Tag: M.W=100-150

Conway, Sarah E. published the artcileCOVID-19 severity is associated with worsened neurological outcomes in multiple sclerosis and related disorders, Product Details of C6H8O4, the publication is Multiple Sclerosis and Related Disorders (2022), 103946, database is CAplus and MEDLINE.

Neurol. outcomes in patients with multiple sclerosis (MS) and related disorders (MSRD) following COVID-19 is not well understood. The objective of this study was to investigate neurol. outcomes in patients with MSRD post-COVID-19. This was a retrospective medical records review study of adult patients with MSRD and COVID-19 infection at the Brigham MS Center. Neurol. worsening post-COVID-19 was defined as having a relapse, pseudorelapse, new brain MRI activity, worsening of preexisting MSRD symptoms, or development of other long-term neurol. symptoms.111 patients, 85 (76.6%) females, with a mean [SD] age of 49.3 [12.2] years and median [range] EDSS of 2.5 [0, 8.5] were identified. 41 patients (36.9%) had neurol. worsening post-COVID-19. Of those, 19 (46.3%) had pseudorelapses, 2 (4.8%) had relapses, and 24 (58.5%) patients reported worsening of preexisting MSRD symptoms, or other new long-term neurol. symptoms. Neurol. worsening was associated with hospitalized (moderate or severe) COVID-19 (p = 0.001), treatment for COVID-19 (p = 0.006), and incomplete COVID-19 recovery (p = 0.0267) but not with age, sex, MS type, race, disease duration, EDSS, vitamin D use, or disease modifying therapy use. COVID-19 severity and lack of complete systemic recovery were associated with new or worsening neurol. symptoms in 36.9% of MSRD patients.

Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Product Details of C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wannenmacher, Nick published the artcileDiastereospecific Enantiodivergent Allylation of Pyrazolones as an Entry to β-Aminoamides, Category: esters-buliding-blocks, the publication is Advanced Synthesis & Catalysis, database is CAplus.

A diastereospecific enantiodivergent allylation of pyrazolones I (R¹ = n-Pr, H₂C:CHCH₂, PhCH₂, etc.; R² = Me, i-Pr, Ph; R³ = Ph, PhCH₂, 4-MeOC₆H₄) with allyl imidates R⁴CH:CHCH₂OC(:NH)CCl₃ (R⁴ = Me, n-Pr, PhCH₂CH₂, MeO₂CCH₂CH₂, PhCH₂OCH₂CH₂), catalyzed by a planar chiral pentaphenylferrocene-based palladacycle, is reported. With the same catalyst, both enantiomeric products II were selectively available from (E)- or (Z)-allyl imidates. The method is applicable to structurally diverse substrates and gave products II with 85-94% enantiomeric excesses. In addition, pyrazolone (S,E)-II (R¹ = 4-FC₆H₄CH₂; R² = Me; R³ = Ph; R⁴ = PhCH₂CH₂) was transformed into acyclic β-aminoamide.

Advanced Synthesis & Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C13H18BNO3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sjoholm, Asa published the artcileInvestigation of the Lewis acid mediated stereoselective cyclization of cationic aminyl radicals leading to substituted pyrrolidines, Formula: C8H16O2, the publication is Journal of the Chemical Society, Perkin Transactions 1 (2001), 891-899, database is CAplus.

Stereoselective Lewis acid mediated radical cyclizations of variously substituted N-chloropentenylamines afforded the corresponding pyrrolidines with good to excellent diastereoselectivities and in high yields. Several Lewis acids have been screened in an attempt to find an efficient and stereoselective protocol for the formation of pyrrolidines; no apparent correlation between the different Lewis acids and the selectivities obtained was observed

Journal of the Chemical Society, Perkin Transactions 1 published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C16H24BF4Ir, Formula: C8H16O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Larsen, Matthew A. published the artcileA Modular and Diastereoselective 5 + 1 Cyclization Approach to N-(Hetero)Aryl Piperidines, HPLC of Formula: 517-23-7, the publication is Journal of the American Chemical Society (2020), 142(2), 726-732, database is CAplus and MEDLINE.

A new general de novo synthesis of pharmaceutically important N-(hetero)aryl piperidines is reported. This protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction sequence to achieve rapid construction of complex polysubstituted ring systems starting from widely available heterocyclic amine nucleophiles and carbonyl electrophiles. Notably, the diastereoselectivity of this process is enhanced by the presence of water, and DFT calculations support a stereochem. model involving a facially selective protonation of a water-coordinated enol intermediate.

Journal of the American Chemical Society published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hay, Michael B. published the artcilePalladium-catalyzed synthesis of tetrahydrofurans from γ-hydroxy terminal alkenes: Scope, limitations, and stereoselectivity, Application of Ethyltert-butylacetate, the publication is Journal of Organic Chemistry (2005), 70(8), 3099-3107, database is CAplus and MEDLINE.

A stereoselective synthesis of substituted tetrahydrofurans, e.g., I, by Pd-catalyzed reactions of aryl and vinyl bromides with γ-hydroxy terminal alkenes is described. This transformation afforded trans-2,5- and trans-2,3-disubstituted tetrahydrofurans with good diastereomeric ratio. This methodol. also provided access to bicyclic and spirocyclic THF derivatives in good yield diastereomeric ratio. The scope and limitations of these transformations are discussed in detail, as are the effect of substrate sterics and electronics on yield and stereoselectivity. A proposed mechanism of these transformations is presented along with a model that rationalizes the stereochem. outcome of the reactions.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ha, Deok Chan published the artcileN-Trimethylsilylimines: applications to the syntheses of β-lactams, Formula: C8H16O2, the publication is Journal of the American Chemical Society (1984), 106(17), 4819-25, database is CAplus.

Ester enolates and N-trimethylsilylimines react to afford β-lactams. The stereochem. course of the reaction depends on the ester enolate geometry. Thus, (E)-enolates give mainly cis β-lactams while (Z)-enolates give ∼1:1 mixtures of cis and trans β-lactams. The use of HOCHMeCH₂CO₂Et as the ester component gives β-lactams of potential use in carbapenem synthesis. The differences in the behavior of N-trimethylsilyl and N-arylimines in the ester-imine condensations are also discussed.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Formula: C8H16O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Makhseed, Saad published the artcileStudies with 2-(arylhydrazono)aldehydes: Synthesis and chemical reactivity of mesoxalaldehyde 2-arylhydrazones and of ethyl 2-arylhydrazono-3-oxopropionates, SDS of cas: 924-99-2, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (2007), 62(4), 529-536, database is CAplus.

The coupling reaction of 3-(dimethylamino)acrolein and Et 3-(dimethylamino)acrylate with arenediazonium chlorides afforded the 2-(arylhydrazono)aldehydes RC₆H₄NHN:CR¹CHO [I, R = 4-Cl, H, 4-OMe, 3-Cl; R¹ = CHO, CO₂Et]. I [R = H, 4-Cl, R¹ = CHO] reacted with hydroxylamine hydrochloride to yield the oximes. The dioxime was obtained from reaction of I [R = 4-Cl, R¹ = CHO] with an excess of hydroxylamine hydrochloride. This dioxime afforded the 1,2,3-triazolecarbonitrile when treated with acetic anhydride, while α-hydrazonopropionitrile was obtained with acetic acid. I could be used for the synthesis of a variety of pyrazoles and arylazolopyrimidines via reaction with hydrazines, halo ketones and amino azoles, resp.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abu Shuheil, Mohammad Y. published the artcileHeterocycles [h]-fused onto 4-oxoquinoline-3-carboxylic acid, III. Facile synthesis and antitumor activity of model heterocycles [a]-fused onto pyrido[2,3-f]quinoxaline-3-carboxylic acids, HPLC of Formula: 924-99-2, the publication is Heterocycles (2007), 71(10), 2155-2172, database is CAplus.

Direct interaction between 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and each of (S)-proline, (2S,4R)-4-hydroxyproline, and (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in hot aqueous ethanolic NaHCO₃ yielded the corresponding optically pure N-(4-oxoquinolin-7-yl)-α-amino acids. The latter derivatives underwent reductive lactamization upon treatment with Na₂S₂O₄ in aqueous ethanol to afford moderate yields of the resp. pyrido[2,3-f]quinoxaline-3-carboxylic acid [fused]- to tetrahydropyrrolo[1,2-a]-, tetrahydrohydroxylpyrrolo[1,2-a]-and tetrahydroisoquinolino[2,3-a]heterocycles, e.g., I, resp. The antitumor activity against four human tumor cell lines showed that all those compounds displayed high levels of cytotoxicity as compared with Cisplatin. Interestingly, these compounds were more potent against breast carcinoma cell lines (MCF-7 and T-47D) than the lymphoid origin tumor cell lines (Jurkat and BHL-89). In particular, the (S)-proline derivative I exhibited preferential cytotoxicity to adherent cells (IC₅₀ = 0.5 μM), indicative of better potential in blocking the growth of solid tumors rather than the disseminated ones.

Heterocycles published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Meng, Qi published the artcileFormation by yeast of 2-furanmethanethiol and ethyl 2-mercaptopropionate aroma compounds in Japanese soy sauce, Formula: C5H10O2S, the publication is Bioscience, Biotechnology, and Biochemistry (2014), 78(1), 109-114, database is CAplus and MEDLINE.

Two aroma compounds of volatile thiols, 2-furanmethanethiol (2FM) and Et 2-mercaptopropionate (ET2MP), were formed in five types of Japanese soy sauce during fermentation by yeast. The concentrations of 2FM and ET2MP in the soy sauce samples increased during alc. fermentation The concentrations of 2FM and ET2MP were higher in the soy sauce fermented by Zygosaccharomyces rouxii than in that fermented by Candida versatilis. The enantiomers of ET2MP were separated by gas chromatog. in a capillary column. The average enantiomeric ratio of ET2MP in the soy sauce was approx. 1:1. 2FM was formed by yeast in a medium prepared from cysteine and furfural, and cysteine is considered the key precursor of 2FM by yeast in soy sauce.

Bioscience, Biotechnology, and Biochemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Qu, Lingzhi published the artcileCharacterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates, Application of Dimethyl fumarate, the publication is Biochemical and Biophysical Research Communications (2022), 9-15, database is CAplus and MEDLINE.

Fumarates (fumaric acid esters), primarily di-Me fumarate (DMF) and monoethyl fumarate (MEF) and its salts, are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. It is widely believed that the pharmaceutical activities of fumarates are exerted through the Keap1-Nrf2 pathway. Although it has been revealed that DMF and MEF differentially modify specific Keap1 cysteine residues and result in the differential activation of Nrf2, how the modification of DMF and MEF impacts the biochem. properties of Keap1 has not been well characterized. Here, we found that both DMF and MEF can only modify the BTB domain of Keap1 and that only C151 is accessible for covalent binding in vitro. Dynamic fluorescence scanning (DSF) assays showed that the modification of DMF to Keap1 BTB increased its thermal stability, while the modification of MEF dramatically decreased its thermal stability. Further crystal structures revealed no significant conformational variation between the DMF-modified and MEF-modified BTBs. Overall, our biochem. and structural study provides a better understanding of the covalent modification of fumarates to Keap1 and may suggest fundamentally different mechanisms adopted by fumarates in regulating the Keap1-Nrf2 pathway.

Biochemical and Biophysical Research Communications published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Application of Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics