Tag: M.W=150-200

Vodicka, Petr; Streinz, Ludvik; Koutek, Bohumir; Budesinsky, Milos; Ondracek, Jan; Cisarova, Ivana published the artcile< (S)-2-chloro-2-fluoroethanoyl isocyanate, a chiral derivative of trichloroacetyl isocyanate>, Reference of 617-55-0, the main research area is carbamoylation chloro fluoroacetyl isocyanate preparation chiral alc; chiral secondary alc carbamoylation chloro fluoroacetyl isocyanate preparation; NMR conformation chiral secondary alc carbamoylation chlorofluoroacetyl carbamate; configuration NMR chiral secondary alc carbamoylation chloro fluoroacetyl carbamate; shift reagent chiral secondary alc carbamoylation chlorofluoroacetyl carbamate preparation.

Carbamate diastereomers were prepared from easily accessible (-)-(2S)-2-chloro-2-fluoroacetyl isocyanate (I) and various secondary chiral alcs. I, a chiral analog of trichloroacetyl isocyanate, undergoes the reaction with alcs. very fast, thus blocking the hydroxyl group for the purposes of NMR investigation. Moreover, the correlation of stereochem. of products with their 1H NMR spectra revealed that the constitution as well as configuration influences regularly the values of chem. shift difference (Δδ = δ(R) – δ(S)) except for those diastereomers bearing simple alkyl groups in the mol. Spectral as well as crystallog. data manifest the predominant planar conformation of the central part of the mol. Due to the good accessibility and high reactivity in particular, I, might be considered, to some extent, an alternative for TAI giving addnl. information on a compound’s spatial structure. For example, diagnostic NMR peaks were compared for [(1S)-chlorofluoroacetyl]carbamic acid (1R)-3-chloro-1-phenylpropyl ester and [(1R)-Chlorofluoroacetyl]carbamic acid (1R)-3-chloro-1-phenylpropyl ester.

Chirality published new progress about Alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Longqin; Liu, Bin; Hacking, Douglas R. published the artcile< 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation>, COA of Formula: C9H9NO4, the main research area is nitrophenylmethylpropionyl deoxyfluorouridine preparation FUDR prodrug; anticancer FUDR reductive activation nitrophenylmethylpropionyl deoxyfluorouridine.

5′-[2-(2-Nitrophenyl)-2-methylpropionyl]-2′-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2′-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to release quickly the parent drug FUDR in quant. yield upon mild chem. reduction

Bioorganic & Medicinal Chemistry Letters published new progress about Prodrugs. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niu, Teng-fei; Li, Liang; Ni, Bang-qing; Bu, Mei-jie; Cai, Chun; Jiang, Hui-liang published the artcile< Visible-Light-Induced Meerwein Cascade Reactions for the Preparation of α-Aryl Esters>, Application In Synthesis of 30095-98-8, the main research area is alpha aryl ester preparation visible light induced Meerwein cascade; oxindole preparation cascade reaction mol oxygen oxidant.

A practical strategy has been developed for preparation of α-aryl ester derivatives by using a visible-light-induced Meerwein cascade reaction. This method uses mol. oxygen as an oxidant at room temperature without the need of hazardous reagents or harsh reaction conditions and provides a straightforward approach to pharmaceutically and synthetically useful α-aryl esters in moderate to good yields from simple and readily available starting materials. Oxindoles were also prepared by this protocol.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shang, Rui; Huang, Zheng; Chu, Ling; Fu, Yao; Liu, Lei published the artcile< Palladium-Catalyzed Decarboxylative Coupling of Potassium Nitrophenyl Acetates with Aryl Halides>, HPLC of Formula: 30095-98-8, the main research area is palladium catalyzed decarboxylative cross coupling diaryl methane preparation; potassium nitrophenylacetate aryl halide reactant palladium catalyzed decarboxylative coupling.

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes, e.g. 1-nitro-2-(4-vinylbenzyl)benzene, and their derivatives

Organic Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dagar, Neha; Singh, Swati; Raha Roy, Sudipta published the artcile< Synergistic Effect of Cerium in Dual Photoinduced Ligand-to-Metal Charge Transfer and Lewis Acid Catalysis: Diastereoselective Alkylation of Coumarins>, Application In Synthesis of 94-02-0, the main research area is carboxylic acid coumarin photoinduced decarboxylative alkylation cerium; alkylcoumarin diastereoselective preparation; cerium diastereoselective decarboxylative alkylation catalyst.

We report the dual role of cerium to promote the photoinduced ligand-to-metal charge transfer (LMCT) process for the generation of the alkyl radical and subsequent Lewis acid catalysis to construct stereodefined C-C bonds. This paradigm utilized ubiquitous carboxylic acids as alkyl radical surrogates and offers excellent diastereoselectivity for the formation of C-4 alkylated coumarins in good to excellent yield. UV-vis spectroscopy studies in combination with in situ Fourier transform IR spectroscopy are consistent with the proposed mechanism, supporting the participation of the CeIV-carboxylate complex in photoinduced LMCT and its subsequent homolysis to generate the alkyl radial through the exclusion of CO2. Finally, the oxophilicity of cerium enables a two-point complexation with the in situ generated enolate intermediate and facilitates the diastereoselective protonation to form the desired product. Furthermore, this mild and atom-economical catalytic manifolds allow the late-stage modification of pharmaceuticals.

Journal of Organic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dias, Luiz C.; Vieira, Adriano S.; Barreiro, Eliezer J. published the artcile< The total synthesis of calcium atorvastatin>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is calcium atorvastatin preparation.

A practical and convergent asym. route to calcium atorvastatin was reported. The synthesis of calcium atorvastatin was performed using the remote 1,5-anti asym. induction in the boron-mediated aldol reaction of β-alkoxy methylketone with pyrrolic aldehyde as a key step. Calcium atorvastatin was obtained from aldehyde after 6 steps, with a 41% overall yield.

Organic & Biomolecular Chemistry published new progress about Aldol condensation, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Downes, Thomas D.; Jones, S. Paul; Klein, Hanna F.; Wheldon, Mary C.; Atobe, Masakazu; Bond, Paul S.; Firth, James D.; Chan, Ngai S.; Waddelove, Laura; Hubbard, Roderick E.; Blakemore, David C.; De Fusco, Claudia; Roughley, Stephen D.; Vidler, Lewis R.; Whatton, Maria Ann; Woolford, Alison J.-A.; Wrigley, Gail L.; O’Brien, Peter published the artcile< Design and Synthesis of 56 Shape-Diverse 3D Fragments>, SDS of cas: 33402-75-4, the main research area is alkyl piperidine pyrrolidine fragment diastereoselective preparation; 3D fragments; conformational diversity; fragment-based drug discovery; medicinal chemistry; synthesis design.

Fragment screening collections were often predominantly populated with flat, 2D mols. A workflow for the design and synthesis of 56 3D disubstituted pyrrolidine and piperidine fragments that occupy under-represented areas of fragment space (as demonstrated by a principal moments of inertia (PMI) anal.) was described. A key, and unique, underpinning design feature of this fragment collection was that assessment of fragment shape and conformational diversity (by considering conformations up to 1.5 kcal mol-1 above the energy of the global min. energy conformer) was carried out prior to synthesis and was also used to select targets for synthesis. The 3D fragments were designed to contain suitable synthetic handles for future fragment elaboration. Finally, by comparing our 3D fragments with six com. libraries, it was clear that our collection was high three-dimensionality and shape diversity.

Chemistry – A European Journal published new progress about Conformers. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, SDS of cas: 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hayashi, H.; Nakanishi, K.; Brandon, C.; Marmur, J. published the artcile< Structure and synthesis of dihydroxypentyluracil from bacteriophage SP-15 deoxyribonucleic acid>, Name: (S)-Dimethyl 2-hydroxysuccinate, the main research area is bacteriophage dihydroxypentyluracil; ribonucleic acid bacteriophage SP15.

(S)-(+)-5-(4′,5′-Dihydroxypentyl)uracil, a base which replaces thymine in bacteriophage SP-15 DNA was prepared starting from (S)-(-)-malic acid establishing the 4′ configuration as being (S). The optical purity (100%) of a synthetic intermediate PhCH:CH(CH2)2CH(OMTPA)CH2OMTPA [MTPA = (+)-MeOCH(CF3)CO] was checked by NMR.

Journal of the American Chemical Society published new progress about DNA Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Name: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jirousek, Michael R.; Gillig, James R.; Neel, David A.; Rito, Christopher J.; O’Bannon, Douglas; Heath, William F.; McDonald, John H. III; Faul, Margaret M.; Winneroski, Leonard L. published the artcile< Synthesis of bisindolylmaleimide macrocycles>, Quality Control of 617-55-0, the main research area is macrocycle bisindolylmaleimide; indolylmaleimide macrocycle; maleimide bisindolyl macrocyclic derivative.

The synthesis of a novel class of N,N’-macrocyclic bisindolylmaleimides, e.g., I, is reported. The key step involves a remarkably efficient intramol. cyclization reaction. The method was further developed to provide an efficient synthesis of this type of macrocycle through an intermol. alkylation with subsequent intramol. cyclization.

Bioorganic & Medicinal Chemistry Letters published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hao, Bao-Yu; Liu, Jin-Qiang; Zhang, Wei-Han; Chen, Xin-Zhi published the artcile< Chiral pool synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-malic acid>, Reference of 617-55-0, the main research area is methylaminomethylpiperidine chiral pool preparation malic acid.

A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and >98% ee.

Bulletin of the Korean Chemical Society published new progress about Diastereoselective synthesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics