Tag: M.W=150-200

Gevorgyan, Ashot published the artcileFormal C-H Carboxylation of Unactivated Arenes, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Chemistry – A European Journal (2020), 26(27), 6064-6069, database is CAplus and MEDLINE.

A formal C-H carboxylation of unactivated arenes e.g., I using CO₂ in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of unactivated arenes e.g., I (1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-sym. substituted benzenes, fluorinated benzenes and different heterocycles). The developed methodol. was applied to the late-stage C-H carboxylation of com. drugs and ligands.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wilke, Olaf published the artcileVolatile organic compounds from building products-Results from six round robin tests with emission test chambers conducted between 2008 and 2018, Name: Dimethyl adipate, the publication is Indoor Air (2021), 31(6), 2049-2057, database is CAplus and MEDLINE.

Emission testing of volatile organic compounds (VOC) from materials and products is commonly based on emission test chamber measurements. To ensure the comparability of results from different testing laboratories, their measurement performance must be verified. For this purpose, Bundesanstalt fuer Materialforschung und -pruefung (BAM) organizes an international proficiency test (round robin test, RRT) every two years using well-characterized test materials (one sealant, one furniture board, and four times a lacquer) with defined VOC emissions. The materials fulfilled the requirements of homogeneity, reproducibility, and stability. Altogether, 36 VOCs were included of which 33 gave test chamber air concentrations between 13 and 83μg/m³. This is the typical concentration range to be expected and to be quantified when performing chamber tests. Three compounds had higher concentrations between 326 and 1105μg/m³. In this paper, the relative standard deviations (RSD) of BAM round robin tests since 2008 are compared and the improvement of the comparability of the emission chamber testing is shown by the decrease of the mean RSD down to 28% in 2018. In contrast, the first large European interlaboratory comparison in 1999 showed a mean RSD of 51%.

Indoor Air published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C11H10O, Name: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Yunqi published the artcileModification and biological evaluation of a series of 1,5-diaryl-1,2,4-triazole compounds as novel agents against pancreatic cancer metastasis through targeting myoferlin, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(10), 4949-4966, database is CAplus and MEDLINE.

Pancreatic cancer is one of the most common cancers with an extremely low survival rate. Metastasis, as one of the key reasons of cancer-related death, is found in more than 50% pancreatic cancer patients at diagnosis. Novel therapeutic targets and drugs blocking cancer metastasis are urgently needed. Herein, we report a series of 1,5-diaryl-1,2,4-triazole derivatives as potent antimetastatic agents. Lead compound 3-(3-ethyl-5-(5-methoxy-2-pyrimidinyl)-1H-1,2,4-triazolyl)-N-(4-phenylbutyl)benzamide (6y) displayed effective antimetastatic activities in pancreatic cancer in vitro and in vivo. Concomitant studies indicated that 6y probably binds with myoferlin (MYOF), a novel potential antitumor metastasis target, which regulates vesicle trafficking and metastasis-related proteins. Subsequent biophys. and biochem. methods verified that 6y bound to MYOF. Mechanism studies revealed that 6y inhibited pancreatic cancer metastasis through reversing the epithelial mesenchymal transition, inhibiting the secretions of matrix metalloproteinase and blocking the receptor tyrosine kinases. Our findings suggest that targeting MYOF with 6y may be a promising therapeutic strategy to prevent pancreatic cancer metastasis.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Xiang-Gui published the artcileCobalt-catalyzed Divergent Markovnikov and Anti-Markovnikov Hydroamination, Synthetic Route of 103-26-4, the publication is Organic Letters (2022), 24(1), 22-26, database is CAplus and MEDLINE.

Catalytic hydroamination of the readily available alkenes is among the most straightforward means to construct diverse alkyl amines. To this end, the facile access to both regioselectivity, i.e., Markovnikov or anti-Markovnikov hydroamination, with min. reaction-parameter alternation, remains challenging. Herein, authors report a cobalt-catalyzed highly selective and divergent Markovnikov and anti-Markovnikov hydroamination of alkenes, in which the switch of regioselectivity is achieved simply by the variation of the addition sequence of 9-BBN.

Organic Letters published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C12H9N3O4, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Choudhary, A. published the artcileCorrelation analysis of reactivity in the oxidation of substituted benzaldehydes by quinolinium chlorochro mate: a kinetic approach, SDS of cas: 1877-71-0, the publication is International Journal of Chemistry (Mumbai, India) (2016), 5(2), 189-200, database is CAplus.

Oxidation of thirty six mo nosubsti tuted benzaldehydes by quinolinium chlorochromate (QCC) in dimethylsulfoxide (DMSO), leads to the formation of corresponding benzoic acids. The reaction is of first order with respect to QCC. A Michaelis-Menten type kinetics was observed with respect to the reactants. The reaction is promoted by hydrogen ions; the hydrogen ion dependence has the form k_obs = a + b[H⁺]. The oxidation of benzaldehyde (PhCDO) exhibited a substantial primary kinetic isotope effect. The reaction was studied in nineteen different organic solvents and the efiect of solvent was analyzed using Taft’s and Swain’s main-parametric equations. The rates of the oxidation of para and meta substituted benzaldehydes showed excellent correlation in terms of Charton’s triparametric LDR equation, whereas the oxidation of ortho-substi tu ted benzaldehydes were correlated well with tetraperametric LDRS equation. The oxidation of para-substituted benzaldehydes is more susceptible to the delocalized effect than the oxidation of ortho- and meta-substituted compounds, which display a greater dependence on the field effect. The pos. value of h suggests the presence of an electron-deficient reaction center in the rate-determining step. The reaction is subjected to steric acceleration by the ortho-substituents. A suitable mechanism has been proposed.

International Journal of Chemistry (Mumbai, India) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, SDS of cas: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ghazy, Ehab published the artcileSynthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is European Journal of Medicinal Chemistry (2021), 113745, database is CAplus and MEDLINE.

In this study, the previously reported benzhydroxamate-based inhibitors I, II [X = H, chloro, methoxy, etc;R = 4-biphenyl, 3-benzyloxyphenyl, 4-propoxyphenyl, etc.] of Schistosoma mansoni histone deacetylase 8 (smHDAC8) were chem. optimized. Crystallog. anal. provided insights into the inhibition mode of smHDAC8 activity by the highly potent inhibitor I[X = methoxy;R = 4-Dibenzofuranyl]. Structure-based optimization of the novel inhibitors was carried out using the available crystal structures as well as docking studies on smHDAC8. The compounds were evaluated in screens for inhibitory activity against schistosome and human HDACs (hHDAC). The in vitro and docking results were used for detailed structure activity relationships. The synthesized compounds were further investigated for their lethality against the schistosome larval stage using a fluorescence-based assay. The most promising inhibitor I[X = methoxy;R = 4-Dibenzofuranyl] showed significant dose-dependent killing of the schistosome larvae and markedly impaired egg laying of adult worm pairs maintained in culture.

European Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brannigan, Ruairi P. published the artcileSynthesis of mechanically robust renewable poly(ester-amide)s through co-polymerisation of unsaturated polyesters and synthetic polypeptides, Safety of Dimethyl itaconate, the publication is European Polymer Journal (2020), 109417, database is CAplus.

As an alternative to polyester-based materials, synthetic polypeptides have received a great deal of attention as bio-derived polymers for various applications. Polypeptide-based materials offer numerous advantages over traditional polyesters such as efficient and complete bio- and ecol. absorption, however, poor mech. robustness and low processability has prevented the com. application of polypeptides. Conversely, copolymers of polyesters and polypeptides have the potential to combine the mech. versatility of aliphatic polyesters while retaining the enhanced bio-absorption of polypeptides. Itaconic acid-based polyesters were crosslinked with modified telechelic poly(L-aspartic acid β-benzyl ester) and the amino acid-derived 2-vinyl-4,4-dimethylazlactone in order to assess their effect on their bulk materials properties. It was found that through variance of the polymer composition that the mech. properties and the hydrolytic degradation of the materials could be modulated. We believe that these crosslinked polymers offer a unique platform for the development of sustainable degradable materials.

European Polymer Journal published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Alves Avelar, Leandro A. published the artcileDesign and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit, Quality Control of 1877-71-0, the publication is Archiv der Pharmazie (Weinheim, Germany) (2017), 350(3-4), n/a, database is CAplus and MEDLINE.

Despite recent declines in mortality, malaria remains an important global health problem. New therapies are needed, including new drugs with novel modes of action compared to existing agents. Among new potential therapeutic targets for malaria, inhibition of parasitic histone deacetylases (HDACs) is a promising approach. Homol. modeling of PfHDAC1, a known target of some anti-plasmodial HDAC inhibitors, revealed a unique threonine residue at the rim of the active site in close proximity to the location of the cap group of vorinostat-type HDAC inhibitors. Aiming to obtain HDAC inhibitors with potent and preferential anti-plasmodial activity, the authors synthesized a mini-library of alkoxyamide-based HDAC inhibitors containing hydrogen bond acceptors in the cap group. Using a 5-step synthetic route, 12 new inhibitors were synthesized and assayed against Plasmodium falciparum asexual blood stage parasites (clones 3D7 and Dd2) and human cells (HepG2). The most active compound 6h (6-[(1-Benzothiophen-2-ylformamido)oxy]-N-hydroxyhexanamide) (Pf3D7 IC₅₀: 0.07 μM; PfDd2 IC₅₀: 0.07 μM) was 25-fold more toxic against the parasite vs. human HepG2 cells. Selected compounds were shown to cause hyperacetylation of P. falciparum histone H4, indicating inhibition of one or more PfHDACs.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lu, Zhichao published the artcileBase-Promoted Radical Azofluoromethylation of Unactivated Alkenes, Safety of 3-Methylbut-2-en-1-yl benzoate, the publication is Organic Letters (2020), 22(11), 4383-4388, database is CAplus and MEDLINE.

The base-induced reaction of aryl diazonium salts with com. available CF₃SO₂Na/CF₂HSO₂Na allows for the generation of the corresponding diazene radicals along with fluoromethyl radicals. The addition of fluoromethyl radicals to alkenes with subsequent diazene trapping provides the azofluoromethylation products in good to excellent yields. This metal-free method under mild reaction conditions has broad functional group compatibility and is applicable in the late-stage modification of various natural products and bioactive mols.

Organic Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Safety of 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Chunmei published the artcileAroma components at various stages of litchi juice processing, Application of 3-Methylbut-2-en-1-yl benzoate, the publication is Journal of the Science of Food and Agriculture (2009), 89(14), 2405-2414, database is CAplus.

BACKGROUND: Considering the importance of flavor on the quality of litchi juice, a study was conducted on how processing and operating stages influence the aroma components of clear litchi juice during processing. RESULTS: The aroma fractions isolated by solid-phase micro-extraction were analyzed by capillary gas chromatog.-mass spectrometry. According to statistical analyses, the amount of total and 7 characteristic aroma compounds (geraniol, citronellol, phenylethyl alc., D-limonene, nonanal, geranial and linalool) increased significantly after enzyme hydrolysis, but decreased significantly during the process of enzyme inactivation, ultra-filtration and sterilization. CONCLUSION: The aromatic fraction of litchi juice decreased greatly during processing. The major losses in aromatic composition of clear litchi juice were related to the ultra-filtration and sterilization processes. With regard to the retention of aroma, an ultra-filtration membrane with a larger pore size is better than a membrane with a smaller pore size, and a high-voltage pulsed elec. field was better than thermal sterilization. Copyright © 2009 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Application of 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics