Tag: M.W=150-200

Hedayati Marzbali, Mojtaba published the artcileHydrothermal carbonisation of raw and dewatered paunch waste: Experimental observations, process modelling and techno-economic analysis, SDS of cas: 110-42-9, the main research area is cellulose glucose xylose dewatered paunch waste hydrothermal carbonization.

In this study, dewatered and raw paunch waste, with 15 and 3 wt% total solids resp., generated at abattoirs was hydrothermally carbonized under subcritical water conditions. Higher solids content was found to produce higher hydrochar yield (i.e. 53% for 15 wt% compared to 33.5% for 3 wt%) at similar operating conditions of 10 bar and 240°C for 5 min. The morphol. differences were noted via SEM (SEM) in the hydrochar samples, and the surface area for processing raw paunch waste was found to be 68.1 m2 g-1 compared to 10.8 m2 g-1 in the case of dewatered paunch waste. The light bio-oil was mostly composed of phenolic compounds while the heavy bio-oil mainly contained long-chain fatty acids and their esters. Following the exptl. work, a full-scale ASPEN Plus process model was developed for a typical abattoir generating 27-tonne dry paunch waste per day. Pre-heater and hydrochar dryer contributed to 73% and 57% of the total energy for processing raw and dewatered paunch waste, resp., because of the high moisture content of the feedstock and hydrochar. After the equipment sizing and estimation of capital and operating costs, the discounted cash flow anal. was performed using the Nth-Plant financing assumptions. It was concluded that treating dewatered paunch waste is preferable as it: needed a smaller reactor i.e. lower overall initial investment, was less sensitive to bio-oil price, and improved the net present value over a period of 30 years to .8 MM. Besides the liquid hourly speed velocity, its com. viability is highly sensitive to the internal rate of return and existence of hydrochar dryer.

Energy Conversion and Management published new progress about Ashes (residues). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, SDS of cas: 110-42-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagy, Antal published the artcileAddition of 4-oxoisophorone improves performance of bisexual lure for Autographa gamma (L.) (Lepidoptera: Noctuidae), Application In Synthesis of 140-11-4, the main research area is oxoisophorone phenylacetaldehyde benzyl acetate eugenol Autographa.

In field trapping tests the addition of 4-oxoisophorone (2,6,6-trimethylcyclohex-2-ene-1,4-dione) to the known ternary bisexual lure (consisting of phenylacetaldehyde + benzyl acetate + eugenol) significantly increased catches of the silver Y moth Autographa gamma, an important migratory noctuid pest. Both female and male moths were attracted, supposedly in the natural sex ratio of the local population. Traps baited with the quaternary lure caught 27.9% of the number of moths in traps baited with synthetic sex pheromone (all males), and the two types of lures showed similar seasonal trends when following the quant. changes in moth flight throughout the whole season. This suggests that the improved quaternary bisexual lure could be efficient enough to yield a new tool for detection and monitoring of A. gamma, resulting in more reliable plant protection decisions based on female catches, and can provide data for studies where the catch of females and data on sex ratio are indispensable.

Journal of Applied Entomology published new progress about Autographa gamma. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Application In Synthesis of 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cabanes, A. published the artcileNew methods to remove volatile organic compounds from post-consumer plastic waste, Recommanded Product: Benzyl acetate, the main research area is volatile organic compound plastic waste hot air stripping extraction; Contaminant; Deodorization; NIA; Odor; Polyethylene; Smell.

While the annual European demand for polyolefins is 25 million tonnes, only 3 million tonnes of recycled polyolefins find their place in the market, despite collecting 15 million tonnes of post-consumer polyolefins every year. Brand owners of care products are showing their interest in using post-consumer recycled plastics for their packaging. However, there is a general concern in using these materials, as recycled polymers can contain unwanted substances that may expose the consumer to health risks or make the packaging unattractive. Accordingly, the presence of these contaminants narrows the market opportunity of recycled plastics to applications with low-quality requirements and in which the product is not in direct contact with the consumer. Though mech. recycling is the most widespread solution presents limitations in terms of decontamination, as only superficial substances are removed. Thereby, the volatile organic compounds (VOCs) migrated to the polymer matrix remain inside. Consequently, there is a need to find a solution to purify recycled plastics and increase their market share. This study focuses on removing VOCs from post-consumer recycled HDPE through two innovative methods applied for the first time in this field, steam stripping and polyethylene glycol (PEG) extraction The methodol. implemented to analyze the volatile organic compounds in HDPE was HS-SPME-GC/MS. Both methods showed a decrease above 70% in the VOCs content compared to extrusion-degassing. Moreover, these were compared to hot air stripping, a new technol. developed at an industrial scale for the removal of VOCs. As a result, steam stripping improved efficiency in reducing the overall VOCs compared to hot air stripping. The PEG extraction method lowered the volatile polar compounds further than using hot air stripping. Addnl., none of these technologies modified the HDPE melting flow index.

Science of the Total Environment published new progress about Biodegradability. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Recommanded Product: Benzyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dou, Dengfeng published the artcilePotent norovirus inhibitors based on the acyclic sulfamide scaffold, Formula: C6H14ClNO2, the main research area is preparation norovirus antiviral acyclic sulfamide scaffold.

The development of small mol. therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility These compounds are suitable for further optimization of pharmacol. and ADMET properties.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, Formula: C6H14ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Jian-Feng published the artcileStructural characterization and aquatic toxicity prediction of esters, Safety of Methyl decanoate, the main research area is aquatic toxicity ester compound structure relationship.

Based on the three-dimensional structures of the compounds, the structures of 48 ester compounds were expressed parametrically. Through multiple linear regression and partial least-squares regression, the relationship models between ester compound structures and aquatic toxicity log(1/IGC50) were established. The correlation coefficients (R2) of the models were 0.9974 and 0.9940, and the standard deviations (SD) were 0.0469 and 0.0646, resp. The stability of the models was evaluated by the leave-one-out internal cross-test. The correlation coefficients (RCV2) of the models of interactive tests were 0.9939 and 0.8952, and the standard deviation (SDCV) was 0.0715 and 0.0925, resp. The external samples were used to test the predictive ability of the models, and the correlation coefficients (Rtest2) of the external predictions were 0.9955 and 0.9955, and the standard deviations (SDtest) were 0.0720 and 0.0716, resp. The mol. structure descriptors could successfully represent the structural characteristics of the compounds, and the built models had good fitting effects, strong stability and high prediction accuracy. The present study has a good reference value for the study of the structure-toxicity relationship of toxic compounds in the environment.

Chinese Journal of Structural Chemistry published new progress about Aquatic toxicity. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Safety of Methyl decanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Raoof, Gehan F. published the artcileCytotoxic effect and phytochemical study of petroleum ether extract of Tilia cordata mill, SDS of cas: 110-42-9, the main research area is Tilia petroleum ether extract anticancer cytotoxicity cancer.

Objective: The aim of this research was to investigate the chem. composition of petroleum ether extract of Tilia cordata aerial parts as well as to evaluate its cytotoxic activity. Methods: Gas chromatog. and gas chromatog.-mass spectrometry (GC-MS) were used to analyze the unsaponifiable matter and fatty acid Me esters. Moreover, the cytotoxicity was examined against human hepatoma HepG2 cell line and breast adenocarcinoma MCF cell line. Results: The result showed that thirteen compounds were identified in the fatty acid Me esters fraction representing 93.71% of the total identified peak area. The major compounds were Octadecanoic acid Me ester (36.26%) and eicosanoic acid Me ester (29.42%), whereas nineteen compounds in the unsaponifiable fraction were identified representing 90.56 % of the total beak area. The major compounds were 1-Nonene (30.44%), 1-Hexadecene (24.83%) and phytol (10.40%). Moreover, petroleum ether extract showed a potent cytotoxic effect against human hepatoma HepG2 cell line and a moderate cytotoxic effect on breast adenocarcinoma MCF7 human tumor cell line. Conclusion: So the current research aims to be the first step toward the use of petroleum ether extract of Tilia cordata aerial parts as a potent cytotoxic drug.

Universal Journal of Pharmaceutical Research published new progress about Antitumor agents. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, SDS of cas: 110-42-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Omar, Sara Ibrahim published the artcileRanking the Binding Energies of p53 Mutant Activators and Their ADMET Properties, Application In Synthesis of 72835-26-8, the main research area is p53 activator antitumor binding pharmacokinetics; ADMET properties; MD simulations; P53 activators; docking; p53-R273H.

The guardian of the genome, p53, is the most mutated protein found in all cancer cells. Restoration of wild-type activity to mutant p53 offers promise to eradicate cancer cells using novel pharmacol. agents. Several mols. have already been found to activate mutant p53. While the exact mechanism of action of these compounds has not been fully understood, a transiently open pocket has been identified in some mutants. In our study, we docked twelve known activators to p53 into the open pocket to further understand their mechanism of action and rank the best binders. In addition, we predicted the absorption, distribution, metabolism, excretion and toxicity properties of these compounds to assess their pharmaceutical usefulness. Our studies showed that alkylating ligands do not all bind at the same position, probably due to their varying sizes. In addition, we found that non-alkylating ligands are capable of binding at the same pocket and directly interacting with Cys124. The comparison of the different ligands demonstrates that stictic acid has a great potential as a p53 activator in terms of less adverse effects although it has poorer pharmacokinetic properties.

Chemical Biology & Drug Design published new progress about Antitumor agents. 72835-26-8 belongs to class esters-buliding-blocks, name is (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, and the molecular formula is C8H9NO4, Application In Synthesis of 72835-26-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sim, Sherina published the artcileAmomum tsao-ko-Chinese Black Cardamom: Detailed Oil Composition and Comparison With Two Other Cardamom Species, COA of Formula: C11H22O2, the main research area is Amomum Elettaria essential oil China.

Two Chinese black cardamom oils (Amomum tsao-ko) were analyzed using GC and GC/MS and compared to 2 Indian cardamom oils from the species Amomum subulatum and Elettaria cardamomum, resp. The main constituents of A. tsao-ko oils were eucalyptol, geranial, geraniol, trans-2,3,3A,7A-tetrahydro-1H-indene-4-carbaldehyde, (2E)-decenal, neral, and 4-indanecarbaldehyde. Special attention was given to the 1H-indene-carbaldehyes, which are frequently wrongly assigned in previous literature. A detailed odor evaluation of the oils was also carried out. In addition, composition variations of 28 main constituents of 8 E. cardamomum oils were investigated, taking various factors like origin, production methods, plant material, and drying stage into consideration.

Natural Product Communications published new progress about Amomum subulatum. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, COA of Formula: C11H22O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moles, R. published the artcileWRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells, Related Products of esters-buliding-blocks, the main research area is WRN NSC apoptosis HTLV Tcell leukemia cell; Adult T-cell leukemia/lymphoma (ATLL); Apoptosis; Cycle arrest; Human T-cell leukemia virus type 1 (HTLV-1); WRN helicase.

Background: Human T-cell leukemia virus type 1 (HTLV-1) infection is associated with adult T-cell leukemia/lymphoma (ATLL), a lymphoproliferative malignancy with a dismal prognosis and limited therapeutic options. Recent evidence shows that HTLV-1-transformed cells present defects in both DNA replication and DNA repair, suggesting that these cells might be particularly sensitive to treatment with a small helicase inhibitor. Because the “”Werner syndrome ATP-dependent helicase”” encoded by the WRN gene plays important roles in both cellular proliferation and DNA repair, we hypothesized that inhibition of WRN activity could be used as a new strategy to target ATLL cells. Methods: Our anal. demonstrates an apoptotic effect induced by the WRN helicase inhibitor in HTLV-1-transformed cells in vitro and ATL-derived cell lines. Inhibition of cellular proliferation and induction of apoptosis were demonstrated with cell cycle anal., XTT proliferation assay, clonogenic assay, annexin V staining, and measurement of mitochondrial transmembrane potential. Results: Targeted inhibition of the WRN helicase induced cell cycle arrest and apoptosis in HTLV-1-transformed leukemia cells. Treatment with NSC 19630 (WRN inhibitor) induces S-phase cell cycle arrest, disruption of the mitochondrial membrane potential, and decreased expression of anti-apoptotic factor Bcl-2. These events were associated with activation of caspase-3-dependent apoptosis in ATL cells. We identified some ATL cells, ATL-55T and LMY1, less sensitive to NSC 19630 but sensitive to another WRN inhibitor, NSC 617145. Conclusions: WRN is essential for survival of ATL cells. Our studies suggest that targeting the WRN helicase with small inhibitors is a novel promising strategy to target HTLV-1-transformed ATL cells.

Journal of Hematology & Oncology published new progress about Antitumor agents. 72835-26-8 belongs to class esters-buliding-blocks, name is (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, and the molecular formula is C8H9NO4, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasheed, Hafiz Majid published the artcileChemical profiling and anti-breast cancer potential of hexane fraction of Sphaeranthus indicus flowers, Category: esters-buliding-blocks, the main research area is Sphaeranthus flower extract anticancer breast cancer.

The current study aimed to determine the phytochems. and anti-breast cancer potential of Sphaeranthus indicus. S. indicus flowers were extracted with methanol followed by fractionation using n-hexane. For the chem. composition of n-hexane fraction, qual. phytochem. and GC-MS anal. were performed. The anti-proliferative activity was measured by MTT assay, whereas, cytotoxic and proapoptotic effects in MCF-7 (breast cancer) cells were determined using propidium iodide, 4,6-diamidino-2-phenylindole, dichlorofluorescin diacetate, and JC-1 staining through fluorescent microscopy. The phytochem. anal. indicated presence of phytosterols, oils and resins in the nhexane fraction. GC-MS anal. showed that n-hexane fraction comprises of 11 compounds including Me esters of caprylic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and behanic acid. The tested fraction showed remarkable cytotoxic activity against breast cancer (MCF-7) cells while it was found less toxic towards non-cancerous (BHK-21) cells. Furthermore, morphol. assessment through fluorescent microscopy revealed cytotoxic and apoptotic effects by improved cell membrane permeability, increased reactive oxygen species level, compromised mitochondrial activity and condensation of chromatin network. Conclusion: The n-hexane fraction of S. indicus contains phytosterols, oils and fatty acid Me esters and produced apoptotic effect against breast cancer cells.

Tropical Journal of Pharmaceutical Research published new progress about Antitumor agents. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics