Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4630-82-4, name is Methyl cyclohexanecarboxylate, A new synthetic method of this compound is introduced below., Formula: C8H14O2

Several others esters (see Table 3) were hydrogenated under identical conditions as reported in Table 4 with RuCl2(L-I)2. The reaction conditions were identical to those reported above for methyl benzoate.Table 3: Structure and name of substrates used EPO Table 4: Results obtained using the general conditions described above EPO Conversion: (in %, analysed by GC after silylation) of ester to alcohol after 2h 30min. Reaction conditions: Substrate (20 mmol), H2 gas (50 bars), RuCl2(L-I)2 0.05 mol%, NaOMe 10 mol%, THF (14 mL) at 1000C during 2h 30min.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FIRMENICH SA; WO2006/106483; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 5616-81-9, name is tert-Butyl 2-(methylamino)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H15NO2

Bromoacetyl bromide (3.56 g, 17.6 mmol,1.55 ml, 1.5 equivalent), dry CH2C12 (50 ml) and K3P04 (6.41 g, 30.2 mmol, 2.5 equ.) was mixed in a flask of 250 ml under N2 atmosphere. Sarcosine tert-butyl ester (1.7 g, 11.7 mmol, 1.0 equivalent) was dissolved in dry CH2C12 (20 ml) and was added dropwise to dichloromethane solution of bromoacetyl bromide at 0 C in 30 minutes, then the reaction mixture was stirred for additional 12 hours at room temperature under N2 atmosphere before the aqueous HC1 solution (0.5 M, 30 ml) was added to the reaction mixture. After the addition of RC1 solution, the reaction mixture was stirred for additional 5 minutes, then the two phases were separated using a separatory funnel. The aqueous phase was washed with CH2C12 (1 x 15 ml) and then the unified organic phases were washed with KHCO3 solution (2 x 30 ml, 10 mlm%) and saturated NaC1 solution(1 x 30 ml). The organic phase was dried with MgSO4, then dichioromethane was evaporated at reduced pressure, and the crude product was stored at -20 C until further use. Yield: 2.01 g (65%). ?H NMR [360 MHz, CDCl3] oe 1.6 (9H, s, CR3) 2.8 (3H, s, CR3), 4.01 (2H, s, CH2), 4.4 (2H, s, CR2)

The synthetic route of tert-Butyl 2-(methylamino)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DEBRECENI EGYETEM; BOTAR, Richard; GARDA, Zoltan; FODOR, Tamas; KALMAN, Ferenc Krisztian; NAGY, Viktoria; TIRCSO, Gyula; TOTH, Imre; (44 pag.)WO2017/89847; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 3618-04-0, These common heterocyclic compound, 3618-04-0, name is trans-Ethyl 4-hydroxycyclohexanecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: ethyl 4-(5 -bromopyridin-2-yloxy)cycl ohexanecarboxylateTo a solution of 5-bromo-2-hydroxypyridine (1.0 g, 5.747 mmol) and ethyl 4- hydroxycyclohexanecarboxylate (0.99 g, 5.75 mmol) in THF (50 mL) was added PPh3 (2.4 g,9.15 mmol) and DIAD (1.8 mL, 9.14 mmol). The reaction mixture was stirred at RT for 17 h.The solution was then concentrated and purified by silica gel column chromatography with anISCO system to yield ethyl 4-(5-bromopyridin-2-yloxy)cyclohexanecarboxylate as a colorless oil.

Statistics shows that trans-Ethyl 4-hydroxycyclohexanecarboxylate is playing an increasingly important role. we look forward to future research findings about 3618-04-0.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TING, Pauline, C.; ASLANIAN, Robert; CAO, Jianhua; KIM, David; ZORN, Nicolas; WO2012/24179; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 5335-05-7, A common heterocyclic compound, 5335-05-7, name is Chloromethyl benzoate, molecular formula is C8H7ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Step 2) Iodomethyl benzoate (0277) (0278) Chloromethyl benzoate (10.0 g, 58.8 mmol) was dissolved in acetonitrile (70.0 ml), sodium iodide (17.6 g, 117 mmol) was added thereto, and the resulting mixture was stirred at room temperature for 24 hours. Acetonitrile was distilled off under reduced pressure, and diethyl ether was added. The precipitated solid was filtered off, washed with diethyl ether, and dried under reduced pressure, and then purified by silica gel column chromatography (petroleum ether:ethyl acetate=30:1 to 10:1) to obtain the title compound (14.5 g, 94%). (0279) 1H NMR (CDCl3, 400 MHz): delta 8.06-8.04 (m, 2H), 7.64-7.62 (m, 1H), 7.49-7.44 (m, 2H), 6.17 (s, 2H)

The synthetic route of 5335-05-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ajinomoto Co., Inc.; UENO, Hirokazu; YAMAMOTO, Takashi; MIYAZAWA, Tomoko; SHINKAI, Kenji; ARISAKA, Harumi; TAKANOHASHI, Toshiyuki; (122 pag.)US2016/244451; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

924-99-2, name is Ethyl 3-(dimethylamino)acrylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 924-99-2

Example 3 71.6 g (0.5 mol) of ethyl dimethylaminoacrylate are dissolved in 150 ml of toluene and added dropwise with stirring at 0-3 C. to a solution of 73.7 g (0.5 mol) of dichloroacetyl fluoride. After stirring at 0-3 C. for 3 h, the reaction mixture is warmed to room temperature. After complete removal of the solvent under reduced pressure (10 mbar), 114 g (90% of theory) of ethyl 2-(dichloroacetyl)-3-(dimethylamino)acrylate are obtained (m.p. 71-72 C.).

The synthetic route of 924-99-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pazenok, Sergii; Lui, Norbert; US2010/204483; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 10601-80-6,Some common heterocyclic compound, 10601-80-6, name is Ethyl 3,3-diethoxypropionate, molecular formula is C9H18O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of montmorillonite K-10 (75 mg), an appropriate aniline 1 (150 mg, 1.2 mmol), ethyl-3,3-diethoxypropionate (3) (579 mg, 3 mmol) and an aldehyde (166 mg, 1.34 mmol) in pure water (7.5 mL) was stirred at 90 C for the time mentioned in Table 2. After completion of the reaction (indicated by TLC), the mixture was cooled to room temperature and filtered. The filtrate was extracted with EtOAc (3 ¡Á 5 mL). The organic layers were collected, combined, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using ethyl acetate-hexane to give the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3,3-diethoxypropionate, its application will become more common.

Reference:
Article; Reddy, T. Ram; Reddy, G. Rajeshwar; Reddy, L. Srinivasula; Meda, Chandana Lakshmi T.; Parsa, Kishore V.L.; Kumar, K. Shiva; Lingappa; Pal, Manojit; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 395 – 404;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 122-63-4, name is Benzyl propionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-63-4, category: esters-buliding-blocks

Carbapenem Intermediate (CPI) 5 was prepared according to the synthetic scheme shown in FIGURE 3. In the first step of the process, benzyl propionate is reacted with isobutoxycarbonyloxy acetic acid methyl ester in a solvent at low temperature in the presence of LDA to form ketoester A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl propionate, and friends who are interested can also refer to it.

Reference:
Patent; FOB SYNTHESIS; WO2005/123066; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 623-53-0, name is Ethyl methyl carbonate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl methyl carbonate

47 mmol of the above intermediate I, 3-trifluoromethyl-4-chloroaniline 47 mmol and 0.4 mmol of benzyltrimethylammonium hydroxide weredissolved in 100 mL of N-methylpyrrolidone, and ethyl methyl carbonate 50 mmol was added dropwise in portions. The temperature was raised to 50 C for 80 min, cooled to room temperature, and the reaction solution was added to a mixed solvent of 60 mL of water and 40 mL of ethyl acetate, stirred, layered, and the aqueous phase was extracted with ethyl acetate. The sodium chloride was washed, dried, and dried under vacuum at 40 C to obtain 20.99 g of crude sorafenib in a yield of 96.1%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Liu Zhenteng; Hou Junkai; Liu Qingli; Tian Song; (13 pag.)CN108276327; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 18583-89-6, A common heterocyclic compound, 18583-89-6, name is Methyl 3-amino-2-methylbenzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

When the same reaction as in Referential Example 18 is carried out using methyl 3-amino-2-methylbenzoate instead of the starting methyl 3-amino-6-methylbenzoate, 2-methyl-3-(1-pyrrolyl)benzyl alcohol is obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Banyu Pharmaceutical Co., Ltd.; US5234946; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 18595-12-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18595-12-5 name is Methyl 5-amino-2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of THF (5 mL) containing compound 3 (350 mg, 1.03 mmol) were added sequentially, HOBT (224 mg,1.6 mmol), EDC.HCl (306 mg, 1.6 mmol), TEA (0.28 mL, 2.0 mmol) and methyl 5-amino-2-methylbenzoate (3a) (198 mg, 1.2 mmol). The resulting mixture was stirred at room temperature for 12 h. The reaction mixture was diluted with dichloromethane (10 mL) followed by water (15 mL), the organic layer was separated, washed with water (2 ¡Á 15 mL) followed by brine solution to obtain the crude compound 4. The crude compound was purified by column chromatography using 60-120 silica gel and eluted with 30 % EtOAc/hexane to afford compound 4. Pale white solid; Yield: 280 mg, 66 %; m.p.: 160-162 C; IR (neat, numax): 3431, 2925, 2858, 1620,1442, 1255, 1219, 1170, 1079, 954; 1H NMR: (CDCl3, 400 MHz): delta 7.96 (br.s, 1H-NH), 7.66 (d, J = 6.4 Hz, 1H), 7.46 (t, J = 7.2 Hz, 1H), 7.34 (d, J = 7.6Hz, 1H), 7.22 – 7.33 (d, 4 H),4.68 (br.p, 1H), 3.90 (s, 3H), 3.8(t,1H),3.06 (br.t, 2H) 2.55 (s,3 H)2.47(q, 1H) 1.87-2.03 (m, 4 H). ESI MS: m/z (rel. abund.%): 465.37 (M+,100).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-amino-2-methylbenzoate, and friends who are interested can also refer to it.

Reference:
Article; Reddy; Prasad; Venkataramana; Asian Journal of Chemistry; vol. 28; 1; (2016); p. 138 – 142;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics