Tag: M.W=150-200

Zhang, Xi; Liu, Dong-yun; Shang, Hai; Jia, Yi; Xu, Xu-Dong; Tian, Yu; Guo, Peng published the artcile< Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation>, Recommanded Product: H-Leu-OEt.HCl, the main research area is amino acid ester coupled caffeoylquinic derivative hypolipidemic agent.

Pandanus tectorius (L.) Parkins.(PTPs) is rich in caffeoylquinic acids and amino acids, especially some essential amino acids, such as valine, phenylalanine, and so forth. A series of novel amino acid ester-coupled caffeoylquinic acid derivatives have been designed and synthesized. Biol. evaluation suggested that some amino acid ester-coupled derivatives exhibited varying degrees of lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 6c, 6d, 6e and 6f exhibited comparable potential lipid-lowering effect with the pos. control simvastatin and chlorogenic acid. Further studies on the mechanism of 6c, 6d, 6e and 6f revealed that the lipid-lowering effects were related to their regulation of TG levels and mRNA levels of lipometabolic-modulating genes, and merit further investigation.

RSC Advances published new progress about Amino acid esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Recommanded Product: H-Leu-OEt.HCl.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Youchi; Zhang, Jingli; Yuan, Ye; Liu, Liran; Chen, Bifeng; Sun, Taolei published the artcile< Synthesis of Polysubstituted 2H-Pyran-2-ones or Phenols via One-Pot Reaction of (E)-β-Chlorovinyl Ketones and Electron-Withdrawing Group Substituted Acetates or β-Diketones>, COA of Formula: C11H12O3, the main research area is pyranone polysubstituted phenol preparation chlorovinyl ketone acetate beta diketone.

This paper describes a facile one-pot synthesis of highly functionalized 2H-pyran-2-ones and phenols through a base-promoted annulation of readily available β-chlorovinyl ketones with various active methylene compounds Conjugate addition of electron-withdrawing group substituted acetates to allenone intermediates and direct conjugate addition of β-diketones to β-chlorovinyl ketones reveal versatile electrophilic pathways of β-chlorovinyl ketones under different reaction conditions. In particular, cyclocondensation is regiospecific for 3,5-disubstituted phenols. Moreover, the utility of [3+3] cyclocondensation is further illustrated by the concise synthesis of benzofuran derivative and penta- or hexa-substituted phenol construction.

European Journal of Organic Chemistry published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regano, Celia; Alla, Abdellilah; De Ilarduya, Antxon Martinez; Munoz-Guerra, Sebastian published the artcile< Linear polyamides from L-malic acid and alkanediamines>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is malic acid linear polyamide synthesis optical thermal mech property.

A series of linear polyamides (PnMLM) derived from O-methyl-protected L-malic acid and 1,n-alkanediamines with even n values ranging from 4 to 12 were prepared and fully characterized. L-Malic acid entered in the chain with a random orientation rendering essentially aregic polymers. PnMLM displayed optical rotation consistent with the content of the polymer in malic units, and they all were crystalline with m.ps. ranging from 158 to 188 °C and glass-transition temperatures varying from 37 to 70 °C. PnMLM appeared to be fairly stable to heat with thermal decomposition starting close to 300 °C. Hydrolytic degradation of PnMLM at 37 °C was slow, but the process was significantly faster at 70 °C. Thermal degradation took place with the formation of cyclic malimides in the residual polymer and released the 1,n-alkanediamine. However, hydrolytic degradation took place in a first stage with the formation of open chains of carboxylic- and amine-ended oligomers.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Hydrolytic polymer degradation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bertus, Philippe; Zhang, Jing-Heng; Sir, Geoffroy; Weibel, Jean-Marc; Pale, Patrick published the artcile< Asymmetric synthesis of the cyclopentanones related to NCS and N1999A2 antitumor antibiotics>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxylated cyclopentanone Bestmann cyclization preparation; NCS N1999A2 hydroxylated cyclopentanone core preparation.

Optically pure protected mono- or dihydroxylated cyclopentanones, precursors for the core of the antitumor antibiotics NCS and N1999A2 were obtained in six to eight steps via a key Bestmann cyclization with excellent overall yields (up to 52%).

Tetrahedron Letters published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagnieres, Olivier; Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A>, Product Details of C9H9NO4, the main research area is stereoselective synthesis monoterpene indole alkaloid; goniomitine stereoselective synthesis; dehydroaspidospermidine stereoselective synthesis; aspidospermidine vincadifformine kopsihainanine stereoselective synthesis; decarboxylative vinylation palladium catalyst monoterpene indole alkaloid synthesis; oxidation reduction cyclization integrated stereoselective synthesis monoterpene indole alkaloid.

Total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A were achieved featuring two common key steps: (1) a palladium-catalyzed decarboxylative vinylation that provides quick access to cyclopentene intermediates containing all of the carbons present in the natural products and (2) an integrated oxidation/reduction/cyclization (iORC) sequence for skeletal reorganization that converts the cyclopentenes to the pentacyclic structures of the natural products. By incorporation of a geometric constraint to iORC substrates, both the chemoselectivity (C7 vs. N1 cyclization) and the stereoselectivity (trans- vs. cis-fused ring system) of the cyclization process can be controlled.

Journal of the American Chemical Society published new progress about Cyclization. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wada, Kojiro; Ishida, Tatsuyoshi published the artcile< A steroid hydroxylase inhibitor, diplodialide A, and related metabolites from Diplodia pinea>, Electric Literature of 617-55-0, the main research area is diplodialide Diplodia lactone structure; steroid hydroxylase inhibition diplodialide.

The structures of diplodialide A (I; RR1 = O), B (I; R = OH, R1 = H), C (II), and D (III) from Diplodia pinea were determined from chem. and spectral data.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Diplodia pinea. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jain, R.; Sundram, A.; Lopez, S.; Neckermann, G.; Wu, C.; Hackbarth, C.; Chen, D.; Wang, W.; Ryder, N. S.; Weidmann, B.; Patel, D.; Trias, J.; White, R.; Yuan, Z. published the artcile< α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents. [Erratum to document cited in CA140:128630]>, Synthetic Route of 617-55-0, the main research area is erratum hydroxamic acid preparation bacterial deformylase inhibitor antibacterial agent; proline hydroxamic preparation bacterial deformylase inhibitor antibacterial agent erratum.

The corrected version of Table 2 is given.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Caixia; Li, Songhua; Li, Yunyi; Ma, Chen published the artcile< An efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot>, Synthetic Route of 94-02-0, the main research area is benzoimidazolyl benzamide preparation.

A metal-free one-pot method for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives such as I [R1 = Ph, 4-MeC6H4, 1-naphthyl, etc.; R2 = Me, Et, Ph] and N-(1H-imidazol-2-yl)benzamide derivatives II [R3 = 4-ClC6H4, 4-MeOC6H4, 4-CF3C6H4, etc.; R4 = Et, Me] was proposed mediated by CBr4. The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields. Easily accessible starting materials, simple operations and high atom economy made this strategy a potential and useful method in organic and pharmaceutical chem.

Tetrahedron published new progress about Atom economy. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RajanBabu, T. V.; Reddy, G. S.; Fukunaga, Tadamichi published the artcile< Nucleophilic addition of silyl enol ethers to aromatic nitro compounds: scope and mechanism of reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is organosilicon alkylation nitro compound; silicon organic nitro alkylation; aromatic nitro organosilicon alkylation; heteroaromatic nitro organosilicon alkylation; benzene nitro organosilicon alkylation; anthracene nitro organosilicon alkylation; naphthalene nitro organosilicon alkylation; isoquinoline nitro organosilicon alkylation; benzothiadiazole nitro organosilicon alkylation.

In contrast to alkali metal enolates, silyl enol ethers and ketene silyl acetals added to aromatic nitro compounds in the presence of a fluoride ion source to give intermediate dihydroarom. nitronates, which could be observed by NMR. In situ oxidation of the intermediate with Br or DDQ gave α-nitroaryl carbonyl compounds in moderate to high yields. The reaction was applicable to alkyl-, alkoxy-, and halogen-substituted nitrobenzenes as well as to heterocyclic and condensed nitroarom. compounds While substitution ortho to the nitro group predominated with sterically undemanding silyl reagents, para-substitution products were exclusively obtained with bulky reagents. However, by blocking the para position with an appropriate group such as chlorine, the addition could be directed to the ortho position. Halogen atoms of halogenated nitro aromatics and p-nitrocumenyl chloride were not displaced in the reaction, suggesting the absence of radical ion intermediates. Dihydroarom. nitro derivatives could be isolated in some cases, such as anthracene and naphthalene systems, which are less prone to rearomatize.

Journal of the American Chemical Society published new progress about Alkylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Papageorgiou, Christos; Benezra, Claude published the artcile< Synthesis of potentially allergenic chiral α-(hydroxyalkyl)acrylates>, Category: esters-buliding-blocks, the main research area is asym synthesis hydroxylalkylacrylate; acrylate hydroxyalkyl asym synthesis; sulfoxide optically active asym induction.

Treating (R)- or (S)-4-MeC6H4S(O)CHMeCO2CMe3 with Me3CMgBr and aldehydes RCH2CHO (R = Me, Bu, octyl), followed by thermal elimination, gave title compounds (R)- or (S)-Me3CO2CC(:CH2)CH(OH)CHR, resp., in 75% enantiomeric excess.

Tetrahedron Letters published new progress about Esters Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics