Tag: M.W=150-200

Meyhoff, Ulrich; Riber, Ulla; Boas, Ulrik published the artcile< Convergent synthesis of degradable dendrons based on L-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is polyester dendrimer degradable dendron malic acid convergent preparation.

New degradable polyester dendrons based on the cellular tricarboxylic acid cycle component L-malic acid were synthesized up to the third generation by convergent synthesis. The dendron wedges could be introduced in a stepwise, highly regioselective fashion. HMBC-NMR revealed that the C1-carbonyl on malic acid was exclusively esterified, before the reaction of the second dendron wedge at C4 took place. Degradation studies on a first generation dendron analyzed by HPLC showed that hydrolytic degradation of the dendron most profoundly takes place at pH 4 and pH 9 with the highest degradation rate at alk. pH. NMR shows that the dendron degrades to malic acid and fumaric acid derivatives Preliminary studies performed in the cell culture show low toxicity of the dendrons in concentrations of up to 50 μg mL-1.

New Journal of Chemistry published new progress about Biodegradable medical goods. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Chang-Xia; Guo, Yu-Ting; Wu, Yu-Huan; Li, Zhao-Yue; Wang, Yao-Zong; Du, Fu-Sheng; Li, Zi-Chen published the artcile< Synthesis and Controlled Organobase-Catalyzed Ring-Opening Polymerization of Morpholine-2,5-Dione Derivatives and Monomer Recovery by Acid-Catalyzed Degradation of the Polymers>, HPLC of Formula: 2743-40-0, the main research area is acid catalyzed degradation polymer morpholine dione ring opening polymerization.

Polydepsipeptides (PDPs) are strictly alternating copolymers of α-hydroxy acids and α-amino acids produced via the ring-opening polymerization (ROP) of morpholino-2,5-dione derivatives (MDs). They have been used as promising biomaterials for their combined high thermal stability and good mech. properties of polyamides as well as the inherent degradability of polyesters. ROP of MDs is usually carried out at high temperatures with metal catalysts or enzymes, with less control over the polymer mol. weights and dispersities. In this work, we developed a simple and efficient synthetic strategy of a new platform MD via the Passerini-type reaction between an isocyano derivative of the amino acid and an aldehyde, followed by intramol. esterification. Nine new MDs were synthesized by using this method, and the organobase-catalyzed ROP of these MDs was investigated. When the ROPs of these MDs were catalyzed by either triazabicyclo[4.4.0]dec-5-ene (TBD) or diazabicyclo[5.4.0]undec-7-ene (DBU) in the presence of benzyl alc. as an initiator, the polymerizations were uncontrolled with the formation of both linear PDPs and cyclic PDPs. By using binary catalytic systems of 1-(3,5-bis(trifluoromethyl)-phenyl-3-cyclohexyl-2-thiourea) (TU) with DBU or TBD ([TU]/[TBD] or [DBU] > 3), the polymerizations became well-controlled, allowing the synthesis of PDPs with controlled mol. weights, low dispersities, as well as block copolymers. Furthermore, cyclic PDPs were obtained when the ROP of these MDs was catalyzed with TBD in the absence of both TU and an initiator. Finally, we used two methods to recover the monomer precursors or pure MD monomers: the TBD-catalyzed alcoholysis of PDPs was very fast and generated the monomer precursors quant., while the acid-catalyzed depolymerization of PDPs led to pure and quant. monomer recovery.

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Heravi, Majid M.; Malakooti, Reihaneh; Kafshdarzadeh, Kosar; Amiri, Zahra; Zadsirjan, Vahideh; Atashin, Hassan published the artcile< Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions>, Computed Properties of 94-02-0, the main research area is aluminum SBA15 supported palladium oxide nanocatalyst preparation; dihydropyranopyrazole green preparation; pyrazolyl coumarin green preparation.

An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazoles such as I [R = H, Ph; R1 = Me, 4-ClC6H4, 4-O2NC6H4, etc.; R2 = H, Me; X = CN, CO2Et] and pyrazolyl-coumarins IV [R4 = H, Ph; R5 = Ph, 4-MeOC6H4, 3-O2NC6H4, 4-O2NC6H4, 4-MeC6H4] had been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and recyclable catalyst in H2O/EtOH under reflux conditions. The significant merits of this method were wide scope, high yields of the desired products, short reaction times and simple workup procedure. In addition, this nanocatalyst was simply recovered and reused five times without significant loss in catalytic activity and also performance.

Research on Chemical Intermediates published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Computed Properties of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sojak, L.; Perjessy, A.; Kubinec, R.; Giumanini, A. G. published the artcile< CGC-FTIR characterization of mononitro and dinitro isomers from nitration mixtures of methyl arylacetates>, HPLC of Formula: 30095-98-8, the main research area is GC FTIR nitration mixture methyl arylacetate; gas chromatog FTIR arylacetate nitration mixture.

Twenty-one isomeric compounds from nitration of Me phenyl-, diphenyl-, and (hydroxy)diphenylacetates and the parent compounds were separated by capillary gas chromatog. with apolar stationary phase HP-5 and detected by FID and FTIRD. The measured retention indexes and IR spectral data of C=O and NO2 groups were correlated with mol. structure of analytes. The regularities in GC retention as well as in the FTIR data of isomeric aromatic nitro compounds were formulated. The obtained results can be useful for GC-FTIR identification of ring positional isomers of nitration products of other Me arylacetates.

Chemical Papers published new progress about Capillary gas chromatography. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Eric J.; Williams, Andrew C. published the artcile< A stereoselective approach to the δ-lactone fragment of the lankacidin antibiotics>, Application In Synthesis of 617-55-0, the main research area is lankacidin lactone fragment stereoselective preparation.

The lactone fragment I of the lankacidins was prepared from dibenzyl aspartate via the azetidinones II (R = SiMe2CMe3, COEt, R1 = R2 = H, R3 = SiMe2CMe3, CH2OCH2Ph). II (R = R3= SiMe2CMe3, R1 = Me, R2 = OCH2OCH2Ph) was similarly prepared

Journal of the Chemical Society, Chemical Communications published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Li; Cui, Jean; Liang, Congxin; Zhou, Yong; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Tang, Cho; Wei, James published the artcile< Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is dihydropyrimidine derivative preparation EGF receptor Her2 tyrosine kinase inhibitor; structure activity dihydropyrimidine derivative preparation EGFR Her2 tyrosine kinase.

A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185erbB). Structure-activity relationships (SARs) for this class of compounds are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dahlgren, Anders; Johansson, Per-Ola; Kvarnstrom, Ingemar; Musil, Djordje; Nilsson, Ingemar; Samuelsson, Bertil published the artcile< Novel Morpholinone-Based D-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex>, Synthetic Route of 617-55-0, the main research area is morpholinone tripeptide analog preparation thrombin inhibitor MSBAR; reductive amination ring closure preparation morpholinone tripeptide thrombin inhibitor; crystal structure thrombin morpholinone tripeptide inhibitor.

A morpholinone structural motif derived from D(+)- and L(-)-malic acid has been used as a mimic of D-Phe-Pro in the thrombin inhibiting tripeptide D-Phe-Pro-Arg. In place of Arg the more rigid P1 truncated p-amidinobenzylamine (Pab) or 2-amino-5-aminomethyl-3-methyl-pyridine have been utilized. The synthetic strategy developed readily delivers these novel thrombin inhibitors used to probe the α-thrombin inhibitor binding site. The best candidate (I) in this series of thrombin inhibitors exhibits an in vitro IC50 of 720 nM.3. The X-ray crystal structure of I co-crystallized with α-thrombin is discussed.

Bioorganic & Medicinal Chemistry published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delso, Ignacio; Marca, Eduardo; Mannucci, Vanni; Tejero, Tomas; Goti, Andrea; Merino, Pedro published the artcile< Tunable Diastereoselection of Biased Rigid Systems by Lewis Acid Induced Conformational Effects: A Rationalization of the Vinylation of Cyclic Nitrones En Route to Polyhydroxylated Pyrrolidines>, Application In Synthesis of 617-55-0, the main research area is tunable diastereoselective vinylation cyclic nitrone Lewis acid conformational effect; pyrrolidine polyhydroxylated diastereoselective preparation.

The diastereofacial selection in addition reactions to biased rigid systems can be modulated by the action of Lewis acids. As an example, the stereoselectivity of the nucleophilic addition of vinylmagnesium bromide (VMB) to cyclic nitrones in the presence of diethylaluminum chloride (DEAC) shows a strong dependence on the temperature and the carbon substituent adjacent at the reaction center; it is remarkable that whereas a high selectivity is obtained at higher temperatures, in the presence of DEAC, a trend to invert the stereochem. course of the reaction is observed at lower temperatures, provided the substituent at C3 of the pyrrolidine ring allows delivery of the vinyl moiety. This behavior and difference in selectivity is to be attributed to the high conformational barriers of the intermediate nitrone-DEAC-VMB complex. A clear inversion of the selectivity is observed at -78 °C for the reaction of the nitrone protected as an O-Me derivative The present study provides a rationalization for the stereocontrolled addition of nucleophiles to rigid systems (cyclic nitrones).

Chemistry – A European Journal published new progress about Conformational barrier (of nitrone-Grignard-Al complex). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bloomer, James L.; Kappler, Francis E. published the artcile< Total synthesis of a α-carboxymethyltetronic acid. (S)-Carlosic acid>, HPLC of Formula: 617-55-0, the main research area is carlosic acid; tetronic acid mold.

The total synthesis of a naturally occurring mold tetronic acid (I) with correct absolute configuration is described, as well as a possible biogenetic precursor for the entire family.

Journal of Organic Chemistry published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki published the artcile< Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy>, Related Products of 39987-25-2, the main research area is hydroxyneolamellarin antitumor agent HIF alpha inhibitor; 7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis.

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-Hydroxyneolamellarin A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-Hydroxyneolamellarin A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion. More importantly, 7-Hydroxyneolamellarin A exhibited profound anti-tumor effect in mice breast cancer model by suppressing the accumulation of HIF-1α in tumor tissue. Mechanism study demonstrated that 7-Hydroxyneolamellarin A might target the protein with the ability of stabilizing HIF-1α in hypoxia. Due to the excellent water solubility, superior anti-tumor activity and good biocompatibility, 7-OH-Neo A shows the promising potential for being exploited as an anti-tumor agent in near future.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Related Products of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics