Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 66315-16-0, name is Methyl 3-amino-4-(methylamino)benzoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H12N2O2

Synthesis of (3R)-1-[1-methyl-2-(5-phenyl-1H-pyrazol-1-yl)-1H-1,3- benzodiazole-5-carbonyl]piperidin-3-amine hydrochloride, I-59, EOAI3426751 (EV- AO7894-001) Methyl 1-methyl-2-oxo-2,3-dihydro- 1H-1,3-benzodiazole-5-carboxylate (EV- AP4075-001)- Step 1 To a solution of methyl 3-amino-4-(methylamino)benzoate (EV-AN2487-001, synthesised as described in Scheme 1, 100 mg, 0.54 mmol) in anhydrous DCM (3 ml) was added 1,1′-carbonyldiimidazole (110 mg, 0.68 mmol). The mixture was stirred at room temperature for 16h. The precipitate was collected by vacuum filtration and washed with ice-cold diethyl ether (2×2 ml). The solid was air dried for 2h to obtain 82 mg (73%) of methyl 1-methyl-2-oxo-2,3- dihydro- 1H-1,3-benzodiazole-5-carboxylate (EV-AP4075-001) as a white powder. LCMS (method D): retention time 0.94min, M/z = 207 (M + 1).

According to the analysis of related databases, 66315-16-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PADLOCK THERAPEUTICS, INC.; DEVRAJ, Rajesh; KUMARAVEL, Gnanasambandam; ATTON, Holly; BEAUMONT, Edward; GADOULEAU, Elise; GLEAVE, Laura; KERRY, Philip Stephen; LECCI, Cristina; MENICONI, Mirco; MONCK, Nat; PALFREY, Jordan; PAPADOPOULOS, Kostas; TYE, Heather; WOODS, Philip A.; (158 pag.)WO2017/147102; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 2216-92-4,Some common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared according to Example 2 steps 2 and 3 except with ethyl N- phenylglycinate instead of ethyl [N-PHENYLALANINATE.] Title compound was obtained as a yellow solid (74%). 1H NMR [(CDCI3)] [5] 7.46 (d, 2H), 6.64 (d, 2H), 4.12 (q, 2H), 4.01 (s, 2H), 3.30 (s, 3H), 1.17 (t, 3H). [ANAL. CALC.] for [C14H15NO3F6] : C, 46.80 ; H, 4.21 ; N, 3.90. Found: C, 47.78 ; H, 4.06 ; N, 3.86. HRMS [(MH+)] [CALC.] : 360.1047. Found: 360.1034.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Phenylglycine Ethyl Ester, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate and 440 mmol of propargyl bromide were added to 210 mL of anhydrous acetonitrile in an ice water bath.Stir the reaction for 8 hours.The product is washed with water,Extract with ethyl acetate and spin dry under reduced pressure.Obtaining a yellow-brown solid product,That is, compound a-1

The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Normal University; Yao Liangliang; Liu Baohua; Yue Hao; Han Mengyao; Hu Yimin; (15 pag.)CN110256253; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 108928-00-3, name is Ethyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108928-00-3, SDS of cas: 108928-00-3

a) step1 : rac-tert-butyl4-(4-(ethoxycarbonyl)-3-fluorophenyl)-2-methylpiperazine-1-carboxylate A solution of ethyl2,4-difluorobenzoate (200 mg, 1.07 mmol) and 2-methylpiperazine (538 mg,5.37 mmol) in DMA (2 ml) was heated to 100C in a microwave reactor for 15 minutes.Ethyl acetate and water was added. The layers were separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were dried over sodium sulfate,filtered and evaporated. A solution of this crude material and triethylamine (131 mg, 180 f..Ll, 1.29mmol) in dichloromethane (2.00 ml) was cooled to 0C. Di-tert-butyl dicarbonate (352 mg, 1.61mmol) in dichloromethane (0.5 ml) was added dropwise. The mixture was stirred at roomtemperature overnight. Water was added. The layers were separated. The aqueous layer was extracted twice with dichloromethane. The combined organic layers were dried oversodiumsulfate, filtered and evaporated. The crude product was purified with flash columnchromatography on silica gel (Eluent: Heptane/ethyl acetate 0 to 20) to provide 155 mg (34 %)of the title compound as a light yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2,4-difluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; DAKKA, Amal; GREEN, Luke; KARP, Gary; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PINARD, Emmanuel; QI, Hongyan; RATNI, Hasane; RISHER, Nicole; WEETALL, Marla; WOLL, Matthew; WO2014/209841; (2014); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57486-67-6, name is Methyl 2-(2-fluorophenyl)acetate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-(2-fluorophenyl)acetate

Example 15: Synthesis of 3-(2-Chloro-phenyl)-6-(2-fluoro-benzyi)-lH-pyrazolo[3,4-b]- pyrazine; Step 1. Preparation of [6-Chloro-5-( 2-chloro-benzoyl)-pyrazin-2-yl]-( 2-fluoro-phenyl)- acetic add methyl ester; To a solution of sodium hydride (0.175 g, 7 mmol) and (2-Chloro-phenyl)-(3,5-dichloro- pyrazin-2-yl)-methanone (0.86 g, 2.99 mmol) in 5 mL DMF was added (2-Fluoro-phenyl)- acetic acid methyl ester (0.503 g, 2.99 mmol). The reaction mixture was stirred for one hour at RT, and then was quenched by addition of water and aqueous HCl. The aqueous mixture was extracted with methylene chloride, and the combined organic phases were dried over MgSO4, filtered, and evaporated under reduced pressure to give 1.19 g of crude [6-Chloro-5-(2-chloro-benzoyl)-pyrazin-2-yl]-(2-fluoro-phenyl)-acetic acid methyl ester. Mass Spec. M+H = 419.

The synthetic route of 57486-67-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/23105; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35598-05-1 as follows. Safety of Methyl 4-methoxy-2-methylbenzoate

To a solution of methyl 4-methoxy-2-methylbenzoate (11.4 g, 63.3 mmol) in THF (65 mL) at 0 C, LiAlH4 (1M in ether, 76.0 mL, 75.9 mmol) was added via addition funnel over 50 min. The ice water bath was removed, and the reaction was allowed to stir at room temperature for 30 min. Upon completion, the reaction was cooled to 0 C and sodium sulfate decahydrate was added portionwise until the bubbling ceased. The reaction was then diluted with ether and filtered. The filtrate was concentrated under reduced pressure to give (4-methoxy-2- methylphenyl)methanol (8.2 g) as a clear oil. ¾ NMR (300MHz, CDC13): delta 7.23 (d, 1H), 6.72 (m, 2H), 4.63 (d, 2H), 3.79 (s, 3H), 2.36 (s, 3H), 1.42 (t, 1H).

According to the analysis of related databases, 35598-05-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.; WO2011/156518; (2011); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14064-10-9, name is Diethyl 2-chloromalonate, A new synthetic method of this compound is introduced below., COA of Formula: C7H11ClO4

EXAMPLE 1 195 g of diethyl chloromalonate were dissolved in 500 ml of acetonitrile, and 320 g of the addition product of 3 mol of hydrogen fluoride and 1 mol of triethylamine were added in the absence of moisture. 100 g of triethylamine were then added and the mixture was stirred at an internal temperature of 80° C. until conversion was complete. The solvent was then distilled off and the residue was poured into water. The diethyl fluoromalonate of formula (Ia) obtained was extracted with methylene chloride and the extract was washed with saturated aqueous sodium hydrogencarbonate solution, dried over magnesium sulphate and fractionated under high vacuum. The yield was 147 g=83percent of theory.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bayer Aktiengesellschaft; US5391811; (1995); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 76308-28-6, name is Ethyl 2-(trans-4-aminocyclohexyl)acetate, A new synthetic method of this compound is introduced below., Recommanded Product: 76308-28-6

Take 5.0 g (0.032 mol) of the compound ethyl 2- (4-aminocyclohexyl) acetate,Add 50ml of dichloromethane, 8.5g (2eq) of 30% sodium hydroxide solution,Added under stirring N, N- dimethylformamide chloride 6.9g (0.064mol),The reaction was stirred at 30 C for 5h.Point the plate to control, and the reaction is over. Add 50ml of water to the reaction system.Stir for 5 minutes and separate the layers, separate the organic phase, dry and spin dry to obtain 5.2 g of the compound of formula I;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shangyu Jing Xin Pharmaceutical Co., Ltd.; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shanghai Jingxin Bio-pharmaceutical Co., Ltd.; Zhang Min; Zheng Fei; (11 pag.)CN110317182; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 91367-05-4,Some common heterocyclic compound, 91367-05-4, name is Methyl 4-chloro-3-methylbenzoate, molecular formula is C9H9ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 2Methyl 3 -bromomethyl-4-chlorobenzoate Into an appropriate flask methyl 4-chloro-3-methylbenzoate (25.26 g), N- bromosuccinimide (24.85 g) and 20 ml of carbon tetrachloride were placed. The reaction mixture was refluxed for about 6 hours. After cooling to 25 0C, 500 ml dichloromethane and 300 ml of aqueous solution Of K2CO3 (5 %) were added. The separated aqueous layer was extracted again with 200 ml of dichloromethane. The combined organic layers were washed with 300 ml of aqueous solution of K2CO3 (5 %), dried over Na2SO4 and concentrated in vacuum to give 35.66 g of pale yellow crystals. Distillation under reduced pressure allowed to separate 6.72 g of the starting methyl 4-chloro-3-methylbenzoate (b.p. 80-100 0C / 0.44-0.40 mbar) and to obtain 25.53 g of the desired product as pale yellow crystals (b.p.110 0C /0.40 mbar, m.p. 93 0C). Yield: 71 % (distilled product) T.L.C.: Silica gel, eluents: cyclohexane-ethyl acetate 85/15

The synthetic route of 91367-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; WO2006/79857; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426-65-3, name is Ethyl Pentafluoropropionate, A new synthetic method of this compound is introduced below., Computed Properties of C5H5F5O2

Sodium ethoxide (7.49 g, 0.11 mol) was suspended in methyl tert-butyl ether (anhydrous, 200ml) under nitrogen. Ethyl 2,2,3, 3,3-pentafluoropropanoate (14.8 ml, 0.1 mol) was added dropwise with stirring followed by ethyl acetate (10.7 ml, 0.11 mol). Stirring was continued for 45 minutes at ambient temparature, for one hour at 50C and overnight at ambient tempeature. The mixture was cooled to 0C and acidified with HC1 (1M, 80 ml), brine was added (80 ml), the layers were separated, and the aqueous layer was back-extracted with in methyl tert-butyl ether (80 ml). The combined organic layers were dried over Na2S04and concentrated under reduced pressure to yield 14.6 gram (0.062 mol, 62% yield). H-NMR (300 MHz, CDC13): delta 1 1.96 (s), 5.59 (s), 4.11-4.26 (m), 3.70 (m), 1.21-1.29 (m);19F-NMR (282 MHz, CDC13): delta -81.8 (s), -83.3 (s), -122.7 (s), -123.6 (s); MS 189 (M-OCH2CH3)

The synthetic route of 426-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; INTERVET INC.; BERGER, Michael; VEIT, Stephan; NIEDERMANN, Hans, Peter; KAPPESSER, Tobias; STUTZ, Alfred; WO2015/177179; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics