Tag: M.W=150-200

Xiang, Lingling; Wu, Haiting; Liang, Yunshi; Deng, Huiying; He, Yiting; Xu, Qin; Zhang, Jing published the artcile< Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry>, SDS of cas: 19241-24-8, the main research area is methylenethiazoline amino preparation chemoselective; propargylamine isothiocyanate addition cyclization silver catalyst tandem reaction.

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis.

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asahara, Haruyasu; Kikuchi, Shuhei; Unno, Yuto; Yokoyama, Soichi; Yoshioka, Kotaro; Tani, Shinki; Umezu, Kazuto; Nishiwaki, Nagatoshi published the artcile< A Facile Synthesis of Oxiranes Possessing Three or Four Carbonyl Groups>, Quality Control of 94-02-0, the main research area is carbonylated oxirane preparation; diethyl mesoxalate bromoketone condensation.

Tri-carbonylated oxiranes I [R = H; Ar = Ph, 4-MeC6H4, 4-BrC6H4, etc.] were efficiently synthesized via condensation of vicinal tricarbonyl compound with α-bromoketones in the presence of a base. This protocol was applicable to α-bromo-β-keto esters to give tetra-carbonylated oxiranes I [R = CO2Et] from which trifunctionalized bromoalkene was competitively formed. The ratio of compounds I was influenced by the solvent and reaction temperature Synthesis of 2,3-bis-organochalcogenyl-benzo[b]chalcogenophenes promoted by oxone.

Current Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Quality Control of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Critcher, Douglas J.; Connolly, Stephen; Mahon, Mary F.; Wills, Martin published the artcile< Synthesis and x-ray crystallographic structure of the right-hand hemisphere of halicholactone and neohalicholactone>, Synthetic Route of 617-55-0, the main research area is halicholactone cyclopropyl lactone preparation crystal structure; neohalicholactone cyclopropyl lactone preparation crystal structure; crystal structure halicholactone cyclopropyl lactone.

The synthesis and X-ray crystallog. structure of the right-hand hemisphere, cyclopropyl lactone I, of the marine natural products halicholactone and neohalicholactone, which contains a nine-membered lactone and cyclopropane ring, is reported.

Journal of the Chemical Society, Chemical Communications published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Heng; Guo, Tianyun; Wu, Mingzhong; Huo, Xing; Tang, Shouchu; Wang, Xiaolei; Liu, Jian published the artcile< 4CzIPN catalyzed photochemical oxidation of benzylic alcohols>, Reference of 94-02-0, the main research area is aldehyde ketone preparation green chem 4CzlPN catalyst; benzylic primary secondary alc photoredox oxidation.

A green photoredox oxidation of benzylic primary and secondary alcs. to aldehydes and ketones with air as an oxidant was reported. The oxidation shows broad substrate scope and excellent selectivity over benzylic alcs. to the aliphatic alcs. Further mechanistic studies revealed a quinuclidine mediated HAT process, and blue LEDs promoted 4CzlPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) photoredox cycle were involved in the oxidation

Tetrahedron Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wroblewski, A. E.; Applequist, J.; Takaya, A.; Honzatko, R.; Kim, S. S.; Jacobson, R. A.; Reitsma, B. H.; Yeung, E. S.; Verkade, J. G. published the artcile< Experimental and theoretical study of the structures and optical rotations of chiral bicyclic ortho esters>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is chiral bicyclic ortho ester preparation; optical rotation chiral trioxabicyclooctane preparation; crystal structure chiral trioxabicyclooctane; mol structure chiral trioxabicyclooctane; induced dipole moment chiral trioxabicyclooctane; asym synthesis bicyclic ortho ester; classical dipole interaction theory trioxabicyclooctane.

Three rigid (-)-1-R-2,7,8-trioxabicyclo[3.2.1]octanes I [R = H (II), Me (III), Ph (IV)] were prepared in high enantiomeric purity from (S)-1,2,4-butanetriol and RC(OMe)3 (same R). The structure of (-)-IV was determined by x-ray crystallog. From the crystallog. data, 4 refined structural models of IV were generated, which differed only in their degree of geometric optimization. Whereas one model is unrestrained, the other models are increasingly restrained to ideal geometry in order to correct the systematically short bonds associated with an unrestrained refinement. Molar rotations were calculated from classical dipole interaction theory with the structural parameters from the 4 models of IV and atom polarizabilities derived earlier. The calculated molar rotations from IV were correct in sign and insensitive to rotations of the Ph group about the C-C bond. The differences between the calculated values and the exptl. rotation decreased to within a factor of 4 concomitantly with the increased level of geometric optimization of the models. The difference between the theor. and exptl. values is attributable to small uncertainties in atom coordinates and atom polarizabilities. Similar results were obtained for II and III with the structural models obtained for IV. The identical signs and similar magnitudes of rotations for II-IV stem primarily from the chiral gauche arrangement of the butane fragment.

Journal of the American Chemical Society published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Application In Synthesis of 19241-24-8, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valeev, R. F.; Davletbaev, A. M.; Talipov, R. F.; Miftakhov, M. S. published the artcile< Synthesis of a chiral building block for the C6-C9fragment of epothilones>, HPLC of Formula: 617-55-0, the main research area is dimethyl trimethylsilyl butynyl dioxolane diastereoselective epothilone preparation.

A procedure for the synthesis of 1,3-dioxolane I was developed via multistep reaction sequence starting from L-malic acid. Compound I could be employed as a chiral building block in the construction of C6-C9 fragment of epothilone analogs. Diastereoselective preparation of dimethyl[(trimethylsilyl)butynyl]dioxolane as chiral building block for epothilone analogs.

Russian Journal of Organic Chemistry published new progress about Acetalization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Henrot, Serge; Larcheveque, Marc; Petit, Yves published the artcile< Amino acids as chiral synthons: preparation of enantiomerically pure (R)- and (S)-malic acids and its application to the synthesis of 3-hydroxy-4-butanolide>, Related Products of 617-55-0, the main research area is aspartic acid deamination nitrous acid; malic acid conversion hydroxybutanolide; enantiomeric purity hydroxybutanolide malic acid; amino acid chiral synthon.

Nitrous acid deamination of (S)-aspartic acid gave (S)-malic acid, which dissolved in AcCl to give anhydride I. Reaction of I with MeOH gave the half ester which was chemoselectively reduced by borohydride to hydroxybutanolide II of high optical purity.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Numao, Naganori; Hamada, Tatsuo; Yonemitsu, Osamu published the artcile< A mechanistic study of the photoreaction of dimethylaniline and methyl chloroacetate. Role of acid-base properties in both the ground state and the excited state>, Product Details of C9H9NO4, the main research area is fluorescence quenching alkylation dimethylaniline; methoxycarbonylmethylation aniline photochem mechanism; exciplex dimethylaniline photochem methoxycarbonylmethylation; kinetics photochem methoxycarbonylmethylation methylaniline.

Quantum yields for fluorescence quenching and disappearance of PhNMe2 (I) were determined for the photochem. alkylation of I with ClCH2CO2Me, in both acidic and basic solutions, to give o- and p-MeO2CCH2C6H4NMe2. Under acidic conditions the reaction occurs via an exciplex, and under basic conditions an exciplex and a charge-transfer complex are involved.

Tetrahedron published new progress about 30095-98-8. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolby, Jorgen; Dahlbom, Richard; Hasselgren, Karl H.; Nilsson, J. L. G. published the artcile< Bicyclic enamines. I. Rearrangement of a quaternary quinuclidine-3-carboxylic acid ester and total synthesis of gentianadine>, COA of Formula: C8H9NO2, the main research area is quinuclidinecarboxylic rearrangement; gentianadine alkaloid preparation; nicotinic lactone; enamines bicyclic.

Me 2,3-didehydroquinuclidine-3-carboxylate methiodide loses MeI and is rearranged to 4-(2-hydroxyethyl)-1-methyl-1,4,5,6-tetrahydronicotinic acid lactone when heated without solvent to its m.p. The structure of the lactone was confirmed by an independent synthesis which also involved the total synthesis of the alkaloid gentianadine.

Acta Chemica Scandinavica (1947-1973) published new progress about Rearrangement. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, COA of Formula: C8H9NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics