Tag: M.W=150-200

Badet, Bernard published the artcilePhase-transfer alkylation with sulfonium salts, COA of Formula: C12H14O2, the publication is Synthesis (1980), 926-9, database is CAplus.

Sulfonium salts are effective alkylating agents under phase-transfer conditions. Thus PhSO₂H was treated with K₂CO₃ and Me₂C:CHCH₂S⁺(C₁₂H₂₅)₂ ClO^4- in CH₂Cl₂ at room temperature to give 78% Me₂C:CHCH₂SO₂Ph. BzOH similarly gave 88% BzOCH₂CH:CMe₂. Treatment of KOAc with C₆H₁₃S⁺Ph₂ ClO₄^– gave 80% hexyl acetate.

Synthesis published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, COA of Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yanwei published the artcileCobalt-catalyzed carboxylation of aryl and vinyl chlorides with CO₂, Synthetic Route of 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(92), 14416-14419, database is CAplus and MEDLINE.

The transition-metal-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ is rarely studied, and has been achieved only with a Ni catalyst or combination of palladium and photoredox. In this work, the cobalt-catalyzed carboxylation of aryl and vinyl chlorides and bromides with CO₂ has been developed. These transformations proceed under mild conditions and exhibit a broad substrate scope, affording the corresponding carboxylic acids in good to high yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C23H23ClN2O4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Sheng published the artcileDimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis, Safety of Dimethyl itaconate, the publication is Inflammation (2021), 44(2), 549-557, database is CAplus and MEDLINE.

Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiol. of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative di-Me itaconate on inflammation in sepsis. We established a lipopolysaccharide (LPS)-induced septic mouse model and administered di-Me itaconate to the septic mice. The survival rate, serum level of pro-inflammatory cytokines, and lung pathol. were evaluated. We also administered di-Me itaconate to LPS-treated bone marrow-derived macrophages (BMDMs), and measured the cytokine production and Nrf2 expression. We also evaluated the effects of di-Me itaconate on Nrf2-deficient mice. Administration of di-Me itaconate enhanced survival rate, decreased serum level of TNF-α and IL-6, and ameliorated lung injury in septic mice. Di-Me itaconate also suppressed LPS-induced production of TNF-α, IL-6, and NOS2 in BMDMs. Di-Me itaconate activated Nrf2 and promoted the expression of Nrf2 and its downstream factor HO-1 and NQO-1. The regulatory activities of di-Me itaconate on inflammatory cytokine production, mouse survival rate were abolished in septic Nrf2^-/- mice. Di-Me itaconate suppressed the inflammatory responses of macrophages in sepsis.

Inflammation published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H5NO3S, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Binbin published the artcileWacker-Type Oxidation Using an Iron Catalyst and Ambient Air: Application to Late-Stage Oxidation of Complex Molecules, Product Details of C12H14O2, the publication is Angewandte Chemie, International Edition (2017), 56(41), 12712-12717, database is CAplus and MEDLINE.

A practical and general iron-catalyzed Wacker-type oxidation of olefins to ketones is presented, and it uses ambient air as the sole oxidant. The mild oxidation conditions enable exceptional functional-group tolerance, which has not been demonstrated for any other Wacker-type reaction to date. The inexpensive and nontoxic reagents [iron(II) chloride, polymethylhydrosiloxane, and air] can, therefore, also be employed to oxidize complex natural-product-derived and polyfunctionalized mols.

Angewandte Chemie, International Edition published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Product Details of C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dai, Qianying published the artcileInvestigating volatile compounds’ contributions to the stale odour of green tea, Recommanded Product: Dimethyl adipate, the publication is International Journal of Food Science and Technology (2020), 55(4), 1606-1616, database is CAplus.

Summary : This study aimed to characterize the volatiles that contribute to stale odor of green tea. Volatiles were extracted using headspace solid-phase microextraction (HS-SPME) and analyzed using gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O). Results showed that a total of ninety-six volatiles were identified by GC-MS, in which forty-four volatiles were screened out based on Principal component anal. (PCA) and orthogonal projections to latent structures-discriminant anal. (OPLS-DA), and thirty-nine volatiles had a significant variation at the level of 0.05 by anal. of variance (ANOVA). From GC-O anal., fifty-four aromatic volatiles with strong aroma intensity (aroma intensity above 2) were perceived. Further investigation revealed that fifteen volatiles, including 1-octen-3-ol, benzyl alc., benzaldehyde, safranal, β-cyclocitral, (E,E)-3,5-octadien-2-one, (Z,E)-3,5-octadien-2-one, di-Me adipate, dihydroactinidiolide, β-ionone, α-ionone, geranyl acetone, phenylethyl alc., Me decanoate and α-terpineol were responsible for stale odor, besides the former nine compounds were only found in stored tea.

International Journal of Food Science and Technology published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Recommanded Product: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zeng, Linwei published the artcilePhoto-induced synthesis of β-sulfonyl imides from carboxylic acids, Formula: C9H8O4, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(55), 6792-6795, database is CAplus and MEDLINE.

A photo-induced imidation process of carboxylic acids is described. Numerous carboxylic acids could convert to β-sulfonyl imides in the presence of N-sulfonyl ynamides under visible light irradiation Control experiments and mechanistic studies demonstrate that this imidation process involves a hydroacyloxylation/radical rearrangement cascade. This protocol represents a direct imidation method from carboxylic acids under mild conditions, with broad scope and high atom-economy.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C7H5I2NO3, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rabeschini, Gabriela published the artcileMeaningful Words in Crowd Noise: Searching for Volatiles Relevant to Carpenter Bees among the Diverse Scent Blends of Bee Flowers, Safety of Methyl 3-phenyl-2-propenoate, the publication is Journal of Chemical Ecology (2021), 47(4-5), 444-454, database is CAplus and MEDLINE.

Olfactory cues constitute one of the most important plant-pollinator communication channels. Specific chem. components can be associated with specific pollinator functional groups due to pollinator-mediated selection on flower volatile (FV) emission. Here, we used multivariate analyses of FV data to detect an association between FVs and the worldwide distributed pollinator group of the carpenter bees (Xylocopa spp.). We compiled FVs of 29 plant species: 9 pollinated by carpenter bees, 20 pollinated by other bee pollinator functional groups. We tested whether FV emission differed between these groups. To rule out any phylogenetic bias in our dataset, we tested FV emission for phylogenetic signal. Finally, using field assays, we tested the attractive function of two FVs found to be associated with carpenter bees. We found no significant multivariate difference between the two plant groups FVs. However, seven FVs (five apocarotenoid terpenoids, one long-chain alkane and one benzenoid) were significantly associated with carpenter bee pollination, thus being “predictor” compounds of pollination by this pollinator functional group. From those, β-ionone and (E)-Me cinnamate presented the highest indicator values and had their behavioral function assessed in field assays. Phylogenetic signal for FVs emission was weak, suggesting that their emission could result from pollinator-mediated selection. In field assays, the apocarotenoid β-ionone attracted carpenter bees, but also bees from other functional groups. The benzenoid (E)-Me cinnamate did not attract significant numbers of pollinators. Thus, β-ionone functions as a non-specific bee attractant, while apocarotenoid FVs emerge as consistent indicators of pollination by large food-foraging bees among bee-pollinated flowers.

Journal of Chemical Ecology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Safety of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Weis, Erik published the artcileIr^III-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds, COA of Formula: C9H8O4, the publication is Chemistry – A European Journal (2020), 26(45), 10185-10190, database is CAplus and MEDLINE.

An iridium-catalyzed selective ortho-monoiodination of benzoic acids with two equivalent C-H bonds was presented. A wide range of electron-rich and electron-poor substrates underwent the reaction under mild conditions, with >20:1 mono/di selectivity. Importantly, the C-H iodination occurred selectively ortho to the carboxylic acid moiety in substrates bearing competing coordinating directing groups. The reaction was performed at room temperature and no inert atm. or exclusion of moisture was required. Mechanistic investigations revealed a substrate-dependent reversible C-H activation/protodemetalation step, a substrate-dependent turnover-limiting step and the crucial role of the AgI additive in the deactivation of the iodination product towards further reaction.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C15H14BNO4S, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Weis, Erik published the artcileLate-Stage Amination of Drug-Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium-Catalyzed C-H Activation, Formula: C9H8O4, the publication is Chemistry – A European Journal (2021), 27(72), 18188-18200, database is CAplus and MEDLINE.

The method presented herein enables the amination of a wide array of benzoic acids RC(O)OH (R = 2-fluorophenyl, naphthalen-1-yl, thiophen-2-yl, 2H-1,3-benzodioxol-4-yl, etc.) with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug-like mols. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug-delivery conjugates, e.g., I, PROTACs II, and probes for chem. biol. This rapid access to valuable analogs, combined with operational simplicity and applicability to high-throughput experimentation has the potential to aid and considerably accelerate drug discovery.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C6H5F4NO3S, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ostergaard, N. published the artcileScope and limitations of chiral bis(oxazoline) ligands in the copper-catalysed asymmetric cyclopropanation of trisubstituted alkenes, Product Details of C12H14O2, the publication is Tetrahedron (2001), 57(28), 6083-6088, database is CAplus.

A series of derivatives of 3-methyl-2-buten-1-ol, Me₂C:CHCH₂OR (R = Ac, PhCH₂, 4-O₂NC₆H₄CO, etc.), has been used to test the scope and limitations of the copper-catalyzed asym. cyclopropanation of trisubstituted alkenes by Et diazoacetate in the presence of C₂-sym. bis(oxazoline) ligands. In the best case, a trans/cis ratio of 91:9, with 92% ee for the major isomer, was obtained from the reaction of the p-methoxybenzoate derivative The highest ee was 95%, for the trans isomer of a 80:20 diastereomer mixture (acetate derivative).

Tetrahedron published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Product Details of C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics