Tag: M.W=100-150

Tran, Van T. published the artcileActivation of diverse carbon-heteroatom and carbon-carbon bonds via palladium(II)-catalyzed β-X elimination, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Nature Chemistry (2018), 10(11), 1126-1133, database is CAplus and MEDLINE.

γ-Substituted N-(8-quinolinyl) alkanecarboxamides and cycloalkanecarboxamides such as I underwent regioselective substitution reactions with nucleophiles such as 1-methyl- and 1,2-dimethylindoles in the presence of Pd(OAc)₂ and 1-adamantanecarboxylic acid (1-AdCO₂H) to yield substitution products such as II (R = H, Me). The substitutions occurred using elimination reactions of the β-palladated carboxamides as a key step; a β-palladation product was isolated and its structure determined by X-ray crystallog. The substitution reactions occurred at alkyl C(sp³)-oxygen, nitrogen, carbon, fluorine and sulfur bonds with high regioselectivity. The method was used for substitution reactions of γ-substituted amino acids such as the 8-aminoquinolinyl amide of L-methionine and its sulfoxide to give functionalized amino acids in 60-98% ee. Unstrained 8-aminoquinolinyl heterocyclylalkanecarboxamides underwent regioselective γ-substitution reactions with ring opening if a heteroatom was in the γ-position; if the heteroatom was in an appropriate position, lactonization and lactamization reactions also occurred with loss of the aminoquinoline moieties.

Nature Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C18H28B2O4, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gordeev, Mikhail F. published the artcileNovel oxazolidinone-quinolone hybrid antimicrobials, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(23), 4213-4216, database is CAplus and MEDLINE.

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogs I and II [racemic and 3-(S)-isomer] display an improved potency vs. linezolid against gram-pos. and fastidious gram-neg. pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Yu published the artcileSolvent extraction of Hulunbeier lignite and oxidation of coal extracted residue with hydrogen peroxide, Synthetic Route of 5340-78-3, the publication is Mei Huagong (2014), 42(2), 27-31, database is CAplus.

Hulunbeier lignite was extracted using CS₂, ethanol and acetone as solvent and the coal extract residues were analyzed with GC/MS. The results showed that CS₂ extracts mainly consisted of long chain aliphatic hydrocarbon and aromatic hydrocarbon. Aliphatic hydrocarbon existed in the three solvent extracts Coal extracted residue was oxidized for 4h at 40°C with hydrogen peroxide at a constant temperature in a water bath with magnetic stirrer and ultrasonic bath, resp. The reaction in ultrasonic bath was sharp. The chem. structure changes of raw coal, coal extracted residue and oxidized coal were analyzed using FTIR. The water soluble products were extracted using Et acetate. The GC/MS anal. of Et acetate extracts detected 30 compounds through oxidation in water bath with magnetic stirrer, among which esters were in higher abundance, while 14 compounds were identified in ultrasonic bath.

Mei Huagong published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Synthetic Route of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rassadin, Valentin A. published the artcileAccess to a Wide Range of Sultams by Cyclodialkylation of α-Substituted Methanesulfonanilides, Synthetic Route of 19788-49-9, the publication is European Journal of Organic Chemistry (2012), 2012(26), 5028-5037, S5028/1-S5028/169, database is CAplus.

A wide range of five- and six-membered sultams bearing an α-ethoxycarbonyl-α-Me substituent or an α-aryl group (17 examples) were synthesized by the cyclodialkylation of α-substituted methanesulfonanilides with α,ω-dihaloalkanes in the presence of K₂CO₃ or under phase-transfer catalysis (PTC) conditions. Upon treatment with K₂CO₃ in N,N-dimethylformamide (DMF) or NaH in DMSO (DMSO), N-(2,3-dibromopropyl)-α-toluenesulfonanilides furnished different 1,3-diaryl-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxides in good to excellent yields (51-88 %, 16 examples). The 4-methoxyphenyl (PMP) group was easily removed from the sultam nitrogen atom by treatment of the corresponding bicyclic sultams with cerium(IV) ammonium nitrate in acetonitrile (71-84 % yield, 6 examples).

European Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chalyk, Bohdan published the artcileUnexpected Isomerization of Oxetane-Carboxylic Acids, Related Products of esters-buliding-blocks, the publication is Organic Letters (2022), 24(26), 4722-4728, database is CAplus and MEDLINE.

Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these mols., as this could dramatically affect the reaction yields and led to neg. results (especially in those reactions that require heating).

Organic Letters published new progress about 1207175-04-9. 1207175-04-9 belongs to esters-buliding-blocks, auxiliary class Oxetane,Ester, name is Ethyl 2-(oxetan-3-yl)acetate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Weiqiang published the artcileSynthesis of ethyl N,N-dimethylaminoacrylate, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Huagong Shengchan Yu Jishu (2008), 15(4), 29-31, database is CAplus.

Synthetic routes of Et N,N-dimethylaminoacrylate, imine complexation, high-pressure of carbon monoxide synthesis, aldol condensation, were compared with their advantages and disadvantages. The method of aldol condensation was started from Et formate and Et acetate, reacted with sodium or sodium hydride, to obtain sodium Et formylacetate, then reacted with dimethylamine hydrochloride to obtain the final product. The total yield was 60%. This process had many advantages, such as mild reaction conditions, simple procedure, high atom economy and less pollution, so it was suitable for industrial production

Huagong Shengchan Yu Jishu published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C15H14O3, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Yu-An published the artcileA Change from Kinetic to Thermodynamic Control Enables trans-Selective Stereochemical Editing of Vicinal Diols, Name: Dimethyl fumarate, the publication is Journal of the American Chemical Society (2022), 144(1), 599-605, database is CAplus and MEDLINE.

Herein, the selective, catalytic isomerization of cis-1,2-diols to trans-diequatorial-1,2-diols is reported. The method employs triphenylsilanethiol (Ph₃SiSH) as a catalyst and proceeds under mild conditions in the presence of a photoredox catalyst and under blue light irradiation The method is highly chemoselective, broadly functional group tolerant and provides concise access to trans-diol products which are not readily obtained using other methods. Mechanistic studies reveal that isomerization proceeds through a reversible hydrogen atom transfer pathway mediated by the silanethiol catalyst.

Journal of the American Chemical Society published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C10H16Br3N, Name: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nicholas, Jacqueline A published the artcileDimethyl fumarate is associated with lower rates of infection and lower infection-related healthcare costs when compared with ocrelizumab., Category: esters-buliding-blocks, the publication is Multiple sclerosis and related disorders (2022), 103921, database is MEDLINE.

BACKGROUND: Infections in people with multiple sclerosis (PwMS) may have a detrimental effect on disease progression, risk of hospitalization, and healthcare resource utilization (HRU). The infection risk and HRU costs may vary between disease-modifying therapies (DMTs); however, the individual risks and differences associated with DMTs are not well characterized. Some DMTs may increase the risk for infections in PwMS; however, previous studies have reported an intact humoral immune response in dimethyl fumarate (DMF)-treated patients. The objective was to compare infection-related HRU and healthcare costs (HCCs) between PwMS treated with DMF or ocrelizumab (OCR). METHODS: Eligible patients were identified from the Optum US claims database between April 2017 and September 2020 (DMF n = 1429; OCR n = 3170). Patients were followed from index date to first occurrence of: (1) end of study, (2) end of insurance eligibility, (3) discontinuation of index DMT, or (4) switch from index DMT to another DMT. Outcomes were annualized rate of infection encounters (defined as infection encounters [n] during follow-up window / days followed [n] × 365); annualized infection-related HCCs (defined as aggregated costs of infection encounters during follow-up window / days followed [n] × 365); location-specific infections, and overall infection-related events. Propensity score matching (PSM) 1:1 method was used; PS was calculated via logistic regression for probability of DMF treatment conditional on demographics and comorbidities. Mean differences (MD) were reported for infection encounter measures. RESULTS: After PSM, DMF and OCR cohorts (n = 1094 in each cohort) were balanced based on baseline characteristics (standardized MD of adjusted baseline characteristics <0.1). Mean (standard deviation) follow-up was 296 (244) days for DMF patients and 297 (243) for OCR patients. DMF patients experienced lower annualized rates of overall infection encounters vs OCR patients (MD -0.51 [95% confidence interval (CI): -0.92 to -0.11], p = 0.01). When stratified by type of infection encounter, DMF patients experienced significantly lower annualized rates of outpatient (MD [95% CI]: -0.44 [-0.80 to -0.08], p = 0.02) and inpatient/hospitalization infection encounters (-0.08 [-0.14 to -0.02], p<0.01) vs OCR patients. A trend towards a shorter duration of infection-related hospitalization in the DMF vs the OCR group was observed (MD [95% CI]: -2.20 [-4.73 to 0.26] days, p = 0.08). The most common infection types in both DMT groups were urinary tract infections, sepsis, and pneumonia. DMF patients experienced lower annualized infection-related HCCs (MD [95% CI]: -$3642 [-$6380 to -$904], p < 0.01) vs OCR patients, which were driven largely by infection-related hospitalization costs (-$3639 [-$6019 to -$1259], p < 0.01). CONCLUSION: DMF-treated patients PS-matched with OCR patients experienced lower annualized rates of infection encounters and lower infection-related HCCs.

Multiple sclerosis and related disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tominaga, Takatoshi published the artcileRole of Certain Volatile Thiols in the Bouquet of Aged Champagne Wines, Application In Synthesis of 19788-49-9, the publication is Journal of Agricultural and Food Chemistry (2003), 51(4), 1016-1020, database is CAplus and MEDLINE.

A method for the specific extraction of volatile thiols by use of p-hydroxymercuribenzoate has made it possible to identify certain flavor-active volatile thiols in Champagne wines. Benzenemethanethiol, 2-furanmethanethiol, and Et 3-mercaptopropionate were present in these wines at concentrations considerably higher than their perception thresholds. Their concentrations increased gradually in proportion to the bottle aging period and sharply as a result of disgorging. The contribution of these volatile thiols to the empyreumatic nuances of the bouquet of aged Champagne wines was demonstrated for the 1st time.

Journal of Agricultural and Food Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C7H12ClNO, Application In Synthesis of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Choudhary, Yogesh S. published the artcileBranched Ligand Ethyl 2-Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu²⁺ Ions Probe in Aqueous Medium, Name: Ethyl 2-mercaptopropanoate, the publication is ChemistrySelect (2020), 5(1), 32-39, database is CAplus.

In the present work, we explored the possibility of using a novel stabilizing ligand namely Et 2-mercaptopropionate for the synthesis of CdTe quantum dots (QDs). The QDs were synthesized and stabilized by the ligand and it was realized to be emitting at 560 nm. Extensive microscopic and photo phys. characterization were carried out in order to unearth the nature of the QDs synthesized. Interestingly, it was observed that, the photoluminescence emission of as synthesized QDs were getting quenched linearly in the presence of Cu²⁺, which prompt us to make use of these QDs for the detection of Cu²⁺ ions in aqueous media. A detailed mechanism of quenching was also proposed. The linear range over which the QDs was selective to Cu²⁺ ions was from 0.5 nM to 129.5 nM with a detection limit (LOD) of 0.5 nM providing a pathway for the QDs based Cu²⁺ probe.

ChemistrySelect published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics