Tag: M.W=150-200

Wang, Xiaoqin; Zhu, Derong; He, Minghua published the artcile< Study on synthesis of drug intermediates (S)-3-hydroxytetrahydrofuran>, Computed Properties of 617-55-0, the main research area is hydroxytetrahydrofuran synthesis malic acid drug intermediate esterification reduction cyclization.

(S)-3-hydroxytetrahydrofuran was synthesized from L-malic acid by esterification, reduction, and cyclization. The chem. structure of the target compound was identified by element anal., IR, NMR and MS spectra. The total yield and the purity of the product were 41% and 99.2%, and the optical purity was 95.8%. This optimal synthetic procedure with lower cost and mild reaction conditions is worthy to have a further pilot manufacture

Huaxue Yanjiu Yu Yingyong published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Jun; Zhu, Shengqing; Wang, Fang; Qing, Feng-Ling; Chu, Lingling published the artcile< Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H>, Computed Properties of 151259-38-0, the main research area is silver mediated oxidative difluoromethylation styrene vinyl trifluoroborate TMSCF2H; regioselective synthesis; alkenes; difluoromethylation; heteroarenes; radical fluoroalkylation; silver.

A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2H is reported for the first time. This method enables direct and facile access to CF2H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CF2H bonds.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Computed Properties of 151259-38-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wenkert, Ernest; Chang, Ching-Jer; Chawla, H. P. S.; Cochran, David W.; Hagaman, Edward W.; King, James C.; Orito, Kazuhiko published the artcile< General methods of synthesis of indole alkaloids. 14. Short routes of construction of yohimboid and ajmalicinoid alkaloid systems and their carbon-13 nuclear magnetic resonance spectral analysis>, Computed Properties of 33402-75-4, the main research area is akuammigine synthesis; alstonine tetrahydro synthesis; pseudoyohimbone synthesis; ajmalicine synthesis; indole alkaloid synthesis; configuration indole alkaloid; NMR carbon 13 alkaloid; yohimboid synthesis; ajmalicinoid synthesis.

Conceptually new schemes of synthesis of indole alkaloids are introduced. The yohimboid ring system is constructed by the sequential treatment of 1-tryptophyl-3-(β-oxobutyl)pyridinium bromide with base and acid. Hydrogenation of the product yields (±)-pseudoyohimbone (I). The ajmalicinoid ring system is formed by the exposure of 1-tryptophyl-3-acetylpyridinium bromide to NaCH(CO2Et)2 and then to acid, followed by hydrogenation. Subsequent reduction of dehydration of the products gives the racemates of the alkaloids tetrahydroalstonine (3α,20α-II), akuammigine (3β,20α-II) and isomers of ajmalicine (3α,20β-II). Complete C shift analyses of yohimboid and ajmalicinoid alkaloids of normal, pseudo, allo, and epiallo configuration were executed. Shifts of specific C are of stereochem. diagnostic value. A general shielding γ effect is observed for the interaction of C-H bonds with spatially rigid and directed electron pair orbitals.

Journal of the American Chemical Society published new progress about Alkaloids. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Computed Properties of 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Xinyue; Shi, Xiaoqing; Yang, Dianna; Jin, Hao; Zhou, Xinghua; Meng, Tianzi; Li, Xin; Jia, Zixing; Zhang, Xuewen; Wu, Zeyu; Wang, Chunnong; Zeng, Taining; Liu, Li; Ai, Chao; Zhu, Huajie published the artcile< Highly efficient axially biscarboline ethers as catalysts used in 1,2- and 1,4-transfer hydrogenations of ketimines and β-enamino esters>, Formula: C11H12O3, the main research area is arylaminopropenoate enantioselective transfer hydrogenation axial chiral catalyst; arylaminopropanoate ethyl stereoselective preparation; ketimine axial chiral catalyst enantioselective transfer hydrogenation; phenylalkylaniline stereoselective preparation.

A series of new axial chiral biscarboline ethers were synthesized using L-tryptophan amino acid after dehydrogenation and oxidations using m-CPBA. These diastereoisomers can be obtained by column chromatog. and used as catalysts in asym. hydrogenation reactions of β-enamine esters and ketimines. Chiral catalysts (R)- and (S)-I exhibited very high enantioselectivity in the reactions. For example, a high up to 98% ee was achieved in the enantioselective hydrogenations when only 1 mol% of catalyst was used.

Journal of Molecular Structure published new progress about Amino acid esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Martyn, Derek C.; Abell, Andrew D. published the artcile< The Synthesis and Testing of α-(Hydroxymethyl)pyrroles as DNA Binding Agents>, Synthetic Route of 7126-50-3, the main research area is DNA binding hydroxymethyl pyrrole preparation.

α-(Hydroxymethyl)pyrroles were prepared and shown to be cytotoxic against the P388 cancer cell line. Et 5-hydroxymethyl-1H-pyrrole-2-carboxylate was inactive, demonstrating that an α-(hydroxymethyl)pyrrole group alone is not sufficient for activity. Compound I has been shown to bind to DNA with reasonable affinity.

Australian Journal of Chemistry published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Synthetic Route of 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Biao; Chen, Wenjun; Zhao, Qiongli; Yu, Wenquan; Chang, Junbiao published the artcile< Synthesis of Functionalized Imidazolium Salts via Iodine-Mediated Annulations of Enamines>, SDS of cas: 94-02-0, the main research area is imidazolium salt preparation; enamine preparation annulation iodine.

A novel annulation reaction of two enamine mols. with iodine under basic conditions to form 4-functionalized imidazolium salts has been established. In this reaction, iodine acts as both an iodinating reagent and a Lewis acid catalyst. Features of this synthetic method include facilitative preparation of substrates, no use of transition metals, mild reaction conditions, simplicity of operation, and gram scale synthesis.

Organic Letters published new progress about Cyclization. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rohrbacher, Florian; Zwicky, Andre; Bode, Jeffrey W. published the artcile< Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation>, COA of Formula: C9H9NO4, the main research area is alphaketoacid hydroxylamine ligation antibacterial protein homoserine mutant.

An antibacterial cyclic AS-48 protein was chem. synthesized by α-ketoacid-hydroxylamine (KAHA) ligation. Initial challenges associated with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were resolved by the development of bespoke reaction conditions for hydrophobic segments, using hexafluoroisopropanol (HFIP) as a co-solvent. The synthetic protein displays similar biol. activity and properties to those of the native protein. To support the current understanding of its antibacterial mode of action, we demonstrate the ability of AS-48 to be incorporated into synthetic multilamellar vesicles (MLVs).

Chemical Science published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei; Zhang, Xing-Guo published the artcile< Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur>, Synthetic Route of 19241-24-8, the main research area is primary amine sodium bromodifluoroacetate sulfur copper iodide catalyst isothiocyanation; isothiocyanate preparation green chem.

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine was established. This approach represented a simple and efficient one-pot synthesis of isothiocyanates and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. This process could directly provided isothiocyanate analogous bioactive mols., thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Berthiaume, Sylvie L.; Bray, Brian L.; Hess, Petr; Liu, Yanzhou; Maddox, Michael L.; Muchowski, Joseph M.; Scheller, Markus E. published the artcile< Synthesis of 5-substituted pyrrole-2-carboxaldehydes. Part I. Generation of formal 5-lithiopyrrole-2-carboxaldehyde equivalents by bromine-lithium exchange of 2-bromo-6-(diisopropylamino)-1-azafulvene derivatives>, Formula: C8H9NO3, the main research area is azafulvene lithiated derivative; pyrrolecarboxaldehyde derivative.

The first known lithiated 1-azafulvene derivatives, e.g., I, were generated by a low-temperature bromine-lithium exchange procedure with tert-butyllithium. These lithio species show substantial stability at ≤-90°C because, at these temperatures, the sterically demanding 6-diisopropylamino moiety, unlike the dimethylamino group, completely inhibits nucleophilic addition to C-6. At higher temperatures, the addition of tert-butyllithium to C-6 is significant and it can become the dominant process. The lithio species I is a useful formal equivalent of 5-lithiopyrrole-2-carboxaldehyde since, on reaction with electrophilic reagents and subsequent hydrolysis, a wide variety of regiochem. pure 5-substituted pyrrole-2-carboxaldehydes is formed. The 6-dialkylamino-1-azafulvenes described herein exist predominantly or exclusively as the syn conformer in solution at room temperature This conformational preference is confirmed by a significant NOE effect between H-4 and H-6 in the parent diisopropylamino-substituted azafulvene. The origin of the syn conformational preference stems from a substantial contribution of the charge-separated form to the ground state structure of these compounds, a phenomenon that is strongly supported by variable temperature NMR measurements on 2-bromo-6-diisopropylamino-1-azafulvene.

Canadian Journal of Chemistry published new progress about Lithiation. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Formula: C8H9NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoelzel, Conner A.; Hu, Hang; Wolstenholme, Charles H.; Karim, Basel A.; Munson, Kyle T.; Jung, Kwan Ho; Zhang, Han; Liu, Yu; Yennawar, Hemant P.; Asbury, John B.; Li, Xiaosong; Zhang, Xin published the artcile< A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents>, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride, the main research area is triazole donor acceptor mol substituent; amines; charge transfer; donor-acceptor systems; fluorescence; solvent effects.

While organic donor-acceptor (D-A) mols. are widely employed in multiple areas, the application of more D-A mols. could be limited because of an inherent polarity sensitivity that inhibits photochem. processes. Presented here is a facile chem. modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and exptl. analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophys. properties of commonly used D-A fluorophores and their enhanced performance in biol. imaging are shown.

Angewandte Chemie, International Edition published new progress about Absorption. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics