Tag: M.W=100-150

Ye, Juan published the artcileUV-Curable Polyurethane Elastomer with UV-Irradiation/Thermo Dual-Activated Self-Healability, SDS of cas: 517-23-7, the publication is Macromolecular Materials and Engineering (2022), 307(6), 2100874, database is CAplus.

Self-healable polyurethane elastomers have potential applications in many fields, however, their use is limited by single self-healing mechanism, intricate preparation process, and long curing time. Herein, a UV-irradiation/thermo dual-induced self-healing polyurethane elastomer is prepared by UV-curing two kinds of acrylates, where one includes a quadruple hydrogen bond (PU-UPy-HEA) and the other contains a disulfide bond (SS-MA). UV-curing kinetics indicate that the conversion of acrylates is significantly improved by tuning the irradiation intensity, photoinitiator dosage, and SS-MA content. A maximum conversion of 80% is achieved within 10 s under 200 mW cm^-2 in the case of the 1.5 weight% photoinitiator. The tensile strength of UV-cured polyurethane elastomer is notably improved by SS-MA, whereas its elongation at break decreases. Tensile shear tests demonstrates that the bisected samples can be re-bonded when they are repaired at 100°C for 15 min, or under 200 mW cm^-2 irradiation for 1 h. After that, ∼90% of shear strength is recovered and the strength is only slightly reduced after two healing cycles. Self-healing mainly relies on thermally reversible hydrogen bonding interactions and UV-induced disulfide metathesis. This UV-cured self-healable polyurethane elastomer can be used in smart coatings as well as in other fields.

Macromolecular Materials and Engineering published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C10H15NS, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Shenfeng published the artcile2-aryl-3-carbonylquinolones: design, synthesis and biological evaluation of novel HCV NS5B polymerase inhibitors, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Huaxue Xuebao (2014), 72(8), 906-913, database is CAplus.

Hepatitis C virus (HCV) infection is a global health problem that impacts approx. 180 million individuals. Until recently the current therapy for treating HCV infection has been regular injections of pegylated α-interferon (PEG-IFN) with daily oral administration of ribavirin (RBV). However, PEG-IFN/RBV treatment is only effective for only 50% of genotype 1 patients and associated with significant adverse effects including fatigue, hemolytic anemia, depression, and flulike symptoms. Therefore, the search for direct acting antivirals (DAAs) that are safe and effective has become an urgent endeavor. HCV NS5B polymerase, an essential enzyme for the HCV RNA replication, has emerged as an attractive and validated target for the direct HCV therapeutic intervention. Since NS5B polymerase needs a divalent metal ion as a cofactor in the active site for its catalytic function, the metal chelation motif-containing quinolone-3-carboxylic scaffold has been explored as a new class of non-nucleoside NS5B inhibitors. Two groups have recently reported a preliminary structure-activity relationship (SAR) study on the 4-quinolone-3-carboxylic acids as HCV NS5B inhibitors, just focused on the N-1, C-3 and C-6/7 substitutions. Based on the binding mode revealed by the cocrystal structure of the quinolone inhibitor bound to the NS5B enzyme, for the first time we proposed to introduce a hydrophobic group at C-2 position on the quinolone ring to improve the anti-HCV potency. By making use of the new method to synthesize 2-substituted quinolone-3-carboxylic acid derivatives recently developed by our group, we conducted a comprehensive SAR study on the 2-aryl-3-carbonylquinolone-based non-nucleoside inhibitors of HCV NS5B polymerase. Starting from the readily accessible amides and 3-oxo-3-arylpropanoates, structurally diverse 2-substituted quinolone-3-carboxylic acid derivatives were efficiently furnished by a tandem addition-elimination reaction/nucleophilic aromatic substitution reaction via an imine-enamine intermediate. The anti-HCV potency and cytotoxicity were evaluated in the HCV-infected host cells Huh7.5.1 assay system. To our delight, the incorporation of a hydrophobic aryl group into 2-position of the quinolone core really enhanced the inhibitory activity against the HCV replication in the host cells with a 2-fold selectivity over the cytotoxicity. Meanwhile, a small size hydrophobic group at N-1 position was favored for the 2-arylquinolone-derived NS5B inhibitors. Further structural variation was investigated on the C-3 and C-7 substituents, with an aromatic ester and an N-Me piperazine being an optimal moiety, resp. The global structural optimization at positions N-1, C-2, C-3 and C-7 resulted in the discovery of novel 2-aryl substituted quinolone inhibitors with low micromolar EC₅₀ values to inhibit the replication of the HCV RNA in the host cell Huh7.5.1 and therapeutic indexes of 2∼6, providing a new promising lead for the further development into anti-HCV drug candidates.

Huaxue Xuebao published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C9H7NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Xin-Ran published the artcileSequential Cobalt/Rhodium-Catalyzed Tandem Cyclization of Aromatic Aldehydes with Acrylates for Preparing 3-Substituted Phthalides in Oxygen Atmosphere and Neat Water, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Asian Journal of Organic Chemistry (2022), 11(2), e202100725, database is CAplus.

Metal-catalyzed C-H activation/tandem reactions of aromatic acids and functionalized alkenes is profound for constructing phthalide skeleton. However, most of these reactions employ stoichiometric amounts of metal additives and metal oxidants/toxic organic solvents. Herein, a sequential cobalt/rhodium-catalyzed tandem cyclization of aromatic aldehydes and acrylates for preparing 3-substituted phthalides in one pot has been described. This protocol features the use of water as a sustainable solvent and oxygen as the singular oxidant free of any additives. The use of aromatic aldehydes instead of aromatic acids as starting materials renders this route high atom economy, and the formation of water as a sole byproduct makes this process practical and environmentally benign.

Asian Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xia, Qi published the artcileCopper-Catalyzed Three-Component Reactions of α-Ketoaldehyde, 1,3-Dicarbonyl Compound, and Organic Boronic Acid in Water: A Route to 1,4-Diketones, Recommanded Product: Methyl 3-oxovalerate, the publication is Journal of Organic Chemistry (2021), 86(14), 9914-9923, database is CAplus and MEDLINE.

A novel three-component reaction of α-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.

Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C7H5Br2F, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bi, Xiaojing published the artcileDCDMH-promoted synthesis of thiophosphates by coupling of H-phosphonates with thiols, Product Details of C5H10O2S, the publication is Tetrahedron (2016), 72(5), 706-711, database is CAplus.

DCDMH-mediated (1,3-dichloro-5,5-dimethylhydantoin) phosphorylation of versatile thiols with H-phosphonates for the preparation of synthetically and biol. important thiophosphates was demonstrated. Without metal catalysts and other additives, phosphorylation occurred to give the desired products with good to excellent yields within 10 min at ambient temperature in the air.

Tetrahedron published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Product Details of C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Gang published the artcileBenzofused Tricycles Based on 2-Quinoxalinol, Application of Ethyl 2-mercaptopropanoate, the publication is Journal of Combinatorial Chemistry (2007), 9(1), 70-78, database is CAplus and MEDLINE.

This paper describes our recent efforts to synthesize novel compound scaffolds integrating 2-quinoxalinol with privileged structures of 1,3-dihydrobenzoimidazol-2-one, 1,3-dihydrobenzoimidazole-2-thione, 3-hydroxy-1H-quinoxalin-2-one, 2H-benzo[1,4]oxazin-3-ol, 2H-benzo[1,4]thiazin-3-ol, and 1,3,4,5-tetrahydro-benzo[1,4]diazepin-2-one, resp. Eight novel benzofused tricycles and their substituent diversity points were developed. These include pyrazino[2,3-g]quinoxaline-2,8-diol, 3-hydroxy-6,8,9,10-tetrahydro-1,4,6,10-tetraazacyclohepta[b]naphthalen-7-one, 6-hydroxy-4H-1-oxa-4,5,8-triazaanthracen-3-one, 6-hydroxy-4H-1-thia-4,5,8-triazaanthracen-3-one, 6-hydroxy-1,1-dioxo-1,4-dihydro-2H-1λ⁶-thia-4,5,8-triazaanthracen-3-one, 6-hydroxy-1,3-dihydroimidazo[4,5-g]quinoxalin-2-one, 6-hydroxy-1,3-dihydroimidazo[4,5-g]quinoxaline-2-thione, and 7-hydroxy-1,4-dihydropyrazino[2,3-g]quinoxaline-2,3-dione. This strategy of integrating two benzofused privileged structures into one mol. may provide a greater chance for the discovery of novel lead compounds

Journal of Combinatorial Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Gang published the artcileBenzofused tricycles based on 2-quinoxalinol. [Erratum to document cited in CA146:251809], Application In Synthesis of 19788-49-9, the publication is Journal of Combinatorial Chemistry (2008), 10(2), 343, database is CAplus.

The quinoxalin-2-ol mol. structure published in the article has been recently corrected to be quinoxalin-2-one by X-ray single-crystal anal. of an unambiguous configuration of chem. compound 1, which indicated that it was a 3,4-dihydroquinoxalin-2-one but not a quinoxalin-2-ol. The correct chem. structure for Compound 1 as synthesized by a published standard method is given in supplemental Figure 1.

Journal of Combinatorial Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application In Synthesis of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Lifu published the artcileVisible-light induced green synthesis of γ-deuterated carbonyl compounds, Quality Control of 19788-49-9, the publication is Tetrahedron Letters (2022), 153914, database is CAplus.

Deuteration is a widely used labeling technique. Through a visible-light induced desulfurization and radical addition process in EtOAc-D₂O, the authors were able to develop the direct synthesis of γ-deuterated carbonyl compounds from α-sulfide ketones and alkenes. Products with different functionalities were efficiently synthesized with high deuteration. This mild and metal-free method provides a valuable tool for medicinal and synthetic chemists.

Tetrahedron Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Quality Control of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Miao, Pannan published the artcileVisible-light induced metal-free cascade Wittig/hydroalkylation reactions, Synthetic Route of 19788-49-9, the publication is Green Chemistry (2021), 23(4), 1638-1641, database is CAplus.

Through a relay olefination and radical addition process, visible light induced cascade Wittig/hydroalkylation reactions were developed. This metal-free radical approach featured mild conditions, robustness and excellent functionality compatibility. It allowed access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method was demonstrated by a two-step synthesis of indolizidine 209D.

Green Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xie, Peizhong published the artcileAlkaline-earth Metal-Catalyzed Dehydrative Allylic Alkylation, Formula: C6H8O3, the publication is Organic Letters (2020), 22(1), 31-35, database is CAplus and MEDLINE.

An alk.-earth metal catalytic system for environmentally benign allylic alkylation was developed. Allylic alcs. can be utilized directly at room temperature in this transition metal-free process, producing water as the only byproduct. A variety of allylic compounds, including the ones containing all-carbonyl quaternary centers, can be obtained with high yields.

Organic Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C8H14O4, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics