Tag: M.W=100-150

Pritykin, L. M. published the artcileTo evaluation of the steric effect in organic compounds, Synthetic Route of 5340-78-3, the publication is Journal of Structural Chemistry (Translation of Zhurnal Strukturnoi Khimii) (2001), 41(5), 901-904, database is CAplus.

A new approach was developed to calculation of solid angles, which are a measure of steric effect in organic mols.; the approach is based on the geometrical model. The solution is implemented as a computer program.

Journal of Structural Chemistry (Translation of Zhurnal Strukturnoi Khimii) published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Synthetic Route of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zahra, Jalal A. published the artcileSynthesis of some ethyl 3-(aryldiazenyl)-7-oxodihydropyrido[2,3-f]quinoxaline-8-carboxylates, Category: esters-buliding-blocks, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (2007), 62(8), 1045-1051, database is CAplus.

Et 7,8-diamino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (6) and its free acid were prepared by chem. reduction of the resp. 7-azido-8-nitroquinoline. Consecutive nucleophilic addition and cyclocondensation reactions of 6 with α-acetyl-N-arylhydrazonoyl chlorides in EtOH and NEt₃ are site-selective and yield the corresponding 3-(arylazo)-2-methylpyrido[2,3-f]quinoxalines.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C8H5F3O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nishimura, Yoshio published the artcileSynthesis of 6-unsubstituted 2-oxo, 2-thioxo, and 2-amino-3,4-dihydropyrimidines and their antiproliferative effect on HL-60 cells, Computed Properties of 924-99-2, the publication is Tetrahedron Letters (2020), 61(28), 151967, database is CAplus.

A general and efficient synthetic method for 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-thiones and -ones I (R = H, C₆H₅, 4-ClC₆H₄, etc., X = S, O) has been developed. In three-component reactions, the reactivity of reagents serving as the C5-C6 fragment of the dihydropyrimidine ring was compared. The reaction of thiourea or urea, aldehydes RCHO, and Et 3-(dimethylamino)acrylate in the presence of a catalytic amount of AlCl₃ by smooth heating proceeds to give I in high yields. Synthetic novelty of the protocol are as follows: (1) Lewis acid-mediated reaction, (2) good to high yields, and (3) broad scope as for aldehydes and ureas. Hitherto unavailable 6-unsubstituted 2-aminodihydropyridimidines II (R = n-Pr, Ph) have been obtained from the 2-thioxo derivative I (X = S) by a stepwise method involving substitution reaction with the amine at the 2-position. The 6-unsubstituted compounds I and 6-Me derivatives III (R = cyclohexyl, n-Pr) were assessed for their antiproliferative effect on the human promyelocytic leukemia cell line, HL-60. The 4-propyl-6-Me derivative III (R = n-Pr) showed relatively strong activity with the IC₅₀ value of 952 nM.

Tetrahedron Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shin, Dongha published the artcileGold nanoparticle-mediated non-covalent functionalization of graphene for field-effect transistors, Formula: C6H8O3, the publication is Nanoscale Advances (2021), 3(5), 1404-1412, database is CAplus.

Since its discovery, graphene has attracted much attention due to its unique elec. transport properties that can be applied to high-performance field-effect transistors (FETs). However, mounting chem. functionalities onto graphene inevitably involves the breaking of sp² bonds, resulting in the degradation of the mech. and elec. properties compared to pristine graphene. Here, we report a new strategy to chem. functionalize graphene for use in FETs without affecting the elec. performance. The key idea is to control the Fermi level of the graphene using the consecutive treatment of gold nanoparticles (AuNPs) and thiol-SAM (self-assembled monolayer) mols., inducing pos. and neg. doping effects, resp., by flipping the elec. dipoles between AuNPs and SAMs. Based on this method, we demonstrate a Dirac voltage switcher on a graphene FET using heavy metal ions on functionalized graphene, where the carboxyl functional groups of the mediating SAMs efficiently form complexes with the metal ions and, as a result, the Dirac voltage can be pos. shifted by different charge doping on graphene. We believe that the nanoparticle-mediated SAM functionalization of graphene can pave the way to developing high-performance chem., environmental, and biol. sensors that fully utilize the pristine properties of graphene.

Nanoscale Advances published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C11H20N2O3, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gembus, Vincent published the artcileRegioselective pinacol rearrangement of unsymmetrical cyclobutane-1,2-diols, Application In Synthesis of 517-23-7, the publication is Bulletin of the Chemical Society of Japan (2018), 91(3), 319-336, database is CAplus.

Hydroxy-sulfone I, prepared as a mixture of trans and cis isomers, was found to rearrange selectively either to the cyclopropanic β-ketosulfone II or the isomeric Me ketone III by using, resp., the tosyl fluoride/DBU and the DAST reagent. The potential of this methodol. has been illustrated by a synthesis of phytal from geranylacetone, and by the preparation from 3,4-hexanedione and prenol – via the cyclopropanic β-ketosulfone IV (X-ray) – of an advanced fragment of the juvenile hormone V.

Bulletin of the Chemical Society of Japan published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Application In Synthesis of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Iliyasov, Taigib M. published the artcileStereoselective one-pot five-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines with two and three stereocenters, COA of Formula: C6H10O3, the publication is ARKIVOC (Gainesville, FL, United States) (2022), 232-244, database is CAplus.

A novel five-component stereoselective synthesis of polysubstituted tetrahydropyridines is reported. The Knoevenagel condensation – Michael addition – Mannich reaction – cyclization – dehydration cascade of aldehydes, esters of 3-oxocarboxylic acids C-H acids and ammonium acetate provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine-3-carboxylates with two stereocenters and 3,5-dialkyl (4RS,5SR,6RS)-5-cyano-2,4,6-triaryl-1,4,5,6-tetrahydropyridine-5,3-carboxylates with three stereocenters in 57-84% yields. It was established that formation of products proceeds via substituted 2-hydroxypiperidines with four stereocenters. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Five bonds are formed as a result of multicomponent process. The formation of single diastereomers was confirmed by singe crystal X-ray diffraction studies and 2D-NMR spectroscopy.

ARKIVOC (Gainesville, FL, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rajmani Singh, Rahul Kumar published the artcileCopper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights, Synthetic Route of 517-23-7, the publication is Molecular Catalysis (2020), 111067, database is CAplus.

Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%.

Molecular Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Synthetic Route of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Hiari, Yusuf M. published the artcileFluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Medicinal Chemistry Research (2014), 23(7), 3336-3346, database is CAplus.

Pancreatic triacylglycerol lipase (PL) has been reported as an interesting pharmacol. target for the management of dyslipidemia, atherosclerosis, and obesity. In the current study, a 4-quinoline-3-carboxylic acid system has been identified as a potent inhibitor of PL. Three new fluoroquinolones (11, 12, (I) and 13 (II)) were synthesized and evaluated in vitro with respect to their anti-lipase efficacy and potency properties and gave IC₅₀ values in the range of 18.4-29.1 μM against PL. The IC₅₀ of the standard drug orlistat was 0.2 μM. The inhibitory activities of these compounds were supported by docking studies, which suggested that they acted according to a similar mechanism to that of the known drug orlistat. In conclusion, these effective PL inhibitors could be used to advance the development of anti-obesity drugs via the regulation of the entire gastrointestinal lipolysis process.

Medicinal Chemistry Research published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Weiping published the artcileFe-Catalyzed Dicarbofunctionalization of Vinylarenes with Alkylsilyl Peroxides and β-Keto Carbonyl Substrates, Related Products of esters-buliding-blocks, the publication is Organic Letters (2022), 24(14), 2641-2645, database is CAplus and MEDLINE.

The formation of two carbon-carbon bonds using vinylarenes with alkylsilyl peroxides and β-keto carbonyl substrates is effected in the presence of catalytic Fe(OTf)₂ under mild reaction conditions. A variety of vinylarenes with different substituents can be utilized in combination with several different alkylsilyl peroxides and β-keto carbonyl substrates.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C9H22OSi, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Giannopoulos, Vasileios published the artcileDichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium, Quality Control of 30414-53-0, the publication is Synthesis (2022), 54(10), 2457-2463, database is CAplus.

A new method for the α,α-dichlorination of β-keto esters using oxone/aluminum trichloride mixture in aqueous medium had been developed. This useful process had also been applied successfully for the dichlorination of 1,3-diketones. The dichlorinated compds of formula I [R¹ = CH₃, C₂H₅, vinyl, etc.; R² = CH₃, C₂H₅, t-Bu]. had been produced in one step, high yields, and short reaction times.

Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics