Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, A new synthetic method of this compound is introduced below., SDS of cas: 924-99-2

General procedure: Ethyl 4-(4-chlorophenyl)-2-thioxo-1,2,3,4-tertahydropyrimidine-5-carboxylate 6a (Table 2, entry 1). To a mixture of thiourea 12a (23.0 mg, 0.302 mmol), 4-chlorobenzaldehyde 13a (63.0 mg, 0.448 mmol), and ethyl 3-dimethylaminoacrylate 9 (64.0 mg, 0.447 mmol) in anhydrous DMF (0.3 mL) was added anhydrous aluminum chloride (8.0 mg, 0.0600 mmol) at room temperature, and the reaction mixture was stirred at 110 C for 3 h. To the mixture was added EtOAc (10 mL) and 1 M HCl aqueous solution (5 mL), and the organic layer was separated. The aqueous layer was extracted with EtOAc (10 mL), and the combined organic layers were washed with water (5 mL) and brine (5 mL), dried over anhydrous MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography [n-hexane-EtOAc (4:1 to 2:1)] to give 6a (78.9 mg, 0.266 mmol, 88%) as pale yellow crystals.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Arai, Rie; Cho, Hidetsura; Gokurakuji, Yuki; Kikuchi, Hidetomo; Kubo, Takanori; Nakamura, Yuri; Nishimura, Yoshio; Sunaga, Katsuyoshi; Yuan, Bo; Tetrahedron Letters; (2020);,
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Related Products of 1459-93-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1459-93-4, name is Dimethyl isophthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis of Compound B3: [Show Image] To a solution of compound B2 (60 g, 0.31 mol) in 500 mL of MeOH was added a solution of NaOH (12.4 g, 0.31 mol) in 200 mL of MeOH. The mixture was stirred overnight at room temperature. It was concentrated and the residue was dissolved in 500 mL of water and extracted with Et2O. The aqueous solution was acidified with conc. HCl solution to pH = 2, the formed white precipitate was collected and dried under vacuum to give 46 g of crude compound B3 as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl isophthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Phenex Pharmaceuticals AG; EP2289883; (2011); A1;,
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Application of 1068471-18-0, These common heterocyclic compound, 1068471-18-0, name is Methyl 3-(4-Ethynylphenyl)propanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 3-(4-ethynylphenyl) propanoate (1c) (243 mg, 1.29 mmol) was dissolved in7mL of N,N?- dimethylformamide (DMF). Copper (I) iodide (156 mg, 0.82 mmol),triethylamine (TEA 1.2mL, 8.23mmol), tetrakis (triphenylphosphine) palladium (0)(Pd(PPh3)4 475mg, 0.41mmol), trimethylsilylacetylene (TMSA 0.74 mL, 5.35 mmol),and iodobenzene (329mg, 1.61mmol) were added and the reaction mixture was stirred at80 C under Ar until all the starting material was consumed, as was monitored by TLC.The reaction mixture was filtered through a pad of celite and organic solvent (ethylacetate: n-hexane = 10:1) was added. The organic phase was washed two times withsaturated ammonium chloride, brine and then dried over magnesium sulfate. Thesolvent was evaporated under reduced pressure to yield the product (308 mg, 90%)

Statistics shows that Methyl 3-(4-Ethynylphenyl)propanoate is playing an increasingly important role. we look forward to future research findings about 1068471-18-0.

Reference:
Article; Ebara, Yasuhito; Hayashi, Tenko; Hori, Sakiko; Kaihatsu, Kunihiro; Kato, Nobuo; Ogata, Katsuya; Okazaki, Miku; Sawada, Shinjiro; Takagi, Kenji; Molecules; vol. 25; 4; (2020);,
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Synthetic Route of 15568-85-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15568-85-1, name is 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The mixture of 6-chloropyridin-3-amine (5.0 g, 38.8 mmol) and 5- (methoxymethylene)-2,2-dimethyl-1 ,3-dioxane-4,6-dione (7.2 g, 38.8 mmol) in i-PrOH (60 ml_) was stirred at reflux for 2 h, and the solvent was removed to afford 5-((6- chloropyridin-3-ylamino)methylene)-2,2-dimethyl-1 ,3-dioxane-4,6-dione as a solid in 91 % yield (10.0 g). m/z 283 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Weiguo; ZHANG, Weihan; YANG, Haibin; WO2012/34526; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4891-38-7, name is Methyl Phenylpropiolate, A new synthetic method of this compound is introduced below., name: Methyl Phenylpropiolate

Methyl phenylpropynoate (0.20 mmol), Pd(OAc) 2 (0.02 mmol, 4.48 mg), R, was added to a 15 ml pressure-resistant tube.R-DIPAMP (0.2 mmol, 18.32 mg), 95% EtOH (10 mmol, 595 L) and CH3CN (1.5 mL), stirring at 145 C36 hours.After the reaction was completed, it was cooled to room temperature, and ethyl acetate (10 mL) was added. The organic phase was washed three times with brine, dried over anhydrous Na. The crude product was separated and purified by column chromatography to give trans-phenyl methacrylate as a colorless liquid, 25.2 mg, yield 82%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nantong University; Wang Chengniu; Sun Fei; Yang Jinfei; Wu Xiaolong; Wang Guishuan; Gong Shengnan; (28 pag.)CN109776253; (2019); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89-91-8, name is Methyl 2,2-dimethoxyacetate, A new synthetic method of this compound is introduced below., COA of Formula: C5H10O4

j00477j A mixture of (3 -chloro-4-fluorophenyl)methanamine (2.0 g, 13 mmol) and methyl 2,2- dimethoxyacetate (1.7 g, 13 mmol) was stirred at 140 C for 1 hour in microwave. On completion, the mixture was concentrated in vacuo to give compound B-103 (3.3 g, cmde) as a yellow gum. LCMS (B): tR = 0.711 mm., (ES) mz (M+H) + = 262.2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
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Electric Literature of 35179-98-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35179-98-7, name is Chloromethyl ethyl carbonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 7J (R)-3-[N-(5′-Chloro-2′-fluorobiphenyl-4-ylmethyl)-N’-(1H-tetrazole-5-carbonyl)-hydrazino]-2-hydroxypropionic acid ethoxycarbonyloxymethyl ester To a suspension of lithium (R)-3-(2-(1-allyl-1H-tetrazole-5-carbonyl)-1-((5′-chloro-2′-fluorobiphenyl-4-yl)methyl)hydrazinyl)-2-hydroxypropanoate (250 mg, 526 mumol) in chloromethyl ethyl carbonate (2 mL) was added NaI (158 mg, 1.1 mmol) and 2,6-lutidine (113 mg, 1.1 mmol). The resulting mixture was stirred at 50 C. for 4 hours, cooled to room temperature, then poured into water (10 mL). The resulting solution was extracted with EtOAc (2*10 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography (PE:EtOAc=4:1?3:1?2:1) to yield Compound 1 as a yellow solid (170 mg). LC-MS: 577 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl ethyl carbonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hughes, Adam D.; Fleury, Melissa; US2013/330365; (2013); A1;,
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Some common heterocyclic compound, 185629-32-7, name is Methyl 4-amino-3-fluorobenzoate, molecular formula is C8H8FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 4-amino-3-fluorobenzoate

General procedure: To a solution 15 (490 mg, 1.0 eq, 0.92 mmol) in CH2Cl2 (50 mL) was added HATU (525 mg, 1.5 eq, 1.38 mmol), 4-methylmorpholine (0.30 mL, 3.0 eq, 2.8 mmol) and methyl 3-aminobenzoate hydrochloride (208 mg, 1.2 eq, 1.1 mmol). The reaction mixture was stirred at room temperature overnight. After the solvent was concentrated in vacuo, the residue was purified by chromatography (petroleum ether/acetone = 3/1) to afford compound 16 as white solid (360 mg, 59%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185629-32-7, its application will become more common.

Reference:
Article; Chen, Yue-Ting; Tang, Chun-Lan; Ma, Wei-Ping; Gao, Li-Xin; Wei, Yi; Zhang, Wei; Li, Jing-Ya; Li, Jia; Nan, Fa-Jun; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 399 – 412;,
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1865-29-8, name is Methyl 2-phenylacrylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 2-phenylacrylate

0.01 mmol Ru (COD)2X and 0.01 mmol of the ferrocenyl ligand are dissolved in 12 ml of the appropriate solvent in a 25 ml shaker vessel. After the addition of 1 mmol of the unsaturated ester the solution is transferred under argon into a 100 ml steel autoclave and heated after multiple rinsing with H2 for 10 min. at the appropriate hydrogen pressure to reaction temperature. The mixture is then agitated, filtered, (the optionally added acid esterified with Me3SiCHN2) and the enantiomeric excess determined by HPLC [(Chiracel OJ, n-heptane/isopropanol 95:5; flow 0.6 mL/min, T=20 C.; tR=18.05 (S), 21.13 (R)]. alpha-phenylacrylic acid: Solvent: THF Reaction temperature: 60 C. Pressure: 5000 kPa

The synthetic route of 1865-29-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Degussa-Huls AG; US6348620; (2002); B1;,
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Synthetic Route of 106614-28-2, The chemical industry reduces the impact on the environment during synthesis 106614-28-2, name is Methyl 2,4-difluorobenzoate, I believe this compound will play a more active role in future production and life.

1H-pyrrolo [2,3-b] pyridin-5-ol(1.20 g, 8.95 mmol, 1.03 eq) and methyl 2,4-difluorobenzoate (1.5 g, 8.71 mmol, 1.0 eq) were added to 20 mL of diethylene glycol dimethyl ether, followed by addition of potassium phosphate heptahydrate (3.5 G,14.0 mmol, 1.6 eq) under nitrogen atmosphere at 115 C overnight. TLC point plate analysis, as well as raw materials, most of which produce ortho products. TLC point plate analysis, as well as raw materials, add 0.3g 2,4-difluorobenzoic acid methyl ester and 0.5g potassium phosphate heptahydrate, continue to react overnight. And then TLC point board analysis, the effect is not very good, as well as raw materials. (30 mL × 3), the organic phase was dried with anhydrous sodium sulfate, spin-dried column, PE / EA (v / v) = 3/1 column, white Solid 525mg. Yield 22.2%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,4-difluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
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