Tag: M.W=150-200

Yang, Ji published the artcileA general platinum-catalyzed alkoxycarbonylation of olefins, Computed Properties of 627-93-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(39), 5235-5238, database is CAplus and MEDLINE.

Herein, the first efficient platinum-catalyzed alkoxycarbonylations of olefins including sterically hindered and functionalized ones was reported. This atom-efficient catalytic transformation provided straightforward access to a variety of valuable Me esters RCO₂Me [R = n-octyl, cyclopentyl, CH₂CH₂SiEt₃, etc.] in good to excellent yields and often with high selectivities. In kinetic experiments the activities of Pd- and Pt-based catalysts were compared. Even at low catalyst loading, Pt showed high catalytic activity.

Chemical Communications (Cambridge, United Kingdom) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C26H41N5O7S, Computed Properties of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ruzi, Rehanguli published the artcileUpgrading ketone synthesis direct from carboxylic acids and organohalides, Product Details of C9H8O4, the publication is Nature Communications (2020), 11(1), 3312, database is CAplus and MEDLINE.

A photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of com. available chems., aromatic acids RCO₂H (R = 4-methylphenyl, thiophen-3-yl, naphthalen-2-yl, etc.) and aryl/alkyl bromides R¹Br (R¹ = 6-(trifluoromethyl)pyridin-3-yl, 2-cyanoethyl, quinolin-3-yl, etc.) was reported. This allows for concise synthesis of highly functionalized ketones RC(O)R¹directly, without the preparation of activated carbonyl intermediates or organometallic compounds, and thus complements the conventional Weinreb ketone synthesis. Use of the appropriate photocatalyst, ligand amount and solvents can match the reaction rate required by any simple catalytic cycle. The practicality and synthetic robustness of the reaction are illustrated by the facile synthesis of complex ketones from readily available feedstock chems.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Kai-Chun published the artcileMultiple-Functional Diphosphines: Synthesis, Characterization, and Application to Pd-Catalyzed Alkoxycarbonylation of Alkynes, HPLC of Formula: 103-26-4, the publication is Organometallics (2022), 41(6), 750-760, database is CAplus.

A series of diphosphine ligands (L1–L5) containing bis-phosphino fragments and bis-amido groups as well as intensive electron-withdrawing F atoms were synthesized and fully characterized. The structures of the prepared complex of Pd–L5 demonstrate that as for L5, the incorporated two phosphino fragments participate in the chelation to the Pd center inversely along with two Cl^– ligands to present a typical square-planar configuration, whereas the two amido groups simultaneously develop a hydrogen-bond interaction with Cl^– ligands to facilitate the timely dissociation of Cl^– ligands from the Pd center. It was found that L5 enabled the Pd complex to be more active in the alkoxycarbonylation of alkynes with MeOH for the synthesis of branched/linear α,β-unsaturated carboxylic esters with general yields of 60-89%. In L5, the incorporated diphosphino fragments, diamino groups, and F atoms conferred a catalytic effect to the Pd complex synergetic toward the reaction.

Organometallics published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C17H18N2O6, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Chin-Wen published the artcileThe influence of 1,4-cyclohexanedicarboxylic acid on the thermal and mechanical properties of copolyamides, Application of Dimethyl adipate, the publication is Polymer Bulletin (Heidelberg, Germany) (2020), 77(1), 235-253, database is CAplus.

The present paper describes the novel aliphatic polyamide 6 (PA6) copolyamides by the melt polymerization reaction of our newly synthesized aliphatic diamine monomer: N¹,N⁶-Bis-(2-aminoethyl)adipamide (BAEA). The BAEA/CHDA (1,4-cyclohexanedicarboxylic acid) salt was prepared by pertinent long-chain polyamide with the cycloaliphatic ring and isolated as white solid, utterly characterized for the first time. The chem. structure of BAEA, BAEA/CHDA salt and copolyamides (PA6-BAEA/CHDA) was identified by ¹H NMR and FT-IR spectroscopy. Depending on the chem. compositions, the viscosity and mol. weight of the copolyamides were in the range of 19,447-13,536 g mol^-1 and 2.74-2.2 dL g^-1. With increasing BAEA/CHDA salt molar ratio in the synthesized copolyamides, their melting temperatures (T_m) decreased from 212.7 to 170.4 °C, and the glass transition temperatures (T_g) increased from 60 to 89.4 °C. Besides, the as-synthesized all copolyamides possess nearly similar thermal stability (T_d-50% = 439.59 – 443.38 °C) as neat PA6. Mech. testing data revealed that with an increase in a proportion of BAEA/CHDA salt, Young’s modulus of copolyamides is increased from 698.54 to 1093.89 MPa, while the tensile strength is increased by 8.1%.

Polymer Bulletin (Heidelberg, Germany) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Application of Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ji, Wei-Wei published the artcileHeteroannulation enabled by a bimetallic Rh(III)/Ag(I) relay catalysis: application in the total synthesis of aristolactam BII, Quality Control of 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(41), 5665-5668, database is CAplus and MEDLINE.

A redox-neutral bimetallic Rh(III)/Ag(I) relay catalysis allowed the efficient construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The Rh(III) catalyst was responsible for the C-H monofluoroalkenylation reaction, whereas the Ag(I) salt was an activator for the follow-up cyclization. The methodol. developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gu, Lingwen published the artcileDimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway, Quality Control of 617-52-7, the publication is Immunology & Cell Biology (2020), 98(3), 229-241, database is CAplus and MEDLINE.

Di-Me itaconate (DI) is a membrane-permeable itaconate derivative with anti-inflammatory functions. However, the anti-inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI against fungal keratitis and assessed the role of Nrf2/HO-1 signaling in this process. Eyes of C57BL/6 (B6) mice were treated with 2 mm DI after infection with Aspergillus fumigatus. HCECs were pretreated with 0.25 mm DI and then incubated with A. fumigatus. Clin. scoring, slit-lamp photog., myeloperoxidase determination, flow cytometry and immunostaining were used to assess the disease response and treatment efficacy. PCR, Western blot and ELISA were used to assess the expression of IL-1β, chemokine (C-X-C motif) ligand 1, IL-6, IL-8, Nrf2 and HO-1. In addition, quantification of viable fungi, absorbance assays and fluorimetry were used to measure DI fungistatic activity. We observed that DI-treated eyes showed decreased clin. scores, fungal loads, PMN infiltration and cytokine expression, compared with phosphate-buffered saline-treated infected eyes. Moreover, DI treatment increased Nrf2 and HO-1 expression in corneas and nuclear Nrf2 accumulation in HCECs. Finally, DI treatment reduced the A. fumigatus absorbance and fungal mass. These data indicate that DI protects against fungal keratitis by limiting inflammation via the Nrf2/HO-1 signaling pathway and that DI inhibits the growth of A. fumigatus.

Immunology & Cell Biology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Zhi-Feng published the artcileComparison of the ability of UV-Vis and UPLC-Q-TOF-MS combined with chemometrics to discriminate recycled and virgin polyethylene, Recommanded Product: Ethyl 4-dimethylaminobenzoate, the publication is Journal of Hazardous Materials (2022), 423(Part_B), 127165, database is CAplus and MEDLINE.

A growing attention is attracted to the use of recycled plastics as food contact materials, and its chem. safety research and discrimination approach are indispensable. In current study, UV-visible spectrometry (UV-Vis) and ultra-performance liquid chromatog. quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) were used to provide spectral and mass fingerprinting for polyethylene (PE). Coupling with chemometrics, two methods were developed to discriminate recycled and virgin PE. UV-Vis combined with chemometrics could be a more accessible, simpler and faster approach. 237-331 nm in UV spectrum was regarded as marker region selected by orthogonal partial least-squares discrimination anal. (OPLS-DA) and the accuracy of both calibration and validation set could reach 100% in linear discrimination anal. (LDA) based on this region. Besides, 2314 ions were detected by UPLC-Q-TOF-MS and processed by MS-DIAL. 48 candidate chems. were identified, including ketone, esters, carboxylic acid, alcs. and phenols, amine, nitriles, aldehydes and others. Possible origins of these compounds could be classified as plastic, food, drug, cosmetics and pesticide related. Many of these compounds are highly toxic, especially pesticide related, indicating that recycling in closed loop or sorting by the recycled plastic articles is very necessary if the recycled PE is going to be used as food contact material.

Journal of Hazardous Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Recommanded Product: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Wenlong published the artcileRuthenium-Catalyzed Intramolecular Arene C(sp²)-H Amidation for Synthesis of 3,4-Dihydroquinolin-2(1H)-ones, COA of Formula: C10H10O2, the publication is Organic Letters (2021), 23(9), 3310-3314, database is CAplus and MEDLINE.

Authors report the [Ru(p-cymene)(L-proline)Cl]-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramol. arene C(sp²)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a neg. ρ value of -0.73.

Organic Letters published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C20H28B2O4S2, COA of Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ondono, Raul published the artcileDesign of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1, Application of Dimethyl itaconate, the publication is Computational and Structural Biotechnology Journal (2021), 51-61, database is CAplus and MEDLINE.

Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallog. data makes noncoding RNA regions challenging targets to study in the field of drug discovery. In DM1, toxic transcripts tend to stall in the nuclei forming complex inclusion bodies called foci and sequester many essential alternative splicing factors such as Muscleblind-like 1 (MBNL1). Most DM1 phenotypic features stem from the reduced availability of free MBNL1 and therefore many therapeutic efforts are focused on recovering its normal activity. For that purpose, herein we present pyrido[2,3-d]pyrimidin-7-(8H)-ones, a privileged scaffold showing remarkable biol. activity against many targets involved in human disorders including cancer and viral diseases. Their combination with a flexible linker meets the requirements to stabilize DM1 toxic transcripts, and therefore, enabling the release of MBNL1. Therefore, a set of novel pyrido[2,3-d]pyrimidin-7-(8H)-ones derivatives (1a-e) were obtained using click chem. 1a exerted over 20% MBNL1 recovery on DM1 toxic RNA activity in primary cell biol. studies using patient-derived myoblasts. 1a promising anti DM1 activity may lead to subsequent generations of ligands, highlighting a new affordable treatment against DM1.

Computational and Structural Biotechnology Journal published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Peckh, Kamil published the artcileOxidation of 1,2-cyclohexanediol as a step for adipic acid synthesis, Category: esters-buliding-blocks, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2022), 131-136, database is CAplus.

Adipic acid is the most important of the com. available aliphatic dicarboxylic acids. It is obtained industrially from cyclohexanone and/or cyclohexanol by oxidation with nitric acid(V). One of the byproducts of the process is nitrous oxide, which is difficult to utilize. In this paper we propose an alternative method of adipic acid synthesis. In the first stage, cyclohexene is oxidized with hydrogen peroxide to epoxide, which hydrolyzes to 1,2-cyclohexanediol that in the second stage is then oxidized with oxygen. From an environmental point of view, this two-stage method can offer a significant and attractive reduction of N₂O production compared to the industrial methods. We apply a simple catalytic system composed of transition metal compounds and HNO₃ or organic nitrites, to the second stage of adipic acid synthesis synthesis, namely 1,2-cyclohexenediol oxidation using oxygen.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics