Tag: M.W=100-150

Gu, Hai-ning published the artcileStudy on new process of synthesizing levofloxacin, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Gaoxiao Huaxue Gongcheng Xuebao (2005), 19(5), 708-711, database is CAplus.

New process for preparing the fluoroquinolone antibacterial drug levofloxacin was described. The object compound was prepared from 2,3,4,5-tetrafluorobenzoic acid, via acyl chlorination, Et N,N-dimethylamino-acrylate coupling, S-(+)-2-aminopropanol displacement, cyclization, hydrolysis, and finally N-methylpiperazine condensation, the total yield is 52.3%. Comparing to the old process conventionally used at present, the application of the new starting material Et N, N-dimethylamino-acrylate can curtail three reaction steps, they are the di-Et malonate condensation, partial hydrolysis decarboxylation and triethylorthoformate condensation. New process has many advantages, such as simple procedure, short reaction period, high optical purity, cheaper raw material, higher yield. So it should have a good prospect for industrial application.

Gaoxiao Huaxue Gongcheng Xuebao published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gu, Hai-ning published the artcileSynthesis of Gatifloxacin hydrochloride, Computed Properties of 924-99-2, the publication is Zhejiang Daxue Xuebao, Lixueban (2005), 32(1), 66-68, 74, database is CAplus.

Gatifloxacin was prepared from 3-methoxy-2,4,5-triflurobenzoic acid via acylation, followed by coupling with Et N,N-dimethylaminoacrylate, replacement with cyclopropyl amine, after cyclization and hydrolysis, condensation with 2-methylpiperazine, further hydrolysis, and saltification, provided title product with overall yield 441.1%.

Zhejiang Daxue Xuebao, Lixueban published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yoshii, Daichi published the artcileGold nanoparticles on OMS-2 for heterogeneously catalyzed aerobic oxidative α,β-dehydrogenation of β-heteroatom-substituted ketones, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(99), 14314-14317, database is CAplus and MEDLINE.

In the presence of Au nanoparticles supported on manganese oxide OMS-2 (Au/OMS-2), various kinds of β-heteroatom-substituted α,β-unsaturated ketones (heteroatom = N, O, S) can be synthesized through α,β-dehydrogenation of the corresponding saturated ketones using O₂ (in air) as the oxidant. The catalysis of Au/OMS-2 is truly heterogeneous, and the catalyst can be reused.

Chemical Communications (Cambridge, United Kingdom) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H12ClNO, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fan, Wuhou published the artcileAchieving fast self-healing and reprocessing of supertough water-dispersed “living” supramolecular polymers containing dynamic ditelluride bonds under visible light, Related Products of esters-buliding-blocks, the publication is ACS Applied Materials & Interfaces (2020), 12(5), 6383-6395, database is CAplus and MEDLINE.

It is very challenging to achieve polymers that are mech. robust and fast self-healable at ambient conditions, which are highly desirable for smart materials of the next-generation. Herein, combining dynamic ditelluride bonds and 2-ureido-4[1H]-pyrimidinone (UPy) moieties in the main chains, a novel type of visible-light-induced self-healing water-dispersed supramol. polymers (DTe-WSPs) with outstanding healing properties were developed. The prepared DTe-WSPs emulsions showed excellent emulsion stability, and highly transparent DTe-WSPs films obtained from these emulsions exhibited much improved mech. properties and fast recoverability after the incorporation of UPy groups, owing to the phys. cross-links formed by quadruple hydrogen-bonded UPy moieties. Supertoughness (105.2 MJ m^-3) and fast self-healability under visible light (healing efficiency of 85.6% within 10 min) could be achieved simultaneously with the adjustment of the ditelluride content and the UPy content, and the toughness of our polymers is higher than those of the reported ambient temperature self-healable polymers. The visible-light-induced ditelluride metathesis is a predominant factor in the healing process of DTe-WSPs, and the ditelluride metathesis triggered by photothermy and hydrogen bonding could also afford the ultimate healing result. Meanwhile, DTe-WSPs can be reprocessed using visible light, providing a facile way to process polymers at mild conditions. To our surprise, the “living” DTe-WSPs exhibited the ability to initiate the polymerization of vinyl monomers under visible light, which is first reported for water-dispersed self-healing polymers. We considered the elaborated design philosophy, based on the readily available, clean, safe, and easily manipulated visible light, which can not only provide inspiration for preparing fast ambient temperature self-healing and reprocessing polymer materials with robust mech. properties but also develop a new macroinitiator to initiate the ambient temperature polymerization of vinyl monomers.

ACS Applied Materials & Interfaces published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kumar, Ish published the artcileA Thioesterase for Chemoselective Hydrolysis of S-Acyl Sulfanylalkanoates, Synthetic Route of 19788-49-9, the publication is Organic Letters (2001), 3(2), 283-285, database is CAplus and MEDLINE.

A thioesterase, isolated from a strain of Alcaligenes sp. ISH108, chemoselectively hydrolyzes the thiol ester moiety of S-acyl sulfanylalkanoates. The application of the enzyme has been demonstrated in the preparation of the antihypertensive agent captopril.

Organic Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dwivedi, Durgesh Kumar published the artcileSimultaneous Modulation of NLRP3 Inflammasome and Nrf2/ARE Pathway Rescues Thioacetamide-Induced Hepatic Damage in Mice: Role of Oxidative Stress and Inflammation, COA of Formula: C6H8O4, the publication is Inflammation (2022), 45(2), 610-626, database is CAplus and MEDLINE.

Chronic tissue injury resulting in fibrosis of multiple organs, responsible for one-third of the death globally. Liver fibrosis is a common pathway/condition involved in all chronic liver diseases. Thioacetamide (TAA), a hepatotoxicant, was used to induce hepatic fibrosis. Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation. Di-Me fumarate (DMF), a multiple sclerosis drug, activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway and maintains the antioxidant status in the cell. The present study was designed to investigate (i) role of NLRP3 inflammasome and Nrf2/ARE pathway in TAA-induced hepatotoxicity and liver fibrosis, (ii) mechanism involved in GLB and DMF mediated hepatoprotection against TAA-induced hepatotoxicity, and (iii) addnl./synergistic hepatoprotective effect of combination treatment with NLRP3 inhibition + Nrf2 activation or GLB + DMF or MCC950 + 4OI to reverse/ameliorate the exptl. liver fibrosis completely. TAA was administered i.p. to mice for seven consecutive weeks, and treatments of GLB, DMF, GLB + DMF, MCC950, 4OI, and MCC950 + 4OI were provided for the last three consecutive weeks. The intervention with GLB, DMF, GLB + DMF, MCC950, 4OI, and MCC950 + 4OI significantly protected TAA-induced oxidative stress and inflammatory conditions by improving biochem., histol., and immunoexpression changes in mice. The GLB, DMF, and GLB + DMF intervention exhibited a better protective effect compared with MCC950, 4OI, and MCC950 + 4OI, which revealed that this specific inhibitor/activator possesses only NLRP3 inflammasome inhibitory/Nrf2 activatory properties. In contrast, the clin. drug GLB and DMF have several other beneficial effects, which are independent of NLRP3 inhibition and Nrf2 activation.

Inflammation published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, COA of Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hansen, Camilla P. published the artcileCarbamoylcholine analogs as nicotinic acetylcholine receptor agonists-Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC), Application In Synthesis of 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(1), 87-91, database is CAplus and MEDLINE.

Compounds based on the 3-(dimethylamino)butyl dimethylcarbamate (DMABC) scaffold were synthesized and pharmacol. characterized at the α₄β₂, α₃β₄, α₄β₄ and α₇ neuronal nicotinic acetylcholine receptors (nAChRs). The carbamate functionality and a small hydrophobic substituent in the C-3 position were found to be vital for the binding affinity to the nAChRs, whereas the carbamate nitrogen substituents were important for nAChR subtype selectivity. Finally, the compounds were found to be agonists at the α₃β₄ nAChR.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application In Synthesis of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Tongyan published the artcileFacile synthesis of penta-substituted pyrroles and pyrrole-fused piperidin-4-ones via four component reactions of 2,3-diketoesters, anilines and enaminones, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Chemistry Frontiers (2021), 8(20), 5716-5721, database is CAplus.

Herein, a novel BF₃.Et₂O mediated four component reaction of 2,3-diketoesters RC(O)C((OH)₂)C(O)R¹ (R = Me, 2-phenylethenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R¹ = OMe, OEt, (2-methylpropyl)oxidanyl, dimethylaminyl, OBn), anilines 4-R²C₆H₄NH₂ (R² = H, Me, Br, methoxycarbonyl, etc.) and enaminones R³C(O)CH=CHN(CH₃)₂ (R³ = OEt, Ph, furan-2-yl, etc.)/R⁴CH=CHC(O)CH=CHN(CH₃)₂ (R⁴ = Ph, 4-methoxyphenyl), providing highly functionalized pyrroles I and pyrrole-fused piperidin-4-ones II in moderate to good yields was presented. The key to success lies in the utilization of enaminone as the substrate and precise capture of the carbocation intermediate by anilines, allowing the amination to occur at the 5-position smoothly. This strategy is potentially applicable to diverse nucleophilic reagents. Moreover, an intramol. version of this strategy can be utilized to form fused heterocycles.

Organic Chemistry Frontiers published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C4H4N2O2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Zhidong published the artcileRadiosynthesis of a carbon-11 labeled PDE5 inhibitor [¹¹C]TPN171 as a new potential PET heart imaging agent, Recommanded Product: Methyl 3-oxovalerate, the publication is Applied Radiation and Isotopes (2020), 109190, database is CAplus and MEDLINE.

To develop PET tracers for imaging of heart disease, a new carbon-11 labeled potent and selective PDE5 inhibitor [¹¹C]TPN171 ([¹¹C]9) has been synthesized. The reference standard TPN171 (9) and its corresponding precursor desmethyl-TPN171 (11) were synthesized from Me 3-oxovalerate and 2-hydroxybenzonitrile in 9 and 10 steps with 31% and 25% overall chem. yield, resp. The radiotracer [¹¹C]TPN171 was prepared from desmethyl-TPN171 with [¹¹C]CH₃OTf through N-¹¹C-methylation and isolated by HPLC purification followed by SPE formulation in 45-55% radiochem. yield, based on [¹¹C]CO₂ and decay corrected to EOB. The radiochem. purity was >99%, and the molar activity (A_m) at EOB was in a range of 370-740 GBq/μmol.

Applied Radiation and Isotopes published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C22H18O2, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yuan, Chuan published the artcileStudy on catalytic pyrolysis mechanism of seaweed polysaccharide monomer, SDS of cas: 517-23-7, the publication is Combustion and Flame (2020), 1-11, database is CAplus.

In this study, L-rhamnose monohydrate (LRM) was used as a model compound of seaweed polysaccharide to study its pyrolysis and catalytic pyrolysis mechanism. Initially, the weight loss curve of LRM was obtained by thermogravimetric anal. The main weight loss temperature was found to be at 350-550°C. Then, the pyrolysis mechanism of LRM was analyzed and verified by macroscopic experiments and mol. simulations. Experiments showed that the bio-oil yield was highest when the temperature reached around 500°C, and the bio-oil contained large amount of furan substances. Finally, the effects of different proportions of catalysts (Mg-Ce/ZSM-5) on bio-oil products were studied, and the catalytic reaction mechanism was discussed.

Combustion and Flame published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C4H3Cl2N3, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics