Tag: M.W=150-200

Gan, Ziyu; Li, Guoqing; Yan, Qiuli; Deng, Weiseng; Jiang, Yuan-Ye; Yang, Daoshan published the artcile< Visible-light-promoted oxidative desulphurisation: a strategy for the preparation of unsymmetrical ureas from isothiocyanates and amines using molecular oxygen>, Computed Properties of 19241-24-8, the main research area is unsym urea preparation photochem green chem; isothiocyanate amine oxidative desulfurization photoredox catalyst.

A green and efficient visible-light promoted oxidative desulfurization protocol has been proposed for the construction of unsym. ureas R1NHC(O)N(R2)R3 [R1 = Ph, propan-2-yl, 4-chlorophenyl, etc.; R2 = H, Et, n-Pr, n-Bu, Bn, cyclohexyl; R3 = n-Bu, Bn, 2-(thiophen-2-yl)ethyl, etc.; R2R3 = -(CH2)5-, -(CH2)2O(CH2)2-] and I under mild conditions with broad substrate scope and good functional group tolerance. Most appealingly, the reaction can proceed smoothly without adding any strong oxidants. Control experiments and computational studies support a mechanism involving water-assisted in situ generation of thioureas and photocatalytic oxidative desulfurization. The present method provides a promising synthesis strategy for the formation of diverse and useful unsym. urea derivatives I in the fields of pharmaceutical and synthetic chem.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Computed Properties of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polonski, Tadeusz published the artcile< Chiroptical properties and molecular geometry of substituted succinic anhydrides and imides>, Computed Properties of 617-55-0, the main research area is CD succinic anhydride succinimide conformation; mol mechanic succinic anhydride succinimide; UV spectra succinic anhydride succinimide; solvent effect CD anhydride imide.

UV and CD spectra have been measured for several α-substituted succinic anhydrides and imides. The Cotton effect signs corresponding to the two n-π* electronic transitions can be explained with the octant rule. The strong substituent and solvent dependence of the spectra is a result of the equilibrium between two skewed conformers of the five-membered ring. The geometry and relative energies of the conformers were found from mol. mechanics (MM2) calculations

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Circular dichroism. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramachandran, P. Veeraraghavan; Otoo, Barnabas published the artcile< Irreversible aldolization of ketones with bisdicyclohexylboron enediolates>, Reference of 94-02-0, the main research area is hydroxy acid preparation diastereoselective; ketone bisdicyclohexylboron enolate irreversible aldolization.

Reversible addition of ketone enolborinates to ketones RCOR1 (R = Et, 4-bromophenyl, cyclohexyl, etc.; R1 = H, chloromethyl, Ph, 3-ethoxy-3-oxoprop-1-en-1-yl, etc.) and the aldolization of ketones with bisboron enediolates derived from carboxylic acids R2CH2C(O)OH (R2 = Me, Cl, ph, etc.) proceed without difficulty. A variety of α,β,β-trisubstituted-β-hydroxy acids syn/anti-RC(OH)(R1)CH(R2)C(O)OH have been thus synthesized in good to excellent yields and diastereoselectivities.

Tetrahedron Letters published new progress about Aldol condensation (irreversible). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Farnier, M.; Drakenberg, T. published the artcile< Nuclear magnetic resonance conformational studies of C-substituted formylpyrroles II. Barrier to internal rotation in 5-substituted 2-formylpyrroles>, HPLC of Formula: 7126-50-3, the main research area is formylpyrrole potential barrier rotation; pyrrole formyl rotation barrier; conformation formylpyrrole NMR temperature.

The effect of temperature on the NMR spectra of Et 5-formylpyrrole-2-carboxylate and 2,5-diformylpyrrole allowed determination of the activation parameters for rotation of the CHO group by line-shape anal. of the CHO signals. Introduction of the EtO2C or CHO at C-5 caused a decrease in the barrier to rotation as expected from their electron-withdrawing properties.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Molecular rotation. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, HPLC of Formula: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Jian; Kong, Han-Han; Li, Si-Jia; Zhang, Rui-Jin; Qian, Hao-Dong; Li, Dan-Ran; He, Jin-Yu; Zheng, Yi-Nuo; Xu, Hao published the artcile< Asymmetric copper-catalyzed propargylic amination with amine hydrochloride salts>, Category: esters-buliding-blocks, the main research area is propargylic amination amine hydrochloride salt.

The highly enantioselective copper-catalyzed propargylic amination of propargylic esters with amine hydrochloride salts has been realized for the first time using copper salts with chiral N,N,P-ligands. This method features a broad substrate scope and wide functional group tolerance, generating propargylic amines in good to excellent yields with high enantioselectivities (up to 99% ee). The utility of the approach was demonstrated by late-stage functionalization of marketed pharmaceuticals.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amination. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Tao; Cheng, Yuan-Yuan; Han, Xu; Zhou, Chao; Yang, Bing; Fan, Xiu-Wei; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published the artcile< Lewis Acid-Relayed Singlet Oxygen Reaction with Enamines: Selective Dimerization of Enamines to Pyrrolin-4-ones>, Reference of 94-02-0, the main research area is pyrrolinone preparation chemoselective photochem; enamine selective dimerization singlet oxygen reaction Lewis acid.

Singlet oxygen (1O2)-mediated oxidation represents an attractive strategy for incorporation of oxygen atoms from air under mild and environmentally benign conditions. However, the 1O2 reaction with enamine suffers from fragmentation, leading to very unsuccessful transformation. Here, Lewis acid is introduced to intercept [2 + 2] or “”ene”” reaction intermediates of the 1O2 reaction and enables oxidative dimerization of enamines to produce pyrrolin-4-ones in good to excellent yields. Mechanistic studies reveal the formation of the imino ketone intermediate from the interaction of 1O2 and enamine, which is able to interact with Lewis acid, relaying the 1O2 reaction in enamine chem. For the first time, selective cross-dimerization of two different enamines is achieved. Due to the advantages of mild conditions, high chemoselectivity, and up to 99% yield, a promising strategy has been developed for synthesizing aza-heterocycles under ambient conditions, which can be further applied for the synthesis of imidazolone, quinoxaline, and highly functionalized imine.

Journal of the American Chemical Society published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Huawen; Qu, Zhonghua; Ji, Xiaochen; Deng, Guo-Jun published the artcile< Three-component bis-heterocyclization for synthesis of 2-aminobenzo[4,5]thieno[3,2-d]thiazoles>, HPLC of Formula: 19241-24-8, the main research area is amino benzothieno thiazole preparation regioselective; methylketoxime acetate isothiocyanate three component heterocyclization.

A cooperative base system has been developed for the novel three component bis-heterocyclization of methylketoxime acetates. The present protocol provides an effective entry to 2-aminobenzo[4,5]thieno[3,2-d]thiazoles, e.g., I. Mechanistically, the formation of trisulfur radical anion [S3] ̇- and Willgerodt-Kindler-type sulfuration would be the key for this transformation.

Organic Chemistry Frontiers published new progress about Fused heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao, Yujie; Zhao, Weijie published the artcile< Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors>, Reference of 39987-25-2 , the main research area is neolamellarin A derivative preparation HIF1 inhibitory activity SAR; Anti-tumor; Hypoxia inducible factor (HIF)-1; Marine alkaloids; Neolamellarin A; Structure-activity relationship.

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A (I) and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, resp. The results showed that neolamellarin A (IC50 = 10.8 ± 1.0 μM) and compound II (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biol. activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small mol. probes for target protein identification.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkaloids Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (pyrrole). 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Reference of 39987-25-2 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cicchi, Stefano; Crea, Saverio; Goti, Andrea; Brandi, Alberto published the artcile< Synthesis of new enantiopure γ-amino alcohols: their use as catalysts in the alkylation of benzaldehyde by diethylzinc>, SDS of cas: 617-55-0, the main research area is amino alc asym synthesis; dipolar cycloaddition cyclic nitrone malic acid.

The straightforward synthesis of new enantiopure γ-amino alcs. through 1,3-dipolar cycloaddition to a chiral cyclic nitrone derived from L-malic acid was described. Results of the application of these compounds as chiral catalysts in the alkylation of benzaldehyde with diethylzinc were also reported. The addition of styrene to (S)-4-(1,1-dimethylethoxy)-3,4-dihydro-2H-pyrrole 1-oxide (I), gave predominantly the adduct II which upon subsequent methylation yielded III. In the presence of III as catalyst, the addition of diethylzinc to benzaldehyde gave (R)-α-ethylbenzenemethanol in 54% enantiomeric excess.

Tetrahedron: Asymmetry published new progress about Addition reaction, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Cheng-Kun; Tao, Ze-Kun; Zhou, Zhi-Hao; Bao, Xiao-Guang; Zhou, Shao-Fang; Zou, Jian-Ping published the artcile< Copper-Catalyzed Oxidative sp3-Carbon Radical Cross-Coupling with Trialkylphosphites Leading to α-Phosphonyl 1,3-Dicarbonyl Compounds>, Quality Control of 94-02-0, the main research area is copper catalyzed oxidative cross coupling alkylphosphite dicarbonyl compound; diketone alpha phosphonyl derivative preparation; ketoester alpha phosphonyl derivative preparation.

A Cu-catalyzed radical Csp3-H/P(OR)3 cross-coupling reaction for the formation of Csp3-P bonds is described. A range of 1,3-dicarbonyl compounds and trialkylphosphites were coupled in this fashion to give the corresponding products in moderate to good yields. This protocol provides direct access to α-phosphonyl 1,3-dicarbonyl compounds

Journal of Organic Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Quality Control of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics