Tag: M.W=100-150

Ullah, Mohammad Shahid published the artcileCinchona Squaramide-Based Chiral Polymers as Highly Efficient Catalysts in Asymmetric Michael Addition Reaction, Related Products of esters-buliding-blocks, the publication is ACS Omega (2018), 3(4), 4573-4582, database is CAplus and MEDLINE.

We have synthesized novel chiral polymers containing a cinchona-based squaramide in the main chain. We designed a novel cinchona squaramide dimer that contains two cinchona squaramide units connected by diamines. The olefinic double bonds in the cinchona squaramide dimer were used for Mizoroki-Heck (MH) polymerization with aromatic diiodides. The MH polymerization of the cinchona squaramide dimer and aromatic diiodide proceeded well to give the corresponding chiral polymers in good yields. The catalytic activity of the chiral polymers was investigated for asym. Michael addition reactions. The effect of the squaramide structure of the polymeric catalyst on the catalytic performance is discussed in detail. We have surveyed the influence of the chiral polymer structure on the catalytic activity and enantioselectivity of the asym. reaction. The asym. Michael addition of β-ketoesters to nitroolefins was successfully catalyzed by polymeric cinchona squaramide organocatalysts to obtain the corresponding Michael adducts in good yields with excellent enantio- and diastereoselectivities. The polymeric catalysts were insoluble in commonly used organic solvents and easily recovered from the reaction mixture and reused several times without the loss of catalytic activity.

ACS Omega published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C15H15OP, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yoshimura, Akira published the artcileHypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones, SDS of cas: 924-99-2, the publication is European Journal of Organic Chemistry (2019), 2019(39), 6682-6689, database is CAplus.

An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from resp. aldoximes using hypervalent iodine reagent was developed for the synthesis of 3,4-disubstituted isoxazoles I [R = n-Pr, Ph, 1-naphthyl, etc.; R¹ = H, Me, Ph, etc.; R² = H, Me]. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of products I in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallog.

European Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C8H5IO, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kantankar, Abhijit published the artcileRational design, synthesis, biological evaluation and molecular docking studies of chromone-pyrimidine derivatives as potent anti-cancer agents, COA of Formula: C6H10O3, the publication is Journal of Molecular Structure (2021), 130502, database is CAplus.

A series of pyrimidine based chromone hybrids I [R = Me, methoxymethyl, 4-fluorophenyl, etc.; R¹ = H, methoxycarbonyl, ethoxycarbonyl, etc.] were synthesized from 7-methoxy-8-formyl-chromone using facile multi-component modified Biginelli reaction. All the synthesized compounds I were characterized and evaluated for their in-vitro anti-cancer activity against three cancer cell lines, human cervical (HeLa), lung (A549), myelogenous leukemia (K562) cancer cell lines and on a normal cell line(HEK-293) for the selectivity reference Among them, compounds I [R = 4-fluorophenyl, 2-fluorophenyl, 4-methoxyphenyl, 4-(trifluoromethoxy)phenyl; R¹ = H] and I [R = methoxymethyl, methyl; R¹ = methoxycarbonyl, ethoxycarbonyl] exhibited potent anti-cancer activities against A549, HeLa and K562 cell lines with IC₅₀ values in micro molar range. The compounds I were displayed selective anti-cancer activity against K562 cell line compared to on other cancer cell lines. All the compounds I showed relative non-toxicity against normal cell line. The selectivity of the compounds against K562 cell line has been substantiated by mol. docking in BCR-ABL Tyrosine kinase using genetic algorithm program (GOLD 3.0.1). These results indicated that the chromones I were promised as the anti-cancer agents for the effective treatment of different types of cancers.

Journal of Molecular Structure published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Awadi, Nouria A. published the artcileEnaminones in a multicomponent synthesis of 4-aryldihydropyridines for potential applications in photoinduced intramolecular electron-transfer systems, Quality Control of 924-99-2, the publication is Beilstein Journal of Organic Chemistry (2012), 441-447, database is CAplus and MEDLINE.

An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1,4-dihydropyridines with different substituents at the 1-, 3-, 4- and 5-positions. Microwaves improved the reaction yield, reducing also considerably the reaction time and the amount of solvent used. Chiral primary amines gave chiral 1-substituted-1,4-dihydropyridines. The 4-(1-naphthyl) and 4-(phenanthren-9-yl)dihydropyridine derivatives exhibited an interesting photoluminescence behavior, which suggests their potential application as suitable photoinduced intramol. electron-transfer systems.

Beilstein Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kolarevic, Ana published the artcileSynthesis and DNase I inhibitory properties of some 4-thiazolidinone derivatives, Synthetic Route of 19788-49-9, the publication is Journal of Cellular Biochemistry (2019), 120(1), 264-274, database is CAplus and MEDLINE.

Twelve new thiazolidinones were synthesized and, together with 41 previously synthesized thiazolidinones, evaluated for inhibitory activity against DNase I (DNase I) in vitro. Ten compounds inhibited com. bovine pancreatic DNase I with an IC50 below 200 μM and showed to be more potent DNase I inhibitors than crystal violet (IC50 = 365.90 ± 47.33 μM), used as a pos. control. Moreover, three compounds were active against DNase I in rat liver homogenate, having an IC50 below 200 μM. (3-Methyl-1,4-dioxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (41) exhibited the most potent DNase I inhibition against both com. and rat liver DNase I with IC50 values of 115.96 ± 11.70 and 151.36 ± 15.85 μM, resp. Site Finder and mol. docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168. The three most active compounds against both com. and rat liver DNase I (31, 38, and 41) exhibited favorable physico-chem., pharmacokinetic, and toxicol. properties. These observations could be utilized to guide the rational design and optimization of novel thiazolidinone inhibitors. Thiazolidinones as novel DNase I inhibitors could have potential therapeutic applications due to the significant involvement of DNase I in the pathophysiol. of many disease conditions.

Journal of Cellular Biochemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vereshchagin, Anatoly N. published the artcileHighly diastereoselective four-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines, Formula: C6H10O3, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2021), 57(9), 929-933, database is CAplus.

A novel four-component diastereoselective synthesis of polysubstituted tetrahydropyridines (4SR,6RS)-I (R = H, 3-F, 4-Me, 4-Cl, etc.; R¹ = Me, Et, Ph, 4-bromophenyl; R² = Me, Et) is reported. The Michael addition – Mannich reaction – cyclization – dehydration cascade of benzylidenemalononitriles RC₆H₄CH=C(CN)₂, esters of 3-oxocarboxylic acids R¹C(O)CH₂C(O)OR², aromatic aldehydes RC₆H₄CHO, and ammonium acetate in methanol provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine- 3-carboxylates (4SR,6RS)-I with two stereocenters in 66-92% yields. The formation of products was highly stereoselective, with only one diastereomer formed. Ammonium acetate plays dual role acting as a base and as a nitrogen source. The formation of single diastereomer was confirmed by singe crystal X-ray diffraction studies.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C8H17Br, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Umemoto, Nao published the artcileDevelopment of regioselective [2 + 3] cycloaddition reactions of nitrile oxides with alkenes using intramolecular reactions through oxime groups [1], Recommanded Product: Dimethyl fumarate, the publication is Tetrahedron (2022), 132833, database is CAplus.

Nitrile oxides afford 2-isoxazoline heterocycles through [2 + 3] cycloaddition reactions with alkenes. These heterocycles can be converted to useful intermediates, such as β-hydroxy ketones and γ-amino alcs., leading to pharmaceutical and agrochem. compounds However, nitrile oxides directly connected to a carbonyl group show low reactivity owing to the decrease in energy of the dipole HOMO. Furthermore, when dissym. internal alkenes are used, regioselective control is difficult. Herein, authors have designed nitrile oxides bound to alkenes through the oxime group and demonstrated their intramol. [2 + 3] cycloaddition reactions. The desired cycloadducts were obtained in high yields and as single regioisomers. Furthermore, face-selective cycloaddition reactions were achieved by introducing a stereocenter into the linker moiety, affording the desired cycloadducts with good diastereoselectivity.

Tetrahedron published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C12H23N3S, Recommanded Product: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lin, Chih-Yu published the artcileRhodium-Catalyzed [4+2] Annulation of N-Aryl Pyrazolones with Diazo Compounds To Access Pyrazolone-Fused Cinnolines, Recommanded Product: Methyl 3-oxovalerate, the publication is European Journal of Organic Chemistry (2021), 2021(35), 4984-4992, database is CAplus.

An efficient synthesis of novel dinitrogen-fused heterocycles such as pyrazolo[1,2-a]cinnoline derivatives have been accomplished by the rhodium(III)-catalyzed reaction of N-arylpyrazol-5-ones with α-diazo compounds This reaction proceeds through a cascade C-H activation/intramol. cyclization with a broad substrate scope. Furthermore, this protocol is successfully extended to the unusual phosphorus-containing α-diazo compounds and cyclic diazo compounds as the cross-coupling partners to deliver the two new kinds of pyrazolo[1,2-a]cinnolinones. The control experiments were performed to reveal insight into the mechanism of this reaction, involving reversible C-H activation, migratory insertion of the diazo compound, and cascade cyclization as the key steps of the transformation. Moreover, gram-scale synthesis and further transformation of the target product demonstrate the synthetic utility of the present protocol.

European Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Zhiyan published the artcileSynthesis of indoles and carbazoles from a lignin model compound α-hydroxyacetophenone, COA of Formula: C6H10O3, the publication is Green Chemistry (2022), 24(7), 2919-2926, database is CAplus.

Herein an efficient strategy of using an oxidized lignin model compound, α-hydroxyacetophenone, as starting material to synthesize indoles or carbazoles in conjunction with using pyrroles or indoles as counterpart reagents was described. The reactions were performed using Sc(OTf)₃ as a catalyst in a bio-based green solvent, glycerol, and moderate to excellent yields were obtained. At the end of the reaction, both solvent and catalyst was recovered and reused. The novel approach presented here not only provided an eco-efficient route for the value-added conversion of lignin degradation products, but also extends the diversity of indole and carbazole derivatives, which are of potential importance in the development of functional photo-elec. materials.

Green Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xi, Yang published the artcileCatalytic Asymmetric Diarylation of Internal Acyclic Styrenes and Enamides, Product Details of C6H8O4, the publication is Journal of the American Chemical Society (2022), 144(18), 8389-8398, database is CAplus and MEDLINE.

Enantioselective transformations of olefins are among the most important strategies for the asym. synthesis of organic compounds Chemo-, diastereo-, and stereoselective control of reactions with internal acyclic alkenes for the construction of functionalized acyclic alkanes still remain a persistent challenge. Here, authors report a palladium-catalyzed asym. regiodivergent Heck-type diarylation of internal acyclic alkenes. The 1,2-diarylation of two accessible acyclic alkenes, cinnamyl carbamates and enamides with diazonium salts and aromatic boronic acids, furnishes products containing vicinal stereogenic centers via the stereospecific formation of carbonyl coordination-assisted transient palladacycles. Moreover, the asym. migratory diarylation of enamides enables the formation of incontiguous stereocenters by an interrupted diastereoselective 1,3-chain-walking process. This protocol streamlines access to highly functionalized multisubstituted enantioenriched carbamates and amine derivatives which are embedded in the key biol. active motifs.

Journal of the American Chemical Society published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C12H14BNO2, Product Details of C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics