Tag: M.W=150-200

Jin, Tianyun; Shen, Tao; Zhou, Mingxing; Li, Ailing; Feng, Da; Zheng, Bolun; Gong, Jie; Sun, Jiawei; Li, Lingyu; Xiang, Lan published the artcile< Chemical constituents from Portulaca oleracea and their bioactivities>, Formula: C6H10O5, the main research area is Portulaca organic acid antiinflammation.

In the present study, we aimed to intensively study the chem. constituents, especially organic acids from a medicinal plant Portulaca oleracea L., and screen their anti-inflammatory and quinone reductase (QR, a phase II detoxyfication enzyme) inductive activity. A total of 20 compounds were isolated and identified based on spectroscopic methods, as succinic acid (1), mono-Me succinate (2), L-malic acid (3), L-1-Me malate (4), L-4-Me malate (5), L-dimethyl malate (6), L-6-Et citrate (7), L-1-Me citrate (8), L-1,5-dimethyl citrate (9), 4-hydroxy-5-methylfuran-3-carboxylic acid (10), 5-hydroxymethyl-furoic acid (11), stearic acid (12), L-pyroglutamic acid (13), cyclo-(tyrosine-leucine) (14), L-isoleucine (15), (-)-dehydrovomifoliol (16), (-)-epiloliolide (17), 3,4-dihydroxyphenylethanol (18), succinimide (19), and uracil (20). Among them, 14 compounds (2, 4-8, 10, 11, 13-18) were isolated from P. oleracea for the first time. Compound 18 (12.5 μM) exhibited potent anti-inflammatory effect in lipopolysaccharide (LPS)-induced macrophage cells (RAW264.7) by reducing NO production, and it also increased QR activity in Hepa lclc7 cells. Compound 16 (50 μM) showed weak QR inductive activity. None of other compounds showed anti-inflammatory or QR inductive activities.

Journal of Chinese Pharmaceutical Sciences published new progress about Portulaca oleracea. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ashcroft, William R.; Beal, Michael G.; Joule, John A. published the artcile< Synthesis of the pyridine analogs of phthalide>, Electric Literature of 33402-75-4, the main research area is furopyridone; pyridinedicarboxylate lactonization; ester pyridine hydrolysis regiospecific; phthalide pyridine analog.

The 4 isomeric pyridine analogs of phthalide I (X ≠ X1 = N, CH; Z ≠ Z1 = H2, O) were prepared from pyridine-2,3- and -3,4-diacids, utilizing the different reactivity of substituents at pyridine 2- vs. 3-, and 3- vs. 4-positions. E.g., hydrolyzing pyridine diester II (R = R1 = CO2Me) with 1 equivalent 0.44 M aqueous NaOH gave 35% of a 3:1 mixture of II (R = CO2Me, R1 = CO2H; R = CO2H, R1 = CO2Me), resp., which was reduced by LiAlH4 to give 64% II (R = CH2OH, R1 = CO2H)(III). Lactonization of III gave 73% I (X = N, X1 = CH, Z = H2, Z1 = O).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Lactonization. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Electric Literature of 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Youguang; Wu, Xiaoqing; Sun, Min; Feng, Liuhai; Li, Mingdong; Ji, Min published the artcile< Design, synthesis, crystal structure and antitumor activity of a new ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative>, Category: esters-buliding-blocks, the main research area is pyrrolecarboxylate quinazolinylamino morpholinopropoxy methoxy preparation antitumor activity crystal structure.

A new Et 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate derivative I was designed and synthesized as an antitumor agent. The antitumor activity of the new compound was tested against human pancreatic cancer Miacapa2, pancreatic cancer Panc1, prostate cancer DU145 and prostate cancer PC3 cells in vitro. The crystal structure of I was characterized by x-ray crystal anal.

Letters in Drug Design & Discovery published new progress about Antitumor agents. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

O’Mahony, Rosella M.; Broderick, Caoimhe M.; Lynch, Denis; Collins, Stuart G.; Maguire, Anita R. published the artcile< Synthesis and use of a cost-effective, aqueous soluble diazo transfer reagent - m-carboxybenzenesulfonyl azide>, SDS of cas: 94-02-0, the main research area is synthesis use water soluble diazo transfer reagent carboxybenzenesulfonyl azide.

Herein, we report the preparation and use of m-carboxybenzenesulfonyl azide as a diazo transfer reagent. This compound is an inexpensive and potentially scalable alternative to many of the diazo transfer reagents currently available, most of which have hazards associated with their use. Its usefulness and suitability as a diazo transfer reagent was assessed on the basis of cost, safety and its effectiveness in diazo transfer to a variety of different substrates.

Tetrahedron Letters published new progress about Diazo transfer reaction. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dayaker, Gandrath; Krishna, Palakodety Radha published the artcile< Olefin Cross-Metathesis: Studies towards the Total Synthesis of (+)-Bitungolide F>, Formula: C6H10O5, the main research area is bitungolide preparation total synthesis.

S stereoselective synthesis of (5S,6S)-6-[(2S,5S,7R,8E,10E)-5-(benzyloxy)-7-{[(tert-butyl)dimethylsilyl]oxy}-11-phenylundeca-8,10-dien-2-yl]-5-ethyl-5,6-dihydro-2H-pyran-2-one [i.e., 9-O-benzyl-11-O-[(tert-butyl)dimethylsilyl]bitungolide F] is reported. The strategy involves Gilman reaction, olefin cross-metathesis, and Horner-Wadsworth-Emmons olefination as key steps. The synthesis of the target compound was achieved using((2S)-2-(hydroxy)butanedioic acid (L-malic acid) as a simple starting material.

Helvetica Chimica Acta published new progress about Alkenylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhaokuo; Yang, Ziwei; Wu, Yujing; Yuan, Zhen; Du, Jianlong; Li, Lijun published the artcile< Reduced amino acid Schiff base containing ruthenium(III) complexes: Synthesis, characterization, DNA interaction, and in vitro cytotoxicity>, Electric Literature of 2743-40-0, the main research area is amino acid Schiff base ruthenium complex DNA interaction cytotoxicity; DNA; cytotoxicity; ruthenium(III) complexes.

A number of reduced amino Schiff base ligands and corresponding ruthenium(III) complexes were designed and prepared based on the fact that amino acids not only possess multiple coordinate atoms but also improve the solubility of drugs in the body. The interaction of the complexes with calf thymus DNA was analyzed with spectroscopic methods of UV-visible absorption spectra, DNA competitive binding with ethidium bromide, CD spectra, and DNA melting experiments, and DNA viscosity measurements, indicating that the complexes bind to DNA primarily in the grooving mode. With respect to the ligands, the cytotoxicity in vitro of the complexes against Hela, A549, and MCF-7 cells was much enhanced, with most of the IC50 values less than 50μM or even comparable with those of cisplatin.

Journal of Biochemical and Molecular Toxicology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Electric Literature of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ikura, Masahiro; Nakatani, Shingo; Yamamoto, Shingo; Habashita, Hiromu; Sugiura, Tsuneyuki; Takahashi, Kanji; Ogawa, Koji; Ohno, Hiroyuki; Nakai, Hisao; Toda, Masaaki published the artcile< Discovery of a new chemical lead for a matrix metalloproteinase inhibitor>, COA of Formula: C6H10O5, the main research area is benzoyl aminobutyric hydroxamic acid derivative preparation matrix metalloproteinase inhibitor.

A series of N-benzoyl γ-aminobutyric hydroxamic acids were synthesized and evaluated as matrix metalloproteinase inhibitors. First, the authors focused on chem. modification of the N-benzoyl residue. Introduction of electron-rich para-substituents was effective to increase the inhibitory activity. Especially, some of the analogs with relatively more planar N-acyl residues, such as (I) and (II), demonstrated more potent activity. Second, chem. modification of the γ-aminobutyric hydroxamic acid moiety was carried out to optimize the three-dimensional arrangement of the two pharmacophores (hydroxamic acid and N-acyl residues). Among the tested, the γ-aminobutyric hydroxamic acid moiety was found to be the best spacer for connecting the above-mentioned two pharmacophores. Synthesis and structure-activity relationships are discussed.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakamura, Seikou; Kozuka, Mutsuo; Bastow, Kenneth F.; Tokuda, Harukuni; Nishino, Hoyoku; Suzuki, Madoka; Tatsuzaki, Jin; Morris Natschke, Susan L.; Kuo, Sheng-Chu; Lee, Kuo-Hsiung published the artcile< Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters>, Application of C9H9NO4, the main research area is antitumor quinolone acridine derivative preparation SAR.

2-Phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives were synthesized and screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Interestingly, compounds 14, 15, and 17 showed similar inhibitory effects (89-92%, 66-69%, and 24-29% at 1000, 500, and 100 mol ratio to TPA, resp.) against EBV-EA with potencies comparable to those of glycyrrhetic acid, a known natural antitumor-promoter.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kozik, Violetta; Bak, Andrzej; Pentak, Danuta; Hachula, Barbara; Pytlakowska, Katarzyna; Rojkiewicz, Marcin; Jampilek, Josef; Sieron, Karolina; Jazowiecka-Rakus, Joanna; Sochanik, Aleksander published the artcile< Derivatives of graphene oxide as potential drug carriers>, Recommanded Product: Dimethyl 2,2′-azanediyldiacetate hydrochloride, the main research area is graphene oxide potential drug carrier.

Chem. functionalized graphene oxides could be used as novel drug carriers. Covalent alterations of graphene oxides lead to surface changes via formation of chem. bonding while non-covalent ones involve van der Waals forces, hydrogen bonding, and π-π stacking interactions. Covalent modifications appear to be superior as they can yield compounds with desired properties and carriers prepared by other methods are less stable. Synthesis of graphene oxide-iminodiacetic acid and graphene oxide-glycine involves nucleophilic substitution of graphene oxide nanoparticles with iminodiacetic acid or glycine. As the first step, iminodiacetic acid or glycine were transformed into iminodiacetic acid or glycine Me ester hydrochlorides, resp., for C-terminus protection. The obtained product, activated in situ, was then used to form amide bonds between graphene oxide and iminodiacetic acid or glycine.

Journal of Nanoscience and Nanotechnology published new progress about Amide group. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Recommanded Product: Dimethyl 2,2′-azanediyldiacetate hydrochloride.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kazmierczak, Jean C.; Cargnelutti, Roberta; Barcellos, Thiago; Silveira, Claudio C.; Schumacher, Ricardo F. published the artcile< Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodium S-organyl sulfurothioates under basic conditions>, Formula: C11H12O3, the main research area is alpha organylthio ester preparation; preparation alpha organylthio ketone; beta keto ester sodium organyl sulfurothioate CS bond formation; Bunte salts; C–C bond cleavage; α-alkylthio esters; α-alkylthio ketones; β-keto esters.

A selective method to prepare α-organylthio esters RSCH2C(O)OR1 [R = (CH2)3CH3, Bn, 4-MeC6H4CH2, etc.; R1 = Me, Et, cyclohexyl, etc.] and α-organylthio ketones R2C(O)CH2SCH2R3 [R2 = Me, Ph; R3 = Bn, 2-MeC6H4CH2, 2-ClC6H4CH2, 4-ClC6H4CH2, 4-F3CC6H4CH2] by the reaction of β-keto esters with sodium S-benzyl sulfurothioate or sodium S-alkyl sulfurothioate (Bunte salts) under basic conditions in toluene as the solvent at 100°C was developed. When 4 equiv of a base were used, a series of differently substituted α-thio esters were obtained with up to 90% yield. On the other hand, employing 2 equiv of a base, α-thio ketones were achieved after 18 h under air. Furthermore, after a shorter reaction time, the isolation of keto-enol tautomers was possible, revealing them as significant intermediates for the mechanism elucidation.

Beilstein Journal of Organic Chemistry published new progress about C-C bond cleavage. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics