Tag: M.W=100-200

Related Products of 3618-04-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3618-04-0, name is trans-Ethyl 4-hydroxycyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step (i) 4-Toluenesulfonyl chloride (18.29 g, 96 mmol) was added in several portions to a solution of ethyl 4-hydroxycyclohexanecarboxylate (ca. 1 : 1 mixture of cis and trans ring isomers) (29.5 g, 90 mmol) in pyridine (100 niL) in an ice-water bath, and the mixture stirred, allowing to warm to RT. After the solid had dissolved, the mixture was allowed to stand. After 24 h, the mixture was concentrated and the residue partitioned between water and EtOAc (100 ml. each). The organic phase was dried and concentrated to give ethyl 4- (tosyloxy)cyclohexanecarboxylate (ca. 1 : 1 mixture of cis and trans ring isomers) (crude, 29.5 g) as a colourless oil which was used in the next step without further purification. NMR (400 MHz, CDC13) delta ppm 1.20-1.30 (m, 3H) 1 .44-2.08 (m, 81 ) 2.2 1 -2.43 (m, 111 ) 2.48 (s, 31 1) 4.08-4.20 (m, 211 ) 4.40-4.50 and 4.70-4.78 (both m, total 1H) 7.28-7.40 (m, 2H) 7.78-7.86 (m, 2H)

The chemical industry reduces the impact on the environment during synthesis trans-Ethyl 4-hydroxycyclohexanecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LIMITED; BUFFHAM, William; CANNING, Hannah; DAVENPORT, Richard; FARNABY, William; MACK, Stephen; PARMAR, Alka; WRIGHT, Susanne; WO2015/25164; (2015); A1;,
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Application of 3618-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3618-04-0 name is trans-Ethyl 4-hydroxycyclohexanecarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 7: c/s-4-hydroxy-4- [2-(6-methoxy- [1,5] naphthyridin-4-yl)-ethyl] – cyclohexanecarboxylic acid (2,3-dihydro-benzo[l,4]dioxin-6-yl)-amide:7.i. 4-oxo-cyclohexanecarboxylic acid ethyl ester.To a solution of oxalyl chloride (6 mL, 68.8 mmol) in DCM (100 mL) at -78C was added dropwise a solution of DMSO (6.4 mL, 90 mmol) in DCM (2O mL). The mixture was stirred at this temperature for 15 min before the dropwise addition of a solution of ethyl4-hydroxycyclohexane carboxylate (4.8 mL, 30 mmol) in DCM (20 mL). The mixture was stirred at -78C for 3 h before addition of TEA (29.3 mL, 210 mmol) in DCM (20 mL).The mixture was then gradually warmed to rt, washed with a sat. aq. NH4Cl solution and brine, dried over MgSO4 and concentrated. The residue was purified by chromatography over SiO2 (Hex/EA 1 :1) to give the title ketone (4.6 g, 90% yield) as a colourless oil.1H NMR (CDCl3) delta: 4.19 (q, J = 7.1 Hz, 2H); 2.80-2.70 (m, IH); 2.55-2.45 (m, 2H);2.40-2.30 (m, 2H); 2.25-2.10 (m, 2H); 2.05-2.00 (m, 2H); 1.29 (t, J = 7.1 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, trans-Ethyl 4-hydroxycyclohexanecarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/107965; (2007); A1;,
Ester – Wikipedia,
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Synthetic Route of 61644-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61644-18-6, name is Chloromethyl isobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Alternatively, a mixture of chioromethyl 2-methyl- propanoate (1.0 eq), fumaric acid (5.0 g, 1.0 eq), and DIEA (2.0 eq) was stirred between 50 to 70 C. overnight. The reaction was diluted with ethyl acetate and washed with water and brine. The organic phase was separated, dried over Na2504, filtered and concentrated in vacuo to yield the crude product. The crude material was then purified by silica gel column chromatography using dichloromethane and methanol to yield compound (6b).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl isobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nguyen, Mark Quang; (47 pag.)US2016/229819; (2016); A1;,
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Related Products of 18595-12-5, A common heterocyclic compound, 18595-12-5, name is Methyl 5-amino-2-methylbenzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 82; Preparation of inhibitor methyl 5-(5-(4-((4~methyipiperazin-1-yl)methyl)- benzamido)-2-methylbenzamido- 1 H-pyrro/o/2, 3-b]pyridine-2-carboxylate (ND0117); Step 1 : Preparation of methyl5-(4-(chloromethyl)benzamido)-2-methylbenzoate; A reactor is charged with 1g (6.06 mmol) of methyl 3-amino-6-methylbenzoate and 1.2g (119 mmol) of triethylamine in 25 ml of dichloromethane. 1.145g (6.05 mmol) of 4-chioromethylbenzoyle chloride is then added and the mixture is stirred at room temperature for 2 hours. The reacting medium is then washed with 10 ml of a saturated NaHCO3 solution, 10 ml of water and 10 ml of a saturated NaCI solution. The organic phase is dried, evaporated and the obtained residue is triturated in ethylic ether and then in pentane to give a white solid (1.2 g, 66%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NOVA DECISION; AZASYNTH; YASRI, Abdelaziz; CHEVE, Gwenael; BORIES, Cedric; DELON, Louis; WO2010/92489; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2216-94-6, name is Ethyl phenylpropiolate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2216-94-6, Formula: C11H10O2

General procedure: In a flame-dried Young-tube ethyl 3-arylpropiolate (16, 1.00 eq.), arylboronic acid (3.00 eq.) and CuOAc (2 mol%) were dissolved in MeOH (0.5 M). The solution was degassed by three freeze-pump-thaw cycles and then stirred over night at room temperature. The resulting suspension was filtered over celite and the solvent was removed under reduced pressure. Purification by column chromatography (Si02, 5 x 20 cm, eluent as listed for the Revalue) afforded the desired ethyl 3,3-diarylacrylate.’

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl phenylpropiolate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ebner, Christian; Pfaltz, Andreas; Tetrahedron; vol. 67; 52; (2011); p. 10287 – 10290;,
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These common heterocyclic compound, 2177-70-0, name is Phenyl methacrylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H10O2

Comparative Example 2 After the dropwise addition of phenyl methacrylate, N,N,N’,N’-tetramethylethylene diamine was not added, and otherwise the reaction was carried out in the same manner as in Example 7, an organic layer was obtained. As a result of gas chromatographic analysis of the organic layer, the yield of the desired 1,3,3,5-tetramethylcyclohexyl methacrylate was found to be less than 1 mol %.; Example 7 2.5 mL of tetrahydrofuran solution of 3.0 mol/L concentration of methylmagnesium chloride was added to 10 mL of anhydrous tetrahydrofuran in a reaction vessel under an atmosphere of argon, and then 1.0 g of 3,3,5-trimethylcyclohexanone was added with stirring while the mixture in the reaction vessel was kept at a temperature of 50 C. or less, followed by stirring for another one hour at the same temperature with stirring. Then, 1.20 g of phenyl methacrylate was added drop wise into the reaction vessel, and then 1.74 g of N,N,N’,N’-tetramethylethylene diamine, and the reaction was carried out with stirring for 24 hours at a temperature of 60 C. After the reaction, an aqueous saturated solution of ammonium chloride was added to the resulting reaction mixture, and the desired product was extracted with ethyl acetate. The obtained organic layer was subjected to gas chromatographic analysis. As a result, the yield of 1,3,3,5-tetramethylcyclohexyl methacrylate was found to be 18.0 mol %.

The synthetic route of Phenyl methacrylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HONSHU CHEMICAL INDUSTRY CO., LTD.; US2006/167305; (2006); A1;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3618-04-0, name is trans-Ethyl 4-hydroxycyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H16O3

Compound 300.1. Ethyl 4-methoxycyclohexanecarboxylate. Into a 100-mL round- bottom flask, was placed a solution of ethyl 4-hydroxycyclohexane-l-carboxylate (1 g, 5.81 mmol) in tetrahydrofuran (20 mL). Sodium hydride (349 mg, 8.72 mmol, 60percent) was added to the reaction at 0 ¡ãC in portions, then stirred for 20 min. This was followed by the addition of CH3I (865 mu, 11.6 mmol) at 0 ¡ãC. The reaction mixture was stirred overnight at room temperature, quenched with 6 mL of brine and extracted with 3 x 40 mL of ether. The combined organic layers were washed with 2 x 20 mL of brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 800 mg (74percent) of the title compound as a colorless oil.

According to the analysis of related databases, 3618-04-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3-V BIOSCIENCES, INC.; HEUER, Timothy Sean; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2015/95767; (2015); A1;,
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Synthetic Route of 50893-36-2,Some common heterocyclic compound, 50893-36-2, name is 1-Chloroethyl ethyl carbonate, molecular formula is C5H9ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4 Preparation of ethyl N,N-di-n-butylcarbamate To a solution of 6.5 g (0.05 mole) of di-n-butylamine and 5.56 g (0.055 mole) of triethylamine in 40 ml of THF, 8.4 g (0.055 mole) of alpha-chloroethyl ethyl carbonate dissolved in 10 ml of THF are added dropwise and with stirring while the temperature is maintained at 5¡ã-10¡ã C. The mixture is allowed to return to room temperature, and is maintained with stirring at this temperature for 2 hours. After removal of the precipitate by filtration, evaporation of the solvent and distillation under reduced pressure, 6.3 g (63percent yield) of the expected carbamate are collected. B.p. 76¡ã C./26.6 Pa (0.2 mm Hg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloroethyl ethyl carbonate, its application will become more common.

Reference:
Patent; Societe Nationale des Poudres et Explosifs; US4725680; (1988); A;,
Ester – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6065-82-3, name is Ethyl diethoxyacetate, A new synthetic method of this compound is introduced below., name: Ethyl diethoxyacetate

General procedure: A mixture of the appropriate nitrile (4, 2 mmol), hydroxylamine50% (0.132 g, 2 mmol), and a catalytic amount of AcOH was stirredat 150 C for 40 min. After nearly complete conversion to thecorresponding amidoxime, as was indicated by TLC monitoring, theappropriate 2,2-dialkoxyacetate (6, 2 mmol) and K2CO3 (0.276 g,2 mmol) were added to the reaction mixture which was stirred at100 C for further 6 h. After completion of the reaction as indicatedby TLC, the reaction mixture was cooled to room temperature andthe residue was purified by column chromatography using n-hexane-EtOAc (6:1) as eluent. The solvent was removed, and the product was obtained.

The synthetic route of 6065-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Adib, Mehdi; Saeedi, Sara; Soheilizad, Mehdi; Bayanati, Maryam; Tajbakhsh, Mahmood; Amanlou, Massoud; Journal of Chemical Research; vol. 40; 5; (2016); p. 314 – 317;,
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Related Products of 4891-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4891-38-7, name is Methyl Phenylpropiolate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 25 mL Schlenk tube equipped with a magnetic stirringbar was charged with I2 (12.7 mg, 0.05 mmol), substituted thiol1 (0.5 mmol) and alkyne 2 (0.75 mmol). The tube was evacuatedtwice and backfilled with nitrogen, and DTBP (2.5 mmol)was added into the tube under nitrogen atmosphere. The tubewas sealed with a balloon and the mixture was stirred undernitrogen atmosphere at 110 C for 18 h. Upon completion of thereaction, the resulting solution was cooled to r.t., and thesolvent was removed with the aid of a rotary evaporator. Theresidue was purified by column chromatography on silica gel(PE-EtOAc) to give 3.

The synthetic route of Methyl Phenylpropiolate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yan, Kelu; Yang, Daoshan; Zhang, Mengqi; Wei, Wei; Liu, Yao; Tian, Laijin; Wang, Hua; Synlett; vol. 26; 13; (2015); p. 1890 – 1894;,
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