Tag: M.W=100-200

Related Products of 34837-84-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34837-84-8, name is Methyl 2-(4-fluorophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 20: 4-Fluorophenylacetic acid 1 (Z = COOCH3, F = 4-F, X = H)10 mL water and 0.8 mL of a 30percent sodium hydroxide solution is added to 0.3 g methyl 4-fluorophenylacetate and the mixture is stirred at 60° C for an hour. Once the conversion is completed, it is acidified with concentrated hydrochloric acid to pH = 1. The product is isolated by filtration as a white solid in a 0.15 g (55percent) amount.1H-NMR (300 MHz, CDCl3): delta (ppm) : 3.63 (s, 2H); 7.02 (t, 2H); 7.24 (t, 2H); 10.1 (bs, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(4-fluorophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.; WO2008/78350; (2008); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 185629-32-7, name is Methyl 4-amino-3-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 4-amino-3-fluorobenzoate

3.101. Compound 95: 4-{[4-(Cyclopropanecarbonyl-amino)-l-methyl-lH-imidazo[4,5- c]pyridin-6-yl]-methyl-amino}-3-difluoromethoxy-5-fluoro-benzamide 3.101.1. Step i): 4-Amino-3-fluoro-5-iodo-benzoic acid methyl ester Iodine (1 eq, 3.76 g) is dissolved in EtOH (80 mL) at room temperature followed by the addition of 4-amino-3-fluoro-benzoic acid methyl ester (1 eq, 2.5 g) and silver sulfate (1 eq, 4.61 g). After lh, the silver salts are filtered off and the filtrate is concentrated under reduced pressure. The residue is dissolved in DCM and washed with sat. Na2S203, passed through a phase separator and concentrated to afford the desired product that is used as such in the next step.

According to the analysis of related databases, 185629-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; MAMMOLITI, Oscar; QUINTON, Evelyne; JOANNESSE, Caroline, Martine, Andree-Marie; DE BLIECK, Ann; BLANC, Javier; (263 pag.)WO2017/12647; (2017); A1;,
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Application of 29006-01-7, The chemical industry reduces the impact on the environment during synthesis 29006-01-7, name is Methyl 4-methoxybutanoate, I believe this compound will play a more active role in future production and life.

Step 1. 4-Methoxybutanal [00207] To a solution of methyl 4-methoxybutanoate (3.43 g, 26 mmol) in DCM (26 mL) was added DIBAL-H (33 mL, 33 mmol, 1 M in toluene) at -78 C. After stirring at -78 C for 50 mins, the reaction was quenched with MeOH (10 mL) and then brine (20 mL). The separated organic layer was dried over Na2S04, concentrated in vacuo to give 4-methoxybutanal (2.25 g, 85%) as colorless liquid, which was used in the next reaction without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-methoxybutanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; GOUTOPOULOS, Andreas; (137 pag.)WO2016/19228; (2016); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29006-01-7, name is Methyl 4-methoxybutanoate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Methyl 4-methoxybutanoate

Description 374-Methoxybutanoic acid (P37)To a solution of methyl 4-methoxybutanoate (555.6 mg) in THF (6 mL), sodium hydroxide (6.31 mL) (2M aqueous solution) was added, the reaction mixture was stirred overnight. Most solvent was removed by rotavap, diluted with water (5 mL), washed with DCM (5 mL). The aqueous layer was acidified with 3 M HC1 (aq.) to pH 2, extracted with EtOAc twice (2x 15 mL). The combined organic layer was dried over Na2504 and filtered. The filtrate was concentrated to afford the titlecompound (491.3 mg) as colorless oil. 111 NMR (400 MHz, DMSO-d6): 12.02 (s, 1H), 3.30 (t, J=6.6 Hz, 2H), 3.21 (s, 3H), 2.23 (t, J= 7.3 Hz, 2H), 1.71 (quin, J= 6.9 Hz, 2H).

According to the analysis of related databases, 29006-01-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
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Related Products of 42122-75-8, These common heterocyclic compound, 42122-75-8, name is Methyl 5-amino-2-chlorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-methyl-5-[(1-methylcyclohexylcarbonylamino)methyl]benzoyl chloride (0.266 g, 0.864 mmol) in 5 mL THF was added to methyl 5-amino-2-chloro-benzoate (0.160 g, 0.864 mmol) and 0.42 mL TEA in 10 mL THF. The mixture was stirred overnight and concentrated. EtOAc was added to the residue and the organic phase was washed with water and 2 M aq. HCl solution and dried with Na2SO4. The crude mixture was purified via MPLC. Yield: 0.21 g (53%). MS [M+H]+=457 (Cl isotope pattern); TLC: Rf=0.44 (silica gel, DCM:EtOH 19:1).

The synthetic route of 42122-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/263556; (2011); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 924-99-2 as follows. Safety of Ethyl 3-(dimethylamino)acrylate

Example 194-Methyl-2- [2-(3-pyridin-2-yl-isoxazol-4-yl)-ethyl] -thiazole-5-carboxylic acid (tetra- hydro-pyran-4-yl)-amidea) 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl esterTo a solution of N-chlorosuccinimide (54.7 g, 409 mmol) in DMF (1 L) was added pyridine-2-carbaldoxime (50 g, 409 mmol) portionwise and the resulting mixture was then stirred for 64 h at room temperature. To this solution was then added ethyl 3-(N5N- dimethylamino)acrylate (58.6 g, 409 mmol) and triethylamine (82.9 mL, 819 mmol) in chloroform (10 mL) and the resulting mixture was then stirred for 14 h at room temperature and poured onto a mixture of ice water and HCl (4 N, 100 mL) and extracted with ethylacetate. The organic extract was then washed with water, saturated aqueous sodium hydrogen carbonate solution, brine, dried with sodium sulfate, filtered and evaporated. Purification by distillation afforded the title product (58.9 g, 66%) which was obtained as a light brown liquid. Bp 125-127C at 0.4 mbar. MS: m/e = 219.2 [M+H]+.

According to the analysis of related databases, 924-99-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; JAKOB-ROETNE, Roland; LUCAS, Matthew, C.; THOMAS, Andrew; WO2010/127974; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 37746-78-4, name is (E)-Ethyl 4-bromobut-2-enoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37746-78-4, name: (E)-Ethyl 4-bromobut-2-enoate

General procedure: To a 50-mL round-bottomed flask were added ethyl pyrazole-5-carboxylate 1 (1.00 mmol), ethyl 4-bromobut-2-enoate 2 (2.00 mmol), potassium carbonate (0.28 g, 2.05 mmol) and C2H5OH (20 mL). The mixture was refluxed for 8 h. And then they were poured into water (100 mL) and extracted with CH2Cl2 (3 × 30 mL). The combined extracts were washed with water, dried over anhydrous Na2SO4 and filtered, and the solvent was removed by rotary evaporation. The crude products were purified by column chromatography to afford compounds 3a-f in 42-60%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Ethyl 4-bromobut-2-enoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yan, Peiling; Duan, Guiyun; Ji, Ruixue; Ge, Yanqing; Tetrahedron Letters; vol. 59; 25; (2018); p. 2426 – 2429;,
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Adding a certain compound to certain chemical reactions, such as: 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 383-62-0, HPLC of Formula: C4H5ClF2O2

100 mg (0.172 mmol) of example 15A are dissolved in 1.5 ml of anhydrous N,N-dimethylformamide, admixed with 121 mg (0.87 mmol) of potassium carbonate and stirred for 30 min. 68.9 mg (0.435 mmol) of ethyl chloro(difluoro)acetate are added and the mixture is heated to 60 C. for 6 h. Then it is filtered and purified by preparative HPLC with a water/acetonitrile gradient. The product fractions are concentrated to dryness under reduced pressure and the residue is dried under reduced pressure. This affords 21 mg (19% of theory) of the desired compound. 1H NMR (400 MHz, DMSO-d6, delta/ppm): delta=9.0 (t, 1H), 7.6 (d, 1H), 7.05 (b, 2H), 7.5 (d, 2H), 7.3 (d, 1H), 7.2 (d, 1H), 7.05 (t, 1H), 6.3 (t, 1H), 4.85 (m, 1H), 4.2 (t, 1H), 3.9 (m, 1H), 3.6 (t, 2H), 2.0 (s, 3H). LC-MS (Method 4): Rt=2.04 min MS (ESIpos): m/z=510 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-chloro-2,2-difluoroacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER SCHERING PHARMA ATIENGESELLSCHAFT; US2010/298293; (2010); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-91-8, name is Methyl 2,2-dimethoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H10O4

12. 55 g (0.094 mol) of methyl 2, 2-dimethoxyacetate and12 g (0.24 mol) of hydrazine hydrate were mixed in a 100 mL round-bottomed flask and heated to 100 C and maintained at 100 C for 5 h, after which the temperature was slowly heated to 160 C over 4 h (15 C) The excess hydrazine hydrate and water produced during the reaction were removed and maintained at 160 C for 10 h. The column was cooled (the volume ratio of the eluent used was ethyl acetate: petroleum ether = 4: 1) 4-amino-3,5-dimethoxymethyl-4-yl-1,2,4-triazole (11) 9.88 was obtained in 45% yield. Melting point: 71-74 (:. The reaction of dimethoxy acetic acid methyl ester and hydrazine hydrate molar ratio is 1: 2.5;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89-91-8.

Reference:
Patent; Tianjin Normal University; Tian, Li; Shang, Zhou; Yong, Li Xin; (13 pag.)CN103980256; (2016); B;,
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Reference of 6065-82-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6065-82-3 as follows.

Under nitrogen protection, Diethoxyacetate (500 mg, 2.84 mmol) was dissolved in freshly prepared tetrahydrofuranin. When the temperature dropped to -78 C, benzylmagnesium chloride (642 mg, 4.26 mmol) was added. -78 C for 3 hours. When the reaction was warmed to room temperature, the reaction was quenched with a protected aqueous ammonium chloride solution. The organic solvent was removed by rotary evaporation and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution, the organic phase was dried over anhydrous sodium sulfate, filtered,200-300 mesh silica gel column chromatography, 380mg colorless oil, yield 60%.

According to the analysis of related databases, 6065-82-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shandong University; Li Minyong; Du Lvpei; Jiang Tianyu; (37 pag.)CN105968114; (2016); A;,
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