Tag: M.W=150-200

Han, Yong-Yue published the artcileProtective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP, Safety of Dimethyl itaconate, the publication is Journal of Cellular Physiology (2021), 236(11), 7734-7744, database is CAplus and MEDLINE.

Fibroblast-myofibroblast differentiation (FMD) is a critical cellular phenotype during the occurrence and deterioration of pulmonary fibrosis (PF). FMD can increase with an elevated level of reactive oxygen species (ROS) on fibroblasts under oxidative stress. Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that regulates the level of intracellular ROS. Nuclear factor erythroid 2-related factor 2 (Nrf2) can protect against FMD in PF. However, the relationship between Nrf2 and TXNIP in FMD remains elusive. Therefore, we established TGF-β1-induced FMD in vitro and bleomycin (BLM)-induced mouse PF model in vivo to explore whether the activation of Nrf2 can inhibit TXNIP-mediated FMD in PF. Di-Me itaconate (DMI) was selected to activate Nrf2. Our results showed that TXNIP was elevated and FMD was aggravated in mice lung tissues after BLM administration compared with the saline group. Inversely, Nrf2 decreased TXNIP expression and alleviated FMD in PF. In vitro, TXNIP overexpression enhanced FMD and increased the level of ROS. In contrast, TXNIP deficiency by small interfering RNA (siRNA) attenuated TGF-β1-induced FMD and reduced ROS. An increase in ROS by H₂O₂ can upregulate TXNIP expression. Moreover, Nrf2 also inhibited TGF-β1-induced FMD and the increase of ROS, with reducing expression of TXNIP, and the inhibitory effect was better than TXNIP siRNA. These results suggest that activation of Nrf2 by DMI can protect against PF via inhibiting TXNIP expression. Our study may provide new therapeutic targets and treatment approaches for PF.

Journal of Cellular Physiology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Il’in, Anton published the artcilePhosphine catalyzed addition of long-chain dialkyl phosphites to electron-deficient alkenes, SDS of cas: 617-52-7, the publication is Synthetic Communications (2020), 50(21), 3287-3297, database is CAplus.

Conjugate addition of the long chain dialkyl phosphites to electron-deficient alkenes under PBu₃ catalysis afforded the corresponding phosphonates in good yields in a short reaction time. Long chain alkyl groups in the phosphites were well tolerated in this transformation. The products of this reaction are of particular interest as components of lubrication oil composition

Synthetic Communications published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Nan published the artcileCobalt-Catalyzed Deprotection of Allyl Carboxylic Esters Induced by Hydrogen Atom Transfer, Category: esters-buliding-blocks, the publication is Organic Letters (2021), 23(21), 8460-8464, database is CAplus and MEDLINE.

A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters RC(O)OCH₂CH=CH₂ (R = cyclohexyl, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) using a Co(II)/TBHP/(Me₂SiH)₂O catalytic system. This facile strategy displays excellent chemoselectivity, functional group tolerance, and high yields. This transformation probably occurs through the hydrogen atom transfer process, and a Co(III)-six-membered cyclic intermediate is recommended.

Organic Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cooksey, John published the artcileThe nucleophilic addition of α-metallated 1,3-dioxanes to planar chiral cationic η³-allylmolybdenum complexes. Synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester, a key component of the Cryptophycins, Application In Synthesis of 5205-11-8, the publication is Organic & Biomolecular Chemistry (2004), 2(12), 1719-1731, database is CAplus and MEDLINE.

Two adjacent stereogenic centers and a pendant alkene were constructed via nucleophilic addition of a 1,3-dioxan-4-ylcopper(I) reagent to a cationic η³-allylmolybdenum complex as part of a synthesis of (2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid Me ester (I), a key component of the Cryptophycins. Oxidative addition of Mo(CO)₄(THF)₂ to allyl benzoates provides an efficient synthesis of η³-allylmolybdenum(dicarbonyl) complexes.

Organic & Biomolecular Chemistry published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Application In Synthesis of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Haifei published the artcileAg(I)/CAAA-Amidphos Complex Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Acrylates for the Formal Synthesis of (+)-Ibophyllidine, HPLC of Formula: 103-26-4, the publication is Synlett (2021), 32(14), 1437-1446, database is CAplus.

In this work, the authors introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asym. 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines, e.g., I, in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N’-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine (II) in eight steps.

Synlett published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C6H3ClIN3, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Suriano, Raffaella published the artcileEnvironmental Profile and Technological Validation of New High-T_gUnsaturated Polyesters from Fully Bio-Based Monomers and Reactive Diluents, Product Details of C7H10O4, the publication is Journal of Polymers and the Environment (2021), 29(4), 1122-1133, database is CAplus.

This study was focused on the synthesis and characterization of a fully bio-based unsaturated polyester resin (UPR) with good thermal properties suitable for the com. production of composite polymers. UPRs based on different ratios of bio-based furan dicarboxylic acid (FDCA), itaconic acid, and diols were synthesized. The unsaturated polymers prepared were evaluated by differential scanning calorimetry, gel permeation chromatog., FTIR and ¹H-NMR spectroscopy. The results showed pos. effects of FDCA on the glass transition temperature (T_g) of these fully bio-based polyesters, especially when FDCA was combined with 1,2-propanediol. Optimal values of T_g were obtained in the range of 30-32°C for UPRs synthesized starting with a higher concentration of FDCA in the monomer feed. The possibility of substituting styrene, which usually acts as a reactive diluent, with a greener and safer alternative during the crosslinking of UPRs, was also explored. Two bio-based reactive diluents were considered: di-Me itaconate (DMI) and butanediol dimethacrylate. After crosslinking, an average T_g of 75°C and a good crosslinking efficiency indicated by a gel content of 90% were achieved for the fully bio-based polyester obtained under milder reaction conditions and dilution with DMI. Life cycle assessment was performed on selected UPRs, and comparison with a reference fossil-based resin in terms of the calculated category indicator results confirmed the lower environmental impact of the newly prepared bio-based polyesters.

Journal of Polymers and the Environment published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C12H15ClO3, Product Details of C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yasui, Kengo published the artcileUse of π-allylpalladium as a nucleophile via an alkyl-allyl exchange reaction with alkylzinc, Category: esters-buliding-blocks, the publication is Tetrahedron Letters (1993), 34(47), 7619-22, database is CAplus.

Allylation of carbonyl compounds (aldehydes, ketones, esters, lactones, acid anhydrides) proceeds smoothly at room temperature by the reaction of a carbonyl compound, an allylic benzoate or allylic Ph ether, diethylzinc, and a catalytic amount of Pd(0)-complex in THF under N₂. E.g., reaction of 1.0 mmol E-PhCH:CHCHO with 1.2 mmol allyl benzoate in THF containing 0.05 mmol Pd(PPh₃)₄ and 2.4 mmol Et₂Zn in hexane gave 97% E-PhCH:CHCH(OH)CH₂CH:CH₂.

Tetrahedron Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C7H11N, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sarki, Naina published the artcileSimple RuCl₃-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol, Synthetic Route of 10287-53-3, the publication is ChemCatChem (2021), 13(7), 1722-1729, database is CAplus.

Methanol is a potential hydrogen source and C₁ synthon, which finds interesting applications in both chem. synthesis and energy technologies. The effective utilization of this simple alc. in organic synthesis is of central importance and attracts scientific interest. Herein, a clean and cost-competitive method with the use of methanol as both C₁ synthon and H₂ source for selective N-methylation of amines by employing relatively cheap RuCl₃.xH₂O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e.g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chems., highlighting synthetic value of this advanced N-methylation reaction. Using this platform, also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H₂-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug mols. (e.g., benzocaine and butamben) as well as key pharmaceutical intermediates. Further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

ChemCatChem published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rahal, Mahmoud published the artcileDesign of keto-coumarin based photoinitiator for free radical photopolymerization: Towards 3D printing and photocomposites applications, HPLC of Formula: 10287-53-3, the publication is European Polymer Journal (2021), 110559, database is CAplus.

In this article, ten organic dyes based on keto-coumarin (KC) derivatives (MeO-Coum1, MeO-Coum10) have been synthesized and characterized as high performance photoinitiators for the Free Radical Photopolymerization (FRP) of acrylates upon visible light exposure using a Light emitting diode (LED) @405 nm. The addition of iodonium salt (Iod), amine [ethyl dimethylaminobenzoate (EDB) or N-phenylglycine (NPG)] and Iod/NPG couple in the photocurable resins have been carried out in order to prove their influences on the improvement on the photoinitiating abilities of keto-coumarins. The different dyes showed a very high ability to initiate the free radical photopolymerization by introduction of these additives, using two or three-component photoinitiating systems based on MeO-Coum/Iod or amine (0.1% or 0.4%/1% weight/weight) or MeO-Coum/Iod/NPG (0.1% or 0.4%/1%/1% weight/weight/w) resp. In fact, these photoinitiators have been tested in different applications. For example: in direct laser write to generate 3D patterns using a laser diode @405 nm, or for the photocomposite synthesis based on glass fibers. To characterize the initiation ability and to explain the reaction mechanisms in the photoinitiation step, several techniques have been used, such as UV-visible spectroscopy and steady state photolysis, fluorescence emission, RT-FTIR and cyclic voltammetry experiments

European Polymer Journal published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, HPLC of Formula: 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Askey, Hannah E. published the artcilePhotocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Journal of the American Chemical Society (2021), 143(39), 15936-15945, database is CAplus and MEDLINE.

A solution to these problems using organophotoredox catalysis, enabling a direct, modular and sustainable preparation of α-(di)substituted γ-arylamines, including challenging electron-neutral and moderately electron-rich aryl groups was reported. A broad range of functionalities were tolerated, and the reactions was run on multigram scale in continuous flow. The method was applied to a concise, protecting-group-free synthesis of the blockbuster drug Fingolimod, as well as a phosphonate mimic of its in-vivo active form (by iterative α-C-H functionalization of ethanolamine). The reaction was sequenced with an intramol. N-arylation to provided a general and modular access to valuable (spirocyclic) 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydronaphthyridines. Mechanistic and kinetic studies supportes an irreversible hydrogen atom transfer activation of the alkylamine by the azidyl radical and some contribution from a radical chain. The reaction was photon-limited and exhibits a zero-order dependence on amine, azide, and photocatalyst, with a first-order dependence on styrene.

Journal of the American Chemical Society published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics