Tag: M.W=150-200

Garcia, Isadora Martini published the artcileMagnetic motion of superparamagnetic iron oxide nanoparticles- loaded dental adhesives: physicochemical/biological properties, and dentin bonding performance studied through the tooth pulpal pressure model, Related Products of esters-buliding-blocks, the publication is Acta Biomaterialia (2021), 337-347, database is CAplus and MEDLINE.

The limited durability of dentin bonding harshly shortens the lifespan of resin composites restorations. The controlled, dynamic movement of materials through non-contacting forces provides exciting opportunities in adhesive dentistry. We, herein, describe comprehensive investigations of a new dental adhesive with superparamagnetic iron oxide nanoparticles (SPIONs) sensitive to magnetic fields for bonding optimization. This contribution outlines a roadmap of (1) designing and tuning of an adhesive formulation containing SPIONs to enhance penetrability into etched dentin guided by magnetic-field; (2) employing a clin. relevant model of simulated hydrostatic pulpal pressure on the microtensile bond to dentin; and (3) investigating a potential antibacterial effect of the formulated adhesives, and their biocompatibility. SPION-concentration-dependency chem. and mech. behavior was shown via the degree of conversion, ultimate tensile strength, and micro shear bond strength to dentin. The effects of SPIONs carried on a dental adhesive on the bonding strength to dentin are studied in depth by combining experiments with in vitro simulated model. The results show that under the guided magnetic field, 0.07 weight% of SPIONs-doped adhesive increased the bond strength that surpasses the reduction caused by hydrostatic pulpal pressure. Using a magnetic guide workflow during the bonding procedures, SPIONs-doped adhesives improved dentin′s adhesion without changing adhesives′ physicochem. properties. This outcome addresses the key challenge of poor resin infiltration of dentin′s conventional total etching during the bonding procedure. The real-time magnetic motion of dental adhesives may open new paths to enhance resin-based restorations′ longevity. In this study, dental adhesives containing superparamagnetic iron oxide nanoparticles (SPIONs) were developed to enhance penetrability into dentin guided by a magnetic field. The adhesives were screened for phys., chem., antibacterial properties, and cytotoxicity. For the first time, simulated pulpal pressure was used concurrently with the magnetic field to simulate a clin. setting. This approach showed that it is feasible to overcome pulpal pressure jeopardization on bond strength when SPIONs and a magnetic field are applied. The magnetic-responsive adhesives had great potential to improve bond strength, opening new paths to enhance resin-based restorations′ longevity without affecting adhesives′ biol. properties. The use of magnetic-responsive particles and magnetically assisted motion is a promising strategy to improve the sealing ability of dental adhesives.

Acta Biomaterialia published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bergeron, Clara published the artcileA low-shrinkage, hydrophobic, degradation-resistant, antimicrobial dental composite using a fluorinated acrylate and an oxirane, Recommanded Product: Ethyl 4-dimethylaminobenzoate, the publication is Journal of Applied Biomaterials & Functional Materials (2022), 1-14, database is CAplus and MEDLINE.

Objective: To develop a low shrinkage, hydrophobic, degradation-resistant, antimicrobial dental composite using a fluorinated acrylate, and a difunctional oxirane. Methods: The effects of a fluorinated acrylate (2-(perfluorooctyl)ethyl acrylate; PFOEA), a difunctional oxirane (EPALLOY 5001; EP5001), and a three-component initiator system (camphorquinone/ethyl 4-dimethylaminobenzoate/4- Isopropyl-4′-methyldiphenyl iodonium Tetrakis (pentafluorophenyl) borate; CQ/EDMAB/Borate) on bisphenol A glycidyl dimethacrylate: triethylene glycol dimethacrylate (BisGMA:TEGDMA) composite surface hardness, degree of monomerto- polymer conversion, hydrophobicity, translucency, mech. properties, polymerization shrinkage and shrinkage stress, degradation, water imbibition, and antimicrobial properties were determined Results: Overall the exptl. composites had comparable mech. properties and lower volumetric polymerization shrinkage and shrinkage stress as compared to BisGMA:TEGDMA controls. Addition of PFOEA increased composite hydrophobicity, but it decreased degree of cure, ultimate transverse strength, and translucency. It also decreased polymerization shrinkage and shrinkage stress. The use of the CQ/EDMAB/Borate initiator system was beneficial for the cure and mech. properties of the 30wt./weight PFOEA group. However, it decreased the hydrophobicity and translucency of those composites. The addition of EP5001, at the low concentration used in this work, did not contribute to reduced polymerization volumetric shrinkage or antimicrobial properties, but it did reduce shrinkage stress. Conclusions: A mech. viable hydrophobic composite system with reduced polymerization shrinkage and shrinkage stress has been developed by adding PFOEA and EP5001. However, the addition of EP5001 did not render the composite antimicrobial due to the low concentration used. Further research is needed to determine the lowest concentration at which EP5001 provides antimicrobial activity. The composites developed here have the potential to improve longevity of traditional BisGMA:TEGDMA composite systems.

Journal of Applied Biomaterials & Functional Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Recommanded Product: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Major, Mate M. published the artcileNew chiral thioether-phosphite ligands and their rhodium-coordination chemistry: steric and electronic properties, dynamic processes and application in catalysis, Computed Properties of 617-52-7, the publication is Journal of Coordination Chemistry (2021), 74(8), 1311-1322, database is CAplus.

Thioether-phosphite ligands (S)-BINOL-PO(CH₂)_nSPh (SP’s, n = 2, 3; BINOL-H₂ = 1,1′-binaphthyl-2,2′-diol, H₈-1,1′-binaphthyl-2,2′-diol) with axially chiral binaphthyl or 5,5′,6,6′,7,7′,8,8′-octahydrobinaphthyl moiety and their [Rh(COD)(SP)]BF₄ complexes have been synthesized to study their coordination chem. and catalytic features and to compare them to those of the structurally analogous phosphine-phosphites (S)-BINOL-PO(CH₂)_nPPh₂ (PP’s). NMR exchange studies on [Rh(COD)(SP)]BF₄ complexes showed selective 1,5-cyclooctadiene dynamics. Firm evidence has been found that this fluxional process involves dissociation of the Rh-sulfur bond. Based on in situ NMR studies, SP ligands can form two types of bis-ligated species at ligand-to-metal ratio higher than 1. Unlike bis-ligated phosphine-phosphite complexes, bis-ligated thioether-phosphite Rh-complexes can efficiently catalyze asym. hydrogenation reactions due to their distinct coordination chem.

Journal of Coordination Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Computed Properties of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Swain, Amanda published the artcileComparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages, Application In Synthesis of 617-52-7, the publication is Nature Metabolism (2020), 2(7), 594-602, database is CAplus and MEDLINE.

Following activation, macrophages undergo extensive metabolic rewiring1,2. Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process3. Itaconate inhibits succinate dehydrogenase4,5, has electrophilic properties6 and is associated with a change in cytokine production4. Here, we compare the metabolic, electrophilic and immunol. profiles of macrophages treated with unmodified itaconate and a panel of commonly used itaconate derivatives to examine its role. Using wild-type and Irg1-/- macrophages, we show that neither di-Me itaconate, 4-octyl itaconate nor 4-monoethyl itaconate are converted to intracellular itaconate, while exogenous itaconic acid readily enters macrophages. We find that only di-Me itaconate and 4-octyl itaconate induce a strong electrophilic stress response, in contrast to itaconate and 4-monoethyl itaconate. This correlates with their immunosuppressive phenotype: di-Me itaconate and 4-octyl itaconate inhibited IκBζ and pro-interleukin (IL)-1β induction, as well as IL-6, IL-10 and interferon-β secretion, in an NRF2-independent manner. In contrast, itaconate treatment suppressed IL-1β secretion but not pro-IL-1β levels and, surprisingly, strongly enhanced lipopolysaccharide-induced interferon-β secretion. Consistently, Irg1-/- macrophages produced lower levels of interferon and reduced transcriptional activation of this pathway. Our work establishes itaconate as an immunoregulatory, rather than strictly immunosuppressive, metabolite and highlights the importance of using unmodified itaconate in future studies.

Nature Metabolism published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H8BClO2, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Alkattan, Rana published the artcileA multi-functional dentine bonding system combining a phosphate monomer with eugenyl methacrylate, Application of Ethyl 4-dimethylaminobenzoate, the publication is Dental Materials, database is CAplus and MEDLINE.

The tooth-resin composite interface is frequently associated with failure because of microbial contamination, hydrolytic and collagenolytic degradation Thus, designing a dentin bonding system (DBS) with an intrinsically antimicrobial polymerisable monomer is of significance especially if it can be used with self-etching primers enabling resistance to degradation of the interface.Exptl. adhesives were developed incorporating eugenyl methacrylate (EgMA) at concentrations of 0,10 or 20 wt%, designated as EgMA0, EgMA10 and EgMA20, resp., for use as a two-step self-etch DBS with the functional monomer bis[2-(methacryloyloxy) ethyl] phosphate (BMEP) in the primer. The curing, thermal and wettability properties of the adhesives were determined, and hybrid layer formation was characterised by confocal laser scanning microscopy, microtensile bond strengths (μTBS) and nanoleakage by back-scattered SEM. In situ zymog. was used to assess MMP inhibitory activity of the BMEP-EgMA DBS.EgMA in the adhesives lowered the polymerization exotherm and resulted in higher Tg, without neg. affecting degree of conversion. Water sorption and solubility were significantly lower with higher concentrations of EgMA in the adhesive. The formation of a distinct hybrid layer was evident from confocal images with the different adhesives, while EgMA20 yielded the highest μTBS post water storage challenges and lowest nanoleakage after 6 mo. The exptl. DBS exhibited minimal to no MMP activity at 3 mo.The hydrophobic nature of EgMA and high cross-link d. exerts considerable benefits in lowering water uptake and polymerization exotherm. The application of EgMA, adhesives in conjunction with BMEP in a multi-functional self-etching DBS can resist MMP activity, hence, enhance longevity of the dentin-resin composite interface.

Dental Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Application of Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wei, Yun published the artcileSynthesis and characterization of rare-earth metallate amido complexes bearing the 2-amidate-functionalized indolyl ligand and their application in the hydroboration of esters with pinacolborane, HPLC of Formula: 103-26-4, the publication is Dalton Transactions (2022), 51(7), 2953-2961, database is CAplus and MEDLINE.

The reactions of 2-amidate-functionalized indolyl proligand 2-(2,6-ⁱPr₂C₆H₃NHC:O)C₈H₅NH (H₂L) with [(Me₃Si)₂N]₃RE(μ-Cl)Li(THF)₃ were studied leading to the synthesis and characterization of a series of novel discrete trinuclear rare-earth metalate amido complexes containing the anion [{η¹:(μ₂-η¹:η¹):η¹-LREN(SiMe₃)₂}₃(μ₃-Cl)]^– and cation Li⁺(THF)₄ (RE = Y(1a), Nd (1b), Sm (1c), Gd (1d), Dy (1e), Er (1f), and Yb (1g)) in good yields by silylamine elimination. All of the complexes were characterized by spectroscopic methods, elemental analyses and single-crystal x-ray diffraction, and complexes 1a and 1c were addnl. characterized by NMR spectroscopy. As proof of principle of their activity, these complexes were used as precatalysts for the hydroboration of esters using HBpin as the hydride source displaying high activity under neat and room temperature conditions. As a result, the ligand, ionic and multinuclear cooperative effects on catalytic activity were observed

Dalton Transactions published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C9H6FNO, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tomasic, Tihomir published the artcileDesign, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors, Application of 3-(Methoxycarbonyl)benzoic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2018), 351(1), n/a, database is CAplus and MEDLINE.

Discovery of novel DNA gyrase B inhibitors remains an attractive field in the search for new antibacterial drugs to overcome the known bacterial resistance mechanisms. In the present study, we designed and synthesized novel ethylurea derivatives of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine, 2-(2-aminothiazol-4-yl)acetic acid, and benzo[1,2-d]thiazole-2,6-diamine and evaluated their Escherichia coli DNA gyrase inhibition. The most potent DNA gyrase inhibitors in the prepared library of compounds were benzo[1,2-d]thiazoles with IC₅₀ values in the low micromolar range. The most promising inhibitors identified were evaluated against selected Gram-pos. and Gram-neg. bacterial strains. Compound I showed a MIC of 50 μM against an E. coli efflux pump-defective strain, which suggests that efflux decreases the on-target concentrations of these compounds

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H13NO2, Application of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cardoso, Ruthinea Faria de Moraes published the artcilePhysicochemical characterization, water sorption and solubility of adhesive systems incorporated with titanium tetrafluoride, and its influence on dentin permeability, Formula: C11H15NO2, the publication is Journal of the Mechanical Behavior of Biomedical Materials (2021), 104453, database is CAplus and MEDLINE.

Titanium tetrafluoride (TiF4) in an aqueous solution can decrease dentin permeability, but some effects of its incorporation into adhesive systems are not yet known. Therefore, the aim of this study was to characterize the physicochem., water sorption (WS) and solubility (SL) properties of two adhesive systems (Clearfil SE Bond/C and Scotchbond Universal/S) incorporated with 0.0% (T0), 2.5% (T2) and 4.0% (T4) titanium tetrafluoride (TiF4), and determine dentin permeability (L) after application of these adhesive systems both immediately afterwards (baseline) and after 6 mo of storage. The physicochem. analyses of the incorporated solutions were performed based on evaluating particle size (PS), polydispersity index (PDI) by dynamic light scattering, and zeta potential (ZP) by electrophoresis. WS and SL tests followed ISO 4049 standards, and used a 7-day water storage period. The L test was performed by analyzing human dentin disks before and after adhesive system application, and after storage. PS and PDI were higher for CT0 and ST4 (p < 0.0001; ANOVA, Tukey). ZP was lower for CT4, ST2 and ST4 (p < 0.0001; ANOVA, Tukey). A 4.0% TiF4 incorporation showed higher WS (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). Higher SL was observed for CT0 and ST4 (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). The L value at baseline was lower for ST4, but was not different from the CT4 groups after storage (p < 0.05; Mann Whitney, Kruskal Wallis, Dunn). It can be concluded that TiF4 affected the colloidal stability of Scotchbond, but did not alter the other properties. The 2.5% TiF4 did not affect the PDI, WS or L of the Clearfil, and can be considered an alternative for reducing hybrid layer degradation

Journal of the Mechanical Behavior of Biomedical Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Formula: C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Alhenaki, Aasem M. published the artcileDentin bond integrity of filled and unfilled resin adhesive enhanced with silica nanoparticles-an SEM, EDX, micro-Raman, FTIR and Micro-tensile bond strength study, Application of Ethyl 4-dimethylaminobenzoate, the publication is Polymers (Basel, Switzerland) (2021), 13(7), 1093, database is CAplus and MEDLINE.

The objective of this study was to synthesize and assess unfilled and filled (silica nanoparticles) dentin adhesive polymer. Methods encompassing SEM (SEM)-namely, energy dispersive X-ray spectroscopy (EDX), micro-tensile bond strength (μTBS) test, Fourier transform IR (FTIR), and micro-Raman spectroscopy-were utilized to investigate Si particles’ shape and incorporation, dentin bond toughness, degree of conversion (DC), and adhesive-dentin interaction. The Si particles were incorporated in the exptl. adhesive (EA) at 0, 5, 10, and 15 weight% to yield Si-EA-0% (neg. control group), Si-EA-5%, Si-EA-10%, and Si-EA-15% groups, resp. Teeth were set to form bonded samples using adhesives in four groups for μTBS testing, with and without aging. Si particles were spherical shaped and resin tags having standard penetrations were detected on SEM micrographs. The EDX anal. confirmed the occurrence of Si in the adhesive groups (maximum in the Si-EA-15% group). Micro-Raman spectroscopy revealed the presence of characteristic peaks at 638, 802, and 1300 cm^-1 for the Si particles. The μTBS test revealed the highest mean values for Si-EA-15% followed by Si-EA-10%. The greatest DC was appreciated for the control group trailed by the Si-EA-5% group. The addition of Si particles of 15 and 10 weight% in dentin adhesive showed improved bond strength. The addition of 15 weight% resulted in a bond strength that was superior to all other groups. The Si-EA-15% group demonstrated acceptable DC, suitable dentin interaction, and resin tag formation.

Polymers (Basel, Switzerland) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Application of Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kikhtyanin, Oleg published the artcileOn the origin of the transesterification reaction route during dimethyl adipate hydrogenolysis, COA of Formula: C8H14O4, the publication is Applied Catalysis, A: General (2020), 117825, database is CAplus.

Esters hydrogenolysis over CuZn catalysts was shown to be accompanied by transesterification lowering the yield of the desired alc. Here we investigate the origin of the transesterification activity by studying Cu, Zn and CuZn based catalysts in transesterification of di-Me adipate (DMA) with hexane-1,6-diol (HDO). The experiments were performed at conditions relevant for hydrogenolysis, i.e. 210°C and 10-70 bar of either N₂ or H₂ atmosphere. Although transterification was found to be catalyzed by acid impurities present in DMA, the main formation of the transesterification products was due to the ZnO phase in the studied catalysts. In contrast, Cu or CuO phase were virtually inactive in transesterification. Moreover, it was shown that the reduced Cu-ZnO catalyst was stable under reaction conditions, whereas its oxide form CuO-ZnO underwent leaching. The obtained catalytic data also evidenced that the transesterification products were important reaction intermediates in the formation of HDO.

Applied Catalysis, A: General published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, COA of Formula: C8H14O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics