Tag: M.W=100-150

Lynch, Denis published the artcileExploring the Scope of Asymmetric Synthesis of β-Hydroxy-γ-lactams via Noyori-type Reductions, Category: esters-buliding-blocks, the publication is Organic Letters (2016), 18(19), 4978-4981, database is CAplus and MEDLINE.

Enantio- and diastereoselective hydrogenation of β-keto-γ-lactams with a ruthenium-BINAP catalyst, involving dynamic kinetic resolution, has been employed to provide a general, asym. approach to β-hydroxy-γ-lactams, a structural motif common to several bioactive compounds Full conversion to the desired β-hydroxy-γ-lactams was achieved with high diastereoselectivity (up to >98% de) by addition of catalytic HCl and LiCl, while β-branching of the ketone substituent demonstrated a pronounced effect on the modest to excellent enantioselectivity (up to 97% ee) obtained.

Organic Letters published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rupp, Tristan published the artcileTherapeutic Potential of Fingolimod and Dimethyl Fumarate in Non-Small Cell Lung Cancer Preclinical Models., SDS of cas: 624-49-7, the publication is International journal of molecular sciences (2022), 23(15), database is MEDLINE.

New therapies are required for patients with non-small cell lung cancer (NSCLC) for which the current standards of care poorly affect the patient prognosis of this aggressive cancer subtype. In this preclinical study, we aim to investigate the efficacy of Fingolimod, a described inhibitor of sphingosine-1-phosphate (S1P)/S1P receptors axis, and Dimethyl Fumarate (DMF), a methyl ester of fumaric acid, both already approved as immunomodulators in auto-immune diseases with additional expected anti-cancer effects. The impact of both drugs was analyzed with in vitro cell survival analysis and in vivo graft models using mouse and human NSCLC cells implanted in immunocompetent or immunodeficient mice, respectively. We demonstrated that Fingolimod and DMF repressed tumor progression without apparent adverse effects in vivo in three preclinical mouse NSCLC models. In vitro, Fingolimod did not affect either the tumor proliferation or the cytotoxicity, although DMF reduced tumor cell proliferation. These results suggest that Fingolimod and DMF affected tumor progression through different cellular mechanisms within the tumor microenvironment. Fingolimod and DMF might uncover potential therapeutic opportunities in NSCLC.

International journal of molecular sciences published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, SDS of cas: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bosco-Levy, Pauline published the artcileComparative effectiveness of dimethyl fumarate in multiple sclerosis, SDS of cas: 624-49-7, the publication is British Journal of Clinical Pharmacology (2022), 88(3), 1268-1278, database is CAplus and MEDLINE.

To assess the effectiveness of di-Me fumarate (DMF) on annual rate of relapse subject to treatment (ARRt) and disability progression in multiple sclerosis (MS) compared to injectable immunomodulators (IMM), teriflunomide (TERI) and fingolimob (FTY), in real-life setting. A population-based cohort study was conducted using data of the French nationwide claims database, SNDS. All patients initiating IMM, TERI, FTY or DMF between 1 July 2015 and 12 Dec. 2017, with 4.5 years of database history and 1-3.5 years of follow-up were included in this study. DMF patients were 1:1 matched to IMM, TERI or FTY using a high dimensional propensity score. Neg. binomial regression and a logistic regression model were used to estimate the relative risk (RR ± [95% CI]) of ARRt and the odds ratio (OR ± [95% CI]) of disability progression, resp. Overall, 9304 subjects were identified: 29.0% initiated DMF, 33.2% TERI, 5.6% FTY and 32.2% an IMM. The matched cohorts consisted of 1779 DMF-IMM patients, 1679 DMF-TERI patients, and 376 DMF-FTY patients. DMF significantly reduced ARRt compared to IMM (RR 0.72 [0.61-0.86]) and TERI (0.81 [0.68-0.96]) and did not show any significant difference when compared with FTY. The risk of the progression of MS-specific disability was not significantly different for any matched cohorts. DMF is associated with lower risk of treated relapse for patients with RRMS than other first-line RRMS agents (TERI and IIM).

British Journal of Clinical Pharmacology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, SDS of cas: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lu, Hongyu published the artcileSynergistic degradation of fluorene in soil by dielectric barrier discharge plasma combined with P25/NH₂-MIL-125(Ti), HPLC of Formula: 624-49-7, the publication is Chemosphere (2022), 133950, database is CAplus and MEDLINE.

Plasma techniques to degrade pollutants are generally more efficient than conventional methods, but exist some problems such as high energy consumption, incomplete degradation of pollutants, and secondary pollution caused by highly toxic intermediates. In this study, the dielec. barrier discharge plasma (DBDP) combined with the Ti-based metal organic frameworks (MOFs) catalysts (P25/NH₂-MIL-125(Ti)) was used to degrade fluorene in the soil. The synergistic treatment technique used in soil remediation can realize a green and promising treatment efficiency with relatively low energy consumption. Compared with DBDP system alone, the synergetic treatment system of DBDP and P25/NH₂-MIL-125(Ti) considerably increased the degradation efficiency of fluorene in the soil to above 90% at 10 min, even with a relatively low discharge voltage (5 kV). The synergistic treatment system achieved 88.8% of fluorene mineralization at 60 min. Optical emission spectroscopy and ESR spectroscopy both showed that •OH and •O₂^– played an important role in the synergetic treatment system. Nine main intermediates were identified using gas chromatog.-mass spectrometry and Fourier transform IR anal. The main degradation of fluorine in soil was caused by the electronic transition of the catalytic material excited by DBDP, and finally mineralized into CO₂ and H₂O. The fluorene and its toxic intermediates were effectively removed. This study provides an insight for achieving high efficiency and environmentally friendly application perspective in soil remediation.

Chemosphere published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yang published the artcileElectrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation, Synthetic Route of 19788-49-9, the publication is ACS Catalysis (2019), 9(3), 1630-1634, database is CAplus.

This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodides under mild electrochem. conditions. The simple undivided cell with graphite felt/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chem. yields. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated by cyclic voltammetry.

ACS Catalysis published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H6N2O, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Randriamahefa, S. published the artcileImproved synthesis of tertiary alkylacetic acids and esters, SDS of cas: 5340-78-3, the publication is Synthesis (1985), 493-5, database is CAplus.

RR¹MeCCH₂CO₂H (R, R¹ = Me, Et) were prepared in 13-90% yield by treating CH₂:CCl₂ with RR¹MeCOH, H₂SO₄, and then H₂O. Similar treatment of CH₂:CCl₂ with Me₃COMe and Me₃CCl gave 55 and 77% Me₃CCH₂CO₂H resp. with some Me₃CCH₂CO₂Me also being formed when the ether was used. Addition of R²OH (R² = Me, Et, Pr, Me₂CH, Bu, Me₂CHCH₂, pentyl) to the reaction-mixture prior to H₂O yielded 13-76% RR¹CMeCH₂CO₂R².

Synthesis published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, SDS of cas: 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yadav, Kalpana published the artcileNano catalyzed Biginelli type reaction in green reaction media, HPLC of Formula: 30414-53-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2020), 59B(1), 102-109, database is CAplus.

Green chem. approach has been developed by using ionic liquid [MIM-H]CCl₃ (1-methyl-3-hydro-1H-imidazol-3-ium trichloromethanide) and TiO₂ nanoparticles (NPs) for the synthesis of 3,4-dihydropyrimidine-2(1H)-one (DHPMs) derivatives I (R¹ = Me, Et, n-Pr; R² = Me, Et, i-Pr, CH₂CH₂OMe; Ar = Ph, CH:CHC₆H₅, 5-Me-2-furyl).

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C7H8BNO4, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jassem, Ahmed M. published the artcileMicrowave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives, SDS of cas: 924-99-2, the publication is Medicinal Chemistry Research (2020), 29(6), 1067-1076, database is CAplus.

Abstract: In targeted therapy of breast cancer, human epidermal growth factor receptor 2 HER2 (PDB ID: 3PP0) is being considered as a promising route to design novel anti-breast cancer drugs. In this work, we report two of novel N-substituted pyrrolidine at C-8 position of quinolone derivatives 18 and 19, their synthesis under microwave technique, spectral methods, mol. docking study and anti-HIV activities. Docking study exhibited hydrogen bonding, polar, and Van der Waals interactions with the active site residues of HER2 target. The binding energy and hydrogen bonding interactions show that synthesized compounds are being considered to have a potential activity against breast cancer. In addition, quinolone derivatives were evaluated in vitro for antiviral activity against the replication of HIV-1 and HIV-2 in MT-4 cells. The results showed that quinolone derivatives 18 and 19 possess a potent activity against HIV-1 replication with IC₅₀ values of ≥15.20 and 14.26μM, SI ≤ 6 and >7, resp.

Medicinal Chemistry Research published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lin, Hongkun published the artcileA Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow, HPLC of Formula: 924-99-2, the publication is Angewandte Chemie, International Edition (2017), 56(30), 8870-8873, database is CAplus and MEDLINE.

Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chem. reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight-step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.

Angewandte Chemie, International Edition published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Wei published the artcileHighly Reactive Cyclic Carbonates with a Fused Ring toward Functionalizable and Recyclable Polycarbonates, Recommanded Product: Dimethyl fumarate, the publication is ACS Macro Letters (2022), 11(2), 173-178, database is CAplus and MEDLINE.

Monomer design plays an important role in the development of polymers with desired thermal properties and chem. recyclability. Here we prepared a class of seven-membered ring carbonates containing trans-cyclohexyl fused rings. These monomers showed excellent activity for ring-opening polymerization (ROP) with turnover frequency (TOF) up to 6 x 10⁵ h^-1 and catalyst loading down to 50 ppm, which yielded high-mol.-weight polycarbonates (M_n up to 673 kg/mol) with great thermostability (T_d > 300°C). Ultimately, the resulting polycarbonates can completely depolymerize into their corresponding cyclic dimers that can repolymerize to synthesize the starting polymers in moderate yields, demonstrating a potential route to achieve chem. recycling. Post-functionalization of the unsaturated polycarbonate was conducted through crosslinking reaction and “click” reaction under UV irradiation

ACS Macro Letters published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C8H7ClO3, Recommanded Product: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics