD) simulation approach was further employed to probe the significant selectivity of M2N12 for Cdc25C relative to its structural homologs Cdc25A and Cdc25B. Overall, above results make M2N12 a promising lead compound for further investigation and structural modification.

99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Formula: C8H9BO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid.

He, Zhangxu;Jiao, Haomiao;An, Qi;Zhang, Xin;Dan, Zengyangzong;Xu, Jiale;Liu, Hongmin;Ma, Liying;Zhao, Wen research published 《 Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis》, the research content is summarized as follows. Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hit 5 bearing 4-phenylquinazoline skeleton through a high-throughput virtual screen using 2,003,400 compound library (enamine). Then, structure-activity relationship (SAR) study was performed and 47 new 4-phenylquinazoline derivatives toward BRD4 were further designed, synthesized and evaluated, using HTRF assay set up in our laboratory Eventually, we identified compound C-34, which possessed better pharmacokinetic and physicochem. properties as well as lower cytotoxicity against NRCF and NRCM cells, compared to the pos. control JQ1. Using computer-based mol. docking and cellular thermal shift assay, we further verified that C-34 could target BRD4 at mol. and cellular levels. Furthermore, treatment with C-34 effectively alleviated fibroblast activation in vitro and cardiac fibrosis in vivo, which was correlated with the decreased expression of BRD4 downstream target c-MYC as well as the depressed TGF-β1/Smad2/3 signaling pathway. Taken together, our findings indicate that novel BRD4 inhibitor C-34 tethering a 4-phenylquinazoline scaffold can serve as a lead compound for further development to treat fibrotic cardiovascular disease.

Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics