Tag: M.W=100-200

Reference of 816-27-3, These common heterocyclic compound, 816-27-3, name is Ethyl 2-ethoxy-2-iminoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 5-Benzyl-1H-[1,2,4]triazole-3-carboxylic acid butyl ester Ethyl-2-ethoxy-2-iminoacetate (1.318 g, 9.08 mmol) and phenyl acetic acid hydrazide (1.364 g, 9.08 mmol) were mixed together in ethanol (20 ml) and stirred at 80 C. for 1 h. Ethanol was evaporated. The residue was dissolved in n-butanol (20 ml). The reaction mixture was stirred at 150 C. for 20 h, then solvents were evaporated. The residue was suspended in acetonitrile and the precipitate was filtered off. The filtrate was purified by prep. HPLC (column: Interchrom C18 ODB, 10 um, 250*28 mm, 23 C.; A: water+0.1% HCOOH, B: ORG+0.1% HCOOH [ORG=methanol/acetonitrile 4:1]; gradient 20% B 2.5 min, 20-100% B in 35 min, 100% B for 2.5 min) to give the title compound. UPLC-MS (method F) Rt=0.85 min, [M+H]+=260.3; HPLC (method G) Rt=1.861 min.

Statistics shows that Ethyl 2-ethoxy-2-iminoacetate is playing an increasingly important role. we look forward to future research findings about 816-27-3.

Reference:
Patent; NOVARTIS AG; US2012/35168; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3618-04-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3618-04-0, name is trans-Ethyl 4-hydroxycyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Tert-butyl(chloro)diphenylsilane (18 ml, 68 mmol, GAS No 58479-61 -1) was added drop wise to a mixture of ethyl 4-hydroxycyclohexanecarboxylate (9.4 ml, 57 mmol, GAS No 17159-80-7), 1H-imidazole (9.68 g, 142 mmol, GAS No 16681 -56-4) and N,N-dimethylpyridin-4-amine (348 mg, 2.85 mmol, GAS No 1122-58-3) in DMF (81 ml), and the mixture was stirred at roomtemperature for 24 h. For work-up, the mixture was poured into water, extracted with ethyl acetate (3x) and the combined organic phases were washed until pH=7 as reached. The organic phase was dried over sodium sulfate and was concentrated under reduced pressure. The residue was purified by flash chromatography (340 g SNAP cartridge, hexane/ethyl acetate gradient, 5% -> 30% ethyl acetate) to give the title compound (21 g).

The synthetic route of trans-Ethyl 4-hydroxycyclohexanecarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; WAGNER, Sarah; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (232 pag.)WO2018/78009; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 625-56-9, name is Chloromethyl acetate, molecular formula is C3H5ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Chloromethyl acetate

Reference Example 15 A mixture of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone (0.30 g) and chloromethyl acetate (1.35 g) was stirred for 24 hours at 100 C. The reaction mixture was concentrated under reduced pressure. The residue was subjected to ODS column chromatography (eluent: methanol/water=3/2) to give 4-acetoxymethyl-1-[(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxy-3-[2-oxo-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-1-imidazolidinyl]butyl]-1H-1,2,4-triazolium chloride (Compound 3, 45 mg) as a white powder. 1H-NMR(d6-DSMO) delta: 0.97(3H,d,J=7 Hz), 2.08(3H,s), 3.61-4.08(4H,m), 4.65-4.75(1H,m), 4.86(1H,d,J=14 Hz), 5.11(1H,d,J=14 Hz), 6.07-6.20(2H,m), 6.69(1H,s), 6.96-7.05(1H,m), 7.25-7.36(2H,m), 7.82-7.95(5H,m), 8.78(1H,s), 9.06(1H,s), 10.46(1H,s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 625-56-9, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6583164; (2003); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 18469-52-8,Some common heterocyclic compound, 18469-52-8, name is Methyl 4-(aminomethyl)benzoate, molecular formula is C9H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid (1.0 equiv) in DMF was added HOBT (1.2 equiv) and EDCI (1.2 equiv), and the mixture was stirred for thirty minutes at room temperature. Triethylamine and corresponding 5a-5e was added, and then reaction was stirred for 8 h at room temperature. Then it was quenched by H2O. The mixture was washed with brine and extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by chromatography on a silica gel chromatography (petroleum ether/ethyl acetate = 1:1 to 1:20) to give corresponding products 6a-6e (yield 43%-62%) as white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-(aminomethyl)benzoate, its application will become more common.

Reference:
Article; Liao, Chenzhong; Tian, Yongbin; Xie, Zhouling; Bioorganic and medicinal chemistry letters; (2020);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 39520-24-6, name is Dimethyl 2-isobutylmalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39520-24-6, category: esters-buliding-blocks

Taken 500mL four-necked flask was added 18.75g isobutyl-butyl malonate, 18.01g1,2,2,6,6- pentamethyl-piperidinol, 180g xylene, fitted with a reflux condenser, a thermometer, a stirrer and nitrogen, with stirring turn, was heated to 120 deg.] C, was added after 0.5h 0.48g dioctyltin oxide (first catalyst), the reaction continued at reflux for 6h, thin layer chromatography analysis showed that only the end of a significant point, transesterification . A flask was supplemented with 20g of xylene, and adding 26.15g2,6- butylated (dimethylaminomethyl) phenol (tradename antioxidant 703), and 0.41g lithium amide (second catalyst), raising the temperature to 145 deg.] C, the reaction was refluxed for 8h, TLC analysis showed that only a clear point, substitution reaction. After the heating was stopped and cooled to room temperature, the reaction mixture was added 3.5g of acetic acid, stirred for 30min, then the reaction solution was filtered dioctyltin oxide and lithium amide, washed 3 times with 70 water, water per 250ml, taken after the liquid separation the organic layer was recovered and the xylene distilled to give a tan solid which was recrystallized from ethanol and the crystals were washed, and dried to give 59.94g of light yellow powder, i.e., containing both a hindered phenol and a hindered amine structure weathering anti-aging agent. Product yield was 85.7% by HPLC analysis of purity of 94.15%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 2-isobutylmalonate, and friends who are interested can also refer to it.

Reference:
Patent; South China University of Technology; Rookie chemical (Yantai) Co., Ltd.; Cai, Zhiqi; Pi, Peng; Wenxiu, Fang; Lu, Yuan; (10 pag.)CN105294543; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 103-09-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 103-09-3, Name is 2-Ethylhexyl acetate, SMILES is CC(OCC(CC)CCCC)=O, belongs to esters-buliding-blocks compound. In a article, author is Becker, Kevin, introduce new discover of the category.

Hybridorubrins A-D: Azaphilone Heterodimers from Stromata of Hypoxylon fragiforme and Insights into the Biosynthetic Machinery for Azaphilone Diversification

The diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone-type compounds were isolated and characterized by NMR spectroscopy and mass spectrometry, and their absolute stereoconfigurations were assigned by using Mosher ester analysis and electronic circular dichroism spectroscopy. Four unprecedented bis-azaphilones, named hybridorubrins A-D, were elucidated, in addition to new fragirubrins F and G and various known mitorubrin derivatives. Only the hybridorubrins, which are composed of mitorubrin and fragirubrin moieties, exhibited strong inhibition of Staphylococcus aureus biofilm formation. Analysis of the genome of H. fragiforme revealed the presence of two separate biosynthetic gene clusters (BGCs) hfaza1 and hfaza2 responsible for azaphilone formation. While the hfaza1 BGC likely encodes the assembly of the backbone and addition of fatty acid moieties to yield the (R)-configured series of fragirubrins, the hfaza2 BGC contains the necessary genes to synthesise the widely distributed (S)-mitorubrins. This study is the first example of two distant cross-acting fungal BGCs collaborating to produce two families of azaphilones and bis-azaphilones derived therefrom.

Synthetic Route of 103-09-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 103-09-3.

6065-82-3, Name is Ethyl diethoxyacetate, molecular formula is C8H16O4, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Hatano, Manabu, once mentioned the new application about 6065-82-3, Application In Synthesis of Ethyl diethoxyacetate.

Enantioselective Aza-Friedel-Crafts Reaction of Indoles and Pyrroles Catalyzed by Chiral C-1-Symmetric Bis(phosphoric Acid)

A hydrogen bonding network in chiral Bronsted acid catalysts is important for the construction of a chiral cavity and the enhancement of catalytic activity. In this regard, we developed a highly enantioselective aza-Friedel-Crafts reaction of indoles and pyrroles with acyclic a-ketimino esters in the presence of a chiral C-1-symmetric BINOL-derived bis(phosphoric acid) catalyst. The desired alkylation products with chiral quaternary carbon centers were obtained in high yields with high enantioselectivities on up to a 1.2-g scale with 0.2 mol % catalyst loading. Interestingly, the absolute configurations of the products from indoles and pyrroles were opposite even with the use of the same chiral catalyst. Moreover, preliminary mechanistic considerations disclosed that a unique hydrogen bonding network with or without pi-pi interactions among the catalyst and substrates might partially play a pivotal role.

If you’re interested in learning more about 6065-82-3. The above is the message from the blog manager. Application In Synthesis of Ethyl diethoxyacetate.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 762-42-5, Name is Dimethyl but-2-ynedioate, molecular formula is C6H6O4, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Matsunaga, Satomi, once mentioned the new application about 762-42-5, HPLC of Formula: C6H6O4.

Light-Embrittled Dental Resin Cements Containing Photodegradable Polyrotaxane Cross-Linkers for Attenuating Debonding Strength

Notwithstanding the progress of dental material adhesion on tooth surfaces in the past several decades, debonding strongly adhered restorative materials from tooth surfaces remains a challenging issue. Herein, we propose the use of photodegradable polyrotaxanes (PRXs), which are supramolecular-interlocked polymers comprising alpha-cyclodextrin threaded along a poly(ethylene glycol) (PEG) axle, as a component of adhesive resin cements to attenuate debonding strength via light irradiation. We synthesized photodegradable PRXs (iNB-PRXs) using internally o-nitrobenzyl esterintroduced PEG as an axle polymer. Notably, approximately 60% of iNB-PRX degraded into its constituent molecules after 5 min of irradiation with ultraviolet (UV) light. Thereafter, iNB-PRX was combined with the clinically utilized adhesive resin cement, and a poly(methyl methacrylate) (PMMA block was adhered on the surface of bovine dentin using an adhesive resin cement cross-linked with iNB-PRX. Although the PMMA block was successfully adhered onto the dentin with a clinically acceptable adhesive force, the tensile strength of the PMMA-dentin specimens decreased significantly upon UV irradiation for 2 min owing to the UV-induced degradation of the iNB-PRX cross-linker. According to these results, the adhesive resin cement containing photodegradable iNB-PRX cross-linkers is a promising candidate for facilitating the debonding of dental materials from tooth surfaces via UV light irradiation.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 762-42-5. The above is the message from the blog manager. HPLC of Formula: C6H6O4.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of Methyl decanoate, 110-42-9, Name is Methyl decanoate, SMILES is CCCCCCCCCC(OC)=O, belongs to esters-buliding-blocks compound. In a document, author is Ahmed, Ashfaq, introduce the new discover.

Sawdust pyrolysis from the furniture industry in an auger pyrolysis reactor system for biochar and bio-oil production

This study investigated the potential of sawdust from the processing of Acacia wood for the furniture making industry to produce bio-oil and biochar in an auger pyrolysis reactor system. The necessary characterization to assess the suitability of feedstock and strategies the pyrolysis parameters was also carried out. The volatile matter, ash content, carbon content and the higher heating value of the sawdust feedstock were reported as 68.46 wt%, 1.13 wt%, 47.40 wt% and 19.33 MJ/kg, respectively, with very low nitrogen and sulfur content. The thermogravimetric (TGA and DTG) analysis of sawdust showed that the weight loss from biomass occurred in three main stages as a result of the removal of moisture and extractives, decomposition of hemicellulose, cellulose, and the lignin components. Based on the decomposition temperature window and peak conversion temperature the pyrolysis experiments were carried out in the range of 400-600 degrees C by maintaining the nitrogen flow rate, biomass feeding rate, rotation speed of the conveyer the residence time of materials and biomass particle size as 300 cm(3)/min, 180 g/h, 4.5 RPM, 5 min, and 0.5-1.0 mm, respectively. The yields of the non condensable gases, biochar and bio-oil were reported in the ranges 16.70-38.47 wt%, 29.72-51.85 wt% and 29.40-45.10 wt%, respectively. The pyrolysis products were pragmatically analyzed to evaluate the influence on yield and their properties. The higher heating values of bio-oil produced were reported in the range 28.781-29.871 MJ/kg while the pH of bio-oil indicated the strongly acidic nature with values in the range of 2.9-3.4. Chemical compounds in bio-oils were categorized as phenols, nitrogen containing compounds, guaiacols, organic acids, ketones, anhydrous sugars, esters, and aldehydes. Biochar characterization showed an energy potential comparable to those of the low ranked coals with the higher heating values reported in the range of 25.01-25.99 MJ/kg. The surface morphological characteristics and Brunauer-Emmett-Teller (BET) analysis of the biochars indicated potential for other valued applications in the adsorption, environmental, catalyst, and agricultural context.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 110-42-9. Application In Synthesis of Methyl decanoate.

In an article, author is Reinisova, Lucie, once mentioned the application of 27492-84-8, HPLC of Formula: C9H11NO3, Name is Methyl 4-amino-2-methoxybenzoate, molecular formula is C9H11NO3, molecular weight is 181.1885, MDL number is MFCD00017202, category is esters-buliding-blocks. Now introduce a scientific discovery about this category.

Poly(trimethylene carbonate-co-valerolactone) copolymers are materials with tailorable properties: from soft to thermoplastic elastomers

Aliphatic poly(ester-carbonates) are receiving extensive research attention as tailorable materials suitable for multiple applications from tissue engineering and 3D scaffold printing to drug delivery. Thus, simple reliable procedures for producing easily tailorable poly(ester-carbonates) without metal residues are continuously sought after. In this work, we report on one-pot synthesis of random copolymers of TMC and delta-VL using metal-free biocompatible 1,5,7-triazabicyclo[4.4.0]dec-5-ene as a catalyst and benzyl alcohol and poly(ethylene oxide) as initiators. Random poly(ester-carbonates) with TMC : VL unit ratios ranging from 80 : 20 to 20 : 80 were synthesized via ring-opening polymerization while displaying excellent agreement of comonomers’ ratios in the feed and copolymer chains. The copolymers’ supramolecular structure, thermal and mechanical properties were thoroughly analyzed by various methods. The obtained results clearly indicated that the physicochemical properties can be controlled simply by varying the ratio of comonomers and the length of segments in the copolymer chain. Several copolymers exhibited behavior of thermoplastic elastomers with the most promising one exhibiting a 2200% increase in elongation at break compared to the poly(valerolactone) homopolymer while retaining tensile strength and Young’s modulus suitable for biomedical applications. Overall, our work contributed to widening the portfolio of tailorable copolymers for specialized bioapplications and possibly paving a way for the use of more sustainable polymers in the biomedical field.

If you are interested in 27492-84-8, you can contact me at any time and look forward to more communication. HPLC of Formula: C9H11NO3.