Tag: M.W=150-200

Papageorgiou, Christos; Benezra, Claude published the artcile< Use of enzymic hydrolysis of dimethyl malates for a short synthesis of tulipalin B and of its enantiomer>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is dimethyl malate regiochem esterase hydrolysis; tulipalin B.

Pig liver esterase hydrolyzes the ester function α to the hydroxyl group in di-Me malate. This regiospecific reaction was used to synthesize (+)- and (-)-tulipalin B.

Journal of Organic Chemistry published new progress about Regiochemistry. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Griffiths, Jon-Paul; Nie, Hui; Brown, R. James; Day, Peter; Wallis, John D. published the artcile< Synthetic strategies to chiral organosulfur donors related to bis(ethylenedithio)tetrathiafulvalene>, Application In Synthesis of 617-55-0, the main research area is tetrathiafulvalene nonracemic preparation oxidation potential; dithiolodithiinylidene dithiolodithiinacetate nonracemic preparation oxidation potential; spirodioxolanedithiolodithiepinylidene spirodioxolanedithiolodithiepine nonracemic preparation oxidation potential; cyclopropadithiolobenzodithiinylidene cyclopropadithiolobenzodithiin stereoselective nonracemic preparation oxidation potential; fused dithiolodithiin stereoselective nonracemic preparation crystal structure; stereoselective Diels Alder cycloaddition dithioletrithione alkene; mol crystal structure nonracemic fused dithiolodithiin; oxidation potential nonracemic tetrathiafulvalene.

Nonracemic tetrathiafulvalenes such as I, II, and III are prepared from nonracemic starting materials. Me (dithiolodithiinylidene)dithiolodithiinacetate I is prepared in six steps from di-Me malate using a double nucleophilic substitution reaction with a dithiolethionedithiolate as the key step. (spirodioxolanedithiolodithiepinylidene)spirodioxolanedithiolodithiepine II is prepared in four steps from trans-stilbene and a thioxodithiolodithiepinone using a ketalization reaction to incorporate absolute stereochem. into the tetrathiafulvalene system. (cyclopropadithiolobenzodithiinylidene)cyclopropadithiolobenzodithiin III (and its double bond stereoisomer) are prepared in three steps from (+)-2-carene using the stereoselective Diels-Alder cycloaddition with dithioletrione IV as the key step. Other nonracemic alkenes undergo stereoselective Diels-Alder reactions with IV to yield nonracemic fused dithiolodithiins. The oxidation potentials of I, II, and III and related tetrathiafulvalenes are determined; the oxidation potential of III differs from that of related racemic compounds The crystal structures of fused dithiolethiones generated by Diels-Alder cycloaddition of (-)-α-pinene, (-)-β-pinene, and (+)-2-carene with IV are determined by X-ray crystallog. and discussed.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Fang; Wang, Yujie; Du, Qian; Ge, Wenxiang; Li, Zhanhui; Wang, Xu; Fu, Chunyan; Luo, Lusong; Tian, Sheng; Ma, Haikuo; Zheng, Jiyue; Zhang, Yi; Sun, Xiaotian; He, Sudan; Zhang, Xiaohu published the artcile< Structural optimization of aminopyrimidine-based CXCR4 antagonists>, Reference of 60705-25-1, the main research area is aminopyrimidine synthesis SAR CXCR4 CXCL12 chemotaxis hERG; Antagonist; CXCR4; Chemokine; GPCR; Structural optimization.

Structural optimization of aminopyrimidine-based CXCR4 antagonists is reported. The optimization is guided by mol. docking studies based on available CXCR4-small mol. crystal complex. The optimization identifies a number of compounds with improved receptor binding affinity and functional activity exemplified by compound 23 (inhibition of APC-conjugate clone 12G5 for CXCR4 binding in a cell based assay: IC50 = 8.8 nM; inhibition of CXCL12 induced cytosolic calcium increase: IC50 = 0.02 nM). In addition, compound 23 potently inhibits CXCR4/CXLC12 mediated chemotaxis in a matrigel invasion assay. Furthermore, compound 23 exhibits good physicochem. properties (MW 367, clogP 2.1, PSA 48, pKa 7.2) and in vitro safety profiles (marginal/moderate inhibition of CYP isoenzymes and hERG). These results represent significant improvement over the initial hit from scaffold hybridization and suggest that compound 23 can be used as a starting point to support lead optimization.

European Journal of Medicinal Chemistry published new progress about Cardiotoxicity. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Reference of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An, Xiaoying; Gao, Lei; Wang, Mingliang; Wu, Haitao; Wang, Lanzhi published the artcile< One-pot synthesis of 1,5-benzodiazepine-2,3-dicarboxylates via three-component domino reactions in the presence of γ-Fe2O3@SiO2/Ce(OTf)3>, Name: Ethyl 3-oxo-3-phenylpropanoate, the main research area is iron oxide silica supported cerium triflate catalyst preparation; benzodiazepine dicarboxylate green preparation; phenylenediamine beta carbonyl ester ethyl glyoxylate three component domino; methyl benzodiazepine dicarboxylate green preparation; ethyl pyruvate phenylenediamine beta carbonyl ester three component domino.

Novel, efficient and environmentally friendly approaches was developed for the synthesis of 1,5-benzodiazepine-2,3-dicarboxylates I [R1 = H, Me, Cl, Br; R2 = Me, Et, Ph; R3 = Me, Et, Pr] and II by one-pot three-component domino reactions in the presence of a catalytic amount of γ-Fe2O3@SiO2/Ce(OTf)3 in EtOH at ambient temperature A total of synthesized 2,5-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates I and 2-methyl-2,3-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates II with enamine or imine structure of the heterocycle, resp., were obtained in good yields by reacting substituted 1,2-phenylenediamine, β-carbonyl esters and Et glyoxylate or Et pyruvate. One-pot reactions were successfully realized to form one new cycle and four new bonds (one C-C, two C-N, one C=C or two C-C, one C-N, one C=N). The salient features of this reaction included short reaction time, mild reaction conditions, moderate to excellent yields, recyclability of the catalyst, and wide substrate scope.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Name: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Yi; Yang, Zheng-Yu; Xia, Peng; Bastow, Kenneth F.; Nakanishi, Yuka; Nampoothiri, Priya; Hamel, Ernest; Brossi, Arnold; Lee, Kuo-Hsiung published the artcile< Antitumor agents. Part 226: Synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is phenylquinoloneacetic acid preparation antitumor agent cytotoxicity.

2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acids displayed potent cytotoxicity with ED50 values at nanomolar concentrations, but had minimal activity against tubulin polymerization 2-(2′-Fluorophenyl)-4-quinolone-6-acetic acid and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acid Me ester moderately inhibited tubulin polymerization

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Jianjing; Zeng, Ting; Yan, Kelu; Qin, Zonghui; Wen, Jiangwei published the artcile< Direct Synthesis of Alkylthioimidazoles: One-Pot Three-Component Cross-Coupling Mediated by Paired Electrolysis>, Synthetic Route of 19241-24-8, the main research area is isothiocyanate cyanoacetate haloalkane electrochem multicomponent cross coupling; alkylthioimidazole preparation.

The direct synthesis of alkylthioimidazoles was initially accomplished via a one-pot three-component cross-coupling mediated by a paired electrolysis strategy using non-activated chloroalkane as the alkylating agent. This protocol provides a straightforward method for the preparation of alkylthioimidazoles by employing water as the co-solvent at room temperature without any exogenous-oxidants and metal catalysts. Inactivated primary, secondary, tertiary haloalkanes and various isothiocyanates was compatible with the established conditions to obtain the corresponding products with a moderate yield. The mechanism of this one-pot three-component cross-coupling reaction undergoes a radical process mediated by paired electrolysis.

Advanced Synthesis & Catalysis published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Correction to ""The Discovery of 3,3′-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection"" [Erratum to document cited in CA168:169484]>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus erratum.

In the original publication, there are errors in two references and a typog. error within the table of contents; the corrections are provided here.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phukan, Prodeep published the artcile< Iodine as an extremely powerful catalyst for the acetylation of alcohols under solvent-free conditions>, Application of C6H10O5, the main research area is alc acetylation acetic anhydride solvent free; acetate preparation.

Iodine was found to promote quant. acetylation of alcs. in a very short time with an equimolar amount of acetic anhydride under solvent-free conditions at room temperature

Tetrahedron Letters published new progress about Acetylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony C.; Prabpai, Samran; Kongsaeree, Palangpon; Parish, Christopher R.; Suksamrarn, Sunit; Kelso, Michael J. published the artcile< Synthesis, Structural Characterisation, and Preliminary Evaluation of Non-Indolin-2-one-based Angiogenesis Inhibitors Related to Sunitinib (Sutent)>, Electric Literature of 30095-98-8, the main research area is sunitinib analog preparation angiogenesis inhibitor SAR.

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent) and predecessor angiogenesis inhibitors that have undergone anticancer clin. trials (e.g. semaxanib, SU5416). In pursuit of novel anti-angiogenic scaffolds, we were interested in identifying whether the indolin-2-one group in these structures could be modified without losing activity. This paper describes novel condensation chem. used to prepare a test series of (E)- and (Z)-alkenes related to SU5416 that retain the 2,4-dimethylpyrrole unit while incorporating ring-opened indolin-2-ones. Unique structural characteristics were identified in the compounds, such as intramol. hydrogen bonds in the (Z)-alkenes, and several examples were shown to possess significant anti-angiogenic activity in a rat aorta in vitro model of angiogenesis. The work demonstrates that the indolin-2-one moiety is not an absolute requirement for angiogenesis inhibition in the sunitinib/SU5416 class.

Australian Journal of Chemistry published new progress about Antiangiogenic agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chunying; Ishige, Ryohei; Yasumatsu, Ryou; Kang, Sungmin; Tokita, Masatoshi; Watanabe, Junji published the artcile< Regular undulation and polarization modulation on the film surface of a planarly aligned SmC* polymer>, Product Details of C6H10O5, the main research area is smectic C polymer regular undulation polarization modulation planarly aligned.

Chiral smectic C (SmC*) in a main-chain type of polymer exhibits undulations on its glassy film surface; these undulations are produced by the helical assembly of polymer conforming to the helical field of SmC*. In this study, we have found a polarization modulation superimposed on the undulation from the combined observations of Kelvin force microscopy (KFM) and at. force microscopy (AFM) images. This modulation is caused by the spontaneous polarization of each smectic layer; its direction is parallel to the layer and perpendicular to the tilt direction of mols. within a layer, and rotates around the helical axis. The polarization modulation length corresponds perfectly to the undulation length, i.e., helical pitch of SmC*. By clarifying the relative direction of the spontaneous polarization to the tilt direction of mesogens, we described how the polymers are accommodated to produce such a regular undulation and polarization modulation.

Soft Matter published new progress about Electrooptical switches. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics