Tag: M.W=150-200

Rysak, Vincent; Dixit, Ruchi; Trivelli, Xavier; Merle, Nicolas; Agbossou-Niedercorn, Francine; Vanka, Kumar; Michon, Christophe published the artcile< Catalytic reductive deoxygenation of esters to ethers driven by hydrosilane activation through non-covalent interactions with a fluorinated borate salt>, Safety of Ethyl 3-oxo-3-phenylpropanoate, the main research area is ether preparation; ester catalytic reductive deoxygenation.

The catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst was reported. Exptl. and theor. studies supported the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Catalysis Science & Technology published new progress about Deoxidation (reductive). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Safety of Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Mengyu; Sun, Deli; Gong, Hegui published the artcile< Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from æµ?Hydroxy Esters with Aryl Halides>, Electric Literature of 617-55-0, the main research area is synthesis aryl ester reductive cross coupling oxalate aryl halide; aryl ester preparation arylation aryl halide oxalate radical fragmentation; oxalate radical fragmentation reduction potential.

A Ni-catalyzed reductive cross-coupling of æµ?hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes æµ?aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates æµ?carbonyl radicals.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakamura, Kazuhito; Morita, Yukari; Suzuki, Toru; Sugiyama, Toru; Sugimori, Akira published the artcile< Radiation-induced reactions of pyridinecarboxylic esters in acidic alcoholic solutions. Substitution by alkyl and hydroxyalkyl groups and reduction of carboxylic esters to alcohol>, Application In Synthesis of 33402-75-4, the main research area is radiolysis pyridinecarboxylate alc; alkylation pyridinecarboxylate alc radiolysis; hydroxyalkylation pyridinecarboxylate alc radiolysis; reduction pyridinecarboxylate alc radiolysis.

The main reactions of pyridinecarboxylic esters induced by 60Co ç»?rays in acidic alc. solutions are substitution on the pyridine ring by alkyl or hydroxyalkyl groups, derived from solvent alcs., and reduction of the carboxylate group to a hydroxymethyl group. Substitution is dominant in MeOH solutions and reduction is dominant in Me2CHOH solutions Carboxylic esters at the 2- and 4-positions are selectivity reduced to alcs. Alkylation results from the attack by H atoms and hydroxyalkyl radicals. Reduction of carboxylic esters to alcs. is effected by the hydroxyalkyl radicals derived from the radiolysis of alcs.

Bulletin of the Chemical Society of Japan published new progress about Radiochemical reduction. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Application In Synthesis of 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sherrill, Lavinia M.; Joya, Elva E.; Walker, AnnMarie; Roy, Anuradha; Alhammad, Yousef M.; Atobatele, Moriama; Wazir, Sarah; Abbas, George; Keane, Patrick; Zhuo, Junlin; Leung, Anthony K. L.; Johnson, David K.; Lehtio, Lari; Fehr, Anthony R.; Ferraris, Dana published the artcile< Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain>, HPLC of Formula: 2743-40-0, the main research area is SARS CoV2 coronavirus nsp3 macrodomain inhibitor COVID19; ADP-ribosylation; COVID-19; Coronavirus; Nsp3 macrodomain inhibitors; SARS-CoV-2.

A series of amino acid based 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replication and pathogenesis. Structure activity studies identified compound 15c as a low-micromolar inhibitor of Mac1 in two ADP-ribose binding assays. This compound also demonstrated inhibition in an enzymic assay of Mac1 and displayed a thermal shift comparable to ADPr in the melting temperature of Mac1 supporting binding to the target protein. A structural model reproducibly predicted a binding mode where the pyrrolo pyrimidine forms a hydrogen bonding network with Asp22 and the amide backbone NH of Ile23 in the adenosine binding pocket and the carboxylate forms hydrogen bonds to the amide backbone of Phe157 and Asp156, part of the oxyanion subsite of Mac1. Compound 15c also demonstrated notable selectivity for coronavirus macrodomains when tested against a panel of ADP-ribose binding proteins. Together, this study identified several low MW, low 娓璏 Mac1 inhibitors to use as small mol. chem. probes for this potential anti-viral target and offers starting points for further optimization.

Bioorganic & Medicinal Chemistry published new progress about Anticoronaviral agents. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xinmou; Yu, Mo; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Radical Transformation of Aliphatic C-H Bonds to Oxime Ethers via Hydrogen Atom Transfer>, HPLC of Formula: 2743-40-0, the main research area is oxime ether preparation regioselective; alkane oxime radical transformation.

Herein, a strategy for conversion of aliphatic C-H bonds to oxime ethers via hydrogen atom transfer was described. In this strategy, the decatungstate anion and sulfate radical played complementary roles in the abstraction of hydrogen atoms from primary, secondary, and tertiary C-H bonds of alkanes. The easy accessibility of alkanes and the broad substrate scope, mild conditions, and excellent regioselectivity of these reactions made this strategy applicable for the transformation of raw materials to high-value chems.

Organic Letters published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dao, Pascal; Smith, Nikaia; Tomkiewicz-Raulet, Celine; Yen-Pon, Expedite; Camacho-Artacho, Marta; Lietha, Daniel; Herbeuval, Jean-Phillipe; Coumoul, Xavier; Garbay, Christiane; Chen, Huixiong published the artcile< Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity>, Application In Synthesis of 30095-98-8, the main research area is imidazo triazine preparation focal adhesion kinase inhibitor antitumor activity.

A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. We report herein that we further explored the heterocyclic core of these inhibitors by a fused imidazole ring with the triazine to provide imidazo[1,2-a][1,3,5]triazines, e.g., I. Importantly, these new compounds displayed 10-7-10-8 M IC50 values, and the best inhibitor showed IC50 value of 50 nM against FAK enzymic activity. Several inhibitors potently inhibited the proliferation of a panel of cancer cell lines expressing high levels of FAK. Apoptosis anal. in U87-MG and HCT-116 cell lines suggested that these compounds delayed cell cycle progression by arresting cells in the G2/M phase of the cell cycle, retarding cell growth. Further investigation demonstrated that these compounds strongly inhibited cell-matrix adhesion, migration, and invasion of U87-MG cells.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patel, Ashvani Kumar; Rathor, Shikha Singh; Samanta, Sampak published the artcile< Regioselective access to di- and trisubstituted pyridines via a metal-oxidant-solvent-free domino reaction involving 3-chloropropiophenones>, Electric Literature of 94-02-0, the main research area is heterocyclic pyridine preparation regioselective chemoselective green chem; chloropropiophenone ketone tandem reaction.

A remarkable metal-oxidant-solvent- and base-free domino route for regioselective access to a wide range of 2,4-di- and 2,3,4/6-trisubstituted pyridines, e.g., I including carbo- and heterocyclic fused pyridines is reported. This [3C + 2C + 1N] cyclization reaction occurs between 3-chloropropiophenones RC(O)(CH2)2Cl (R = Ph, 4-iodophenyl, 5-methylthiophen-2-yl, etc.) (3C units), enolizable acyclic/cyclic ketones, e.g., 1,2,3,4-tetrahydronaphthalen-1-one (2C sources) and NH4OAc as a robust N source under neat conditions under an open atm., producing new C=C and C=N-C bonds in highly chemo- and regioselective manners. Interestingly, this eco-friendly method has many pos. features: excellent functional group tolerance, broad substrate scope, good to excellent regioselectivities, promising yields, no-unwanted products, neutral reaction conditions and appropriateness for large-scale synthesis. Mechanism studies reveal that the in situ generated 灏?amino ketone from 3-chloropropiophenone and an ammonium salt undergoes C=N bond formation with a ketone followed by an intramol. cyclization process (C=C bond), which are the decisive steps for pyridine synthesis.

Organic & Biomolecular Chemistry published new progress about C-C bond formation (cn). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Electric Literature of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Djurovic, Alexandre; Vayer, Marie; Li, Zhilong; Guillot, Regis; Baltaze, Jean-Pierre; Gandon, Vincent; Bour, Christophe published the artcile< Synthesis of Medium-Sized Carbocycles by Gallium-Catalyzed Tandem Carbonyl-Olefin Metathesis/Transfer Hydrogenation>, SDS of cas: 94-02-0, the main research area is medium sized carbocycle preparation; alkenyl ketone preparation tandem metathesis transfer hydrogenation.

The first examples of a catalytic tandem process involving a ring-closing carbonyl-olefin metathesis and a transfer hydrogenation are described. 1,4-Cyclohexadiene has been used as an H2 surrogate to reduce the cyclic alkenes formed after the metathesis step. The same cationic gallium(III) complex, [IPr璺疓aCl2][SbF6], performs the two steps with functional group tolerance. This stereoselective reaction leads to 1,2-cis-disubstituted cyclopentanes and various cyclohexanes. DFT computations support an unexpected mechanism involving activation of 1,4-cyclohexadiene by superelectrophilic gallium(III) dimers.

Organic Letters published new progress about Diastereoselective synthesis. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Shengzheng; Fang, Kun; Dong, Guoqiang; Chen, Shuqiang; Liu, Na; Miao, Zhenyuan; Yao, Jianzhong; Li, Jian; Zhang, Wannian; Sheng, Chunquan published the artcile< Scaffold diversity inspired by the natural product evodiamine: discovery of highly potent and multitargeting antitumor agents>, Recommanded Product: Ethyl 3-amino-1H-pyrrole-2-carboxylate, the main research area is evodiamine scaffold antitumor neoplasm.

A critical question in natural product-based drug discovery is how to translate the product into drug-like mols. with optimal pharmacol. properties. The generation of natural product-inspired scaffold diversity is an effective but challenging strategy to investigate the broader chem. space and identify promising drug leads. Extending the efforts to the natural product evodiamine, a diverse library containing 11 evodiamine-inspired novel scaffolds and their derivatives were designed and synthesized. Most of them showed good to excellent antitumor activity against various human cancer cell lines. In particular, 3-chloro-10-hydroxyl thio-evodiamine I showed excellent in vitro and in vivo antitumor efficacy with good tolerability and low toxicity. Antitumor mechanism and target profiling studies indicate that compound I is the first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor. Overall, this study provided an effective strategy for natural product-based drug discovery.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Recommanded Product: Ethyl 3-amino-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Villani, Frank J.; Wefer, Elizabeth A.; Mann, Thomas A.; Mayer, Joseph; Peer, Lydia; Levy, Alfred S. published the artcile< Derivatives of 10, 11-dihydro-5H-benzo(a,d)cycloheptane and related compounds. VII. Improved syntheses of 11-H-benzo(5,6)cyclohepta(1,2-c)pyridin-11-one>, SDS of cas: 33402-75-4, the main research area is benzocycloheptapyridine; nicotinamide styryl thienyl; nicotinate styryl benzocycloheptapyridine.

An improved synthesis of the title compound (I) was described. The base-catalyzed condensation of 4-methylnicotinonitrile with PhCHO resulted in the isolation of trans-4-styrylnicotinamide (II, R = NH2) in high yield. Hydrolysis to II (R = OH) and heating with polyphosphoric acid gave I in good yields. Even higher yields of I were obtained in the presence of catalytic quantities of selenium. Also described are two other syntheses of the title compound and the preparation of a series of compounds related to II.

Journal of Heterocyclic Chemistry published new progress about Condensation reaction. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, SDS of cas: 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics